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Protein Page:
RasGRP3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RasGRP3 Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Belongs to the RASGRP family. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, Ras
Cellular Component: perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane
Molecular Function: diacylglycerol binding; signal transducer activity; Ras GTPase binding; guanyl-nucleotide exchange factor activity; calcium ion binding; Rap GTPase activator activity; kinase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: small GTPase mediated signal transduction; Ras protein signal transduction; MAPKKK cascade; positive regulation of Rap GTPase activity
Reference #:  Q8IV61 (UniProtKB)
Alt. Names/Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor III; GRP3; Guanine nucleotide exchange factor for Rap1; KIAA0846; RAS guanyl releasing protein 3 (calcium and DAG-regulated); Ras guanyl-releasing protein 3; RASGRP3
Gene Symbols: RASGRP3
Molecular weight: 78,332 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RasGRP3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 T133-p YDWMRRVtQRKKVSK
0 1 S254 GLSHSSISRLkETHS
0 2 K257-u HSSISRLkETHSHLS
0 1 T259 SISRLkETHSHLSSE
0 1 S265 ETHSHLSSEVTKNWN
0 1 S552 RRFARAPSLSSGHGS
  mouse

 
T133 YDWMRRVTQRKKVSK
S254 GLSHSSISRLkDTHS
K257-u HSSISRLkDTHSHLS
T259 SISRLkDTHSHLSSE
S265 DTHSHLSSEVTKNWN
S552-p RRLARAPsLSSNPGS
  rat

 
T133 YDWMRRVTQRKKVSK
S254-p GLSHSSIsRLKDtHS
K257 HSSIsRLKDtHSHLS
T259-p SIsRLKDtHSHLSsE
S265-p DtHSHLSsEVTKNWN
S464 RRLARAPSLSSNPES
  chicken

 
T133-p YDWMRRVtQRKKISK
S254 GLSHSSISRLKETHS
K257 HSSISRLKETHSHLS
T259 SISRLKETHSHLSSE
S265 ETHSHLSSEVTKDWN
S551 RKFSRGTSVGSNHGS
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