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Protein Page:
CDK8 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CDK8 a protein kinase of the CDK family. Along with cyclin C forms part of the RNA polymerase II holoenzyme complex. Phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. Regulates transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, CMGC; EC 2.7.11.23; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK8 subfamily
Cellular Component: nucleoplasm; Srb-mediator complex; nucleus
Molecular Function: RNA polymerase subunit kinase activity; protein binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression
Reference #:  P49336 (UniProtKB)
Alt. Names/Synonyms: CDK8; CDK8 protein kinase; Cell division protein kinase 8; Cyclin-dependent kinase 8; K35; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; Protein kinase K35
Gene Symbols: CDK8
Molecular weight: 53,284 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
CST Pathways:  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDK8

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S11-p DFKVKLSsERERVED
0 3 K52-u DDKDYALkQIEGTGI
0 3 S80-p LKHPNVIsLQKVFLS
0 2 K402-a HTQGPPLkKVRVVPP
0 1 S413-p VVPPTTTsGGLIMTS
  mouse

 
S11 DFKVKLSSERERVED
K52 DDKDYALKQIEGTGI
S80 LKHPNVISLLKVFLS
K402 HAQGPPLKKVRVVPP
S413 VVPPTTTSGGLIMTS
  rat

 
S11 DFKVKLSSERERVED
K52 DDKDYALKQIEGTGI
S80 LKHPNVISLQKVFLS
K402 HAQGPPLKKVRVVPP
S413 VVPPTTTSGGLIMTS
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