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Protein Page:
Alix (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Alix an adaptor protein that may regulate the function of receptor and cytoskeleton-associated tyrosine kinases. A class E vacuolar protein sorting (VPS) factor involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. In case of infection, the HIV-1 virus directly takes advantage of its function for viral exocytosis and budding, via its interaction with HIV-1 p6 protein. May play a role in the regulation of both apoptosis and cell proliferation. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 3p22.3
Cellular Component: membrane; cytoplasm; melanosome; microtubule organizing center; immunological synapse; cytosol
Molecular Function: protein binding; protein homodimerization activity; SH3 domain binding; calcium-dependent protein binding
Biological Process: protein transport; viral reproduction; cell division; apoptosis; viral infectious cycle; cell cycle
Reference #:  Q8WUM4 (UniProtKB)
Alt. Names/Synonyms: AIP1; ALG-2 interacting protein 1; ALG-2 interacting protein X; ALG-2-interacting protein 1; ALIX; apoptosis-linked gene 2-interacting protein X; dopamine receptor interacting protein 4; DRIP4; Hp95; KIAA1375; MGC17003; PDC6I; PDCD6-interacting protein; PDCD6IP; programmed cell death 6 interacting protein; Programmed cell death 6-interacting protein
Gene Symbols: PDCD6IP
Molecular weight: 96,023 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Alix

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y319‑p
molecular association, regulation: Y319‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K19 TSEVDLAKPLVkFIQ
0 2 K19-ub TSEVDLAkPLVkFIQ
0 1 K23-ac DLAkPLVkFIQQTYP
0 1 K23-ub DLAkPLVkFIQQTYP
0 7 Y39-p GGEEQAQyCRAAEEL
0 2 K48-ac RAAEELSkLRRAAVG
0 2 K48-ub RAAEELSkLRRAAVG
0 1 K60 AVGRPLDKHEGALET
0 1 K101 TWKDAFDKGsLFGGs
0 2 K101-ub TWKDAFDkGsLFGGs
0 1 S103-p KDAFDkGsLFGGsVK
0 1 S108-p kGsLFGGsVKLALAS
0 1 S169-p HIKETVLsALSREPT
0 1 T186-p ISPDTVGtLSLIMLA
0 2 K215-ac MKDAIIAkLANQAAD
0 5 K215-ub MKDAIIAkLANQAAD
0 4 Y223-p LANQAADyFGDAFKQ
0 1 Y258-p IMQANAEyHQSILAK
0 1 K268 SILAKQQKKFGEEIA
0 1 K269 ILAKQQKKFGEEIAR
0 1 K285 QHAAELIKTVASRYD
0 3 Y294-p VASRYDEyVNVKDFS
0 1 K298 YDEyVNVKDFSDKIN
0 1 K298 YDEyVNVKDFSDKIN
0 1 K298 YDEyVNVKDFSDKIN
2 76 Y319-p KKDNDFIyHDRVPDL
0 1 K350-ac VNVPISQkFTDLFEk
0 2 K350-ub VNVPISQkFTDLFEk
0 1 K357-ub kFTDLFEkMVPVSVQ
0 1 S366-p VPVSVQQsLAAyNQR
0 1 Y370-p VQQsLAAyNQRKADL
0 2 T479-p FKERWQRtPsNELyk
0 1 S481-p ERWQRtPsNELykPL
0 5 Y485-p RtPsNELykPLRAEG
0 1 K486-ac tPsNELykPLRAEGT
0 2 K486-ub tPsNELykPLRAEGT
0 1 K486-sc tPsNELykPLRAEGT
0 19 K501-ub NFRTVLDkAVQADGQ
0 1 S575-p GLENDLKsVNFDMTS
0 1 K627 KKQEGLLKNIQVSHQ
0 12 K638-ub VSHQEFSkMkQSNNE
0 46 K640-ub HQEFSkMkQSNNEAN
0 9 K707-ub TERDELLkDLQQsIA
0 1 S712-p LLkDLQQsIAREPsA
0 5 S718-p QsIAREPsAPsIPtP
0 1 S721-p AREPsAPsIPtPAyQ
0 6 T724-p PsAPsIPtPAyQssP
0 100 Y727-p PsIPtPAyQssPAGG
0 1 S729-p IPtPAyQssPAGGHA
0 6 S730-p PtPAyQssPAGGHAP
0 9 T738-p PAGGHAPtPPtPAPr
0 7 T741-p GHAPtPPtPAPrTMP
0 2 R745-m1 tPPtPAPrTMPPTkP
0 1 K751-ac PrTMPPTkPQPPArP
0 7 K751-ub PrTMPPTkPQPPArP
0 1 R757-m1 TkPQPPArPPPPVLP
  mouse

 
K19-ac TSEVDLAkPLVKFIQ
K19-ub TSEVDLAkPLVKFIQ
K23 DLAkPLVKFIQQTYP
K23 DLAkPLVKFIQQTYP
Y39 GGEEQAQYCRAAEEL
K48-ac RAAEELSkLRRSALG
K48-ub RAAEELSkLRRSALG
K60-ub ALGRPLDkHEGALET
K101-ac TWKDAFDkGSLFGGS
K101-ub TWKDAFDkGSLFGGS
S103 KDAFDkGSLFGGSVK
S108 kGSLFGGSVKLALAS
S169 HIKDTVLSALSREPT
T186 ISPDTVGTLSLIMLA
K215-ac MKDAIIAkLANQAAD
K215 MKDAIIAKLANQAAD
Y223 LANQAADYFGDAFKQ
Y258 IMQANAEYHQSILAK
K268-ac SILAKQQkkFGEEIA
K269-ac ILAKQQkkFGEEIAR
K285-ub QHAAELIkNVASRYD
Y294 VASRYDEYVNVkDFS
K298-ac YDEYVNVkDFSDKIN
K298-ub YDEYVNVkDFSDKIN
K298-sc YDEYVNVkDFSDKIN
Y319 KKDNDFIYHDRVPDL
K350 VNVPVSQKFTDLFEK
K350-ub VNVPVSQkFTDLFEK
K357 kFTDLFEKMVPVSVQ
S366 VPVSVQQSLAVFSQR
F370 VQQSLAVFSQRKADL
T479 FKDRWQRTPSNDLYk
S481 DRWQRTPSNDLYkPL
Y485 RTPSNDLYkPLRAEG
K486-ac TPSNDLYkPLRAEGA
K486 TPSNDLYKPLRAEGA
K486 TPSNDLYKPLRAEGA
K501-ub KFRAVLDkAVQADGQ
S575 SLENDLKSVNFDMTS
K627-ub KKQEGLLkNIQVSHQ
K638-ub VSHQEFSkMkQSNNE
K640-ub HQEFSkMkQSNNEAN
K707-ub TERDELLkDLQQSIA
S712 LLkDLQQSIAREPsA
S718-p QSIAREPsAPSIPPP
S721 AREPsAPSIPPPAyQ
P724 PsAPSIPPPAyQSSP
Y727-p PSIPPPAyQSSPAAG
S729 IPPPAyQSSPAAGHA
S730 PPPAyQSSPAAGHAA
A738 PAAGHAAAPPTPAPR
T741 GHAAAPPTPAPRTMP
R745 APPTPAPRTMPPAKP
K751 PRTMPPAKPQPPARP
K751 PRTMPPAKPQPPARP
R757 AKPQPPARPPPPVLP
  rat

 
K19-ac TSEVDLAkPLVKFIQ
K19 TSEVDLAKPLVKFIQ
K23 DLAkPLVKFIQQTYP
K23 DLAkPLVKFIQQTYP
Y39 GGEEQAQYCRAAEEL
K48-ac RAAEELSkLRRSALG
K48 RAAEELSKLRRSALG
K60 ALGRPLDKHEGALET
K101 TWKDAFDKGSLFGGS
K101 TWKDAFDKGSLFGGS
S103 KDAFDKGSLFGGSVK
S108 KGSLFGGSVKLALAS
S169 HIKDTVLSALSREPT
T186 ISPDTVGTLSLIMLA
K215-ac MKDAIIAkLANQAAD
K215 MKDAIIAKLANQAAD
Y223 LANQAADYFGDAFKQ
Y263 IMQANAEYHQSILAK
K273 SILAKQQKkFGEEIA
K274-ac ILAKQQKkFGEEIAR
K290 QHAAELIKNVASRYD
Y299 VASRYDEYVNVkDFS
K303-ac YDEYVNVkDFSDKIN
K303 YDEYVNVKDFSDKIN
K303 YDEYVNVKDFSDKIN
Y324 KKDNDFIYHDRVPDL
K355 VNVPISQKFTDLFEK
K355 VNVPISQKFTDLFEK
K362 KFTDLFEKMVPVSVQ
S371 VPVSVQQSLAVFSQR
F375 VQQSLAVFSQRKADL
T484 FKDRWQRTPSNDLYk
S486 DRWQRTPSNDLYkPL
Y490 RTPSNDLYkPLRAEG
K491-ac TPSNDLYkPLRAEGA
K491 TPSNDLYKPLRAEGA
K491 TPSNDLYKPLRAEGA
K506 KFRAVLDKAVQADGQ
S580 GLENDLKSVNFDMTS
K632 KKQEGLLKNIQVSHQ
K643 VSHQEFSKMKQSNSE
K645 HQEFSKMKQSNSEAS
K712 TERDELLKDLQQSIA
S717 LLKDLQQSIAREPSA
S723 QSIAREPSAPSIPPP
S726 AREPSAPSIPPPAYQ
P729 PSAPSIPPPAYQSSP
Y732 PSIPPPAYQSSPAGG
S734 IPPPAYQSSPAGGHA
S735 PPPAYQSSPAGGHAT
A743 PAGGHATAPTPAPrT
T745 GGHATAPTPAPrTMP
R749-m1 TAPTPAPrTMPPAKP
K755 PrTMPPAKPQPPARP
K755 PrTMPPAKPQPPARP
R761 AKPQPPARPPPPVLP
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