a zinc finger protein that plays an important role in the assembly of the RNA polymerase III initiation factor TFIIIB. Regulates mRNA levels by targeting transcripts containing AREs (AU-rich elements) into the decay pathway. Phosphorylation by Akt apparently generates 14-3-3 binding sites and inhibits BRF1 from promoting mRNA activity.Contains 2 C3H1-type zinc fingers. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: cytosol; nucleus
Molecular Function: mRNA binding; protein binding; DNA binding; zinc ion binding; AU-rich element binding; transcription factor activity
Biological Process: regulation of translation; regulation of transcription, DNA-dependent; RNA metabolic process; T cell differentiation in the thymus; gene expression; regulation of mRNA stability; vasculogenesis; mRNA catabolic process, deadenylation-dependent decay; mRNA metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.