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TUBA1A (human)

Overview TUBA1A Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Expressed at a high level in fetal brain. Belongs to the tubulin family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: microtubule cytoskeleton; microtubule; cytoplasmic microtubule; cytosol Molecular Function: GTPase activity; protein domain specific binding; GTP binding; structural molecule activity Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; mitotic cell cycle; cytoskeleton-dependent intracellular transport; G2/M transition of mitotic cell cycle; microtubule-based movement; microtubule-based process Reference #:  Q71U36 (UniProtKB) Alt. Names/Synonyms: Alpha-tubulin 3; B-ALPHA-1; FLJ25113; hum-a-tub1; hum-a-tub2; LIS3; TBA1A; TUBA1A; TUBA3; Tubulin alpha-1A chain; Tubulin alpha-3 chain; Tubulin B-alpha-1; tubulin, alpha 1a; tubulin, alpha 3; tubulin, alpha, brain-specific Gene Symbols: TUBA1A Molecular weight: 50,136 Da Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TUBA1A 3J2U - A/C=1-451 (cow) 4I4T - A/C=1-450 (cow) 4I50 - A/C=1-451 (cow) 4I55 - A/C=1-450 (cow) 4IHJ - A/C=1-450 (cow) 4IIJ - A/C=1-451 (cow)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 602529 611603  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
10	13		K40-a	DGQMPSDktIGGGDD
0	10		K40-u	DGQMPSDktIGGGDD
0	2		T41-p	GQMPSDktIGGGDDs
0	43		S48-p	tIGGGDDsFNtFFSE
0	14		T51-p	GGDDsFNtFFSETGA
0	5		K60-a	FSETGAGkHVPRAVF
1	1		K60	FSETGAGKHVPRAVF
0	101		K60-u	FSETGAGkHVPRAVF
1	1		H61	SETGAGkHVPRAVFV
1	1		R64	GAGkHVPRAVFVDLE
1	1		R64	GAGkHVPRAVFVDLE
0	11		T73-p	VFVDLEPtVIDEVRt
0	13		T80-p	tVIDEVRtGtYRQLF
0	60		T82-p	IDEVRtGtYRQLFHP
0	4		K96-a	PEQLITGkEDAANNy
0	140		K96-u	PEQLITGkEDAANNy
0	508		Y103-p	kEDAANNyARGHytI
0	37		Y108-p	NNyARGHytIGkEII
0	6		T109-p	NyARGHytIGkEIID
0	7		K112-a	RGHytIGkEIIDLVL
0	99		K112-u	RGHytIGkEIIDLVL
0	4		K124-a	LVLDRIRkLADQCTG
0	24		K124-u	LVLDRIRkLADQCTG
0	4		S158-p	SLLMERLsVDyGkkS
0	50		Y161-p	MERLsVDyGkkSkLE
0	24		K163-a	RLsVDyGkkSkLEFS
0	84		K163-u	RLsVDyGkkSkLEFS
0	28		K164-u	LsVDyGkkSkLEFSI
0	22		K166-u	VDyGkkSkLEFSIYP
0	382		Y210-p	MVDNEAIyDICRRNL
0	33		T223-p	NLDIERPtytNLNRL
0	202		Y224-p	LDIERPtytNLNRLI
0	2		T225-p	DIERPtytNLNRLIG
0	3		S237-p	LIGQIVSsITASLRF
0	24		T271-p	RIHFPLAtyAPVIsA
0	368		Y272-p	IHFPLAtyAPVIsAE
0	16		S277-p	AtyAPVIsAEkAyHE
0	12		K280-u	APVIsAEkAyHEQLs
0	69		Y282-p	VIsAEkAyHEQLsVA
0	37		S287-p	kAyHEQLsVAEITNA
0	91		K304-u	EPANQMVkCDPRHGk
0	10		K311-a	kCDPRHGkyMACCLL
0	77		K311-u	kCDPRHGkyMACCLL
0	67		Y312-p	CDPRHGkyMACCLLy
0	166		Y319-p	yMACCLLyRGDVVPk
0	4		K326-a	yRGDVVPkDVNAAIA
0	117		K326-u	yRGDVVPkDVNAAIA
0	13		T334-p	DVNAAIAtIktkRTI
0	1		K336	NAAIAtIKtkRTIQF
0	130		K336-u	NAAIAtIktkRTIQF
0	17		T337-p	AAIAtIktkRTIQFV
0	34		K338-u	AIAtIktkRTIQFVD
0	15		K352-a	DWCPTGFkVGINyQP
0	29		K352-u	DWCPTGFkVGINyQP
0	565		Y357-p	GFkVGINyQPPtVVP
0	82		T361-p	GINyQPPtVVPGGDL
0	163		K370-u	VPGGDLAkVQRAVCM
0	9		K394-a	AWARLDHkFDLMyAk
0	119		K394-u	AWARLDHkFDLMyAk
0	379		Y399-p	DHkFDLMyAkRAFVH
0	14		K401-a	kFDLMyAkRAFVHWY
0	115		K401-u	kFDLMyAkRAFVHWY
0	150		Y432-p	MAALEKDyEEVGVDs
0	61		S439-p	yEEVGVDsVEGEGEE
0	152		Y451-p	GEEEGEEy_______

	mouse
K40-a	DGQMPSDktIGGGDD
K40-u	DGQMPSDktIGGGDD
T41-p	GQMPSDktIGGGDDs
S48-p	tIGGGDDsFNtFFSE
T51-p	GGDDsFNtFFSETGA
K60-a	FSETGAGkHVPRAVF
K60	FSETGAGKHVPRAVF
K60-u	FSETGAGkHVPRAVF
H61	SETGAGkHVPRAVFV
R64	GAGkHVPRAVFVDLE
R64	GAGkHVPRAVFVDLE
T73-p	VFVDLEPtVIDEVRT
T80	tVIDEVRTGtYRQLF
T82-p	IDEVRTGtYRQLFHP
K96	PEQLITGKEDAANNy
K96-u	PEQLITGkEDAANNy
Y103-p	kEDAANNyARGHYtI
Y108	NNyARGHYtIGkEII
T109-p	NyARGHYtIGkEIID
K112	RGHYtIGKEIIDLVL
K112-u	RGHYtIGkEIIDLVL
K124-a	LVLDRIRkLADQCTG
K124	LVLDRIRKLADQCTG
S158-p	SLLMERLsVDyGkkS
Y161-p	MERLsVDyGkkSkLE
K163-a	RLsVDyGkkSkLEFS
K163-u	RLsVDyGkkSkLEFS
K164-u	LsVDyGkkSkLEFSI
K166-u	VDyGkkSkLEFSIYP
Y210-p	MVDNEAIyDICRRNL
T223-p	NLDIERPtytNLNRL
Y224-p	LDIERPtytNLNRLI
T225-p	DIERPtytNLNRLIG
S237-p	LIGQIVSsITASLRF
T271	RIHFPLATyAPVIsA
Y272-p	IHFPLATyAPVIsAE
S277-p	ATyAPVIsAEkAYHE
K280-u	APVIsAEkAYHEQLS
Y282	VIsAEkAYHEQLSVA
S287	kAYHEQLSVAEITNA
K304-u	EPANQMVkCDPRHGk
K311	kCDPRHGKYMACCLL
K311-u	kCDPRHGkYMACCLL
Y312	CDPRHGkYMACCLLy
Y319-p	YMACCLLyRGDVVPk
K326	yRGDVVPKDVNAAIA
K326-u	yRGDVVPkDVNAAIA
T334-p	DVNAAIAtIktkRTI
K336	NAAIAtIKtkRTIQF
K336-u	NAAIAtIktkRTIQF
T337-p	AAIAtIktkRTIQFV
K338-u	AIAtIktkRTIQFVD
K352-a	DWCPTGFkVGINyQP
K352-u	DWCPTGFkVGINyQP
Y357-p	GFkVGINyQPPtVVP
T361-p	GINyQPPtVVPGGDL
K370-u	VPGGDLAkVQRAVCM
K394	AWARLDHKFDLMyAk
K394-u	AWARLDHkFDLMyAk
Y399-p	DHkFDLMyAkRAFVH
K401-a	kFDLMyAkRAFVHWY
K401-u	kFDLMyAkRAFVHWY
Y432-p	MAALEKDyEEVGVDs
S439-p	yEEVGVDsVEGEGEE
Y451-p	GEEEGEEy_______

	rat
K40	DGQMPSDKTIGGGDD
K40	DGQMPSDKTIGGGDD
T41	GQMPSDKTIGGGDDS
S48	TIGGGDDSFNTFFSE
T51	GGDDSFNTFFSETGA
K60	FSETGAGKhVPrAVF
K60-m2	FSETGAGkhVPrAVF
K60-u	FSETGAGkhVPrAVF
H61-m1	SETGAGkhVPrAVFV
R64-m1	GAGkhVPrAVFVDLE
R64-m2	GAGkhVPrAVFVDLE
T73	VFVDLEPTVIDEVRT
T80	TVIDEVRTGTYRQLF
T82	IDEVRTGTYRQLFHP
K96	PEQLITGKEDAANNy
K96-u	PEQLITGkEDAANNy
Y103-p	kEDAANNyARGHYTI
Y108	NNyARGHYTIGKEII
T109	NyARGHYTIGKEIID
K112	RGHYTIGKEIIDLVL
K112	RGHYTIGKEIIDLVL
K124	LVLDRIRKLADQCTG
K124	LVLDRIRKLADQCTG
S158	SLLMERLSVDYGkkS
Y161	MERLSVDYGkkSKLE
K163-a	RLSVDYGkkSKLEFS
K163-u	RLSVDYGkkSKLEFS
K164-u	LSVDYGkkSKLEFSI
K166	VDYGkkSKLEFSIYP
Y210	MVDNEAIYDICRRNL
T223	NLDIERPTyTNLNRL
Y224-p	LDIERPTyTNLNRLI
T225	DIERPTyTNLNRLIG
S237	LIGQIVSSITASLRF
T271	RIHFPLATyAPVISA
Y272-p	IHFPLATyAPVISAE
S277	ATyAPVISAEKAyHE
K280	APVISAEKAyHEQLS
Y282-p	VISAEKAyHEQLSVA
S287	KAyHEQLSVAEITNA
K304-u	EPANQMVkCDPRHGk
K311	kCDPRHGKyMACCLL
K311-u	kCDPRHGkyMACCLL
Y312-p	CDPRHGkyMACCLLy
Y319-p	yMACCLLyRGDVVPk
K326	yRGDVVPKDVNAAIA
K326-u	yRGDVVPkDVNAAIA
T334-p	DVNAAIAtIkTkRTI
K336-a	NAAIAtIkTkRTIQF
K336-u	NAAIAtIkTkRTIQF
T337	AAIAtIkTkRTIQFV
K338-u	AIAtIkTkRTIQFVD
K352	DWCPTGFKVGINyQP
K352-u	DWCPTGFkVGINyQP
Y357-p	GFkVGINyQPPTVVP
T361	GINyQPPTVVPGGDL
K370-u	VPGGDLAkVQRAVCM
K394-a	AWARLDHkFDLMyAk
K394-u	AWARLDHkFDLMyAk
Y399-p	DHkFDLMyAkRAFVH
K401-a	kFDLMyAkRAFVHWY
K401-u	kFDLMyAkRAFVHWY
Y432	MAALEKDYEEVGVDS
S439	YEEVGVDSVEGEGEE
Y451	GEEEGEEY_______

	cow
K40	DGQMPSDKTIGGGDD
K40	DGQMPSDKTIGGGDD
T41	GQMPSDKTIGGGDDS
S48	TIGGGDDSFNTFFSE
T51	GGDDSFNTFFSETGA
K60	FSETGAGKHVPRAVF
K60	FSETGAGKHVPRAVF
K60	FSETGAGKHVPRAVF
H61	SETGAGKHVPRAVFV
R64	GAGKHVPRAVFVDLE
R64	GAGKHVPRAVFVDLE
T73	VFVDLEPTVIDEVRT
T80	TVIDEVRTGTYRQLF
T82	IDEVRTGTYRQLFHP
K96	PEQLITGKEDAANNY
K96	PEQLITGKEDAANNY
Y103	KEDAANNYARGHYTI
Y108	NNYARGHYTIGKEII
T109	NYARGHYTIGKEIID
K112	RGHYTIGKEIIDLVL
K112	RGHYTIGKEIIDLVL
K124	LVLDRIRKLADQCTG
K124	LVLDRIRKLADQCTG
S158	SLLMERLSVDYGKKS
Y161	MERLSVDYGKKSKLE
K163	RLSVDYGKKSKLEFS
K163	RLSVDYGKKSKLEFS
K164	LSVDYGKKSKLEFSI
K166	VDYGKKSKLEFSIYP
Y210	MVDNEAIYDICRRNL
T223	NLDIERPTYTNLNRL
Y224	LDIERPTYTNLNRLI
T225	DIERPTYTNLNRLIS
S237	LISQIVSSITASLRF
T271	RIHFPLATYAPVISA
Y272	IHFPLATYAPVISAE
S277	ATYAPVISAEKAYHE
K280	APVISAEKAYHEQLS
Y282	VISAEKAYHEQLSVA
S287	KAYHEQLSVAEITNA
K304	EPANQMVKCDPRHGK
K311	KCDPRHGKYMACCLL
K311	KCDPRHGKYMACCLL
Y312	CDPRHGKYMACCLLY
Y319	YMACCLLYRGDVVPK
K326	YRGDVVPKDVNAAIA
K326	YRGDVVPKDVNAAIA
T334	DVNAAIATIKTKRSI
K336	NAAIATIKTKRSIQF
K336	NAAIATIKTKRSIQF
T337	AAIATIKTKRSIQFV
K338	AIATIKTKRSIQFVD
K352	DWCPTGFKVGINYQP
K352	DWCPTGFKVGINYQP
Y357	GFKVGINYQPPTVVP
T361	GINYQPPTVVPGGDL
K370	VPGGDLAKVQRAVCM
K394	AWARLDHKFDLMYAK
K394	AWARLDHKFDLMYAK
Y399	DHKFDLMYAKRAFVH
K401	KFDLMYAKRAFVHWY
K401	KFDLMYAKRAFVHWY
Y432	MAALEKDYEEVGVDS
S439	YEEVGVDSVEGEGEE
Y451	GEEEGEEY_______

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