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Protein Page:
GM130 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GM130 Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1. Belongs to the GOLGA2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: Golgi membrane; Golgi apparatus; cis-Golgi network
Molecular Function: protein binding
Biological Process: mitotic cell cycle
Reference #:  Q08379 (UniProtKB)
Alt. Names/Synonyms: 130 kDa cis-Golgi matrix protein; GM130; GM130 autoantigen; GOGA2; GOLGA2; golgi autoantigen, golgin subfamily a, 2; Golgi matrix protein GM130; golgin A2; Golgin subfamily A member 2; Golgin-95; MGC20672; SY11 protein
Gene Symbols: GOLGA2
Molecular weight: 113,086 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GM130

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S37‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S20-p MSEETRQsKLAAAKK
4 8 S37-p REYQQRNsPGVPTGA
0 1 K47-ac VPTGAKKkKKIkNGS
0 1 K51-ub AKKkKKIkNGSNPEt
0 5 N55 KKIkNGSNPEtTTSG
0 1 T58-p kNGSNPEtTTSGGCH
0 3 S66-p TTSGGCHsPEDTPKD
0 1 - gap
0 1 - gap
0 1 S81 NAATLQPSDDTVLPG
0 1 T84 TLQPSDDTVLPGGVP
0 2 S123 DETKTFSSTESLRQL
0 1 S126 KTFSSTESLRQLsQQ
0 12 S131-p TESLRQLsQQLNGLV
0 1 Y174-p AVALDSSyVTNKQLN
0 1 T195-p KQQNQEItDQLEEEk
0 1 K202 tDQLEEEKKECHQKQ
0 1 K202-ub tDQLEEEkKECHQKQ
0 1 K203 DQLEEEkKECHQKQG
0 1 S251-p ARQKEGEsEDLASRL
0 3 S273-p GELERALsAVSTQQK
0 4 A274 ELERALsAVSTQQKK
0 1 Y396 LQMERDKYAENLKGE
0 6 S438-p RVQELETsLAELRNQ
0 1 K546 LSQNRELKEQLAELQ
0 1 K590-ub KLGELQEkLSELKET
0 1 K595 QEkLSELKETVELKS
0 2 S690-p QQLRAQLsLMAHPGE
0 2 A769 RVRCRRLAHLLAsAQ
0 1 S774-p RLAHLLAsAQKEPEA
0 3 S792-p APGTGGDsVCGETHR
0 1 K807 ALQGAMEKLQSRFME
0 1 K819 FMELMQEKADLKERV
0 1 Y850-p IGEYIALyQSQRAVL
0 1 K864 LKERHREKEEYISRL
0 1 P921 PTSGAPAPQELGAAN
0 1 S937-p QGDLCEVsLAGSVEP
0 4 S953-p QGEAREGsPRDNPtA
0 1 T959-p GsPRDNPtAQQIMQL
0 6 S981-p RERPGLGsNPCIPFF
  GM130 iso3  
S20 MSEETRQSKLAAAKK
S37 REYQQRNSPGVPTGA
K47 VPTGAKKKKKIKNGS
K51 AKKKKKIKNGSNPET
N55 KKIKNGSNPETTTSG
T58 KNGSNPETTTSGGCH
S66-p TTSGGCHsPEDIQDI
S84 LVSDLNRSNGVALPP
- gap
S108 NAATLQPSDDTVLPG
T111 TLQPSDDTVLPGGVP
S150 DETKTFSSTESLRQL
S153 KTFSSTESLRQLSQQ
S158 TESLRQLSQQLNGLV
Y201 AVALDSSYVTNKQLN
T222 KQQNQEITDQLEEEK
K229 TDQLEEEKKECHQKQ
K229 TDQLEEEKKECHQKQ
K230 DQLEEEKKECHQKQG
S278 ARQKEGESEDLASRL
S300 GELERALSAVSTQQK
A301 ELERALSAVSTQQKK
Y423 LQMERDKYAENLKGE
S465 RVQELETSLAELRNQ
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S20 MSEETRQSKLAAAKK
S37-p REYQQKNsPGVPAGA
K47 VPAGAKKKKKIKNGH
K51 AKKKKKIKNGHSPER
S55 KKIKNGHSPERPTAS
R58 KNGHSPERPTASDCQ
S66 PTASDCQSPENVPtD
- gap
T72-p QSPENVPtDHIAPAP
T81-p HIAPAPPtAAtDTMF
T84-p PAPPtAAtDTMFLGV
S120-p EETKTFSsTEsLRQL
S123-p KTFSsTEsLRQLsQQ
S128-p TEsLRQLsQQLNGLV
Y170 AVALDSSYVTNKQLS
L191 KQQNQDTLDQLEKEk
K198-ac LDQLEKEkkDYQQKL
K198 LDQLEKEKkDYQQKL
K199-ac DQLEKEkkDYQQKLA
S251 ARQKAGESEDLASRL
S273-p GELERTLstVSTQQK
T274-p ELERTLstVSTQQKQ
Y396-p LQVERDQyAENLKGE
S438-p QVQELETsLAALRSQ
K546-ub LSQNRELkEQLAELQ
R590 KLGELQERLGELkET
K595-ub QERLGELkETVELKS
S697 QQLQAQLSLLVLPGE
S766-p KARCRSLsHLAAPVQ
P771 SLsHLAAPVQSKLEK
S789-p VPRNVDDsASEESNQ
K804-ub ALHVAMEkLQSRFLE
K816-ub FLEVMQEkVELKERV
Y847 IGEYIALYQNQRAVL
K861-ub LKARHLEkEEYISRL
S918-p LTPVPTGsQEFGAAD
S934 QDDLREVSLADDIEP
A950 QGEAGVPAPHENPTA
T956 PAPHENPTAQQIMQL
S978-p RERPGLGsNPCIPFF
  GM130 iso3  
S20 MSEETRQSKLAAAKK
S37 REYQQKNSPGVPAGA
K47 VPAGAKKKKKIKNGH
K51 AKKKKKIKNGHsPER
S55-p KKIKNGHsPERPTAS
R58 KNGHsPERPTASDCQ
S66 PTASDCQSPENIKDI
S84-p LVSDLNRsNGVSLPP
T99 LDKRKVPTDHIAPAP
T108 HIAPAPPTAATDTMF
T111 PAPPTAATDTMFLGV
S147 EETKTFSSTESLRQL
S150 KTFSSTESLRQLSQQ
S155 TESLRQLSQQLNGLV
Y197 AVALDSSYVTNKQLS
L218 KQQNQDTLDQLEKEK
K225 LDQLEKEKKDYQQKL
K225 LDQLEKEKKDYQQKL
K226 DQLEKEKKDYQQKLA
S278 ARQKAGESEDLASRL
S300 GELERTLSTVSTQQK
T301 ELERTLSTVSTQQKQ
Y423 LQVERDQYAENLKGE
S465 QVQELETSLAALRSQ
K573 LSQNRELKEQLAELQ
R617 KLGELQERLGELKET
K622 QERLGELKETVELKS
S724 QQLQAQLSLLVLPGE
S793 KARCRSLSHLAAPVQ
P798 SLSHLAAPVQSKLEK
S816 VPRNVDDSASEESNQ
K831 ALHVAMEKLQSRFLE
K843 FLEVMQEKVELKERV
Y874 IGEYIALYQNQRAVL
K888 LKARHLEKEEYISRL
S945 LTPVPTGSQEFGAAD
S961 QDDLREVSLADDIEP
A977 QGEAGVPAPHENPTA
T983 PAPHENPTAQQIMQL
S1005 RERPGLGSNPCIPFF
  rat

 
S20 MSEETRQSKLAAAKK
S37-p REYQQKNsPGVPAGA
K47 VPAGAKKKKKIKNGH
K51 AKKKKKIKNGHsPER
S55-p KKIKNGHsPERTSAS
R58 KNGHsPERTSASDCQ
S66 TSASDCQSAENVPTD
- gap
T72 QSAENVPTDHTAPAP
S81 HTAPAPPSTAAATMF
A84 PAPPSTAAATMFLGV
S120 EETKTFSSTESLRQL
S123 KTFSSTESLRQLSQQ
S128 TESLRQLSQQLNGLV
Y170 AVALDSSYVTNKQLS
L191 KQQNQDTLDQLEKEK
K198 LDQLEKEKKDYQQKL
K198 LDQLEKEKKDYQQKL
K199 DQLEKEKKDYQQKLA
S251 ARQKAGESEDLASRL
S273 GELERTLSTVSTQQK
T274 ELERTLSTVSTQQKQ
Y396 LQVERDQYAENLKGE
S438 QVQELEASLAELRSQ
K546 LSQNRELKEQLAELQ
R590 KLGELQERLGELKET
K595 QERLGELKETVELKS
S697 QQLQAQLSLLVLPGE
A765 KARCRSLAHLAAPVQ
P770 SLAHLAAPVQSKLEK
S788 VPRDMGDSVSEESNQ
K803 ALHVAMEKLQSRFLE
K815 FLEVMQEKVELKERV
Y846 IGEYIALYQNQRAVL
K860 LKARHLEKEEYISRL
S917 PAPVPTGSQEFGAAD
S933 QGDLREVSLADDTEP
A949 QGEAGVPAPQENPTA
T955 PAPQENPTAQQIMQL
S977 QERPGLGSNPCIPFF
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