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Protein Page:
TrkA (human)

Overview
TrkA a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Membrane protein, integral; TK group; Trk family
Cellular Component: protein complex; cell surface; integral to plasma membrane; late endosome membrane; dendrite; early endosome; cell soma; axon; early endosome membrane; late endosome; plasma membrane; cytoplasmic vesicle; receptor complex; endosome
Molecular Function: neurotrophin p75 receptor binding; neurotrophin binding; protein binding; nerve growth factor receptor activity; protein homodimerization activity; ephrin receptor binding; nerve growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: axon guidance; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; activation of MAPKK activity; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; positive regulation of synaptic transmission, glutamatergic; olfactory nerve development; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; positive regulation of Ras GTPase activity; sympathetic nervous system development; response to radiation; learning and/or memory; small GTPase mediated signal transduction; negative regulation of neuron apoptosis; response to axon injury; response to electrical stimulus; detection of temperature stimulus involved in sensory perception of pain; response to hydrostatic pressure; aging; response to drug; response to nutrient levels; phosphoinositide-mediated signaling; adenylate cyclase activation; Sertoli cell development; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of programmed cell death; positive regulation of angiogenesis; response to ethanol; phospholipase C activation; B cell differentiation; Ras protein signal transduction; response to activity; positive regulation of Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P04629 (UniProtKB)
Alt. Names/Synonyms: DKFZp781I14186; High affinity nerve growth factor receptor; MTC; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; NTRK1; Oncogene TRK; p140-TrkA; TRK; Trk-A; TRK1; TRK1-transforming tyrosine kinase protein; TRKA; tyrosine kinase receptor A
Gene Symbols: NTRK1
Molecular weight: 87,497 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TrkA

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: Y496‑p, Y791‑p
cell differentiation, altered: Y496‑p, Y701‑p
cell growth, altered: Y496‑p, Y701‑p, Y791‑p
activity, induced: Y757‑p
enzymatic activity, induced: Y496‑p, Y680‑p, Y681‑p, Y791‑p
enzymatic activity, inhibited: Y701‑p
molecular association, regulation: Y496‑p, Y701‑p, Y791‑p
phosphorylation: Y701‑p
protein processing: Y701‑p
protein stabilization: Y701‑p
receptor internalization, altered: Y496‑p, Y680‑p, Y681‑p, Y701‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S123-p RLSRLNLsFNALESL
18 2 Y496-p HIIENPQyFSDACVH
2 8 Y676-p FGMSRDIySTDyyRV
9 7 Y680-p RDIySTDyyRVGGRT
9 2 Y681-p DIySTDyyRVGGRTM
1 1 Y701-p MPPESILyRKFTTES
3 0 Y757-p RACPPEVyAIMRGCW
7 2 Y791-p LAQAPPVyLDVLG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
9141 : Phospho-TrkA (Tyr490) Antibody
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkA iso2  
S123 RLSRLNLSFNALESL
Y490-p HIIENPQyFSDACVH
Y670-p FGMSRDIySTDyyRV
Y674-p RDIySTDyyRVGGRT
Y675-p DIySTDyyRVGGRTM
Y695 MPPESILYRKFTTES
Y751-p RACPPEVyAIMRGCW
Y785-p LAQAPPVyLDVLG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
9141 : Phospho-TrkA (Tyr490) Antibody
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  mouse

 
S123 RLSHLNLSSNALESL
Y499-p HIMENPQyFSDTCVH
Y679 FGMSRDIYSTDYYRV
Y683 RDIYSTDYYRVGGRT
Y684 DIYSTDYYRVGGRTM
Y704 MPPESILYRKFSTES
Y760 RACPPDVYAIMRGCW
Y794 LAQAPPSYLDVLG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  rat

► Hide Isoforms
 
S123 RLSHLNLSSNALESL
Y499-p HIMENPQyFSDTCVH
Y679-p FGMSRDIySTDyyRV
Y683-p RDIySTDyyRVGGRT
Y684-p DIySTDyyRVGGRTM
Y704 MPPESILYRKFSTES
Y760-p RACPPDVyAIMRGCW
Y794-p LAQAPPSyLDVLG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
9141 : Phospho-TrkA (Tyr490) Antibody
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkA iso2  
S123 RLSHLNLSSNALESL
Y493-p HIMENPQyFSDTCVH
Y673-p FGMSRDIySTDyyRV
Y677-p RDIySTDyyRVGGRT
Y678-p DIySTDyyRVGGRTM
Y698 MPPESILYRKFSTES
Y754 RACPPDVYAIMRGCW
Y788 LAQAPPSYLDVLG__
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
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