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Protein Page:
TUBA1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TUBA1A Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Expressed at a high level in fetal brain. Belongs to the tubulin family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: microtubule; recycling endosome; cytoplasmic microtubule; nucleus; cytosol
Molecular Function: GTPase activity; protein domain specific binding; protein binding; GTP binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; organelle organization and biogenesis; mitotic cell cycle; cytoskeleton-dependent intracellular transport; G2/M transition of mitotic cell cycle; microtubule-based process
Disease: Lissencephaly 3
Reference #:  Q71U36 (UniProtKB)
Alt. Names/Synonyms: Alpha-tubulin 3; B-ALPHA-1; FLJ25113; hum-a-tub1; hum-a-tub2; LIS3; TBA1A; TUBA1A; TUBA3; Tubulin alpha-1A chain; Tubulin alpha-3 chain; Tubulin B-alpha-1; tubulin, alpha 1a; tubulin, alpha 3; tubulin, alpha, brain-specific
Gene Symbols: TUBA1A
Molecular weight: 50,136 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TUBA1A

Protein Structure Not Found.


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Sites Implicated In
acetylation: K40‑ac

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S38-p QPDGQMPsDktIGGG
17 14 K40-ac DGQMPsDktIGGGDD
0 10 K40-ub DGQMPsDktIGGGDD
0 5 T41-p GQMPsDktIGGGDDs
0 58 S48-p tIGGGDDsFNtFFsE
0 18 T51-p GGDDsFNtFFsETGA
0 15 S54-p DsFNtFFsETGAGkH
0 7 K60-ac FsETGAGkHVPRAVF
1 1 K60 FsETGAGKHVPRAVF
0 100 K60-ub FsETGAGkHVPRAVF
1 1 H61 sETGAGkHVPRAVFV
1 1 R64 GAGkHVPRAVFVDLE
1 1 R64 GAGkHVPRAVFVDLE
0 15 T73-p VFVDLEPtVIDEVRt
0 14 T80-p tVIDEVRtGtYRQLF
0 61 T82-p IDEVRtGtYRQLFHP
0 6 K96-ac PEQLITGkEDAANNy
0 139 K96-ub PEQLITGkEDAANNy
0 519 Y103-p kEDAANNyARGHytI
0 45 Y108-p NNyARGHytIGkEII
0 6 T109-p NyARGHytIGkEIID
0 8 K112-ac RGHytIGkEIIDLVL
0 98 K112-ub RGHytIGkEIIDLVL
0 4 K124-ac LVLDRIRkLADQCTG
0 24 K124-ub LVLDRIRkLADQCTG
0 7 S158-p SLLMERLsVDyGkkS
0 55 Y161-p MERLsVDyGkkSkLE
0 25 K163-ac RLsVDyGkkSkLEFS
0 84 K163-ub RLsVDyGkkSkLEFS
0 28 K164-ub LsVDyGkkSkLEFSI
0 22 K166-ub VDyGkkSkLEFSIYP
0 394 Y210-p MVDNEAIyDICRRNL
0 34 T223-p NLDIERPtytNLNRL
0 204 Y224-p LDIERPtytNLNRLI
0 4 T225-p DIERPtytNLNRLIG
0 3 S237-p LIGQIVSsITASLRF
0 371 Y272-p IHFPLATyAPVIsAE
0 19 S277-p ATyAPVIsAEkAyHE
0 12 K280-ub APVIsAEkAyHEQLs
0 77 Y282-p VIsAEkAyHEQLsVA
0 41 S287-p kAyHEQLsVAEITNA
0 90 K304-ub EPANQMVkCDPRHGk
0 11 K311-ac kCDPRHGkyMACCLL
0 76 K311-ub kCDPRHGkyMACCLL
0 73 Y312-p CDPRHGkyMACCLLy
0 171 Y319-p yMACCLLyRGDVVPk
0 6 K326-ac yRGDVVPkDVNAAIA
0 116 K326-ub yRGDVVPkDVNAAIA
0 24 T334-p DVNAAIAtIktkRtI
0 3 K336-ac NAAIAtIktkRtIQF
0 129 K336-ub NAAIAtIktkRtIQF
0 21 T337-p AAIAtIktkRtIQFV
0 34 K338-ub AIAtIktkRtIQFVD
0 3 T340-p AtIktkRtIQFVDWC
0 15 K352-ac DWCPTGFkVGINyQP
0 29 K352-ub DWCPTGFkVGINyQP
0 582 Y357-p GFkVGINyQPPtVVP
0 93 T361-p GINyQPPtVVPGGDL
0 2 K370-ac VPGGDLAkVQRAVCM
0 162 K370-ub VPGGDLAkVQRAVCM
0 11 K394-ac AWARLDHkFDLMyAk
0 119 K394-ub AWARLDHkFDLMyAk
0 381 Y399-p DHkFDLMyAkRAFVH
0 15 K401-ac kFDLMyAkRAFVHWY
0 114 K401-ub kFDLMyAkRAFVHWY
0 151 Y432-p MAALEKDyEEVGVDs
0 67 S439-p yEEVGVDsVEGEGEE
0 141 Y451-p GEEEGEEy_______
5335 : Acetyl-alpha-Tubulin (Lys40) (D20G3) XP(R) Rabbit mAb
14652 : Acetyl-alpha-Tubulin (Lys40) (D20G3) XP(R) Rabbit mAb (HRP Conjugate)
  mouse

 
S38 QPDGQMPSDktIGGG
K40-ac DGQMPSDktIGGGDD
K40-ub DGQMPSDktIGGGDD
T41-p GQMPSDktIGGGDDs
S48-p tIGGGDDsFNtFFSE
T51-p GGDDsFNtFFSETGA
S54 DsFNtFFSETGAGkH
K60-ac FSETGAGkHVPRAVF
K60 FSETGAGKHVPRAVF
K60-ub FSETGAGkHVPRAVF
H61 SETGAGkHVPRAVFV
R64 GAGkHVPRAVFVDLE
R64 GAGkHVPRAVFVDLE
T73-p VFVDLEPtVIDEVRT
T80 tVIDEVRTGtYRQLF
T82-p IDEVRTGtYRQLFHP
K96 PEQLITGKEDAANNy
K96-ub PEQLITGkEDAANNy
Y103-p kEDAANNyARGHYtI
Y108 NNyARGHYtIGkEII
T109-p NyARGHYtIGkEIID
K112 RGHYtIGKEIIDLVL
K112-ub RGHYtIGkEIIDLVL
K124-ac LVLDRIRkLADQCTG
K124 LVLDRIRKLADQCTG
S158-p SLLMERLsVDyGkkS
Y161-p MERLsVDyGkkSkLE
K163-ac RLsVDyGkkSkLEFS
K163-ub RLsVDyGkkSkLEFS
K164-ub LsVDyGkkSkLEFSI
K166-ub VDyGkkSkLEFSIYP
Y210-p MVDNEAIyDICRRNL
T223-p NLDIERPtytNLNRL
Y224-p LDIERPtytNLNRLI
T225-p DIERPtytNLNRLIG
S237-p LIGQIVSsITASLRF
Y272-p IHFPLATyAPVIsAE
S277-p ATyAPVIsAEkAYHE
K280-ub APVIsAEkAYHEQLS
Y282 VIsAEkAYHEQLSVA
S287 kAYHEQLSVAEITNA
K304-ub EPANQMVkCDPRHGk
K311 kCDPRHGKYMACCLL
K311-ub kCDPRHGkYMACCLL
Y312 CDPRHGkYMACCLLy
Y319-p YMACCLLyRGDVVPk
K326 yRGDVVPKDVNAAIA
K326-ub yRGDVVPkDVNAAIA
T334-p DVNAAIAtIktkRtI
K336 NAAIAtIKtkRtIQF
K336-ub NAAIAtIktkRtIQF
T337-p AAIAtIktkRtIQFV
K338-ub AIAtIktkRtIQFVD
T340-p AtIktkRtIQFVDWC
K352-ac DWCPTGFkVGINyQP
K352-ub DWCPTGFkVGINyQP
Y357-p GFkVGINyQPPtVVP
T361-p GINyQPPtVVPGGDL
K370 VPGGDLAKVQRAVCM
K370-ub VPGGDLAkVQRAVCM
K394 AWARLDHKFDLMyAk
K394-ub AWARLDHkFDLMyAk
Y399-p DHkFDLMyAkRAFVH
K401-ac kFDLMyAkRAFVHWY
K401-ub kFDLMyAkRAFVHWY
Y432-p MAALEKDyEEVGVDs
S439-p yEEVGVDsVEGEGEE
Y451-p GEEEGEEy_______
5335 : Acetyl-alpha-Tubulin (Lys40) (D20G3) XP(R) Rabbit mAb
14652 : Acetyl-alpha-Tubulin (Lys40) (D20G3) XP(R) Rabbit mAb (HRP Conjugate)
  rat

 
S38 QPDGQMPSDkTIGGG
K40-ac DGQMPSDkTIGGGDD
K40 DGQMPSDKTIGGGDD
T41 GQMPSDkTIGGGDDs
S48-p TIGGGDDsFNTFFSE
T51 GGDDsFNTFFSETGA
S54 DsFNTFFSETGAGkh
K60-ac FSETGAGkhVPrAVF
K60-m2 FSETGAGkhVPrAVF
K60-ub FSETGAGkhVPrAVF
H61-m1 SETGAGkhVPrAVFV
R64-m1 GAGkhVPrAVFVDLE
R64-m2 GAGkhVPrAVFVDLE
T73 VFVDLEPTVIDEVRT
T80 TVIDEVRTGTYRQLF
T82 IDEVRTGTYRQLFHP
K96-ac PEQLITGkEDAANNy
K96-ub PEQLITGkEDAANNy
Y103-p kEDAANNyARGHYTI
Y108 NNyARGHYTIGKEII
T109 NyARGHYTIGKEIID
K112 RGHYTIGKEIIDLVL
K112 RGHYTIGKEIIDLVL
K124 LVLDRIRKLADQCTG
K124 LVLDRIRKLADQCTG
S158-p SLLMERLsVDYGkkS
Y161 MERLsVDYGkkSKLE
K163-ac RLsVDYGkkSKLEFS
K163-ub RLsVDYGkkSKLEFS
K164-ub LsVDYGkkSKLEFSI
K166 VDYGkkSKLEFSIYP
Y210-p MVDNEAIyDICRRNL
T223 NLDIERPTytNLNRL
Y224-p LDIERPTytNLNRLI
T225-p DIERPTytNLNRLIG
S237 LIGQIVSSITASLRF
Y272-p IHFPLATyAPVISAE
S277 ATyAPVISAEKAyHE
K280 APVISAEKAyHEQLS
Y282-p VISAEKAyHEQLSVA
S287 KAyHEQLSVAEITNA
K304-ub EPANQMVkCDPRHGk
K311 kCDPRHGKyMACCLL
K311-ub kCDPRHGkyMACCLL
Y312-p CDPRHGkyMACCLLy
Y319-p yMACCLLyRGDVVPk
K326-ac yRGDVVPkDVNAAIA
K326-ub yRGDVVPkDVNAAIA
T334-p DVNAAIAtIkTkRTI
K336-ac NAAIAtIkTkRTIQF
K336-ub NAAIAtIkTkRTIQF
T337 AAIAtIkTkRTIQFV
K338-ub AIAtIkTkRTIQFVD
T340 AtIkTkRTIQFVDWC
K352 DWCPTGFKVGINyQP
K352-ub DWCPTGFkVGINyQP
Y357-p GFkVGINyQPPtVVP
T361-p GINyQPPtVVPGGDL
K370-ac VPGGDLAkVQRAVCM
K370-ub VPGGDLAkVQRAVCM
K394-ac AWARLDHkFDLMyAk
K394-ub AWARLDHkFDLMyAk
Y399-p DHkFDLMyAkRAFVH
K401-ac kFDLMyAkRAFVHWY
K401-ub kFDLMyAkRAFVHWY
Y432 MAALEKDYEEVGVDs
S439-p YEEVGVDsVEGEGEE
Y451 GEEEGEEY_______
5335 : Acetyl-alpha-Tubulin (Lys40) (D20G3) XP(R) Rabbit mAb
14652 : Acetyl-alpha-Tubulin (Lys40) (D20G3) XP(R) Rabbit mAb (HRP Conjugate)
  cow

 
S38 QPDGQMPSDkTIGGG
K40-ac DGQMPSDkTIGGGDD
K40 DGQMPSDKTIGGGDD
T41 GQMPSDkTIGGGDDS
S48 TIGGGDDSFNTFFSE
T51 GGDDSFNTFFSETGA
S54 DSFNTFFSETGAGKH
K60 FSETGAGKHVPRAVF
K60 FSETGAGKHVPRAVF
K60 FSETGAGKHVPRAVF
H61 SETGAGKHVPRAVFV
R64 GAGKHVPRAVFVDLE
R64 GAGKHVPRAVFVDLE
T73 VFVDLEPTVIDEVRT
T80 TVIDEVRTGTYRQLF
T82 IDEVRTGTYRQLFHP
K96 PEQLITGKEDAANNy
K96 PEQLITGKEDAANNy
Y103-p KEDAANNyARGHYTI
Y108 NNyARGHYTIGKEII
T109 NyARGHYTIGKEIID
K112 RGHYTIGKEIIDLVL
K112 RGHYTIGKEIIDLVL
K124 LVLDRIRKLADQCTG
K124 LVLDRIRKLADQCTG
S158 SLLMERLSVDYGKKS
Y161 MERLSVDYGKKSKLE
K163 RLSVDYGKKSKLEFS
K163 RLSVDYGKKSKLEFS
K164 LSVDYGKKSKLEFSI
K166 VDYGKKSKLEFSIYP
Y210 MVDNEAIYDICRRNL
T223 NLDIERPTYTNLNRL
Y224 LDIERPTYTNLNRLI
T225 DIERPTYTNLNRLIS
S237 LISQIVSSITASLRF
Y272 IHFPLATYAPVISAE
S277 ATYAPVISAEKAYHE
K280 APVISAEKAYHEQLS
Y282 VISAEKAYHEQLSVA
S287 KAYHEQLSVAEITNA
K304 EPANQMVKCDPRHGK
K311 KCDPRHGKYMACCLL
K311 KCDPRHGKYMACCLL
Y312 CDPRHGKYMACCLLY
Y319 YMACCLLYRGDVVPK
K326 YRGDVVPKDVNAAIA
K326 YRGDVVPKDVNAAIA
T334 DVNAAIATIKTKRSI
K336 NAAIATIKTKRSIQF
K336 NAAIATIKTKRSIQF
T337 AAIATIKTKRSIQFV
K338 AIATIKTKRSIQFVD
S340 ATIKTKRSIQFVDWC
K352 DWCPTGFKVGINYQP
K352 DWCPTGFKVGINYQP
Y357 GFKVGINYQPPTVVP
T361 GINYQPPTVVPGGDL
K370 VPGGDLAKVQRAVCM
K370 VPGGDLAKVQRAVCM
K394 AWARLDHKFDLMYAK
K394 AWARLDHKFDLMYAK
Y399 DHKFDLMYAKRAFVH
K401 KFDLMYAKRAFVHWY
K401 KFDLMYAKRAFVHWY
Y432 MAALEKDYEEVGVDS
S439 YEEVGVDSVEGEGEE
Y451 GEEEGEEY_______
5335 : Acetyl-alpha-Tubulin (Lys40) (D20G3) XP(R) Rabbit mAb
14652 : Acetyl-alpha-Tubulin (Lys40) (D20G3) XP(R) Rabbit mAb (HRP Conjugate)
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