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Protein Page:
DSG2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DSG2 Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Calcium-binding protein; Cell adhesion
Cellular Component: desmosome; apical plasma membrane; integral to membrane; plasma membrane; intercellular junction; lateral plasma membrane
Molecular Function: calcium ion binding
Biological Process: maternal process involved in pregnancy; apoptosis; cell adhesion; homophilic cell adhesion; response to progesterone stimulus; cell structure disassembly during apoptosis
Reference #:  Q14126 (UniProtKB)
Alt. Names/Synonyms: ARVC10; ARVD10; Cadherin family member 5; CDHF5; CMD1BB; desmoglein 2; Desmoglein-2; DSG2; HDGC; MGC117034; MGC117036; MGC117037
Gene Symbols: DSG2
Molecular weight: 122,294 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DSG2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y207-p IVSLEPAyPPVFyLN
0 1 Y212-p PAyPPVFyLNKDTGE
0 1 Y221-p NKDTGEIyTTSVTLD
0 2 Y235-p DREEHSSyTLTVEAR
0 3 S551-p WKIARQEstSVLLQQ
0 1 T552-p KIARQEstSVLLQQS
0 1 K561-u VLLQQSEkKLGRSEI
0 1 T645-p GKGAKGFtPIPGtIE
0 1 T650-p GFtPIPGtIEMLHPW
0 1 K667-u EGAPPEDkVVPSFLP
0 107 S680-p LPVDQGGsLVGRNGV
0 1 K692 NGVGGMAKEAtMkGs
0 4 T695-p GGMAKEAtMkGsssA
0 2 K697-u MAKEAtMkGsssAsI
0 1 S699-p KEAtMkGsssAsIVk
0 1 S700-p EAtMkGsssAsIVkG
0 2 S701-p AtMkGsssAsIVkGQ
0 3 S703-p MkGsssAsIVkGQHE
0 3 K706-u sssAsIVkGQHEMsE
0 2 S712-p VkGQHEMsEMDGRWE
0 4 S723-p GRWEEHRsLLsGRAT
0 2 S726-p EEHRsLLsGRATQFT
0 1 A735 RATQFTGATGAIMTT
0 4 K746-u IMTTETTkTARATGA
0 2 Y775-p NEEFLRNyFTDKAAs
0 1 K779 LRNyFTDKAAsyTEE
0 3 S782-p yFTDKAAsyTEEDEN
0 1 Y783-p FTDKAAsyTEEDENH
0 5 K832-u FLDDLGLkFKtLAEV
0 1 T835-p DLGLkFKtLAEVCLG
0 3 T881-p TMVNSENtySSGSSF
0 15 Y882-p MVNSENtySSGSSFP
0 1 K901-u LQEANAEkVtQEIVT
0 1 T903-p EANAEkVtQEIVTER
0 2 A917 RSVSSRQAQKVAtPL
0 3 T922-p RQAQKVAtPLPDPMA
0 75 Y968-p LIVTERVyAPASTLV
0 62 Y979-p STLVDQPyANEGtVV
0 2 T984-p QPyANEGtVVVTERV
0 1 T984 QPyANEGTVVVTERV
0 176 Y1013-p QHLQDVPyVMVRERE
0 2 S1055-p ERVLAPAsTLQssyQ
0 8 S1059-p APAsTLQssyQIPTE
0 20 S1060-p PAsTLQssyQIPTEN
0 52 Y1061-p AsTLQssyQIPTENS
0 2 Y1117-p HSTVQHSys______
0 9 S1118-p STVQHSys_______
  mouse

 
N212 IVSQEPANSHMFYLN
Y217 PANSHMFYLNKDTGE
Y226 NKDTGEIYTTSFTLD
Y240 DREEHSSYSLTVEAR
S556 WKITHQESTSVLLQQ
T557 KITHQESTSVLLQQS
R566 VLLQQSERKRGRSEI
T650 GGGAKGFTPIPGTIE
T655 GFTPIPGTIEMLHPW
K672 EGAPPEDKVVPSLLV
S685-p LVADHAEsSAVRGGV
K698-u GVGGAMLkEGMMKGs
M701 GAMLkEGMMKGsssA
K703 MLkEGMMKGsssAsV
S705-p kEGMMKGsssAsVTk
S706-p EGMMKGsssAsVTkG
S707-p GMMKGsssAsVTkGQ
S709-p MKGsssAsVTkGQHE
K712-u sssAsVTkGQHELsE
S718-p TkGQHELsEVDGRWE
S729-p GRWEEHRsLLTAGAT
T732 EEHRsLLTAGATHHV
T741-p GATHHVRtAGTIAAN
R752 IAANEAVRTRATGSS
Y779 NEEFLRSYFTEkAAS
K783-u LRSYFTEkAASYNGE
S786 YFTEkAASYNGEDDL
Y787 FTEkAASYNGEDDLH
K836 FLDDLGLKFKtLAEV
T839-p DLGLKFKtLAEVCLG
- under review  
Y886 VTSSESAYSSNTGFP
K905 LHEVHTEKVTQEIVT
T907 EVHTEKVTQEIVTES
S921-p SSVSSRQsQKVVPPP
P926 RQsQKVVPPPDPVAS
Y971 LIVTERVYAPTSTLV
Y982 STLVDQHYANEEkVL
K987 QHYANEEKVLVTERV
K987-u QHYANEEkVLVTERV
Y1016 QHLKDAQYVMVRERE
S1059 ERILTPASTLQSSYQ
S1063 TPASTLQSSYQIPSE
S1064 PASTLQSSYQIPSET
Y1065 ASTLQSSYQIPSETS
Y1121 HSTMQHSYS______
S1122 STMQHSYS_______
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