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Protein Page:
CDK6 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CDK6 a protein kinase of the CDK family. Important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. Phosphorylates and regulates the activity of the Rb tumor suppressor protein. Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas and rodent cancers. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; EC 2.7.11.22; CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily
Cellular Component: ruffle; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleus
Molecular Function: cyclin binding; protein binding; cyclin-dependent protein kinase activity; ATP binding
Biological Process: negative regulation of myeloid cell differentiation; dentate gyrus development; response to virus; gliogenesis; astrocyte development; protein amino acid phosphorylation; negative regulation of cell cycle; regulation of erythrocyte differentiation; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; negative regulation of cell differentiation; generation of neurons; regulation of gene expression; cell division; cell dedifferentiation; negative regulation of osteoblast differentiation; mitotic cell cycle; cell cycle arrest; positive regulation of cell-matrix adhesion; lateral ventricle development; negative regulation of epithelial cell proliferation; G1/S transition of mitotic cell cycle
Reference #:  Q00534 (UniProtKB)
Alt. Names/Synonyms: CDK6; Cell division protein kinase 6; cyclin-dependent kinase 6; MGC59692; PLSTIRE; Serine/threonine-protein kinase PLSTIRE
Gene Symbols: CDK6
Molecular weight: 36,938 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDK6

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K3-a _____MEkDGLCRAD
0 312 Y13-p LCRADQQyECVAEIG
1 249 Y24-p AEIGEGAyGkVFkAR
0 30 K26-u IGEGAyGkVFkARDL
0 2 K29-u GAyGkVFkARDLKNG
0 7 K43-a GGRFVALkRVRVQtG
0 1 T49-p LkRVRVQtGEEGMPL
0 1 S57-p GEEGMPLsTIREVAV
0 1 T70-p AVLRHLEtFEHPNVV
0 1 S86-p LFDVCTVsRTDRETK
0 20 K147-u RVVHRDLkPQNILVT
0 1 S155-p PQNILVTsSGQIKLA
2 0 T177-p YSFQMALtSVVVTLW
0 2 S223-p KPLFRGSsDVDQLGk
1 0 D224 PLFRGSsDVDQLGkI
0 8 K230-u sDVDQLGkILDVIGL
0 8 K257-u PRQAFHSkSAQPIEk
0 1 K264-a kSAQPIEkFVTDIDE
0 7 K264-u kSAQPIEkFVTDIDE
0 14 K274-u TDIDELGkDLLLkCL
0 9 K279-u LGkDLLLkCLTFNPA
0 15 K287-u CLTFNPAkRISAysA
0 27 Y292-p PAkRISAysALsHPy
0 4 S293-p AkRISAysALsHPyF
0 2 S296-p ISAysALsHPyFQDL
0 7 Y299-p ysALsHPyFQDLERC
0 2 K307-u FQDLERCkENLDSHL
0 1 S317-p LDSHLPPsQNTSELN
0 2 N319 SHLPPsQNTSELNtA
0 1 S321 LPPsQNTSELNtA__
0 1 T325-p QNTSELNtA______
  mouse

 
K3 _____MEKDSLSRAD
Y13 LSRADQQYECVAEIG
Y24 AEIGEGAYGKVFKAR
K26 IGEGAYGKVFKARDL
K29 GAYGKVFKARDLKNG
K43 GGRFVALKRVRVQTS
T49 LKRVRVQTSEEGMPL
S57 SEEGMPLSTIREVAV
T70 AVLRHLETFEHPNVV
S86 LFDVCTVSRTDRETK
K147 RVVHRDLKPQNILVT
S155 PQNILVTSSGQIKLA
T177 YSFQMALTSVVVTLW
S223 KPLFRGSSdVDQLGK
D224-p PLFRGSSdVDQLGKI
K230 SdVDQLGKILDIIGL
K257 PRQAFHSKSAQPIEK
K264 KSAQPIEKFVTDIDE
K264 KSAQPIEKFVTDIDE
K274 TDIDELGKDLLLKCL
K279 LGKDLLLKCLTFNPA
K287 CLTFNPAKRISAYGA
Y292 PAKRISAYGALNHPY
G293 AKRISAYGALNHPYF
N296 ISAYGALNHPYFQDL
Y299 YGALNHPYFQDLERY
K307 FQDLERYKDNLNSHL
N317 LNSHLPSNQsTsELN
S319-p SHLPSNQsTsELNTA
S321-p LPSNQsTsELNTA__
T325 QsTsELNTA______
  rat

 
K3 _____MEKDSLSRAD
Y13-p LSRADQQyECVAEIG
Y24-p AEIGEGAyGKVFKAR
K26 IGEGAyGKVFKARDL
K29 GAyGKVFKARDLKNG
K43 GGRFVALKRVRVQTG
T49 LKRVRVQTGEEGMPL
S57 GEEGMPLSTIREVAV
T70 AVLRHLETFEHPNVV
S86 LFDVCTVSRTDRETK
K147 RVVHRDLKPQNILVT
S155 PQNILVTSSGQIKLA
T177 YSFQMALTSVVVTLW
S223 KPLFRGSSDVDQLGK
D224 PLFRGSSDVDQLGKI
K230 SDVDQLGKILDVIGL
K257 PRQAFHSKSAQPIEK
K264 KSAQPIEKFVTDIDE
K264 KSAQPIEKFVTDIDE
K274 TDIDELGKDLLLKCL
K279 LGKDLLLKCLTFNPA
K287 CLTFNPAKRISAYGA
Y292 PAKRISAYGALNHPY
G293 AKRISAYGALNHPYF
N296 ISAYGALNHPYFQDL
Y299 YGALNHPYFQDLERY
K307 FQDLERYKDNLHSHL
S317 LHSHLSSSQsTSELN
S319-p SHLSSSQsTSELNTA
S321 LSSSQsTSELNTA__
T325 QsTSELNTA______
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