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Protein Page:
DCBLD2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DCBLD2 a type-I transmembrane protein. May be involved in vascular remodeling and influence vascular smooth muscle cell proliferation. Contains a CUB domain and a coagulation factor V/VIII homology domain, similar to the structure of the neuropilins. Plays a role in cell motility. SEMA4B appears to be one of its ligands. Strongly expressed in nerve bundles. Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells. Increased in lung cancers during the process of tumor progression. A target of EGF signaling in the A431 cervical cancer cell-line. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion
Cellular Component: cell surface; integral to plasma membrane
Molecular Function: protein binding
Biological Process: intracellular receptor-mediated signaling pathway; wound healing; negative regulation of cell growth; cell adhesion
Reference #:  Q96PD2 (UniProtKB)
Alt. Names/Synonyms: 1700055P21Rik; CLCP1; coagulation factor V/VIII-homology domains protein 1; CUB, LCCL and coagulation factor V/VIII-homology domains protein 1; DCBD2; DCBLD2; discoidin, CUB and LCCL domain containing 2; Discoidin, CUB and LCCL domain-containing protein 2; Endothelial and smooth muscle cell-derived neuropilin-like protein; ESDN
Gene Symbols: DCBLD2
Molecular weight: 85,035 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DCBLD2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y134-p HFNYLRIyNGIGVSR
0 1 K391-u LYSDDGQkWTVYREP
0 1 K404-u EPGVEQDkIFQGNkD
0 1 K410-a DkIFQGNkDYHQDVR
0 1 K410-u DkIFQGNkDYHQDVR
0 1 K439-u NPTQWQQkIAMKMEL
0 1 K473-u PRNSNDLkNTTAPPK
0 1 T476 SNDLkNTTAPPKIAK
0 1 T490-ga KGRAPKFtQPLQPRS
0 1 K560-u HWRNRKKkTEGTyDL
1 51 Y565-p KKkTEGTyDLPyWDR
0 6 Y569-p EGTyDLPyWDRAGWW
0 1 K577-u WDRAGWWkGMkQFLP
0 1 K580-u AGWWkGMkQFLPAkA
0 2 K586-u MkQFLPAkAVDHEET
0 2 Y597-p HEETPVRysssEVNH
0 2 S598-p EETPVRysssEVNHL
0 3 S599-p ETPVRysssEVNHLs
0 3 S600-p TPVRysssEVNHLsP
0 3 S606-p ssEVNHLsPREVTTV
1 93 Y621-p LQADSAEyAQPLVGG
0 1 K640-u LHQRSTFkPEEGKEA
0 6 Y649-p EEGKEAGyADLDPyN
1 8 Y655-p GyADLDPyNSPGQEV
0 3 Y663-p NSPGQEVyHAyAEPL
1 2 Y666-p GQEVyHAyAEPLPIT
1 3 Y677-p LPITGPEyATPIIMD
0 14 T714-p QPPPLVGtyNtLLsR
1 76 Y715-p PPPLVGtyNtLLsRt
0 8 T717-p PLVGtyNtLLsRtDs
0 6 S720-p GtyNtLLsRtDsCss
0 2 T722-p yNtLLsRtDsCssAQ
0 6 S724-p tLLsRtDsCssAQAQ
0 5 S726-p LsRtDsCssAQAQyD
0 5 S727-p sRtDsCssAQAQyDt
1 197 Y732-p CssAQAQyDtPKAGk
0 2 T734-p sAQAQyDtPKAGkPG
0 1 K739-u yDtPKAGkPGLPAPD
1 211 Y750-p PAPDELVyQVPQSTQ
  mouse

 
F131 HLNYLKIFNGIGVSR
R388 LYSDDGQRWTVYREP
K401 EPGVDQDKIFQGNKD
K407 DKIFQGNKDYHKDVR
K407 DKIFQGNKDYHKDVR
K436 NPVQWQQKIAMKVEL
R468 PRNGNNLRNTtARPK
T471-p GNNLRNTtARPKLGK
T485 KGRAPKFTQVLQPRS
K555 HWRNRKKKTEGAyDL
Y560-p KKKTEGAyDLPHWDR
H564 EGAyDLPHWDRAGWW
K572 WDRAGWWKGMKQLLP
K575 AGWWKGMKQLLPAKS
K581 MKQLLPAKSVDHEET
Y592 HEETPVRYSTSEVSH
S593 EETPVRYSTSEVSHL
T594 ETPVRYSTSEVSHLS
S595 TPVRYSTSEVSHLSA
S601 TSEVSHLSAREVTTV
Y616-p LQADSAEyAQPLVGG
K635 LHQRSTFKPEEGKEA
Y644 EEGKEAGYADLDPYN
Y650 GYADLDPYNSPMQEV
Y658 NSPMQEVYHAYAEPL
Y661 MQEVYHAYAEPLPVT
Y672 LPVTGPEYATPIVMD
T709-p QPHALVGtyNtLLsR
Y710-p PHALVGtyNtLLsRT
T712-p ALVGtyNtLLsRTDs
S715-p GtyNtLLsRTDsCSS
T717 yNtLLsRTDsCSSGQ
S719-p tLLsRTDsCSSGQAQ
S721 LsRTDsCSSGQAQyD
S722 sRTDsCSSGQAQyDT
Y727-p CSSGQAQyDTPKGGK
T729 SGQAQyDTPKGGKSA
K734 yDTPKGGKSAATPEE
Y744-p ATPEELVyQVPQSTQ
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