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NGFR
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1. Note: This description may include information from UniProtKB.
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| Protein type: Receptor, misc.; Membrane protein, integral |
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Cellular Component: nucleoplasm; cell surface; integral to plasma membrane; plasma membrane; extracellular region; cytosol; endosome
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Molecular Function: protein binding; signal transducer activity; transmembrane receptor activity; ubiquitin protein ligase binding; death receptor activity; nerve growth factor binding; receptor activity
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Biological Process: skin development; detection of temperature stimulus; axon guidance; central nervous system development; negative regulation of muscle development; hair follicle morphogenesis; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of odontogenesis of dentine-containing teeth; regulation of axonogenesis; negative regulation of hair follicle development; negative regulation of cell cycle; positive regulation of fibroblast proliferation; regulation of gene expression; induction of apoptosis; response to wounding; negative regulation of axonogenesis; nerve development; positive regulation of axonogenesis
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Reference #:
P08138 (UniProtKB)
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| Alt. Names/Synonyms: CD271; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); NGF receptor; NGFR; p75 ICD; p75(NTR); p75NTR; TNFRSF16; TNR16; Tumor necrosis factor receptor superfamily member 16 |
| Gene Symbols: NGFR |
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Molecular weight: 45,183 Da
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Basal Isoelectric point: 4.59
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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