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SOX2
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Interacts with ZSCAN10. Interacts with SOX3 and FGFR1. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; Cell development/differentiation; DNA binding protein |
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Cellular Component: transcription factor complex; cytoplasm; cytosol; nucleus
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Molecular Function: identical protein binding; protein binding; miRNA binding; DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
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Biological Process: tongue development; establishment and/or maintenance of chromatin architecture; somatic stem cell maintenance; endodermal cell fate specification; positive regulation of transcription, DNA-dependent; diencephalon morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of caspase activity; forebrain neuron differentiation; olfactory placode formation; detection of mechanical stimulus involved in equilibrioception; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; forebrain development; response to wounding; male genitalia development; positive regulation of epithelial cell differentiation; adenohypophysis development; negative regulation of osteoblast differentiation; cell cycle arrest; inner ear development; positive regulation of Notch signaling pathway; negative regulation of epithelial cell proliferation; positive regulation of neuroblast proliferation; inner ear morphogenesis; response to retinoic acid; transcription, DNA-dependent; neuron fate commitment; detection of mechanical stimulus involved in sensory perception of sound; osteoblast differentiation; negative regulation of neuron differentiation; eye development; regulation of gene expression; pituitary gland development; glial cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; pigment biosynthetic process; alveolus development; retina morphogenesis in camera-type eye
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Reference #:
P48431 (UniProtKB)
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| Alt. Names/Synonyms: ANOP3; MCOPS3; MGC2413; SOX2; SRY (sex determining region Y)-box 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2 |
| Gene Symbols: SOX2 |
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Molecular weight: 34,310 Da
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Basal Isoelectric point: 9.74
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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