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CDK6 (human)

Overview CDK6 a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CMGC; EC 2.7.11.22; CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily Cellular Component: ruffle; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; nucleus; cytosol Molecular Function: protein binding; cyclin binding; cyclin-dependent protein kinase activity; ATP binding Biological Process: T cell differentiation in the thymus; protein amino acid phosphorylation; negative regulation of cell cycle; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; negative regulation of osteoblast differentiation; G1 phase of mitotic cell cycle; cell cycle arrest; positive regulation of cell-matrix adhesion; lateral ventricle development; negative regulation of epithelial cell proliferation; Notch signaling pathway; negative regulation of myeloid cell differentiation; dentate gyrus development; gliogenesis; response to virus; astrocyte development; regulation of erythrocyte differentiation; negative regulation of cell differentiation; cell division; regulation of gene expression; generation of neurons; cell dedifferentiation; hemopoietic progenitor cell differentiation; mitotic cell cycle; G1/S transition of mitotic cell cycle Reference #:  Q00534 (UniProtKB) Alt. Names/Synonyms: CDK6; Cell division protein kinase 6; cyclin-dependent kinase 6; MGC59692; PLSTIRE; Serine/threonine-protein kinase PLSTIRE Gene Symbols: CDK6 Molecular weight: 36,938 Da Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDK6 1BI7 - A=1-326 (human) 1BI8 - A/C=1-326 (human) 1BLX - A=1-326 (human) 1G3N - A/E=1-326 (human) 1JOW - B=1-308 (human) 1XO2 - B=1-308 (human) 2EUF - B=1-308 (human) 2F2C - B=1-308 (human) 3NUP - A=1-301 (human) 3NUX - A=1-301 (human) 4AUA - A=1-301 (human) 4EZ5 - A=1-301 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5  |  ENZYME  |  Phospho3D  |  DISEASE 603368 612223  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K3-a	_____MEkDGLCRAD
0	312		Y13-p	LCRADQQyECVAEIG
0	249		Y24-p	AEIGEGAyGkVFkAR
0	30		K26-u	IGEGAyGkVFkARDL
0	2		K29-u	GAyGkVFkARDLKNG
0	7		K43-a	GGRFVALkRVRVQtG
0	1		T49-p	LkRVRVQtGEEGMPL
0	1		S57-p	GEEGMPLsTIREVAV
0	1		T70-p	AVLRHLEtFEHPNVV
0	1		S86-p	LFDVCTVsRTDRETK
0	20		K147-u	RVVHRDLkPQNILVT
0	1		S155-p	PQNILVTsSGQIKLA
1	0		T177-p	YSFQMALtSVVVTLW
0	1		S222-p	RKPLFRGssDVDQLG
0	2		S223-p	KPLFRGssDVDQLGk
1	0		D224	PLFRGssDVDQLGkI
0	8		K230-u	sDVDQLGkILDVIGL
0	8		K257-u	PRQAFHSkSAQPIEk
0	1		K264-a	kSAQPIEkFVTDIDE
0	7		K264-u	kSAQPIEkFVTDIDE
0	14		K274-u	TDIDELGkDLLLkCL
0	9		K279-u	LGkDLLLkCLTFNPA
0	15		K287-u	CLTFNPAkRISAysA
0	27		Y292-p	PAkRISAysALsHPy
0	4		S293-p	AkRISAysALsHPyF
0	2		S296-p	ISAysALsHPyFQDL
0	7		Y299-p	ysALsHPyFQDLERC
0	2		K307-u	FQDLERCkENLDSHL
0	2		N319	SHLPPSQNTSELNtA
0	1		S321	LPPSQNTSELNtA__
0	1		T325-p	QNTSELNtA______

	mouse
K3	_____MEKDSLSRAD
Y13	LSRADQQYECVAEIG
Y24	AEIGEGAYGKVFKAR
K26	IGEGAYGKVFKARDL
K29	GAYGKVFKARDLKNG
K43	GGRFVALKRVRVQTS
T49	LKRVRVQTSEEGMPL
S57	SEEGMPLSTIREVAV
T70	AVLRHLETFEHPNVV
S86	LFDVCTVSRTDRETK
K147	RVVHRDLKPQNILVT
S155	PQNILVTSSGQIKLA
T177	YSFQMALTSVVVTLW
S222	RKPLFRGSSdVDQLG
S223	KPLFRGSSdVDQLGK
D224-p	PLFRGSSdVDQLGKI
K230	SdVDQLGKILDIIGL
K257	PRQAFHSKSAQPIEK
K264	KSAQPIEKFVTDIDE
K264	KSAQPIEKFVTDIDE
K274	TDIDELGKDLLLKCL
K279	LGKDLLLKCLTFNPA
K287	CLTFNPAKRISAYGA
Y292	PAKRISAYGALNHPY
G293	AKRISAYGALNHPYF
N296	ISAYGALNHPYFQDL
Y299	YGALNHPYFQDLERY
K307	FQDLERYKDNLNSHL
S319-p	SHLPSNQsTsELNTA
S321-p	LPSNQsTsELNTA__
T325	QsTsELNTA______

	rat
K3	_____MEKDSLSRAD
Y13-p	LSRADQQyECVAEIG
Y24-p	AEIGEGAyGKVFKAR
K26	IGEGAyGKVFKARDL
K29	GAyGKVFKARDLKNG
K43	GGRFVALKRVRVQTG
T49	LKRVRVQTGEEGMPL
S57	GEEGMPLSTIREVAV
T70	AVLRHLETFEHPNVV
S86	LFDVCTVSRTDRETK
K147	RVVHRDLKPQNILVT
S155	PQNILVTSSGQIKLA
T177	YSFQMALTSVVVTLW
S222	RKPLFRGSSDVDQLG
S223	KPLFRGSSDVDQLGK
D224	PLFRGSSDVDQLGKI
K230	SDVDQLGKILDVIGL
K257	PRQAFHSKSAQPIEK
K264	KSAQPIEKFVTDIDE
K264	KSAQPIEKFVTDIDE
K274	TDIDELGKDLLLKCL
K279	LGKDLLLKCLTFNPA
K287	CLTFNPAKRISAYGA
Y292	PAKRISAYGALNHPY
G293	AKRISAYGALNHPYF
N296	ISAYGALNHPYFQDL
Y299	YGALNHPYFQDLERY
K307	FQDLERYKDNLHSHL
S319-p	SHLSSSQsTSELNTA
S321	LSSSQsTSELNTA__
T325	QsTSELNTA______

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