Home

Akt3 (human)

Overview Akt3 an AGC kinase that plays a critical role in controlling the balance between survival and apoptosis. Stimulated by platelet-derived growth factor, insulin, and insulin-like growth factor 1. Alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; AKT family Cellular Component: Golgi apparatus; cytoplasm; nucleolus; plasma membrane; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; phospholipid binding; ATP binding; protein kinase activity Biological Process: mitochondrial genome maintenance; signal transduction; protein amino acid phosphorylation Reference #:  Q9Y243 (UniProtKB) Alt. Names/Synonyms: AKT3; DKFZp434N0250; PKB gamma; PKB-GAMMA; PKBG; PRKBG; Protein kinase Akt-3; Protein kinase B gamma; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; serine threonine protein kinase, Akt-3; STK-2; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) Gene Symbols: AKT3 Molecular weight: 55,775 Da Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis  |  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  Regulation of Microtubule Dynamics  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Akt3 2X18 - F/A/E/B/H/C/D/G=466-583 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, induced: S472‑p enzymatic activity, induced: Y434‑p molecular association, regulation: Y434‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	3		S34-p	FLLKTDGsFIGyKEK
0	1		Y38-p	TDGsFIGyKEKPQDV
1	2		S120-p	EEERMNCsPTsQIDN
0	1		S123-p	RMNCsPTsQIDNIGE
0	2		Y173-p	REKASGKyyAMKILK
0	2		Y174-p	EKASGKyyAMKILKK
0	1		S197-p	VAHTLTEsRVLKNTR
0	2		K273-u	KIVYRDLkLENLMLD
0	1		T298-p	GLCKEGItDAATMKt
5	6		T305-p	tDAATMKtFCGtPEy
0	1		T309-p	TMKtFCGtPEyLAPE
0	11		Y312-p	tFCGtPEyLAPEVLE
0	26		Y323-p	EVLEDNDyGRAVDWW
0	5		Y434-p	TSETDTRyFDEEFtA
0	2		T440-p	RyFDEEFtAQTITIt
1	1		T447-p	tAQTITItPPEKYDE
4	19		S472-p	RPHFPQFsysAsGRE
0	3		Y473-p	PHFPQFsysAsGRE_
0	9		S474-p	HFPQFsysAsGRE__
0	15		S476-p	PQFsysAsGRE____

	mouse
S34-p	FLLKTDGsFIGYKEK
Y38	TDGsFIGYKEKPQDV
S120-p	EEERMNCsPTSQIDN
S123	RMNCsPTSQIDNIGE
Y173-p	REKASGKyyAMKILK
Y174-p	EKASGKyyAMKILKK
S197	VAHTLTESRVLKNTR
K273-u	KIVYRDLkLENLMLD
T298-p	GLCKEGItDAATMKt
T305-p	tDAATMKtFCGtPEY
T309-p	TMKtFCGtPEYLAPE
Y312	tFCGtPEYLAPEVLE
Y323-p	EVLEDNDyGRAVDWW
Y434	TSETDTRYFDEEFTA
T440	RYFDEEFTAQTITIt
T447-p	TAQTITItPPEKYDD
S472-p	RPHFPQFsysAsGRE
Y473-p	PHFPQFsysAsGRE_
S474-p	HFPQFsysAsGRE__
S476-p	PQFsysAsGRE____

	rat
S34-p	FLLKTDGsFIGYKEK
Y38	TDGsFIGYKEKPQDV
S120	EEERMNCSPTSQIDN
S123	RMNCSPTSQIDNIGE
Y173	REKASGKYYAMKILK
Y174	EKASGKYYAMKILKK
S197	VAHTLTESRVLKNTR
K273	KIVYRDLKLENLMLD
T298	GLCKEGITDAATMKt
T305-p	TDAATMKtFCGTPEY
T309	TMKtFCGTPEYLAPE
Y312	tFCGTPEYLAPEVLE
Y323	EVLEDNDYGRAVDWW
Y434	TSETDTRYFDEEFTA
T440	RYFDEEFTAQTITIT
T447	TAQTITITPPEKDDD
S472	RPHFPQFSYSASGRE
Y473	PHFPQFSYSASGRE_
S474	HFPQFSYSASGRE__
S476	PQFSYSASGRE____

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.