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BRF1 (human)

Overview BRF1 a zinc finger protein that plays an important role in the assembly of the RNA polymerase III initiation factor TFIIIB. Regulates mRNA levels by targeting transcripts containing AREs (AU-rich elements) into the decay pathway. Phosphorylation by Akt apparently generates 14-3-3 binding sites and inhibits BRF1 from promoting mRNA activity.Contains 2 C3H1-type zinc fingers. Note: This description may include information from UniProtKB. Protein type: Transcription factor Cellular Component: cytosol; nucleus Molecular Function: mRNA binding; protein binding; DNA binding; zinc ion binding; AU-rich element binding; transcription factor activity Biological Process: regulation of translation; regulation of transcription, DNA-dependent; RNA metabolic process; T cell differentiation in the thymus; gene expression; regulation of mRNA stability; vasculogenesis; mRNA catabolic process, deadenylation-dependent decay; mRNA metabolic process Reference #:  Q07352 (UniProtKB) Alt. Names/Synonyms: BERG36; BRF1; Butyrate response factor 1; cMG1; early response factor Berg36; EGF-response factor 1; ERF-1; ERF1; Protein TIS11B; RNF162B; TIS11B; TISB; ZFP36L1; zinc finger protein 36, C3H type-like 1; zinc finger protein, C3H type, 36-like 1 Gene Symbols: ZFP36L1 Molecular weight: 36,314 Da Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BRF1 1W0V - C=325-333 (human) 1W0W - C=325-333 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1W0V 1W0W  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
RNA stability, altered: S92‑p, S203‑p transcription, altered: S54‑p, S92‑p, S203‑p intracellular localization: S92‑p molecular association, regulation: S54‑p, S92‑p, S203‑p protein stabilization: S92‑p, S203‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S27-p	GNKMLNYsAPsAGGC
0	1		S30-p	MLNYsAPsAGGCLLD
1	25		S54-p	GGFPRRHsVTLPSSK
0	1		T56	FPRRHsVTLPSSKFH
0	1		S70	HQNQLLSSLkGEPAP
0	1		K72-u	NQLLSSLkGEPAPAL
0	3		S90-p	DSRFRDRsFsEGGER
3	3		S92-p	RFRDRsFsEGGERLL
0	3		K103-a	ERLLPTQkQPGGGQV
0	7		K103-u	ERLLPTQkQPGGGQV
0	2		Y115-p	GQVNSSRyKTELCRP
0	1		S201-p	DRPRLQHsFsFAGFP
2	20		S203-p	PRLQHsFsFAGFPSA
0	2		S331-p	SRRLPIFsRLsISDD
0	7		S334-p	LPIFsRLsISDD___

	mouse
S27	GNKMLNYSTPSAGGC
S30	MLNYSTPSAGGCLLD
S54-p	GGFPRRHsVtLPSSK
T56-p	FPRRHsVtLPSSKFH
S70-p	HQNQLLSsLKGEPAP
K72	NQLLSsLKGEPAPSL
S90	DSRFRDRSFsEGGER
S92-p	RFRDRSFsEGGERLL
K103	ERLLPTQKQPGSGQV
K103-u	ERLLPTQkQPGSGQV
Y115	GQVNSSRYKTELCRP
S201	DRPRLQHSFSFAGFP
S203	PRLQHSFSFAGFPSA
S331-p	SRRLPIFsRLsISDD
S334-p	LPIFsRLsISDD___

	rat
S27	GNKMLNYSTPSAGGC
S30	MLNYSTPSAGGCLLD
S54-p	GGFPRRHsVTLPSSK
T56	FPRRHsVTLPSSKFH
S70	HQNQLLSSLKGEPAP
K72	NQLLSSLKGEPAPTL
S90	DSRFRDRSFsEGGER
S92-p	RFRDRSFsEGGERLL
K103	ERLLPTQKQPGSGQV
K103	ERLLPTQKQPGSGQV
Y115	GQVNSSRYKTELCRP
S201	DRPRLQHSFSFAGFP
S203	PRLQHSFSFAGFPSA
S331	SRRLPIFSRLsISDD
S334-p	LPIFSRLsISDD___

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