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Protein Page:
CAMK2B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CAMK2B a widely expressed protein kinase of the calcium/calmodulin-dependent protein kinase (CAMK) group. Functions autonomously after Ca2+/calmodulin-binding and autophosphorylation. Involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban, an endogenous inhibitor of SERCA2. The holoenzyme is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with SYNGAP1 and CAMK2N2. Interacts with MPDZ. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle and induced during exercise. Eight isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.11.17; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.1.123; Protein kinase, CAMK; CAMK group; CAMK2 family
Cellular Component: nucleoplasm; sarcoplasmic reticulum membrane; plasma membrane; microtubule organizing center; spindle midzone; cytosol
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; actin binding; ATP binding
Biological Process: regulation of long-term neuronal synaptic plasticity; regulation of skeletal muscle adaptation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; regulation of calcium ion transport; signal transduction; protein amino acid phosphorylation; regulation of synaptic transmission, cholinergic; inhibitory G-protein coupled receptor phosphorylation; synaptic transmission; peptidyl-serine phosphorylation; response to cadmium ion; calcium ion transport; regulation of synapse structural plasticity; neuromuscular process controlling balance; G1/S transition of mitotic cell cycle
Reference #:  Q13554 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II beta subunit; CaM kinase II subunit beta; CaM-kinase II beta chain; CAM2; CaMK-II subunit beta; CAMK2; CaMK2-beta; CAMK2B; CAMKB; CaMKII; KCC2B; MGC29528; proline rich calmodulin-dependent protein kinase
Gene Symbols: CAMK2B
Molecular weight: 72,678 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CAMK2B

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 10 Y14 CTRFTDEYQLYEDIG
0 29 Y17 FTDEYQLYEDIGKGA
0 8 K22 QLYEDIGKGAFSVVR
0 3 S26 DIGKGAFSVVRRCVK
0 1 K33 SVVRRCVKLCTGHEY
0 6 K33 SVVRRCVKLCTGHEY
0 9 Y40 KLCTGHEYAAKIINT
0 7 K43 TGHEYAAKIINTKKL
0 7 K48 AAKIINTKKLSARDH
0 1 K48 AAKIINTKKLSARDH
0 7 K49 AKIINTKKLSARDHQ
0 8 K69 ARICRLLKHSNIVRL
0 3 S79-p NIVRLHDsISEEGFH
0 8 K138 GVVHRDLKPENLLLA
0 8 K147 ENLLLASKCKGAAVK
0 6 K149 LLLASKCKGAAVKLA
0 4 K154 KCKGAAVKLADFGLA
1 1 K221 FWDEDQHKLYQQIkA
0 3 K227-ac HKLYQQIkAGAyDFP
0 18 K227-ub HKLYQQIkAGAyDFP
0 28 Y231-p QQIkAGAyDFPsPEW
0 12 S235-p AGAyDFPsPEWDTVT
0 17 K246-ub DTVTPEAkNLINQML
1 5 T254-p NLINQMLtINPAKRI
0 2 K259 MLtINPAKRITAHEA
0 8 K259 MLtINPAKRITAHEA
0 8 K268-ub ITAHEALkHPWVCQR
0 4 S276-p HPWVCQRsTVAsMMH
0 1 T277 PWVCQRsTVAsMMHR
0 5 S280-p CQRsTVAsMMHRQEt
14 116 T287-p sMMHRQEtVECLKKF
0 6 K292 QEtVECLKKFNARRK
0 6 K293 EtVECLKKFNARRKL
0 5 K299 KKFNARRKLkGAILt
0 1 K299 KKFNARRKLkGAILt
0 7 K301 FNARRKLKGAILttM
0 3 K301-m1 FNARRKLkGAILttM
1 3 T306-p KLkGAILttMLAtRN
0 7 T307-p LkGAILttMLAtRNF
0 5 T311-p ILttMLAtRNFsVGR
2 13 S315-p MLAtRNFsVGRQTTA
0 1 T321 FsVGRQTTAPATMSt
0 1 T325 RQTTAPATMStAASG
0 1 S327 TTAPATMStAASGTT
0 1 T328-p TAPATMStAASGTTM
0 1 T328 TAPATMSTAASGTTM
0 1 K342-ac MGLVEQAkSLLNKKA
0 6 K342 MGLVEQAKSLLNKKA
0 4 S343 GLVEQAkSLLNKKAD
0 1 K347 QAkSLLNKKADGVKP
0 2 K347 QAkSLLNKKADGVKP
0 3 K348 AkSLLNKKADGVKPQ
0 3 K353 NKKADGVKPQTNSTK
0 1 S358 GVKPQTNSTKNSAAA
0 6 K360 KPQTNSTKNSAAATS
0 3 A363 TNSTKNSAAATSPKG
0 1 T366 TKNSAAATSPKGTLP
0 11 S367 KNSAAATSPKGTLPP
0 1 K369 SAAATSPKGTLPPAA
1 3 T371 AATSPKGTLPPAALE
0 1 T381 PAALEPQTTVIHNPV
0 5 S394-p PVDGIKEssDsANtt
0 5 S395-p VDGIKEssDsANttI
0 12 S397-p GIKEssDsANttIED
0 7 A398 IKEssDsANttIEDE
0 7 T400-p EssDsANttIEDEDA
0 8 T401-p ssDsANttIEDEDAK
0 14 S423-p LSSVRRGsGAPEAEG
0 2 S436 EGPLPCPSPAPFsPL
0 4 S441-p CPSPAPFsPLPAPSP
0 1 S456-p RISDILNsVRRGsGt
0 1 S461-p LNsVRRGsGtPEAEG
0 1 T463-p sVRRGsGtPEAEGPL
0 1 S471-p PEAEGPLsAGPPPCL
0 1 S499-p RISDILNsVRRGsGt
0 4 S504-p LNsVRRGsGtPEAEG
0 3 T506-p sVRRGsGtPEAEGPS
0 2 S522-p VGPPPCPsPTIPGPL
0 2 K535 PLPTPSRKQEIIKTT
0 3 K540 SRKQEIIKTTEQLIE
0 2 K593 YFENLLAKNSKPIHT
0 4 K596 NLLAKNSKPIHTTIL
0 12 Y625 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
  CAMK2B iso3  
Y14 CTRFTDEYQLYEDIG
Y17 FTDEYQLYEDIGKGA
K22 QLYEDIGKGAFSVVR
S26 DIGKGAFSVVRRCVK
K33 SVVRRCVKLCTGHEY
K33 SVVRRCVKLCTGHEY
Y40 KLCTGHEYAAKIINT
K43 TGHEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHSNIVRL
S79 NIVRLHDSISEEGFH
K138 GVVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
K221 FWDEDQHKLYQQIKA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITAHEA
K259 MLTINPAKRITAHEA
K268 ITAHEALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQET
T287 SMMHRQETVECLKKF
K292 QETVECLKKFNARRK
K293 ETVECLKKFNARRKL
K299 KKFNARRKLKGAILT
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLAtRN
T307 LKGAILTTMLAtRNF
T311-p ILTTMLAtRNFsAAK
S315-p MLAtRNFsAAKsLLN
- gap
- gap
- gap
- gap
- gap
K318 tRNFsAAKsLLNKKA
K318 tRNFsAAKsLLNKKA
S319-p RNFsAAKsLLNKKAD
K323 AAKsLLNKKADGVKP
K323 AAKsLLNKKADGVKP
K324 AKsLLNKKADGVKPQ
K329 NKKADGVKPQTNSTK
S334 GVKPQTNSTKNSAAA
K336 KPQTNSTKNSAAATS
A339 TNSTKNSAAATSPKG
T342 TKNSAAATSPKGTLP
S343 KNSAAATSPKGTLPP
K345 SAAATSPKGTLPPAA
T347 AATSPKGTLPPAALE
- gap
S355 LPPAALESSDSANTT
S356 PPAALESSDSANTTI
S358 AALESSDSANTTIED
A359 ALESSDSANTTIEDE
T361 ESSDSANTTIEDEDA
T362 SSDSANTTIEDEDAK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K372 DEDAKARKQEIIKTT
K377 ARKQEIIKTTEQLIE
K430 YFENLLAKNSKPIHT
K433 NLLAKNSKPIHTTIL
Y462 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
  CAMK2B iso4  
Y14 CTRFTDEYQLYEDIG
Y17 FTDEYQLYEDIGKGA
K22 QLYEDIGKGAFSVVR
S26 DIGKGAFSVVRRCVK
K33 SVVRRCVKLCTGHEY
K33 SVVRRCVKLCTGHEY
Y40 KLCTGHEYAAKIINT
K43 TGHEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHSNIVRL
S79 NIVRLHDSISEEGFH
K138 GVVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
K221 FWDEDQHKLYQQIKA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITAHEA
K259 MLTINPAKRITAHEA
K268 ITAHEALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQET
T287 SMMHRQETVECLKKF
K292 QETVECLKKFNARRK
K293 ETVECLKKFNARRKL
K299 KKFNARRKLKGAILT
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLATRN
T307 LKGAILTTMLATRNF
T311 ILTTMLATRNFsAAK
S315-p MLATRNFsAAKsLLN
- gap
- gap
- gap
- gap
- gap
K318 TRNFsAAKsLLNKKA
K318 TRNFsAAKsLLNKKA
S319-p RNFsAAKsLLNKKAD
K323 AAKsLLNKKADGVKE
K323 AAKsLLNKKADGVKE
K324 AKsLLNKKADGVKES
K329 NKKADGVKESSDsAN
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S331 KADGVKESSDsANTT
S332 ADGVKESSDsANTTI
S334-p GVKESSDsANTTIED
A335 VKESSDsANTTIEDE
T337 ESSDsANTTIEDEDA
T338 SSDsANTTIEDEDAK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K348 DEDAKARKQEIIKTT
K353 ARKQEIIKTTEQLIE
K406 YFENLLAKNSKPIHT
K409 NLLAKNSKPIHTTIL
Y438 AYIRLTQYIDGQGRP
3361 : Phospho-CaMKII (Thr286) Antibody
  CAMK2B iso6  
Y14 CTRFTDEYQLYEDIG
Y17 FTDEYQLYEDIGKGA
K22 QLYEDIGKGAFSVVR
S26 DIGKGAFSVVRRCVK
K33 SVVRRCVKLCTGHEY
K33 SVVRRCVKLCTGHEY
Y40 KLCTGHEYAAKIINT
K43 TGHEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHSNIVRL
S79 NIVRLHDSISEEGFH
K138 GVVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
K221 FWDEDQHKLYQQIKA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITAHEA
K259 MLTINPAKRITAHEA
K268 ITAHEALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQEt
T287-p SMMHRQEtVECLKKF
K292 QEtVECLKKFNARRK
K293 EtVECLKKFNARRKL
K299 KKFNARRKLKGAILT
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLATRN
T307 LKGAILTTMLATRNF
T311 ILTTMLATRNFSVGR
S315 MLATRNFSVGRQTTA
T321 FSVGRQTTAPATMST
T325 RQTTAPATMSTAASG
S327 TTAPATMSTAASGTT
T328 TAPATMSTAASGTTM
T328 TAPATMSTAASGTTM
K342 MGLVEQAKSLLNKKA
K342 MGLVEQAKSLLNKKA
S343 GLVEQAKSLLNKKAD
K347 QAKSLLNKKADGVKE
K347 QAKSLLNKKADGVKE
K348 AKSLLNKKADGVKEP
K353 NKKADGVKEPQTTVI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T357 DGVKEPQTTVIHNPV
S370 PVDGIKESSDSANTT
S371 VDGIKESSDSANTTI
S373 GIKESSDSANTTIED
A374 IKESSDSANTTIEDE
T376 ESSDSANTTIEDEDA
T377 SSDSANTTIEDEDAK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K387 DEDAKARKQEIIKTT
K392 ARKQEIIKTTEQLIE
K419 YFENLLAKNSKPIHT
K422 NLLAKNSKPIHTTIL
Y451 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
  CAMK2B iso8  
Y14 CTRFTDEYQLYEDIG
Y17 FTDEYQLYEDIGKGA
K22 QLYEDIGKGAFSVVR
S26 DIGKGAFSVVRRCVK
K33 SVVRRCVKLCTGHEY
K33 SVVRRCVKLCTGHEY
Y40 KLCTGHEYAAKIINT
K43 TGHEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHSNIVRL
S79 NIVRLHDSISEEGFH
K138 GVVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
K221 FWDEDQHKLYQQIKA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITAHEA
K259 MLTINPAKRITAHEA
K268 ITAHEALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQET
T287 SMMHRQETVECLKKF
K292 QETVECLKKFNARRK
K293 ETVECLKKFNARRKL
K299 KKFNARRKLKGAILT
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLATRN
T307 LKGAILTTMLATRNF
T311 ILTTMLATRNFsAKS
S315-p MLATRNFsAKSLLNK
- gap
- gap
- gap
- gap
- gap
K317 ATRNFsAKSLLNKKA
K317 ATRNFsAKSLLNKKA
S318 TRNFsAKSLLNKKAD
K322 sAKSLLNKKADGVKP
K322 sAKSLLNKKADGVKP
K323 AKSLLNKKADGVKPQ
K328 NKKADGVKPQTNSTK
S333 GVKPQTNSTKNSAAA
K335 KPQTNSTKNSAAATS
A338 TNSTKNSAAATSPKG
T341 TKNSAAATSPKGTLP
S342 KNSAAATSPKGTLPP
K344 SAAATSPKGTLPPAA
T346 AATSPKGTLPPAALE
T356 PAALEPQTTVIHNPV
S369 PVDGIKESSDSANTT
S370 VDGIKESSDSANTTI
S372 GIKESSDSANTTIED
A373 IKESSDSANTTIEDE
T375 ESSDSANTTIEDEDA
T376 SSDSANTTIEDEDAK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K386 DEDAKARKQEIIKTT
K391 ARKQEIIKTTEQLIE
K444 YFENLLAKNSKPIHT
K447 NLLAKNSKPIHTTIL
Y476 AYIRLTQYIDGQGRP
  mouse

► Hide Isoforms
 
Y14 CTRFTDEYQLyEDIG
Y17-p FTDEYQLyEDIGkGA
K22-ub QLyEDIGkGAFsVVR
S26-p DIGkGAFsVVRRCVk
K33 sVVRRCVKLCTGHEY
K33-ub sVVRRCVkLCTGHEY
Y40 kLCTGHEYAAkIINT
K43-ub TGHEYAAkIINTkkL
K48-ub AAkIINTkkLSARDH
K48-ac AAkIINTkkLSARDH
K49-ub AkIINTkkLSARDHQ
K69-ub ARICRLLkHSNIVRL
S79-p NIVRLHDsISEEGFH
K138-ub GVVHRDLkPENLLLA
K147-ub ENLLLASkCKGAAVK
K149 LLLASkCKGAAVKLA
K154 kCKGAAVKLADFGLA
K221 FWDEDQHKLYQQIkA
K227 HKLYQQIKAGAyDFP
K227-ub HKLYQQIkAGAyDFP
Y231-p QQIkAGAyDFPsPEW
S235-p AGAyDFPsPEWDTVT
K246-ub DTVTPEAkNLINQML
T254-p NLINQMLtINPAkRI
K259 MLtINPAKRITAHEA
K259-ub MLtINPAkRITAHEA
K268-ub ITAHEALkHPWVCQR
S276-p HPWVCQRstVAsMMH
T277-p PWVCQRstVAsMMHR
S280-p CQRstVAsMMHRQEt
T287-p sMMHRQEtVECLKKF
K292 QEtVECLKKFNARRk
K293 EtVECLKKFNARRkL
K299 KKFNARRKLkGAILt
K299-m1 KKFNARRkLkGAILt
K301-ub FNARRkLkGAILttM
K301-m1 FNARRkLkGAILttM
T306-p kLkGAILttMLAtRN
T307-p LkGAILttMLAtRNF
T311-p ILttMLAtRNFsVGR
S315-p MLAtRNFsVGRQTtA
T321-p FsVGRQTtAPAtMst
T325-gl RQTtAPAtMstAASG
S327-gl TtAPAtMstAASGTT
T328 tAPAtMsTAASGTTM
T328-gl tAPAtMstAASGTTM
K342 MGLVEQAKsLLNkKA
K342 MGLVEQAKsLLNkKA
S343-p GLVEQAKsLLNkKAD
K347-ac QAKsLLNkKADGVKP
K347 QAKsLLNKKADGVKP
K348 AKsLLNkKADGVKPQ
K353 NkKADGVKPQTNsTK
S358-p GVKPQTNsTKNSsAI
K360 KPQTNsTKNSsAIts
S363-p TNsTKNSsAItsPKG
T366-p TKNSsAItsPKGsLP
S367-p KNSsAItsPKGsLPP
K369 SsAItsPKGsLPPAA
S371-p AItsPKGsLPPAALE
T381-p PAALEPQtTVIHNPV
S394-p PVDGIKEssDstNtt
S395-p VDGIKEssDstNttI
S397-p GIKEssDstNttIED
T398-p IKEssDstNttIEDE
T400-p EssDstNttIEDEDA
T401-p ssDstNttIEDEDAK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K411 DEDAKARKQEIIKTT
K416 ARKQEIIKTTEQLIE
K469-ub YFENLLAkNSKPIHT
K472 NLLAkNSKPIHTTIL
Y501 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
  CAMK2B iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K9 GVVHRDLKPENLLLA
K18 ENLLLASKCKGAAVK
K20 LLLASKCKGAAVKLA
K25 KCKGAAVKLADFGLA
K92 FWDEDQHKLYQQIKA
K98 HKLYQQIKAGAYDFP
K98 HKLYQQIKAGAYDFP
Y102 QQIKAGAYDFPsPEW
S106-p AGAYDFPsPEWDTVT
K117 DTVTPEAKNLINQML
T125 NLINQMLTINPAKRI
K130 MLTINPAKRITAHEA
K130 MLTINPAKRITAHEA
K139 ITAHEALKHPWVCQR
S147-p HPWVCQRstVAsMMH
T148-p PWVCQRstVAsMMHR
S151-p CQRstVAsMMHRQEt
T158-p sMMHRQEtVECLKKF
K163 QEtVECLKKFNARRk
K164 EtVECLKKFNARRkL
K170 KKFNARRKLkGAILT
K170-m1 KKFNARRkLkGAILT
K172 FNARRkLKGAILTTM
K172-m1 FNARRkLkGAILTTM
T177 kLkGAILTTMLATRN
T178 LkGAILTTMLATRNF
T182 ILTTMLATRNFsAAK
S186-p MLATRNFsAAKsLLN
- gap
- gap
- gap
- gap
- gap
K189 TRNFsAAKsLLNKKA
K189 TRNFsAAKsLLNKKA
S190-p RNFsAAKsLLNKKAD
K194 AAKsLLNKKADGVKP
K194 AAKsLLNKKADGVKP
K195 AKsLLNKKADGVKPQ
K200 NKKADGVKPQTNSTK
S205 GVKPQTNSTKNSsAI
K207 KPQTNSTKNSsAITs
S210-p TNSTKNSsAITsPKG
T213 TKNSsAITsPKGsLP
S214-p KNSsAITsPKGsLPP
K216 SsAITsPKGsLPPAA
S218-p AITsPKGsLPPAALE
- gap
S226-p LPPAALEssDstNtt
S227-p PPAALEssDstNttI
S229-p AALEssDstNttIED
T230-p ALEssDstNttIEDE
T232-p EssDstNttIEDEDA
T233-p ssDstNttIEDEDAK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K243 DEDAKARKQEIIKTT
K248 ARKQEIIKTTEQLIE
K301 YFENLLAKNSKPIHT
K304 NLLAKNSKPIHTTIL
Y333 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
  CAMK2B iso3  
Y14 CTRFTDEYQLYEDIG
Y17 FTDEYQLYEDIGKGA
K22 QLYEDIGKGAFSVVR
S26 DIGKGAFSVVRRCVK
K33 SVVRRCVKLCTGHEY
K33 SVVRRCVKLCTGHEY
Y40 KLCTGHEYAAKIINT
K43 TGHEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHSNIVRL
S79 NIVRLHDSISEEGFH
K138 GVVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
K221 FWDEDQHKLYQQIKA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITAHEA
K259 MLTINPAKRITAHEA
K268 ITAHEALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQET
T287 SMMHRQETVECLKKF
K292 QETVECLKKFNARRK
K293 ETVECLKKFNARRKL
K299 KKFNARRKLKGAILT
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLATRN
T307 LKGAILTTMLATRNF
T311 ILTTMLATRNFSVGR
S315 MLATRNFSVGRQTTA
T321 FSVGRQTTAPATMST
T325 RQTTAPATMSTAASG
S327 TTAPATMSTAASGTT
T328 TAPATMSTAASGTTM
T328 TAPATMSTAASGTTM
K342 MGLVEQAKSLLNKKA
K342 MGLVEQAKSLLNKKA
S343 GLVEQAKSLLNKKAD
K347 QAKSLLNKKADGVKP
K347 QAKSLLNKKADGVKP
K348 AKSLLNKKADGVKPQ
K353 NKKADGVKPQTNSTK
S358 GVKPQTNSTKNSSAI
K360 KPQTNSTKNSSAITS
S363 TNSTKNSSAITSPKG
T366 TKNSSAITSPKGSLP
S367 KNSSAITSPKGSLPP
K369 SSAITSPKGSLPPAA
S371 AITSPKGSLPPAALE
T381 PAALEPQTTVIHNPV
S394 PVDGIKESSDSTNTT
S395 VDGIKESSDSTNTTI
S397 GIKESSDSTNTTIED
T398 IKESSDSTNTTIEDE
T400 ESSDSTNTTIEDEDA
T401 SSDSTNTTIEDEDAK
S423-p LSLVRRAsGAPEAEG
S436-p EGPLSCQsPVPIsPL
S441-p CQsPVPIsPLPTPSP
S456 RISDILNSVRRGCGT
C461 LNSVRRGCGTPEAEG
T463 SVRRGCGTPEAEGPL
S471 PEAEGPLSVGPPPCL
S499 RISDILNSVRRGsGt
S504-p LNSVRRGsGtPEAEG
T506-p SVRRGsGtPEAEGLP
S522-p VGPPPCPsPTLPGPL
K535 PLPTPSRKQEIIKTT
K540 SRKQEIIKTTEQLIE
K593 YFENLLAKNSKPIHT
K596 NLLAKNSKPIHTTIL
Y625 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
  rat

► Hide Isoforms
 
Y14-p CTRFTDEyQLyEDIG
Y17-p FTDEyQLyEDIGkGA
K22-ub QLyEDIGkGAFSVVR
S26 DIGkGAFSVVRRCVk
K33-ac SVVRRCVkLCTGHEy
K33-ub SVVRRCVkLCTGHEy
Y40-p kLCTGHEyAAkIINT
K43-ub TGHEyAAkIINTkkL
K48-ub AAkIINTkkLSARDH
K48 AAkIINTKkLSARDH
K49-ub AkIINTkkLSARDHQ
K69-ub ARICRLLkHSNIVRL
S79 NIVRLHDSISEEGFH
K138-ub GVVHRDLkPENLLLA
K147-ub ENLLLASkCkGAAVk
K149-ub LLLASkCkGAAVkLA
K154-ub kCkGAAVkLADFGLA
K221-m2 FWDEDQHkLYQQIkA
K227-ac HkLYQQIkAGAyDFP
K227-ub HkLYQQIkAGAyDFP
Y231-p QQIkAGAyDFPsPEW
S235-p AGAyDFPsPEWDTVT
K246-ub DTVTPEAkNLINQML
T254-p NLINQMLtINPAkRI
K259-ac MLtINPAkRITAHEA
K259-ub MLtINPAkRITAHEA
K268-ub ITAHEALkHPWVCQR
S276-p HPWVCQRstVAsMMH
T277-p PWVCQRstVAsMMHR
S280-p CQRstVAsMMHRQEt
T287-p sMMHRQEtVECLkkF
K292-ub QEtVECLkkFNARRk
K293-ub EtVECLkkFNARRkL
K299-ub kkFNARRkLkGAILt
K299 kkFNARRKLkGAILt
K301-ub FNARRkLkGAILttM
K301 FNARRkLKGAILttM
T306-p kLkGAILttMLAtRN
T307-p LkGAILttMLAtRNF
T311-p ILttMLAtRNFsVGR
S315-p MLAtRNFsVGRQTTA
T321 FsVGRQTTAPATMST
T325 RQTTAPATMSTAASG
S327 TTAPATMSTAASGTT
T328 TAPATMSTAASGTTM
T328 TAPATMSTAASGTTM
K342 MGLVEQAKSLLNkkA
K342-ub MGLVEQAkSLLNkkA
S343 GLVEQAkSLLNkkAD
K347 QAkSLLNKkADGVkP
K347-ub QAkSLLNkkADGVkP
K348-ub AkSLLNkkADGVkPQ
K353-ub NkkADGVkPQTNSTk
S358 GVkPQTNSTkNSSAI
K360-ub kPQTNSTkNSSAITs
S363 TNSTkNSSAITsPkG
T366 TkNSSAITsPkGsLP
S367-p kNSSAITsPkGsLPP
K369-ub SSAITsPkGsLPPAA
S371-p AITsPkGsLPPAALE
T381 PAALEPQTTVIHNPV
S394-p PVDGIKEssDsTNtt
S395-p VDGIKEssDsTNttI
S397-p GIKEssDsTNttIED
T398 IKEssDsTNttIEDE
T400-p EssDsTNttIEDEDA
T401-p ssDsTNttIEDEDAK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K411-ub DEDAKARkQEIIkTT
K416-ub ARkQEIIkTTEQLIE
K469-ub YFENLLAkNSkPIHT
K472-ub NLLAkNSkPIHTTIL
Y501-p AYIRLTQyIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
3361 : Phospho-CaMKII (Thr286) Antibody
  CAMK2B iso3  
Y14 CTRFTDEYQLYEDIG
Y17 FTDEYQLYEDIGKGA
K22 QLYEDIGKGAFSVVR
S26 DIGKGAFSVVRRCVK
K33 SVVRRCVKLCTGHEY
K33 SVVRRCVKLCTGHEY
Y40 KLCTGHEYAAKIINT
K43 TGHEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHSNIVRL
S79 NIVRLHDSISEEGFH
K138 GVVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
K221 FWDEDQHKLYQQIKA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITAHEA
K259 MLTINPAKRITAHEA
K268 ITAHEALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQET
T287 SMMHRQETVECLKKF
K292 QETVECLKKFNARRK
K293 ETVECLKKFNARRKL
K299 KKFNARRKLKGAILT
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLATRN
T307 LKGAILTTMLATRNF
T311 ILTTMLATRNFsAAK
S315-p MLATRNFsAAKSLLN
- gap
- gap
- gap
- gap
- gap
K318 TRNFsAAKSLLNKKA
K318 TRNFsAAKSLLNKKA
S319 RNFsAAKSLLNKKAD
K323 AAKSLLNKKADGVKP
K323 AAKSLLNKKADGVKP
K324 AKSLLNKKADGVKPQ
K329 NKKADGVKPQTNSTK
S334 GVKPQTNSTKNSSAI
K336 KPQTNSTKNSSAITS
S339 TNSTKNSSAITSPKG
- gap
- gap
- gap
- gap
T342 TKNSSAITSPKGSLP
S355-p LPPAALEsSDSTNTT
S356 PPAALEsSDSTNTTI
S358 AALEsSDSTNTTIED
T359 ALEsSDSTNTTIEDE
T361 EsSDSTNTTIEDEDA
T362 sSDSTNTTIEDEDAK
- gap
- gap
- gap
S379-p RISDILNsVRRGCGT
C384 LNsVRRGCGTPEAEG
T386 sVRRGCGTPEAEGPL
S394 PEAEGPLSVGPPPCL
S422-p RISDILNsVRRGSGT
S427 LNsVRRGSGTPEAEG
T429 sVRRGSGTPEAEGLP
S445 VGPPPCPSPTLPGPL
K458 PLPTPSRKQEIIKTT
K463 SRKQEIIKTTEQLIE
K516 YFENLLAKNSKPIHT
K519 NLLAKNSKPIHTTIL
Y548 AYIRLTQYIDGQGRP
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