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Akt2 (human)

Overview Akt2 an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; AGC group; AKT family Cellular Component: nucleoplasm; mitochondrion; lamellipodium; plasma membrane; cytosol; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C binding; phospholipid binding; kinase activity; ATP binding Biological Process: fat cell differentiation; response to muscle activity; positive regulation of positive chemotaxis; positive regulation of nitric oxide biosynthetic process; positive regulation of glycogen biosynthetic process; negative regulation of caspase activity; signal transduction; regulation of cell migration; regulation of JNK cascade; regulation of translation; positive regulation of glucose import; negative regulation of RNA splicing; protein kinase B signaling cascade; glycogen biosynthetic process; positive regulation of signal transduction; carbohydrate transport; myelin maintenance in the peripheral nervous system; protein modification process; glucose metabolic process; response to osmotic stress; positive regulation of peptidyl-serine phosphorylation; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis; positive regulation of cell migration Reference #:  P31751 (UniProtKB) Alt. Names/Synonyms: AKT2; Murine thymoma viral (v-akt) homolog-2; PKB beta; PKBB; PKBBETA; PRKBB; Protein kinase Akt-2; Protein kinase B beta; rac protein kinase beta; RAC-BETA; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; v-akt murine thymoma viral oncogene homolog 2 Gene Symbols: AKT2 Molecular weight: 55,769 Da Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis  |  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Jak/Stat/IL-6 Signaling  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  Regulation of Microtubule Dynamics  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Akt2 1GZK - A=146-460 (human) 1GZN - A=146-480 (human) 1GZO - A=146-460 (human) 1MRV - A=143-481 (human) 1MRY - A=143-481 (human) 1O6K - A=146-481 (human) 1O6L - A=146-467 (human) 1P6S - A=1-111 (human) 2UW9 - A=146-477 (human) 2X39 - A=146-467 (human) 2XH5 - A=146-479 (human) 3D0E - A/B=146-480 (human) 3E87 - A/B=146-480 (human) 3E88 - A/B=146-480 (human) 3E8D - A/B=146-480 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D  |  ENZYME  |  Phospho3D  |  DISEASE 125853 164731  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: T309‑p, S474‑p intracellular localization: T309‑p, S474‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K30-u	RPRYFLLkSDGSFIG
0	1		Y38-p	SDGSFIGyKERPEAP
0	1		T81-p	VIRCLQWtTVIERTF
1	4		S126-p	PMDYKCGsPSDSSTT
0	1		S130	KCGsPSDSSTTEEME
0	1		Y177-p	REKATGRyyAMKILR
0	1		Y178-p	EKATGRyyAMKILRK
0	1		S242-p	GELFFHLsRERVFTE
0	1		Y255	TEERARFYGAEIVSA
0	1		S261	FYGAEIVSALEYLHS
0	1		Y265	EIVSALEYLHSRDVV
0	1		K277-u	DVVYRDIkLENLMLD
0	3		S302-p	GLCKEGIsDGAtMKt
0	7		T306-p	EGIsDGAtMKtFCGt
9	14		T309-p	sDGAtMKtFCGtPEy
0	4		T313-p	tMKtFCGtPEyLAPE
0	12		Y316-p	tFCGtPEyLAPEVLE
0	26		Y327-p	EVLEDNDyGRAVDWW
0	1		K378-a	RTLSPEAksLLAGLL
0	1		K378-u	RTLSPEAksLLAGLL
0	1		S379-p	TLSPEAksLLAGLLK
0	3		Y438-p	TSEVDTRyFDDEFTA
0	2		S447-p	DDEFTAQsItItPPD
0	1		T449-p	EFTAQsItItPPDRy
1	16		T451-p	TAQsItItPPDRyDs
0	1		Y456-p	tItPPDRyDsLGLLE
0	3		S458-p	tPPDRyDsLGLLELD
16	46		S474-p	RTHFPQFsysAsIRE
0	18		Y475-p	THFPQFsysAsIRE_
0	8		S476-p	HFPQFsysAsIRE__
0	43		S478-p	PQFsysAsIRE____

	mouse
K30	RPRYFLLKSDGSFIG
Y38	SDGSFIGYKERPEAP
T81	VIRCLQWTTVIERTF
S126-p	AMDYKCGsPSDsSTS
S130-p	KCGsPSDsSTSEMME
Y177	REKATGRYYAMKILR
Y178	EKATGRYYAMKILRK
S242	GELFFHLSRERVFTE
Y255-p	TEDRARFyGAEIVsA
S261-p	FyGAEIVsALEyLHS
Y265-p	EIVsALEyLHSRDVV
K277	DVVYRDIKLENLMLD
S302	GLCKEGISDGAtMKt
T306-p	EGISDGAtMKtFCGt
T309-p	SDGAtMKtFCGtPEY
T313-p	tMKtFCGtPEYLAPE
Y316	tFCGtPEYLAPEVLE
Y327-p	EVLEDNDyGRAVDWW
K378	RTLGPEAKSLLAGLL
K378	RTLGPEAKSLLAGLL
S379	TLGPEAKSLLAGLLK
Y438	TSEVDTRYFDDEFTA
S447-p	DDEFTAQsITItPPD
T449	EFTAQsITItPPDRY
T451-p	TAQsITItPPDRYDs
Y456	TItPPDRYDsLDPLE
S458-p	tPPDRYDsLDPLELD
S474-p	RTHFPQFsysAsIRE
Y475-p	THFPQFsysAsIRE_
S476-p	HFPQFsysAsIRE__
S478-p	PQFsysAsIRE____

	rat
K30	RPRYFLLKSDGSFIG
Y38	SDGSFIGYKERPEAP
T81	VIRCLQWTTVIERTF
S126	AMDYKCGSPSDSSTS
S130	KCGSPSDSSTSEMME
Y177	REKATGRYYAMKILR
Y178	EKATGRYYAMKILRK
S242	GDLFFHLSRERVFTE
Y255	TEDRARFYGAEIVSA
S261	FYGAEIVSALEYLHS
Y265	EIVSALEYLHSTDVV
K277	DVVYRDIKLENLMLD
S302	GLSKEGISDGATMKt
T306	EGISDGATMKtFCGT
T309-p	SDGATMKtFCGTPEY
T313	TMKtFCGTPEYLAPE
Y316	tFCGTPEYLAPEVLE
Y327	EVLEDNDYGRAVDWW
K378	RTLGPEAKSLLAGLL
K378	RTLGPEAKSLLAGLL
S379	TLGPEAKSLLAGLLK
Y438	TSEVDTRYFDDEFTA
S447	DDEFTAQSITITPPD
T449	EFTAQSITITPPDRY
T451	TAQSITITPPDRYDS
Y456	TITPPDRYDSLGSLE
S458	TPPDRYDSLGSLELD
S474-p	RTHFPQFsYSASIRE
Y475	THFPQFsYSASIRE_
S476	HFPQFsYSASIRE__
S478	PQFsYSASIRE____

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