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Protein Page:
Akt3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Akt3 an AGC kinase that plays a critical role in controlling the balance between survival and apoptosis. Stimulated by platelet-derived growth factor, insulin, and insulin-like growth factor 1. Alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.1; AGC group; AKT family
Cellular Component: Golgi apparatus; cytoplasm; nucleolus; plasma membrane; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity
Biological Process: mitochondrial genome maintenance; signal transduction; protein amino acid phosphorylation
Reference #:  Q9Y243 (UniProtKB)
Alt. Names/Synonyms: AKT3; DKFZp434N0250; PKB gamma; PKB-GAMMA; PKBG; PRKBG; Protein kinase Akt-3; Protein kinase B gamma; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; serine threonine protein kinase, Akt-3; STK-2; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Gene Symbols: AKT3
Molecular weight: 55,775 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Akt3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 3 S34-p FLLKTDGsFIGyKEK
0 1 Y38-p TDGsFIGyKEKPQDV
1 3 S120-p EEERMNCsPTsQIDN
0 1 S123-p RMNCsPTsQIDNIGE
0 2 Y173 REKASGKYYAMKILK
0 2 Y174 EKASGKYYAMKILKK
0 1 S197-p VAHTLTEsRVLKNTR
0 2 K273-ub KIVYRDLkLENLMLD
0 1 T298-p GLCKEGItDAATMKt
6 9 T305-p tDAATMKtFCGtPEy
0 1 T309-p TMKtFCGtPEyLAPE
0 11 Y312-p tFCGtPEyLAPEVLE
0 27 Y323-p EVLEDNDyGRAVDWW
0 4 Y434-p TSETDTRyFDEEFtA
0 2 T440-p RyFDEEFtAQTITIt
1 2 T447-p tAQTITItPPEKYDE
4 22 S472-p RPHFPQFsysAsGRE
0 3 Y473-p PHFPQFsysAsGRE_
0 9 S474-p HFPQFsysAsGRE__
0 16 S476-p PQFsysAsGRE____
13038 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb
13842 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb (PE Conjugate)
9267 : Phospho-Akt (Thr450) Antibody
12178 : Phospho-Akt (Thr450) (D5G4) Rabbit mAb
2336 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2337 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
3787 : Phospho-Akt (Ser473) (736E11) Rabbit mAb
4051 : Phospho-Akt (Ser473) (587F11) Mouse mAb
4058 : Phospho-Akt (Ser473) (193H12) Rabbit mAb
4060 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb
4070 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
4071 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4075 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5012 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Biotinylated)
5102 : Phospho-Akt (Ser473) (587F11) Mouse mAb (Biotinylated)
5315 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (PE Conjugate)
9271 : Phospho-Akt (Ser473) Antibody
9563 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Magnetic Bead Conjugate)
12694 : Phospho-Akt (Ser473) (D9W9U) Mouse mAb
  mouse

 
S34-p FLLKTDGsFIGYKEK
Y38 TDGsFIGYKEKPQDV
S120-p EEERMNCsPTSQIDN
S123 RMNCsPTSQIDNIGE
Y173-p REKASGKyyAMKILK
Y174-p EKASGKyyAMKILKK
S197 VAHTLTESRVLKNTR
K273-ub KIVYRDLkLENLMLD
T298-p GLCKEGItDAATMKt
T305-p tDAATMKtFCGtPEY
T309-p TMKtFCGtPEYLAPE
Y312 tFCGtPEYLAPEVLE
Y323-p EVLEDNDyGRAVDWW
Y434 TSETDTRYFDEEFTA
T440 RYFDEEFTAQTITIt
T447-p TAQTITItPPEKYDD
S472-p RPHFPQFsysAsGRE
Y473-p PHFPQFsysAsGRE_
S474-p HFPQFsysAsGRE__
S476-p PQFsysAsGRE____
13038 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb
13842 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb (PE Conjugate)
9267 : Phospho-Akt (Thr450) Antibody
12178 : Phospho-Akt (Thr450) (D5G4) Rabbit mAb
2336 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2337 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
3787 : Phospho-Akt (Ser473) (736E11) Rabbit mAb
4051 : Phospho-Akt (Ser473) (587F11) Mouse mAb
4058 : Phospho-Akt (Ser473) (193H12) Rabbit mAb
4060 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb
4070 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
4071 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4075 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5012 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Biotinylated)
5102 : Phospho-Akt (Ser473) (587F11) Mouse mAb (Biotinylated)
5315 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (PE Conjugate)
9271 : Phospho-Akt (Ser473) Antibody
9563 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Magnetic Bead Conjugate)
12694 : Phospho-Akt (Ser473) (D9W9U) Mouse mAb
  rat

 
S34-p FLLKTDGsFIGYKEK
Y38 TDGsFIGYKEKPQDV
S120 EEERMNCSPTSQIDN
S123 RMNCSPTSQIDNIGE
Y173 REKASGKYYAMKILK
Y174 EKASGKYYAMKILKK
S197 VAHTLTESRVLKNTR
K273 KIVYRDLKLENLMLD
T298 GLCKEGITDAATMKt
T305-p TDAATMKtFCGTPEY
T309 TMKtFCGTPEYLAPE
Y312 tFCGTPEYLAPEVLE
Y323 EVLEDNDYGRAVDWW
Y434 TSETDTRYFDEEFTA
T440 RYFDEEFTAQTITIT
T447 TAQTITITPPEKDDD
S472 RPHFPQFSYSASGRE
Y473 PHFPQFSYSASGRE_
S474 HFPQFSYSASGRE__
S476 PQFSYSASGRE____
13038 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb
13842 : Phospho-Akt (Thr308) (D25E6) XP(R) Rabbit mAb (PE Conjugate)
9267 : Phospho-Akt (Thr450) Antibody
12178 : Phospho-Akt (Thr450) (D5G4) Rabbit mAb
2336 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2337 : Phospho-Akt (Ser473) (193H12) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
3787 : Phospho-Akt (Ser473) (736E11) Rabbit mAb
4051 : Phospho-Akt (Ser473) (587F11) Mouse mAb
4058 : Phospho-Akt (Ser473) (193H12) Rabbit mAb
4060 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb
4070 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
4071 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
4075 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
5012 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Biotinylated)
5102 : Phospho-Akt (Ser473) (587F11) Mouse mAb (Biotinylated)
5315 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (PE Conjugate)
9271 : Phospho-Akt (Ser473) Antibody
9563 : Phospho-Akt (Ser473) (D9E) XP(R) Rabbit mAb (Magnetic Bead Conjugate)
12694 : Phospho-Akt (Ser473) (D9W9U) Mouse mAb
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