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Protein Page:
BMPR2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BMPR2 a serine/threonine-protein kinase receptor for bone morphogenetic protein (BMP). Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1), a weakly penetrant dominant disorder, associated with lesions in pulmonary arterioles, elevated pulmonary arterial pressure, and right ventricular failure. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, TKL; Cell cycle regulation; Membrane protein, integral; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily
Cellular Component: cell surface; cell soma; integral to plasma membrane; cytoplasm; apical plasma membrane; dendrite; plasma membrane; basal plasma membrane; caveola
Molecular Function: transforming growth factor beta receptor activity; protein binding; growth factor binding; metal ion binding; activin receptor activity, type II; ATP binding
Biological Process: transcription from RNA polymerase II promoter; regulation of lung blood pressure; negative regulation of systemic arterial blood pressure; cellular response to starvation; positive regulation of bone mineralization; negative regulation of vasoconstriction; regulation of cell proliferation; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of osteoblast differentiation; mesoderm formation; lymphangiogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of endothelial cell proliferation; blood vessel remodeling; negative regulation of cell growth; brain development; vascular endothelial growth factor receptor signaling pathway; alveolus development; positive regulation of BMP signaling pathway
Reference #:  Q13873 (UniProtKB)
Alt. Names/Synonyms: BMP type II receptor; BMP type-2 receptor; BMPR-2; BMPR-II; BMPR2; BMPR3; BMPRII; BMR2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); BRK-3; FLJ41585; FLJ76945; PPH1; T-ALK; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Gene Symbols: BMPR2
Molecular weight: 115,201 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BMPR2
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 T128 DLCNVNFTENFPPPD
0 1 K180 RMLTGDRKQGLHSMN
0 3 S375-p EEDNAAIsEVGtIRY
0 1 T379-p AAIsEVGtIRYMAPE
0 1 K512 MMIWERNKSVsPTVN
0 2 S513 MIWERNKSVsPTVNP
0 2 S515-p WERNKSVsPTVNPMS
0 1 T517 RNKSVsPTVNPMSTA
0 2 Y546-p KIGPYPDysSSsyIE
0 1 S547-p IGPYPDysSSsyIED
0 1 S548 GPYPDysSSsyIEDS
0 1 S550-p YPDysSSsyIEDSIH
0 3 Y551-p PDysSSsyIEDSIHH
0 1 S561 DSIHHTDSIVKNISS
0 1 S574-p SSEHSMSstPLTIGE
0 3 T575-p SEHSMSstPLTIGEK
0 2 S586-p IGEKNRNsINyERQQ
0 1 Y589-p KNRNsINyERQQAQA
0 4 S680-p VDKNLKEssDENLME
0 4 S681-p DKNLKEssDENLMEH
0 19 Y708-p STSSSLLyPLIKLAV
1 2 S757-p NLPKRPTsLPLNTKN
0 1 K782 SKHKSNLKQVETGVA
0 1 T803-p AAEPHVVtVtMNGVA
0 1 T805-p EPHVVtVtMNGVAGR
0 2 Y825-p SHAATTQyANGTVLS
0 1 A843 TNIVTHRAQEMLQNQ
0 3 S862-p DTRLNINssPDEHEP
0 6 S863-p TRLNINssPDEHEPL
0 1 T900 RPLEGGRTNSNNNNS
0 1 S902 LEGGRTNSNNNNSNP
0 1 S907 TNSNNNNSNPCSEQD
0 1 S911 NNNSNPCSEQDVLAQ
0 1 T977-p KIKKRVKtPySLKRW
0 1 Y979-p KKRVKtPySLKRWRP
  mouse

 
T128-p DLCNVNFtENFPPPD
K180-u RMLTGDRkQGLHSMN
S375-p EEDNAAIsEVGTIRY
T379 AAIsEVGTIRYMAPE
K512-u MMIWERNksVsPtVN
S513-p MIWERNksVsPtVNP
S515-p WERNksVsPtVNPMS
T517-p RNksVsPtVNPMSTA
Y546 KIGPYPDYSsSSYIE
S547 IGPYPDYSsSSYIED
S548-p GPYPDYSsSSYIEDS
S550 YPDYSsSSYIEDSIH
Y551 PDYSsSSYIEDSIHH
S561-p DSIHHTDsIVKNISS
S574 SSEHSMSStPLTIGE
T575-p SEHSMSStPLTIGEK
S586-p IGEKNRNsINYERQQ
Y589 KNRNsINYERQQAQA
S680-p VDKNLKEssDENLME
S681-p DKNLKEssDENLMEH
Y708 STSSSLLYPLIKLAV
S757 NLPKRPTSLPLNTKN
K782-u NKHKSNLkQVETGVA
T803 AAEPHVVTVTMNGVA
T805 EPHVVTVTMNGVAGR
Y825 SHAATTQYANGAVPA
S843-p ANIVAHRsQEMLQNQ
S862-p DTRLNINssPDEHEP
S863-p TRLNINssPDEHEPL
T900-p RPLEGGRtNsNNNNs
S902-p LEGGRtNsNNNNsNP
S907-p tNsNNNNsNPCsEQD
S911-p NNNsNPCsEQDILTQ
T977 KIKRRVKTPYSLKRW
Y979 KRRVKTPYSLKRWRP
  rat

 
T128 DLCNVNFTENFPPPD
K180 RMLTGDRKQGLHSVS
S375 EEDNAAISEVGTIRY
T379 AAISEVGTIRYMAPE
K512 MMIWERNKSVSPTVN
S513 MIWERNKSVSPTVNP
S515 WERNKSVSPTVNPMS
T517 RNKSVSPTVNPMSTA
Y546 KIGPYPDYSSSSyIE
S547 IGPYPDYSSSSyIED
S548 GPYPDYSSSSyIEDS
S550 YPDYSSSSyIEDSIH
Y551-p PDYSSSSyIEDSIHH
S561 DSIHHTDSIVKNISS
S574 SSEHSMSSTPLTIGE
T575 SEHSMSSTPLTIGEK
S586 IGEKNRNSINYERQQ
Y589 KNRNSINYERQQAQA
S680 VDKNLKESSDENLME
S681 DKNLKESSDENLMEH
Y708-p STSSSLLyPLIKLAV
S757 NLPKRPTSLPLNTKN
K782 NKHKSNLKQVETGVA
T803 AAEPHVVTVTMNGVA
T805 EPHVVTVTMNGVAGR
Y825 SHAATTQYANGVVPS
A843 ANIVAHRAQEMLQNQ
S862 DTRLNINSSPDEHEP
S863 TRLNINSSPDEHEPL
T900 RPLEGGRTNSNNNNS
S902 LEGGRTNSNNNNSNP
S907 TNSNNNNSNPCSEQD
S911 NNNSNPCSEQDVPTQ
T977 KIKRRVKTPYSLKRW
Y979 KRRVKTPYSLKRWRP
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