Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
BRF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BRF1 a zinc finger protein that plays an important role in the assembly of the RNA polymerase III initiation factor TFIIIB. Regulates mRNA levels by targeting transcripts containing AREs (AU-rich elements) into the decay pathway. Phosphorylation by Akt apparently generates 14-3-3 binding sites and inhibits BRF1 from promoting mRNA activity.Contains 2 C3H1-type zinc fingers. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 14q22-q24
Cellular Component: nucleus; cytosol
Molecular Function: mRNA binding; protein binding; DNA binding; metal ion binding; transcription factor activity
Biological Process: regulation of translation; regulation of transcription, DNA-dependent; RNA metabolic process; T cell differentiation in the thymus; gene expression; regulation of mRNA stability; vasculogenesis; mRNA metabolic process; mRNA catabolic process, deadenylation-dependent decay
Reference #:  Q07352 (UniProtKB)
Alt. Names/Synonyms: BERG36; BRF1; Butyrate response factor 1; cMG1; early response factor Berg36; EGF-response factor 1; ERF-1; ERF1; Protein TIS11B; RNF162B; TIS11B; TISB; ZFP36L1; zinc finger protein 36, C3H type-like 1; zinc finger protein, C3H type, 36-like 1
Gene Symbols: ZFP36L1
Molecular weight: 36,314 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRF1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Sites Implicated In
RNA stability, altered: S92‑p, S203‑p
transcription, altered: S54‑p, S92‑p, S203‑p
intracellular localization: S92‑p
molecular association, regulation: S54‑p, S92‑p, S203‑p
protein stabilization: S92‑p, S203‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S27-p GNKMLNYsAPsAGGC
0 1 S30-p MLNYsAPsAGGCLLD
0 1 T43-p LDRKAVGtPAGGGFP
1 35 S54-p GGFPRRHsVtLPSSK
0 2 T56-p FPRRHsVtLPSSKFH
0 1 S70 HQNQLLSSLkGEPAP
0 1 K72-ub NQLLSSLkGEPAPAL
0 4 S90-p DSRFRDRsFsEGGER
3 6 S92-p RFRDRsFsEGGERLL
0 3 K103-ac ERLLPTQkQPGGGQV
0 7 K103-ub ERLLPTQkQPGGGQV
0 2 Y115-p GQVNSSRyKTELCRP
0 1 S192-p LAGARDLsADRPRLQ
0 1 S201-p DRPRLQHsFsFAGFP
2 20 S203-p PRLQHsFsFAGFPSA
0 1 S314-p SSSSSSHsGsDsPTL
0 1 S316-p SSSSHsGsDsPTLDN
0 1 S318-p SSHsGsDsPTLDNSR
0 3 S331-p SRRLPIFsRLsISDD
0 14 S334-p LPIFsRLsISDD___
0 1 S336 IFsRLsISDD_____
  mouse

 
S27 GNKMLNYSTPSAGGC
S30 MLNYSTPSAGGCLLD
T43 LDRKAVGTPAGGGFP
S54-p GGFPRRHsVtLPSSK
T56-p FPRRHsVtLPSSKFH
S70-p HQNQLLSsLKGEPAP
K72 NQLLSsLKGEPAPSL
S90 DSRFRDRSFsEGGER
S92-p RFRDRSFsEGGERLL
K103 ERLLPTQKQPGSGQV
K103-ub ERLLPTQkQPGSGQV
Y115 GQVNSSRYKTELCRP
S192 LAGGRDLSADRPRLQ
S201 DRPRLQHSFSFAGFP
S203 PRLQHSFSFAGFPSA
S314 SSSSSSHSGSDSPTL
S316 SSSSHSGSDSPTLDN
S318 SSHSGSDSPTLDNSR
S331-p SRRLPIFsRLsIsDD
S334-p LPIFsRLsIsDD___
S336-p IFsRLsIsDD_____
  rat

 
S27 GNKMLNYSTPSAGGC
S30 MLNYSTPSAGGCLLD
T43 LDRKAVGTPAGGGFP
S54-p GGFPRRHsVTLPSSK
T56 FPRRHsVTLPSSKFH
S70 HQNQLLSSLKGEPAP
K72 NQLLSSLKGEPAPTL
S90 DSRFRDRSFsEGGER
S92-p RFRDRSFsEGGERLL
K103 ERLLPTQKQPGSGQV
K103 ERLLPTQKQPGSGQV
Y115 GQVNSSRYKTELCRP
S192 LAGGRDLSADRPRLQ
S201 DRPRLQHSFSFAGFP
S203 PRLQHSFSFAGFPSA
S314 SSSSSSHSGSDSPTL
S316 SSSSHSGSDSPTLDN
S318 SSHSGSDSPTLDNSR
S331 SRRLPIFSRLsIsDD
S334-p LPIFSRLsIsDD___
S336-p IFSRLsIsDD_____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.