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14-3-3 theta (rat)

Overview 14-3-3 theta a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Associates with c-BCR and BCR-Abl. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: protein complex; cytoplasm Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding Biological Process: small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; protein targeting Reference #:  P68255 (UniProtKB) Alt. Names/Synonyms: 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3t; 1433T; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; Ywhaq Gene Symbols: Ywhaq Molecular weight: 27,778 Da Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Cell Cycle: G2/M DNA Damage Checkpoint  |  Hippo Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below 14-3-3 theta 2BTP - A/B=1-234 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			rat
0	11		K3	_____MEKTELIQkA
0	29		K9-u	EKTELIQkAkLAEQA
0	1		K9	EKTELIQKAkLAEQA
0	37		K11-u	TELIQkAkLAEQAER
0	2		Y19	LAEQAERYDDMATCM
0	1		K27	DDMATCMKAVTEQGA
0	15		K27	DDMATCMKAVTEQGA
0	9		S45	NEERNLLSVAYkNVV
0	5		Y48	RNLLSVAYkNVVGGR
0	58		K49-u	NLLSVAYkNVVGGRR
0	2		K49	NLLSVAYKNVVGGRR
0	1		K68	VISSIEQKTDTSDKK
0	11		K68	VISSIEQKTDTSDKK
0	3		K74	QKTDTSDKKLQLIKD
0	3		K75	KTDTSDKKLQLIKDY
0	11		K80	DKKLQLIKDYREKVE
0	1		Y82	KLQLIKDYREKVESE
0	1		K85	LIKDYREKVESELRS
0	1		S92	KVESELRSICTTVLE
0	1		T110	KYLIANATNPESKVF
0	15		K115	NATNPESKVFYLkMK
0	4		K115	NATNPESKVFYLkMK
0	4		K120	ESKVFYLKMKGDYFR
0	72		K120-u	ESKVFYLkMKGDYFR
0	10		K122	KVFYLkMKGDYFRYL
0	4		Y125	YLkMKGDYFRYLAEV
0	2		K139	VACGDDRKQTIENSQ
0	8		K139	VACGDDRKQTIENSQ
0	1		T141	CGDDRKQTIENSQGA
0	8		Y149	IENSQGAYQEAFDIS
0	1		S156	YQEAFDISKKEMQPT
0	8		K157	QEAFDISKKEMQPTH
0	7		K157	QEAFDISKKEMQPTH
0	1		K158	EAFDISKKEMQPTHP
0	55		K158	EAFDISKKEMQPTHP
0	2		K193	ELACTLAKTAFDEAI
0	1		S210	LDTLNEDSYKDSTLI
0	1		K212	TLNEDSYKDSTLIMQ
0	1		T229	RDNLTLWTSDSAGEE
0	2		S230	DNLTLWTSDSAGEEC
2	8		S232	LTLWTSDSAGEECDA

	human
K3-a	_____MEkTELIQkA
K9-u	EkTELIQkAkLAEQA
K9-a	EkTELIQkAkLAEQA
K11-u	TELIQkAkLAEQAER
Y19-p	LAEQAERyDDMATCM
K27-a	DDMATCMkAVTEQGA
K27-u	DDMATCMkAVTEQGA
S45-p	NEERNLLsVAykNVV
Y48-p	RNLLsVAykNVVGGR
K49-u	NLLsVAykNVVGGRR
K49-a	NLLsVAykNVVGGRR
K68-a	VISSIEQkTDTSDkk
K68-u	VISSIEQkTDTSDkk
K74-u	QkTDTSDkkLQLIkD
K75-u	kTDTSDkkLQLIkDy
K80-u	DkkLQLIkDyREKVE
Y82-p	kLQLIkDyREKVESE
K85	LIkDyREKVESELRS
S92	KVESELRSICTTVLE
T110	KYLIANATNPESkVF
K115-a	NATNPESkVFYLkMk
K115-u	NATNPESkVFYLkMk
K120-a	ESkVFYLkMkGDyFR
K120-u	ESkVFYLkMkGDyFR
K122-u	kVFYLkMkGDyFRYL
Y125-p	YLkMkGDyFRYLAEV
K139-a	VACGDDRkQtIDNSQ
K139-u	VACGDDRkQtIDNSQ
T141-p	CGDDRkQtIDNSQGA
Y149-p	IDNSQGAyQEAFDIs
S156-p	yQEAFDIskkEMQPT
K157-a	QEAFDIskkEMQPTH
K157-u	QEAFDIskkEMQPTH
K158-a	EAFDIskkEMQPTHP
K158-u	EAFDIskkEMQPTHP
K193-u	ELACTLAkTAFDEAI
S210-p	LDTLNEDsYkDSTLI
K212-m1	TLNEDsYkDSTLIMQ
T229-p	RDNLTLWtsDsAGEE
S230-p	DNLTLWtsDsAGEEC
S232-p	LTLWtsDsAGEECDA

	mouse
K3-a	_____MEkTELIQkA
K9-u	EkTELIQkAkLAEQA
K9	EkTELIQKAkLAEQA
K11-u	TELIQkAkLAEQAER
Y19	LAEQAERYDDMATCM
K27	DDMATCMKAVTEQGA
K27	DDMATCMKAVTEQGA
S45-p	NEERNLLsVAykNVV
Y48-p	RNLLsVAykNVVGGR
K49-u	NLLsVAykNVVGGRR
K49	NLLsVAyKNVVGGRR
K68	VISSIEQKTDTSDkK
K68-u	VISSIEQkTDTSDkK
K74-u	QkTDTSDkKLQLIkD
K75	kTDTSDkKLQLIkDY
K80-u	DkKLQLIkDYREkVE
Y82	KLQLIkDYREkVESE
K85-u	LIkDYREkVESELRs
S92-p	kVESELRsICTTVLE
T110-p	KYLIANAtNPESkVF
K115	NAtNPESKVFYLkMk
K115-u	NAtNPESkVFYLkMk
K120-a	ESkVFYLkMkGDYFR
K120-u	ESkVFYLkMkGDYFR
K122-u	kVFYLkMkGDYFRYL
Y125	YLkMkGDYFRYLAEV
K139	VACGDDRKQTIENSQ
K139-u	VACGDDRkQTIENSQ
T141	CGDDRkQTIENSQGA
Y149	IENSQGAYQEAFDIS
S156	YQEAFDISkkEMQPT
K157	QEAFDISKkEMQPTH
K157-u	QEAFDISkkEMQPTH
K158	EAFDISkKEMQPTHP
K158-u	EAFDISkkEMQPTHP
K193-u	ELACTLAkTAFDEAI
S210	LDTLNEDSYKDSTLI
K212	TLNEDSYKDSTLIMQ
T229-p	RDNLTLWtsDsAGEE
S230-p	DNLTLWtsDsAGEEC
S232-p	LTLWtsDsAGEECDA

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