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TrkA (human)

Overview TrkA a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; TK group; Trk family Cellular Component: Golgi membrane; cell surface; early endosome membrane; integral to plasma membrane; plasma membrane; endosome Molecular Function: neurotrophin binding; protein binding; nerve growth factor receptor activity; protein homodimerization activity; nerve growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: mechanoreceptor differentiation; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPKK activity; protein amino acid autophosphorylation; adenylate cyclase activation; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; positive regulation of programmed cell death; positive regulation of Ras GTPase activity; sympathetic nervous system development; positive regulation of angiogenesis; phospholipase C activation; small GTPase mediated signal transduction; B cell differentiation; Ras protein signal transduction; positive regulation of Ras protein signal transduction; negative regulation of neuron apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway Reference #:  P04629 (UniProtKB) Alt. Names/Synonyms: DKFZp781I14186; High affinity nerve growth factor receptor; MTC; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; NTRK1; Oncogene TRK; p140-TrkA; TRK; Trk-A; TRK1; TRK1-transforming tyrosine kinase protein; TRKA; tyrosine kinase receptor A Gene Symbols: NTRK1 Molecular weight: 87,497 Da Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TrkA 1HE7 - A=285-413 (human) 1SHC - B=489-500 (human) 1WWA - X/Y=278-386 (human) 1WWW - X/Y=282-382 (human) 2IFG - A/B=36-382 (human) 4AOJ - A/C/B=473-796 (human) 4F0I - A/B=498-796 (human) 4GT5 - A=498-796 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1HE7 1SHC 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5  |  ENZYME  |  Phospho3D  |  DISEASE 155240 164970 191315 256800  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, induced: Y496‑p, Y791‑p cell differentiation, altered: Y496‑p, Y701‑p cell growth, altered: Y496‑p, Y701‑p, Y791‑p activation: Y757‑p enzymatic activity, induced: Y496‑p, Y680‑p, Y681‑p, Y791‑p enzymatic activity, inhibited: Y701‑p molecular association, regulation: Y496‑p, Y701‑p, Y791‑p phosphorylation: Y701‑p protein processing: Y701‑p protein stabilization: Y701‑p receptor internalization, altered: Y496‑p, Y680‑p, Y681‑p, Y701‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S123-p	RLSRLNLsFNALESL
18	2		Y496-p	HIIENPQyFSDACVH
2	9		Y676-p	FGMSRDIySTDyyRV
9	6		Y680-p	RDIySTDyyRVGGRT
9	4		Y681-p	DIySTDyyRVGGRTM
1	1		Y701-p	MPPESILyRKFTTES
3	0		Y757-p	RACPPEVyAIMRGCW
7	3		Y791-p	LAQAPPVyLDVLG__

	TrkA iso2
S123	RLSRLNLSFNALESL
Y490-p	HIIENPQyFSDACVH
Y670-p	FGMSRDIySTDyyRV
Y674-p	RDIySTDyyRVGGRT
Y675-p	DIySTDyyRVGGRTM
Y695	MPPESILYRKFTTES
Y751-p	RACPPEVyAIMRGCW
Y785-p	LAQAPPVyLDVLG__

	mouse
S123	RLSHLNLSSNALESL
Y499-p	HIMENPQyFSDTCVH
Y679	FGMSRDIYSTDYYRV
Y683	RDIYSTDYYRVGGRT
Y684	DIYSTDYYRVGGRTM
Y704	MPPESILYRKFSTES
Y760	RACPPDVYAIMRGCW
Y794	LAQAPPSYLDVLG__

	rat ► Hide Isoforms
S123	RLSHLNLSSNALESL
Y499-p	HIMENPQyFSDTCVH
Y679-p	FGMSRDIySTDyyRV
Y683-p	RDIySTDyyRVGGRT
Y684-p	DIySTDyyRVGGRTM
Y704	MPPESILYRKFSTES
Y760-p	RACPPDVyAIMRGCW
Y794-p	LAQAPPSyLDVLG__

	TrkA iso2
S123	RLSHLNLSSNALESL
Y493-p	HIMENPQyFSDTCVH
Y673-p	FGMSRDIySTDyyRV
Y677-p	RDIySTDyyRVGGRT
Y678-p	DIySTDyyRVGGRTM
Y698	MPPESILYRKFSTES
Y754	RACPPDVYAIMRGCW
Y788	LAQAPPSYLDVLG__

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