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DCBLD2 (human)

Overview DCBLD2 a type-I transmembrane protein. May be involved in vascular remodeling and influence vascular smooth muscle cell proliferation. Contains a CUB domain and a coagulation factor V/VIII homology domain, similar to the structure of the neuropilins. Plays a role in cell motility. SEMA4B appears to be one of its ligands. Strongly expressed in nerve bundles. Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells. Increased in lung cancers during the process of tumor progression. A target of EGF signaling in the A431 cervical cancer cell-line. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Membrane protein, integral Cellular Component: cell surface; integral to plasma membrane Biological Process: intracellular receptor-mediated signaling pathway; wound healing; negative regulation of cell growth; cell adhesion Reference #:  Q96PD2 (UniProtKB) Alt. Names/Synonyms: 1700055P21Rik; CLCP1; coagulation factor V/VIII-homology domains protein 1; CUB, LCCL and coagulation factor V/VIII-homology domains protein 1; DCBD2; DCBLD2; discoidin, CUB and LCCL domain containing 2; Discoidin, CUB and LCCL domain-containing protein 2; Endothelial and smooth muscle cell-derived neuropilin-like protein; ESDN Gene Symbols: DCBLD2 Molecular weight: 85,035 Da Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DCBLD2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3-p	_____MAsRAVVRAR
0	1		S35-p	AALPLSRsLPPCSNS
0	2		Y134-p	HFNYLRIyNGIGVSR
0	1		T366-p	KKITGIItTGSTMVE
0	1		K391-u	LYSDDGQkWTVYREP
0	1		K404-u	EPGVEQDkIFQGNkD
0	1		K410-a	DkIFQGNkDYHQDVR
0	1		K410-u	DkIFQGNkDYHQDVR
0	1		K439-u	NPTQWQQkIAMKMEL
0	1		K454-a	LGCQFIPkGRPPKLT
0	1		K473-u	PRNSNDLkNTTAPPK
0	1		T476	SNDLkNTTAPPKIAK
0	1		K560-u	HWRNRKKkTEGTyDL
0	49		Y565-p	KKkTEGTyDLPyWDR
0	5		Y569-p	EGTyDLPyWDRAGWW
0	1		K577-u	WDRAGWWkGMkQFLP
0	1		K580-u	AGWWkGMkQFLPAkA
0	2		K586-u	MkQFLPAkAVDHEET
0	2		Y597-p	HEETPVRysssEVNH
0	2		S598-p	EETPVRysssEVNHL
0	3		S599-p	ETPVRysssEVNHLs
0	3		S600-p	TPVRysssEVNHLsP
0	2		S606-p	ssEVNHLsPREVTTV
0	1		S618-p	TTVLQADsAEyAQPL
0	92		Y621-p	LQADsAEyAQPLVGG
0	1		K640-u	LHQRSTFkPEEGKEA
0	6		Y649-p	EEGKEAGyADLDPyN
0	8		Y655-p	GyADLDPyNSPGQEV
0	3		Y663-p	NSPGQEVyHAyAEPL
0	2		Y666-p	GQEVyHAyAEPLPIT
0	3		Y677-p	LPITGPEyATPIIMD
0	13		T714-p	QPPPLVGtyNtLLsR
0	74		Y715-p	PPPLVGtyNtLLsRt
0	7		T717-p	PLVGtyNtLLsRtDs
0	5		S720-p	GtyNtLLsRtDsCss
0	2		T722-p	yNtLLsRtDsCssAQ
0	6		S724-p	tLLsRtDsCssAQAQ
0	5		S726-p	LsRtDsCssAQAQyD
0	5		S727-p	sRtDsCssAQAQyDt
0	194		Y732-p	CssAQAQyDtPKAGk
0	2		T734-p	sAQAQyDtPKAGkPG
0	1		K739-u	yDtPKAGkPGLPAPD
0	209		Y750-p	PAPDELVyQVPQSTQ

	mouse
S3	_____MASRAPLRAA
P37	LPSAGCCPLPPGRNS
F131	HLNYLKIFNGIGVSR
T363	KKITGIVTTGSTMIE
R388	LYSDDGQRWTVYREP
K401	EPGVDQDKIFQGNKD
K407	DKIFQGNKDYHKDVR
K407	DKIFQGNKDYHKDVR
K436	NPVQWQQKIAMKVEL
K451	LGCQFTLKGRLPKLT
R468	PRNGNNLRNTtARPK
T471-p	GNNLRNTtARPKLGK
K555	HWRNRKKKTEGAyDL
Y560-p	KKKTEGAyDLPHWDR
H564	EGAyDLPHWDRAGWW
K572	WDRAGWWKGMKQLLP
K575	AGWWKGMKQLLPAKS
K581	MKQLLPAKSVDHEET
Y592	HEETPVRYSTSEVSH
S593	EETPVRYSTSEVSHL
T594	ETPVRYSTSEVSHLS
S595	TPVRYSTSEVSHLSA
S601	TSEVSHLSAREVTTV
S613	TTVLQADSAEyAQPL
Y616-p	LQADSAEyAQPLVGG
K635	LHQRSTFKPEEGKEA
Y644	EEGKEAGYADLDPYN
Y650	GYADLDPYNSPMQEV
Y658	NSPMQEVYHAYAEPL
Y661	MQEVYHAYAEPLPVT
Y672	LPVTGPEYATPIVMD
T709-p	QPHALVGtYNtLLsR
Y710	PHALVGtYNtLLsRT
T712-p	ALVGtYNtLLsRTDs
S715-p	GtYNtLLsRTDsCSS
T717	YNtLLsRTDsCSSGQ
S719-p	tLLsRTDsCSSGQAQ
S721	LsRTDsCSSGQAQyD
S722	sRTDsCSSGQAQyDT
Y727-p	CSSGQAQyDTPKGGK
T729	SGQAQyDTPKGGKSA
K734	yDTPKGGKSAATPEE
Y744-p	ATPEELVyQVPQSTQ

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