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Protein Page:
NGFR (human)

Overview
NGFR Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q21-q22
Cellular Component: nucleoplasm; cell surface; integral to plasma membrane; extracellular region; plasma membrane; cytosol; endosome
Molecular Function: signal transducer activity; protein binding; transmembrane receptor activity; death receptor activity; ubiquitin protein ligase binding; nerve growth factor binding; receptor activity; Rab GTPase binding
Biological Process: detection of temperature stimulus; axon guidance; central nervous system development; hair follicle morphogenesis; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of odontogenesis of dentine-containing teeth; regulation of caspase activity; glucose homeostasis; regulation of axonogenesis; negative regulation of hair follicle development; negative regulation of cell cycle; intracellular protein transport; positive regulation of fibroblast proliferation; induction of apoptosis via death domain receptors; negative regulation of axonogenesis; nerve development; positive regulation of axonogenesis; circadian regulation of gene expression; negative regulation of apoptosis
Reference #:  P08138 (UniProtKB)
Alt. Names/Synonyms: CD271; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); NGF receptor; NGFR; p75 ICD; p75(NTR); p75NTR; TNFRSF16; TNR16; Tumor necrosis factor receptor superfamily member 16
Gene Symbols: NGFR
Molecular weight: 45,183 Da
Basal Isoelectric point: 4.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NGFR

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S303‑p
cytoskeletal reorganization: S303‑p
intracellular localization: S303‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 S277-p IAFKRWNsCKQNKQG
0 2 T293-p NSRPVNQtPPPEGEK
1 0 S303-p PEGEKLHsDSGISVD
0 1 S311-p DSGISVDsQsLHDQQ
0 1 S313-p GISVDsQsLHDQQPH
0 1 S325-p QPHTQTAsGQALKGD
1 4 Y336-p LKGDGGLySSLPPAK
0 1 A342 LySSLPPAKREEVEK
  mouse

 
S270 IAFKRWNSCKQNKQG
T286-p NSRPVNQtPPPEGEK
S296 PEGEKLHSDSGISVD
S304 DSGISVDSQSLHDQQ
S306 GISVDSQSLHDQQTH
S318 QTHTQTASAQALKGD
Y329-p LKGDGNLySSLPLtK
T335-p LySSLPLtKREEVEK
  rat

 
S278-p IAFKRWNsCKQNKQG
T294 NSRPVNQTPPPEGEK
S304 PEGEKLHSDSGISVD
S312 DSGISVDSQSLHDQQ
S314 GISVDSQSLHDQQTH
S326 QTHTQTASGQALKGD
Y337-p LKGDGNLySSLPLTK
T343 LySSLPLTKREEVEK
  chicken

 
S266-p IAFKRWNsCKQNKQG
T282 NNRPVNQTPSPEGEK
S292 PEGEKLHSDSGISVD
S300 DSGISVDSQSLHDQQ
S302 GISVDSQSLHDQQPP
- under review  
Y325 PKGDGSLYASLPPSK
S331 LYASLPPSKQEEVEK
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