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Protein Page:
GM130 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GM130 Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1. Belongs to the GOLGA2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: Golgi apparatus
Molecular Function: protein binding
Reference #:  Q08379 (UniProtKB)
Alt. Names/Synonyms: 130 kDa cis-Golgi matrix protein; GM130; GM130 autoantigen; GOGA2; GOLGA2; golgi autoantigen, golgin subfamily a, 2; Golgi matrix protein GM130; golgin A2; Golgin subfamily A member 2; Golgin-95; MGC20672; SY11 protein
Gene Symbols: GOLGA2
Molecular weight: 113,086 Da
Basal Isoelectric point: 5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GM130
Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S37‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 S20-p MSEETRQsKLAAAKK
4 6 S37-p REYQQRNsPGVPTGA
0 1 K47-a VPTGAKKkKKIkNGS
0 1 K51-u AKKkKKIkNGSNPEt
0 3 N55 KKIkNGSNPEtTTSG
0 1 T58-p kNGSNPEtTTSGGCH
0 1 S66-p TTSGGCHsPEDTPKD
0 1 - gap
0 2 S123 DETKTFSSTESLRQL
0 13 S131-p TESLRQLsQQLNGLV
0 1 Y174-p AVALDSSyVTNKQLN
0 1 T195-p KQQNQEItDQLEEEk
0 1 K202 tDQLEEEKKECHQKQ
0 1 K202-u tDQLEEEkKECHQKQ
0 1 K203 DQLEEEkKECHQKQG
0 1 S251-p ARQKEGEsEDLASRL
0 2 S273-p GELERALsAVSTQQK
0 4 A274 ELERALsAVSTQQKK
0 1 Y396 LQMERDKYAENLKGE
0 4 S438-p RVQELETsLAELRNQ
0 1 K546 LSQNRELKEQLAELQ
0 1 K590-u KLGELQEkLSELKET
0 1 K595 QEkLSELKETVELKS
0 1 S690-p QQLRAQLsLMAHPGE
0 2 A769 RVRCRRLAHLLAsAQ
0 1 S774-p RLAHLLAsAQKEPEA
0 3 S792-p APGTGGDsVCGETHR
0 1 K807 ALQGAMEKLQSRFME
0 1 K819 FMELMQEKADLKERV
0 1 Y850-p IGEYIALyQSQRAVL
0 1 K864 LKERHREKEEYISRL
0 1 P921 PTSGAPAPQELGAAN
0 2 S953-p QGEAREGsPRDNPTA
0 4 S981-p RERPGLGsNPCIPFF
  GM130 iso3  
S8 MSEETRQSKLAAAKK
S25 REYQQRNSPGVPTGA
K35 VPTGAKKKKKIKNGS
K39 AKKKKKIKNGSNPET
N43 KKIKNGSNPETTTSG
T46 KNGSNPETTTSGGCH
S54-p TTSGGCHsPEDIQDI
S72 LVSDLNRSNGVALPP
S138 DETKTFSSTESLRQL
S146 TESLRQLSQQLNGLV
Y189 AVALDSSYVTNKQLN
T210 KQQNQEITDQLEEEK
K217 TDQLEEEKKECHQKQ
K217 TDQLEEEKKECHQKQ
K218 DQLEEEKKECHQKQG
S266 ARQKEGESEDLASRL
S288 GELERALSAVSTQQK
A289 ELERALSAVSTQQKK
Y411 LQMERDKYAENLKGE
S453 RVQELETSLAELRNQ
K561 LSQNRELKEQLAELQ
K605 KLGELQEKLSELKET
K610 QEKLSELKETVELKS
S705 QQLRAQLSLMAHPGE
A784 RVRCRRLAHLLASAQ
S789 RLAHLLASAQKEPEA
S807 APGTGGDSVCGETHR
K822 ALQGAMEKLQSRFME
K834 FMELMQEKADLKERV
Y865 IGEYIALYQSQRAVL
K879 LKERHREKEEYISRL
P936 PTSGAPAPQELGAAN
S968 QGEAREGSPRDNPTA
S996 RERPGLGSNPCIPFF
  mouse

 
S20 MSEETRQSKLAAAKK
S37 REYQQKNSPGVPAGA
K47 VPAGAKKKKKIKNGH
K51 AKKKKKIKNGHsPER
S55-p KKIKNGHsPERPTAS
R58 KNGHsPERPTASDCQ
S66 PTASDCQSPENIKDI
S84-p LVSDLNRsNGVSLPP
S147-p EETKTFSsTESLRQL
S155-p TESLRQLsQQLNGLV
Y197 AVALDSSYVTNKQLS
L218 KQQNQDTLDQLEKEk
K225-a LDQLEKEkkDYQQKL
K225 LDQLEKEKkDYQQKL
K226-a DQLEKEkkDYQQKLA
S278 ARQKAGESEDLASRL
S300-p GELERTLstVSTQQK
T301-p ELERTLstVSTQQKQ
Y423-p LQVERDQyAENLKGE
S465-p QVQELETsLAALRSQ
K573-u LSQNRELkEQLAELQ
R617 KLGELQERLGELkET
K622-u QERLGELkETVELKS
S724 QQLQAQLSLLVLPGE
S793-p KARCRSLsHLAAPVQ
P798 SLsHLAAPVQSKLEK
S816-p VPRNVDDsASEESNQ
K831-u ALHVAMEkLQSRFLE
K843-u FLEVMQEkVELKERV
Y874 IGEYIALYQNQRAVL
K888-u LKARHLEkEEYISRL
S945-p LTPVPTGsQEFGAAD
A977 QGEAGVPAPHENPTA
S1005-p RERPGLGsNPCIPFF
  rat

 
S20 MSEETRQSKLAAAKK
S37-p REYQQKNsPGVPAGA
K47 VPAGAKKKKKIKNGH
K51 AKKKKKIKNGHSPER
S55 KKIKNGHSPERTSAS
R58 KNGHSPERTSASDCQ
S66 TSASDCQSAENVPTD
- gap
S120 EETKTFSSTESLRQL
S128 TESLRQLSQQLNGLV
Y170 AVALDSSYVTNKQLS
L191 KQQNQDTLDQLEKEK
K198 LDQLEKEKKDYQQKL
K198 LDQLEKEKKDYQQKL
K199 DQLEKEKKDYQQKLA
S251 ARQKAGESEDLASRL
S273 GELERTLSTVSTQQK
T274 ELERTLSTVSTQQKQ
Y396 LQVERDQYAENLKGE
S438 QVQELEASLAELRSQ
K546 LSQNRELKEQLAELQ
R590 KLGELQERLGELKET
K595 QERLGELKETVELKS
S697 QQLQAQLSLLVLPGE
A765 KARCRSLAHLAAPVQ
P770 SLAHLAAPVQSKLEK
S788 VPRDMGDSVSEESNQ
K803 ALHVAMEKLQSRFLE
K815 FLEVMQEKVELKERV
Y846 IGEYIALYQNQRAVL
K860 LKARHLEKEEYISRL
S917 PAPVPTGSQEFGAAD
A949 QGEAGVPAPQENPTA
S977 QERPGLGSNPCIPFF
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