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CDK8 (human)

Overview CDK8 a protein kinase of the CDK family. Along with cyclin C forms part of the RNA polymerase II holoenzyme complex. Phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. Regulates transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.23; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; CMGC group; CDK family; CDK8 subfamily Cellular Component: nucleoplasm; Srb-mediator complex; nucleus Molecular Function: RNA polymerase subunit kinase activity; protein binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter Reference #:  P49336 (UniProtKB) Alt. Names/Synonyms: CDK8; CDK8 protein kinase; Cell division protein kinase 8; Cyclin-dependent kinase 8; K35; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; Protein kinase K35 Gene Symbols: CDK8 Molecular weight: 53,284 Da Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states CST Pathways:  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDK8 3RGF - A=1-403 (human) 4F6S - B=1-283 (human) 4F6U - B=1-283 (human) 4F6W - B=1-283 (human) 4F70 - B=1-283 (human) 4F7J - B=1-283 (human) 4F7L - B=1-283 (human) 4F7N - B=1-283 (human) 4F7S - B=1-283 (human) 4G6L - B=1-283 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3RGF 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L  |  ENZYME 2.7.11.22 2.7.11.23  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S11-p	DFKVKLSsERERVED
0	1		Y36	RGTYGHVYKAKRKDG
0	3		K52-u	DDKDYALkQIEGTGI
0	3		S80-p	LKHPNVIsLQKVFLS
0	1		S130-p	LPRGMVKsLLyQILD
0	1		Y133-p	GMVKsLLyQILDGIH
0	1		Y141-p	QILDGIHyLHANWVL
0	2		K402-a	HTQGPPLkKVRVVPP
0	1		S413-p	VVPPTTTsGGLIMTS

	mouse
S11	DFKVKLSSERERVED
Y36	RGTYGHVYKAKRKDG
K52	DDKDYALKQIEGTGI
S80	LKHPNVISLLKVFLS
S130	LPRGMVKSLLYQILD
Y133	GMVKSLLYQILDGIH
Y141	QILDGIHYLHANWVL
K402	HAQGPPLKKVRVVPP
S413	VVPPTTTSGGLIMTS

	rat
S11	DFKVKLSSERERVED
Y36-p	RGTYGHVyKAKRKDG
K52	DDKDYALKQIEGTGI
S80	LKHPNVISLQKVFLS
S130	LPRGMVKSLLYQILD
Y133	GMVKSLLYQILDGIH
Y141	QILDGIHYLHANWVL
K402	HAQGPPLKKVRVVPP
S413	VVPPTTTSGGLIMTS

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