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Protein Page:
CK1D (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CK1D an ubiquitous protein kinase of the CK1 family. Enriched at the centrosomes in interphase and at the spindle during mitosis. May play a role in cell cycle progression. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.26; Kinase, protein; EC 2.7.11.1; Protein kinase, CK1; CK1 group; CK1 family
Cellular Component: Golgi apparatus; centrosome; spindle microtubule; perinuclear region of cytoplasm; plasma membrane; spindle; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; phosphoprotein binding; glycoprotein binding; peptide binding; ATP binding; protein kinase activity
Biological Process: Wnt receptor signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; circadian regulation of gene expression; spindle assembly; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; G2/M transition of mitotic cell cycle; DNA repair; signal transduction; regulation of circadian rhythm; protein amino acid phosphorylation
Reference #:  P48730 (UniProtKB)
Alt. Names/Synonyms: casein kinase 1, delta; Casein kinase I isoform delta; CKI-delta; CKId; CSNK1D; HCKID; KC1D
Gene Symbols: CSNK1D
Molecular weight: 47,330 Da
Basal Isoelectric point: 9.77  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CK1D

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K57 HIESKIYKMMQGGVG
0 2 K140-ub NFLMGLGkKGNLVYI
0 1 K242-ac TPIEVLCkGYPSEFA
0 2 K263-ub RSLRFDDkPDYSYLR
1 7 S328-p PATRGLPstAsGRLR
0 1 T329-p ATRGLPstAsGRLRG
1 14 S331-p RGLPstAsGRLRGTQ
0 5 T344-p TQEVAPPtPLtPtsH
0 10 T347-p VAPPtPLtPtsHTAN
0 2 T349-p PPtPLtPtsHTANts
0 3 S350-p PtPLtPtsHTANtsP
0 3 T355-p PtsHTANtsPRPVsG
0 5 S356-p tsHTANtsPRPVsGM
0 3 S361-p NtsPRPVsGMERERK
2 0 S370 MERERKVSMRLHRGA
0 1 R375 KVSMRLHRGAPVNIs
0 22 S382-p RGAPVNIsssDLtGR
0 8 S383-p GAPVNIsssDLtGRQ
0 11 S384-p APVNIsssDLtGRQD
0 2 T387-p NIsssDLtGRQDTSR
0 3 S396-p RQDTSRMsTsQIPGR
1 4 T397 QDTSRMsTsQIPGRV
0 4 S398-p DTSRMsTsQIPGRVA
0 8 - gap
0 2 S406-p QIPGRVAssGLQsVV
0 2 S407-p IPGRVAssGLQsVVH
0 1 S411-p VAssGLQsVVHR___
  CK1D iso2  
K57 HIESKIYKMMQGGVG
K140 NFLMGLGKKGNLVYI
K242 TPIEVLCKGYPSEFA
K263 RSLRFDDKPDYSYLR
S328 PATRGLPSTASGRLR
T329 ATRGLPSTASGRLRG
S331 RGLPSTASGRLRGTQ
T344 TQEVAPPTPLTPTSH
T347 VAPPTPLTPTSHTAN
T349 PPTPLTPTSHTANTS
S350 PTPLTPTSHTANTSP
T355 PTSHTANTSPRPVSG
S356 TSHTANTSPRPVSGM
S361 NTSPRPVSGMERERK
S370 MERERKVSMRLHRGA
R375 KVSMRLHRGAPVNIS
S382 RGAPVNISSSDLTGR
S383 GAPVNISSSDLTGRQ
S384 APVNISSSDLTGRQD
T387 NISSSDLTGRQDTSR
S396-p RQDTSRMstsQNsIP
T397-p QDTSRMstsQNsIPF
S398-p DTSRMstsQNsIPFE
S401-p RMstsQNsIPFEHHG
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
K57-ub HIESKIYkMMQGGVG
K140-ub NFLMGLGkKGNLVYI
K242 TPIEVLCKGYPSEFA
K263-ub RSLRFDDkPDYSYLR
S328-p PATRGLPsTAsGRLR
T329 ATRGLPsTAsGRLRG
S331-p RGLPsTAsGRLRGTQ
T344-p TQEVAPPtPLtPTSH
T347-p VAPPtPLtPTSHTAN
T349 PPtPLtPTSHTANts
S350 PtPLtPTSHTANtsP
T355-p PTSHTANtsPRPVsG
S356-p TSHTANtsPRPVsGM
S361-p NtsPRPVsGMERERK
S370 MERERKVSMRLHrGA
R375-m1 KVSMRLHrGAPVNVs
S382-p rGAPVNVsssDLTGR
S383-p GAPVNVsssDLTGRQ
S384-p APVNVsssDLTGRQD
T387 NVsssDLTGRQDTSR
S396 RQDTSRMSTSQIPGR
T397 QDTSRMSTSQIPGRV
S398 DTSRMSTSQIPGRVA
- gap
S406 QIPGRVASSGLQSVV
S407 IPGRVASSGLQSVVH
S411 VASSGLQSVVHR___
  CK1D iso2  
K57 HIESKIYKMMQGGVG
K140 NFLMGLGKKGNLVYI
K242 TPIEVLCKGYPSEFA
K263 RSLRFDDKPDYSYLR
S328 PATRGLPSTASGRLR
T329 ATRGLPSTASGRLRG
S331 RGLPSTASGRLRGTQ
T344 TQEVAPPTPLTPTSH
T347 VAPPTPLTPTSHTAN
T349 PPTPLTPTSHTANTS
S350 PTPLTPTSHTANTSP
T355 PTSHTANTSPRPVSG
S356 TSHTANTSPRPVSGM
S361 NTSPRPVSGMERERK
S370 MERERKVSMRLHRGA
R375 KVSMRLHRGAPVNVS
S382 RGAPVNVSSSDLTGR
S383 GAPVNVSSSDLTGRQ
S384 APVNVSSSDLTGRQD
T387 NVSSSDLTGRQDTSR
S396 RQDTSRMSTSQNsIP
T397 QDTSRMSTSQNsIPF
S398 DTSRMSTSQNsIPFE
S401-p RMSTSQNsIPFEHHG
- gap
- gap
- gap
  rat

 
K57 HIESKIYKMMQGGVG
K140 NFLMGLGKKGNLVYI
K242 TPIEVLCKGYPSEFA
K263 RSLRFDDKPDYSYLR
S328-p PATRGLPsTAsGRLR
T329 ATRGLPsTAsGRLRG
S331-p RGLPsTAsGRLRGTQ
T344 TQEVAPPTPLTPTSH
T347 VAPPTPLTPTSHTAN
T349 PPTPLTPTSHTANTS
S350 PTPLTPTSHTANTSP
T355 PTSHTANTSPRPVSG
S356 TSHTANTSPRPVSGM
S361 NTSPRPVSGMERERK
S370-p MERERKVsMRLHRGA
R375 KVsMRLHRGAPVNVs
S382-p RGAPVNVsSSDLTGR
S383 GAPVNVsSSDLTGRQ
S384 APVNVsSSDLTGRQD
T387 NVsSSDLTGRQDTSR
S396 RQDTSRMStSQIPGR
T397-p QDTSRMStSQIPGRV
S398 DTSRMStSQIPGRVA
- gap
S406 QIPGRVASSGLQSVV
S407 IPGRVASSGLQSVVH
S411 VASSGLQSVVHR___
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