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SPRY1 (human)

Overview SPRY1 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. Induced by FGF signaling. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; Inhibitor protein Cellular Component: lamellipodium; cytoplasm; plasma membrane; cytosol Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of cell proliferation; negative regulation of MAP kinase activity; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of nerve growth factor receptor signaling pathway; ureteric bud development; induction of an organ; negative regulation of Ras protein signal transduction; metanephros development Reference #:  O43609 (UniProtKB) Alt. Names/Synonyms: hSPRY1; Protein sprouty homolog 1; sprouty homolog 1, antagonist of FGF signaling (Drosophila); sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling); Spry-1; SPRY1; SPY1 Gene Symbols: SPRY1 Molecular weight: 35,122 Da Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SPRY1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S40	IQPTAILSLDQIKAI
0	2		S50-p	QIKAIRGsNEytEGP
0	231		Y53-p	AIRGsNEytEGPSVV
0	3		T54-p	IRGsNEytEGPSVVK
0	39		Y89-p	PINVNNNyEHRHTSH
0	2		S123-p	STGSAASsGSNSSAS
0	1		S127	AASsGSNSSASsEQG
0	1		S131-p	GSNSSASsEQGLLGR
0	1		S139	EQGLLGRSPPTRPVP
0	1		T142	LLGRSPPTRPVPGHR
0	1		K167	QLIVDDLKGSLKEDL
0	7		Y304-p	CKNSNTVyCKLESCP

	mouse
S40-p	TQPATILsLDQIKAI
S50-p	QIKAIRGsNEyTEGP
Y53-p	AIRGsNEyTEGPSVA
T54	IRGsNEyTEGPSVAR
Y89	PANVNSSYEHRPASH
S117	STGSAASSGSSSSVS
S121	AASSGSSSSVSSEQG
S125	GSSSSVSSEQGLLGR
S133-p	EQGLLGRsPPTRPIP
T136	LLGRsPPTRPIPGHR
K161-u	QLLVEDLkASLKEDP
Y298	CRNSNTVYCKLESCP

	rat
S40	TQPATILSLDQIKAI
S50	QIKAIRGSNEYTEGP
Y53	AIRGSNEYTEGPSVA
T54	IRGSNEYTEGPSVAR
Y89	PANVNSSYVHRPAGH
S117-p	STGSAASsGSSsSVS
S121-p	AASsGSSsSVSSEQG
S125	GSSsSVSSEQGLLGR
S133	EQGLLGRSPPtRPIP
T136-p	LLGRSPPtRPIPGHR
K161	QLLVDDLKASLKEDP
Y298	CRNSNTVYCKLESCP

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