a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; EC 18.104.22.168; Protein kinase, TK; TK group; Trk family
Cellular Component: Golgi membrane; cell surface; early endosome membrane; integral to plasma membrane; plasma membrane; endosome
Molecular Function: neurotrophin binding; protein binding; nerve growth factor receptor activity; protein homodimerization activity; nerve growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: mechanoreceptor differentiation; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPKK activity; protein amino acid autophosphorylation; adenylate cyclase activation; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; positive regulation of programmed cell death; positive regulation of Ras GTPase activity; sympathetic nervous system development; positive regulation of angiogenesis; phospholipase C activation; small GTPase mediated signal transduction; B cell differentiation; Ras protein signal transduction; positive regulation of Ras protein signal transduction; negative regulation of neuron apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.