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RasGRP3 (human)

Overview RasGRP3 Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Belongs to the RASGRP family. Note: This description may include information from UniProtKB. Protein type: Guanine nucleotide exchange factor, Ras Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane Molecular Function: diacylglycerol binding; signal transducer activity; Ras GTPase binding; guanyl-nucleotide exchange factor activity; calcium ion binding; Rap GTPase activator activity; kinase binding; Ras guanyl-nucleotide exchange factor activity Biological Process: small GTPase mediated signal transduction; Ras protein signal transduction; MAPKKK cascade; positive regulation of Rap GTPase activity Reference #:  Q8IV61 (UniProtKB) Alt. Names/Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor III; GRP3; Guanine nucleotide exchange factor for Rap1; KIAA0846; RAS guanyl releasing protein 3 (calcium and DAG-regulated); Ras guanyl-releasing protein 3; RASGRP3 Gene Symbols: RASGRP3 Molecular weight: 78,332 Da Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  GPCRs Signaling to MAPK/Erk Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RasGRP3

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	0		T133-p	YDWMRRVtQRKKVSK
0	1		S254	GLSHSSISRLkETHS
0	2		K257-u	HSSISRLkETHSHLS
0	1		T259	SISRLkETHSHLSSE
0	1		S265	ETHSHLSSEVTKNWN
0	1		S552	RRFARAPSLSSGHGS
0	1		T610-p	VRLQRATtSQATQTE
0	1		S638-p	HTFPKMKskFHDKAA
0	1		K639-a	TFPKMKskFHDKAAk
0	1		K646-a	kFHDKAAkDKGFAKW

	mouse
T133	YDWMRRVTQRKKVSK
S254	GLSHSSISRLkDTHS
K257-u	HSSISRLkDTHSHLS
T259	SISRLkDTHSHLSSE
S265	DTHSHLSSEVTKNWN
S552-p	RRLARAPsLSSNPGS
T610	VRLQRATTSQATQTE
S638	HTFPKMKSkFHDKAA
K639-a	TFPKMKSkFHDKAAk
K646-a	kFHDKAAkDKGFAKW

	rat
T133	YDWMRRVTQRKKVSK
S254-p	GLSHSSIsRLKDtHS
K257	HSSIsRLKDtHSHLS
T259-p	SIsRLKDtHSHLSsE
S265-p	DtHSHLSsEVTKNWN
S464	RRLARAPSLSSNPES
T522	VRVQRATTSQATQTE
S550	HTFPKMKSKLHDKAA
K551	TFPKMKSKLHDKAAK
K558	KLHDKAAKDKGFAKW

	chicken
T133-p	YDWMRRVtQRKKISK
S254	GLSHSSISRLKETHS
K257	HSSISRLKETHSHLS
T259	SISRLKETHSHLSSE
S265	ETHSHLSSEVTKDWN
S551	RKFSRGTSVGSNHGS
A609	VRLQRATASQATQTE
S637	HTFPKMKSKFHGKAG
K638	TFPKMKSKFHGKAGK
K645	KFHGKAGKNKGFAKW

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