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Protein Page:
RasGRP3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RasGRP3 Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Belongs to the RASGRP family. Note: This description may include information from UniProtKB.
Protein type: GEFs, Ras; GEFs
Cellular Component: perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane
Molecular Function: diacylglycerol binding; signal transducer activity; Ras GTPase binding; guanyl-nucleotide exchange factor activity; calcium ion binding; Rap GTPase activator activity; kinase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: small GTPase mediated signal transduction; Ras protein signal transduction; MAPKKK cascade; positive regulation of Rap GTPase activity
Reference #:  Q8IV61 (UniProtKB)
Alt. Names/Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor III; GRP3; Guanine nucleotide exchange factor for Rap1; KIAA0846; RAS guanyl releasing protein 3 (calcium and DAG-regulated); Ras guanyl-releasing protein 3; RASGRP3
Gene Symbols: RASGRP3
Molecular weight: 78,332 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RasGRP3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y45-p VLLMHRWyLSSTELA
2 0 T133-p YDWMRRVtQRKKVSK
0 1 S254 GLSHSSISRLkETHS
0 2 K257-ub HSSISRLkETHSHLS
0 1 T259 SISRLkETHSHLSSE
0 1 S265 ETHSHLSSEVTKNWN
0 1 S391 NSKSQPTSPTTPNKP
0 1 T394 SQPTSPTTPNKPVVP
0 2 S552 RRFARAPSLSSGHGS
0 1 S555 ARAPSLSSGHGSLPG
0 1 S559 SLSSGHGSLPGSPSL
0 1 S563 GHGSLPGSPSLPPAQ
0 1 S598 ITLVTGSSRKISVRL
0 1 T610-p VRLQRATtSQATQTE
0 1 S621-p TQTEPVWsEAGWGDS
0 1 S638-p HTFPKMKsKFHDKAA
0 1 K639 TFPKMKsKFHDKAAK
0 1 K646 KFHDKAAKDKGFAKW
  mouse

 
Y45 VLLMHRWYLSSTELA
T133 YDWMRRVTQRKKVSK
S254 GLSHSSISRLkDTHS
K257-ub HSSISRLkDTHSHLS
T259 SISRLkDTHSHLSSE
S265 DTHSHLSSEVTKNWN
S391-p NSKSQPTsPTtPNKP
T394-p SQPTsPTtPNKPVVP
S552-p RRLARAPsLSsNPGs
S555-p ARAPsLSsNPGsLPG
S559-p sLSsNPGsLPGsPAL
S563-p NPGsLPGsPALPPVQ
S598-p ITLVTGSsRKISVRL
T610 VRLQRATTSQATQTE
S621 TQTEPVWSEAVWGDS
S638 HTFPKMKSkFHDKAA
K639-ac TFPKMKSkFHDKAAk
K646-ac kFHDKAAkDKGFAKW
  rat

 
Y45 MLLMHRWYLSSTELA
T133 YDWMRRVTQRKKVSK
S254-p GLSHSSIsRLKDtHS
K257 HSSIsRLKDtHSHLS
T259-p SIsRLKDtHSHLSsE
S265-p DtHSHLSsEVTKNWN
S391 NSKSQPTSPTTPNKP
T394 SQPTSPTTPNKPVVP
S464 RRLARAPSLSSNPES
S467 ARAPSLSSNPESLPG
S471 SLSSNPESLPGSPAL
S475 NPESLPGSPALPPVQ
S510 ITLVTGSSRKISVRV
T522 VRVQRATTSQATQTE
S533 TQTEPVWSEAVWGDS
S550 HTFPKMKSKLHDKAA
K551 TFPKMKSKLHDKAAK
K558 KLHDKAAKDKGFAKW
  chicken

 
Y45 FLLMHRWYLPSTELA
T133-p YDWMRRVtQRKKISK
S254 GLSHSSISRLKETHS
K257 HSSISRLKETHSHLS
T259 SISRLKETHSHLSSE
S265 ETHSHLSSEVTKDWN
S390 RNSKSPTSPTTPSKP
T393 KSPTSPTTPSKPVVP
S551 RKFSRGTSVGSNHGS
S554 SRGTSVGSNHGSLPS
S558 SVGSNHGSLPSSPSL
S562 NHGSLPSSPSLPPAQ
S597 ITLVTGSSRKISVRL
A609 VRLQRATASQATQTE
H620 TQTEPLWHEPGWSDS
S637 HTFPKMKSKFHGKAG
K638 TFPKMKSKFHGKAGK
K645 KFHGKAGKNKGFAKW
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