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Protein Page:
DCBLD2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DCBLD2 a type-I transmembrane protein. May be involved in vascular remodeling and influence vascular smooth muscle cell proliferation. Contains a CUB domain and a coagulation factor V/VIII homology domain, similar to the structure of the neuropilins. Plays a role in cell motility. SEMA4B appears to be one of its ligands. Strongly expressed in nerve bundles. Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells. Increased in lung cancers during the process of tumor progression. A target of EGF signaling in the A431 cervical cancer cell-line. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q12.1|3
Cellular Component: cell surface; integral to plasma membrane
Molecular Function: protein binding
Biological Process: intracellular receptor-mediated signaling pathway; wound healing; negative regulation of cell growth
Reference #:  Q96PD2 (UniProtKB)
Alt. Names/Synonyms: 1700055P21Rik; CLCP1; coagulation factor V/VIII-homology domains protein 1; CUB, LCCL and coagulation factor V/VIII-homology domains protein 1; DCBD2; DCBLD2; discoidin, CUB and LCCL domain containing 2; Discoidin, CUB and LCCL domain-containing protein 2; Endothelial and smooth muscle cell-derived neuropilin-like protein; ESDN
Gene Symbols: DCBLD2
Molecular weight: 85,035 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DCBLD2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S3-p _____MAsRAVVRAR
0 1 S35-p AALPLSRsLPPCSNS
0 2 Y134-p HFNYLRIyNGIGVSR
0 1 T366-p KKITGIItTGSTMVE
0 1 K391-ub LYSDDGQkWTVYREP
0 1 K404-ub EPGVEQDkIFQGNkD
0 1 K410-ac DkIFQGNkDYHQDVR
0 1 K410-ub DkIFQGNkDYHQDVR
0 1 K439-ub NPTQWQQkIAMKMEL
0 1 K454-ac LGCQFIPkGRPPKLT
0 1 K473-ub PRNSNDLkNTTAPPK
0 1 T476 SNDLkNTTAPPKIAK
0 1 T490-ga KGRAPKFtQPLQPRS
0 1 K560-ub HWRNRKKkTEGtyDL
0 1 T564-p RKKkTEGtyDLPyWD
1 54 Y565-p KKkTEGtyDLPyWDR
0 6 Y569-p EGtyDLPyWDRAGWW
0 1 K577-ub WDRAGWWkGMkQFLP
0 1 K580-ub AGWWkGMkQFLPAkA
0 2 K586-ub MkQFLPAkAVDHEEt
0 2 T593-p kAVDHEEtPVRysss
0 4 Y597-p HEEtPVRysssEVNH
0 2 S598-p EEtPVRysssEVNHL
0 3 S599-p EtPVRysssEVNHLs
0 3 S600-p tPVRysssEVNHLsP
0 6 S606-p ssEVNHLsPREVTTV
0 1 S618-p TTVLQADsAEyAQPL
1 95 Y621-p LQADsAEyAQPLVGG
0 1 K640-ub LHQRSTFkPEEGKEA
0 6 Y649-p EEGKEAGyADLDPyN
1 8 Y655-p GyADLDPyNSPGQEV
0 3 Y663-p NSPGQEVyHAyAEPL
1 2 Y666-p GQEVyHAyAEPLPIT
1 3 Y677-p LPITGPEyATPIIMD
0 16 T714-p QPPPLVGtyNtLLsR
1 79 Y715-p PPPLVGtyNtLLsRt
0 9 T717-p PLVGtyNtLLsRtDs
0 6 S720-p GtyNtLLsRtDsCss
0 3 T722-p yNtLLsRtDsCssAQ
0 6 S724-p tLLsRtDsCssAQAQ
0 5 S726-p LsRtDsCssAQAQyD
0 6 S727-p sRtDsCssAQAQyDt
1 195 Y732-p CssAQAQyDtPKAGk
0 2 T734-p sAQAQyDtPKAGkPG
0 1 K739-ub yDtPKAGkPGLPAPD
1 211 Y750-p PAPDELVyQVPQSTQ
  DCBLD2 iso2  
S3 _____MASRAVVRAR
S35 AALPLSRSLPPCSNS
Y134 HFNYLRIYNGIGVSR
T366 KKITGIITTGSTMVE
K391 LYSDDGQKWTVYREP
K404 EPGVEQDKIFQGNKD
K410 DKIFQGNKDYHQDVR
K410 DKIFQGNKDYHQDVR
K439 NPTQWQQKIAMKMEL
K454 LGCQFIPKGRPPKLT
K473 PRNSNDLKNTTAPPK
T476 SNDLKNTTAPPKIAK
T490 KGRAPKFTQPLQPRS
K560 HWRNRKKKTEGTYDL
T564 RKKKTEGTYDLPYWD
Y565 KKKTEGTYDLPYWDR
Y569 EGTYDLPYWDRAGFY
K591 RHNEGWWKGMKQFLP
K594 EGWWKGMKQFLPAKA
K600 MKQFLPAKAVDHEET
T607 KAVDHEETPVRYSSS
Y611 HEETPVRYSSSEVNH
S612 EETPVRYSSSEVNHL
S613 ETPVRYSSSEVNHLS
S614 TPVRYSSSEVNHLSP
S620 SSEVNHLSPREVTTV
S632 TTVLQADSAEYAQPL
Y635 LQADSAEYAQPLVGG
K654 LHQRSTFKPEEGKEA
Y663 EEGKEAGYADLDPYN
Y669 GYADLDPYNSPGQEV
Y677 NSPGQEVYHAYAEPL
Y680 GQEVYHAYAEPLPIT
Y691 LPITGPEYATPIIMD
T728 QPPPLVGTYNTLLSR
Y729 PPPLVGTYNTLLSRT
T731 PLVGTYNTLLSRTDS
S734 GTYNTLLSRTDSCSS
T736 YNTLLSRTDSCSSAQ
S738 TLLSRTDSCSSAQAQ
S740 LSRTDSCSSAQAQYD
S741 SRTDSCSSAQAQYDT
Y746 CSSAQAQYDTPKAGK
T748 SAQAQYDTPKAGKPG
K753 YDTPKAGKPGLPAPD
Y764 PAPDELVYQVPQSTQ
  mouse

 
S3 _____MASRAPLRAA
P37 LPSAGCCPLPPGRNS
F131 HLNYLKIFNGIGVSR
T363 KKITGIVTTGSTMIE
R388 LYSDDGQRWTVYREP
K401 EPGVDQDKIFQGNKD
K407 DKIFQGNKDYHKDVR
K407 DKIFQGNKDYHKDVR
K436 NPVQWQQKIAMKVEL
K451 LGCQFTLKGRLPKLT
R468 PRNGNNLRNTtARPK
T471-p GNNLRNTtARPKLGK
T485 KGRAPKFTQVLQPRS
K555 HWRNRKKKTEGAyDL
A559 RKKKTEGAyDLPHWD
Y560-p KKKTEGAyDLPHWDR
H564 EGAyDLPHWDRAGWW
K572 WDRAGWWKGMKQLLP
K575 AGWWKGMKQLLPAKS
K581 MKQLLPAKSVDHEET
T588 KSVDHEETPVRYSTS
Y592 HEETPVRYSTSEVSH
S593 EETPVRYSTSEVSHL
T594 ETPVRYSTSEVSHLs
S595 TPVRYSTSEVSHLsA
S601-p TSEVSHLsAREVTTV
S613 TTVLQADSAEyAQPL
Y616-p LQADSAEyAQPLVGG
K635 LHQRSTFKPEEGKEA
Y644 EEGKEAGYADLDPYN
Y650 GYADLDPYNSPMQEV
Y658 NSPMQEVYHAYAEPL
Y661 MQEVYHAYAEPLPVT
Y672 LPVTGPEYATPIVMD
T709-p QPHALVGtyNtLLsR
Y710-p PHALVGtyNtLLsRT
T712-p ALVGtyNtLLsRTDs
S715-p GtyNtLLsRTDsCSS
T717 yNtLLsRTDsCSSGQ
S719-p tLLsRTDsCSSGQAQ
S721 LsRTDsCSSGQAQyD
S722 sRTDsCSSGQAQyDT
Y727-p CSSGQAQyDTPKGGK
T729 SGQAQyDTPKGGKSA
K734 yDTPKGGKSAATPEE
Y744-p ATPEELVyQVPQSTQ
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