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Protein Page:
CK1E (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CK1E an ubiquitous protein kinase of the CK1 family. Together with Dvl-1 and Frat-1 activate the Wnt signaling pathway. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. May play a role in cell cycle progression. Two splice variant isoforms have been described. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CK1-D and/or CK1-E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with SOCS3. Mutations in hamster and Drosophila orthologs have circadian rhythm phenotypes, and the circadian gene period (per) is a substrate in both human and fly. A coding SNP variant in human, which increases CK1 activity, is negatively associated with circadian disorder. LOF mutations and LOH seen in mammary ductal carcinoma. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CK1; Kinase, protein; CK1 group; CK1 family
Reference #:  P49674 (UniProtKB)
Alt. Names/Synonyms: casein kinase 1, epsilon; Casein kinase I isoform epsilon; CKI-epsilon; CKIe; CSNK1E; HCKIE; KC1E; MGC10398
Gene Symbols: CSNK1E
Molecular weight: 47,315 Da
Basal Isoelectric point: 9.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CK1E

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
transcription, altered: S389‑p
enzymatic activity, induced: T44‑p
enzymatic activity, inhibited: S323‑p, T325‑p, T334‑p, T337‑p, S368‑p, S405‑p, T407‑p, S408‑p
protein degradation: S389‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S17-p RLGRKIGsGSFGDIY
1 0 T44-p IKLECVKtKHPQLHI
0 2 K140-ub NFLMGLGkKGNLVYI
0 1 K242-ac TPIEVLCkGYPSEFS
0 2 K263-ub RSLRFDDkPDYSYLR
2 3 S323-p RMGQLRGsAtRALPP
2 1 T325-p GQLRGsAtRALPPGP
2 0 T334-p ALPPGPPtGAtANRL
2 0 T337-p PGPPtGAtANRLRsA
0 4 S343-p AtANRLRsAAEPVAs
0 2 S350-p sAAEPVAstPAsRIQ
0 10 T351-p AAEPVAstPAsRIQP
0 5 S354-p PVAstPAsRIQPAGN
0 2 T362-p RIQPAGNtsPRAIsR
0 20 S363-p IQPAGNtsPRAIsRV
2 0 S368-p NtsPRAIsRVDRERK
0 6 S377-p VDRERKVsMRLHRGA
0 3 R382 KVsMRLHRGAPANVs
1 21 S389-p RGAPANVsssDLtGR
0 1 S390-p GAPANVsssDLtGRQ
0 5 S391-p APANVsssDLtGRQE
0 6 T394-p NVsssDLtGRQEVsR
0 1 S400-p LtGRQEVsRIPAsQt
2 10 S405-p EVsRIPAsQtsVPFD
2 2 T407-p sRIPAsQtsVPFDHL
2 18 S408-p RIPAsQtsVPFDHLG
  mouse

 
S17 RLGRKIGSGSFGDIY
T44 IKLECVKTKHPQLHI
K140-ub NFLMGLGkKGNLVYI
K242 TPIEVLCKGYPSEFS
K263-ub RSLRFDDkPDYSYLR
S323 RMGQLRGSATRALPP
T325 GQLRGSATRALPPGP
T334 ALPPGPPTGATANRL
T337 PGPPTGATANRLRSA
S343 ATANRLRSAAEPVAS
S350 SAAEPVASTPASRIQ
T351 AAEPVASTPASRIQQ
S354 PVASTPASRIQQTGN
T362 RIQQTGNTsPRAISR
S363-p IQQTGNTsPRAISRA
S368 NTsPRAISRADRERK
S377 ADRERKVSMRLHrGA
R382-m1 KVSMRLHrGAPANVs
S389-p rGAPANVsSSDLTGR
S390 GAPANVsSSDLTGRQ
S391 APANVsSSDLTGRQE
T394 NVsSSDLTGRQEVSR
S400 LTGRQEVSRLAAsQt
S405-p EVSRLAAsQtsVPFD
T407-p SRLAAsQtsVPFDHL
S408-p RLAAsQtsVPFDHLG
  rat

 
S17 RLGRKIGSGSFGDIY
T44 IKLECVKTKHPQLHI
K140 NFLMGLGKKGNLVYI
K242 TPIEVLCKGYPSEFS
K263 RSLRFDDKPDYSYLR
S323 RMGQLRGSATRALPP
T325 GQLRGSATRALPPGP
T334 ALPPGPPTGATANRL
T337 PGPPTGATANRLRSA
S343 ATANRLRSAAEPVAS
S350 SAAEPVASTPASRIQ
T351 AAEPVASTPASRIQQ
S354 PVASTPASRIQQAGN
T362 RIQQAGNTsPRAISR
S363-p IQQAGNTsPRAISRA
S368 NTsPRAISRADRERK
S377 ADRERKVSMRLHRGA
R382 KVSMRLHRGAPANVS
S389 RGAPANVSSSDLTGR
S390 GAPANVSSSDLTGRQ
S391 APANVSSSDLTGRQE
T394 NVSSSDLTGRQEVSR
S400 LTGRQEVSRIAASQT
S405 EVSRIAASQTSVPFD
T407 SRIAASQTSVPFDHL
S408 RIAASQTSVPFDHLG
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