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Protein Page:
SOX2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SOX2 Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Interacts with ZSCAN10. Interacts with SOX3 and FGFR1. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Transcription factor; DNA binding protein
Cellular Component: transcription factor complex; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein binding; miRNA binding; DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: tongue development; establishment and/or maintenance of chromatin architecture; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; endodermal cell fate specification; diencephalon morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of caspase activity; forebrain neuron differentiation; olfactory placode formation; detection of mechanical stimulus involved in equilibrioception; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; forebrain development; response to wounding; male genitalia development; adenohypophysis development; positive regulation of epithelial cell differentiation; negative regulation of osteoblast differentiation; cell cycle arrest; inner ear development; positive regulation of Notch signaling pathway; negative regulation of epithelial cell proliferation; positive regulation of neuroblast proliferation; inner ear morphogenesis; response to retinoic acid; transcription, DNA-dependent; neuron fate commitment; detection of mechanical stimulus involved in sensory perception of sound; osteoblast differentiation; negative regulation of neuron differentiation; eye development; regulation of gene expression; pituitary gland development; glial cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; pigment biosynthetic process; alveolus development; retina morphogenesis in camera-type eye
Reference #:  P48431 (UniProtKB)
Alt. Names/Synonyms: ANOP3; MCOPS3; MGC2413; SOX2; SRY (sex determining region Y)-box 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2
Gene Symbols: SOX2
Molecular weight: 34,310 Da
Basal Isoelectric point: 9.74  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SOX2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K35 AAAGGNQKNsPDRVK
0 1 S37-p AGGNQKNsPDRVKRP
0 1 K58 WSRGQRRKMAQENPK
0 1 K65 KMAQENPKMHNSEIS
1 2 K73-ac MHNSEISkRLGAEWK
0 1 K87 KLLSETEKRPFIDEA
0 1 K95 RPFIDEAKRLRALHM
0 1 K103 RLRALHMKEHPDYKY
1 0 K109 MKEHPDYKYRPRRKT
1 0 K115 YKYRPRRKTKtLMKK
1 0 T116 KYRPRRKTKtLMKKD
1 0 K117 YRPRRKTKtLMKKDK
0 1 T118-p RPRRKTKtLMKKDKy
1 0 K121 RKTKtLMKKDKytLP
0 2 Y125-p tLMKKDKytLPGGLL
0 2 T126-p LMKKDKytLPGGLLA
0 1 S138-p LLAPGGNsMASGVGV
3 0 K245-sm GSMGSVVksEAsssP
0 1 S246-p SMGSVVksEAsssPP
0 2 S246 SMGSVVkSEAsssPP
0 4 S249-p SVVksEAsssPPVVT
0 3 S250-p VVksEAsssPPVVTS
0 5 S251-p VksEAsssPPVVTSS
0 1 T256 sssPPVVTSSSHSRA
0 1 S275 GDLRDMISMYLPGAE
0 1 Y277 LRDMISMYLPGAEVP
  mouse

 
K37-ac AATGGNQkNSPDRVK
S39 TGGNQkNSPDRVKRP
K60-ac WSRGQRRkMAQENPk
K67-ac kMAQENPkMHNSEIS
K75-ac MHNSEISkRLGAEWK
K89-ac KLLSETEkRPFIDEA
K97-ac RPFIDEAkRLRALHM
K105-ac RLRALHMkEHPDYkY
K111-ac MkEHPDYkYRPRRkt
K117-ac YkYRPRRktkTLMkK
T118-p kYRPRRktkTLMkKD
K119-ac YRPRRktkTLMkKDK
T120 RPRRktkTLMkKDKY
K123-ac RktkTLMkKDKYTLP
Y127 TLMkKDKYTLPGGLL
T128 LMkKDKYTLPGGLLA
S140 LLAPGGNSMASGVGV
K247-sm GSMGSVVksEASSSP
S248 SMGSVVkSEASSSPP
S248-gl SMGSVVksEASSSPP
S251 SVVksEASSSPPVVt
S252 VVksEASSSPPVVtS
S253 VksEASSSPPVVtSS
T258-gl SSSPPVVtSSSHSRA
S277-p GDLRDMIsMyLPGAE
Y279-p LRDMIsMyLPGAEVP
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