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Protein Page:
SPRY1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SPRY1 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. Induced by FGF signaling. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein; Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of cell proliferation; negative regulation of fibroblast growth factor receptor signaling pathway; ureteric bud development; negative regulation of nerve growth factor receptor signaling pathway; induction of an organ; negative regulation of Ras protein signal transduction; metanephros development
Reference #:  O43609 (UniProtKB)
Alt. Names/Synonyms: hSPRY1; Protein sprouty homolog 1; sprouty homolog 1, antagonist of FGF signaling (Drosophila); sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling); Spry-1; SPRY1; SPY1
Gene Symbols: SPRY1
Molecular weight: 35,122 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SPRY1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S40 IQPTAILSLDQIKAI
0 2 S50-p QIKAIRGsNEytEGP
2 243 Y53-p AIRGsNEytEGPSVV
0 3 T54-p IRGsNEytEGPSVVK
0 50 Y89-p PINVNNNyEHRHTSH
0 2 S123-p STGSAASsGSNSSAS
0 1 S127 AASsGSNSSASsEQG
0 1 S131-p GSNSSASsEQGLLGR
0 1 S139 EQGLLGRSPPTRPVP
0 1 T142 LLGRSPPTRPVPGHR
0 1 K167 QLIVDDLKGSLKEDL
0 7 Y304-p CKNSNTVyCKLESCP
  mouse

 
S40-p TQPATILsLDQIKAI
S50-p QIKAIRGsNEyTEGP
Y53-p AIRGsNEyTEGPSVA
T54 IRGsNEyTEGPSVAR
Y89 PANVNSSYEHRPASH
S117 STGSAASSGSSSSVS
S121 AASSGSSSSVSSEQG
S125 GSSSSVSSEQGLLGR
S133-p EQGLLGRsPPTRPIP
T136 LLGRsPPTRPIPGHR
K161-ub QLLVEDLkASLKEDP
Y298 CRNSNTVYCKLESCP
  rat

 
S40 TQPATILSLDQIKAI
S50 QIKAIRGSNEYTEGP
Y53 AIRGSNEYTEGPSVA
T54 IRGSNEYTEGPSVAR
Y89 PANVNSSYVHRPAGH
S117-p STGSAASsGSSsSVS
S121-p AASsGSSsSVSSEQG
S125 GSSsSVSSEQGLLGR
S133 EQGLLGRSPPtRPIP
T136-p LLGRSPPtRPIPGHR
K161 QLLVDDLKASLKEDP
Y298 CRNSNTVYCKLESCP
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