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Protein Page:
MCR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MCR Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. Defects in NR3C2 are a cause of autosomal dominant pseudohypoaldosteronism type I (AD-PHA1). PHA1 is characterized by urinary salt wasting, resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal dominant form that is mild, and the recessive form which is more severe and due to defects in any of the epithelial sodium channel subunits. In AD-PHA1 the target organ defect is confined to kidney. Clinical expression can vary from asymptomatic to moderate. It may be severe at birth, but symptoms remit with age. Familial and sporadic cases have been reported. Defects in NR3C2 are a cause of early-onset hypertension with severe exacerbation in pregnancy (EOHSEP). Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion. Belongs to the nuclear hormone receptor family. NR3 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Cellular Component: nucleoplasm; endoplasmic reticulum membrane; receptor complex
Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; steroid binding
Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; steroid hormone mediated signaling; gene expression; signal transduction
Reference #:  P08235 (UniProtKB)
Alt. Names/Synonyms: aldosterone receptor; FLJ41052; MCR; MGC133092; Mineralocorticoid receptor; mineralocorticoid receptor 1; mineralocorticoid receptor delta; MLR; MR; NR3C2; NR3C2VIT; Nuclear receptor subfamily 3 group C member 2; nuclear receptor subfamily 3, group C, member 2
Gene Symbols: NR3C2
Molecular weight: 107,067 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
Select Structure to View Below

MCR

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: S843‑p
intracellular localization: S843‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T3-p _____MEtKGyHsLP
0 1 Y6-p __MEtKGyHsLPEGL
0 1 S8-p MEtKGyHsLPEGLDM
0 1 S23-p ERRWGQVsQAVERSS
3 0 K89-sm GILTSDIkTELESKE
0 1 S129-p QNQQGSMsPAKIYQN
0 1 S168-p LRSFMSDsGSSVNGG
0 2 S183-p VMRAIVKsPIMCHEK
1 0 S196-p EKSPSVCsPLNMTSS
1 0 S227-p FGSFPVHsPITQGTP
1 0 S238-p QGTPLTCsPNAENRG
0 2 S248-p AENRGSRsHsPAHAs
0 3 S250-p NRGSRsHsPAHAsNV
0 1 S255-p sHsPAHAsNVGsPLs
0 2 S259-p AHAsNVGsPLssPLS
0 2 S262-p sNVGsPLssPLSSMK
1 1 S263-p NVGsPLssPLSSMKS
0 1 S274-p SMKSSISsPPSHCSV
0 3 S283-p PSHCSVKsPVSsPNN
1 2 S287-p SVKsPVSsPNNVTLR
0 3 S299-p TLRSSVSsPANINNS
0 1 S311-p NNSRCSVsSPSNTNN
1 1 S361-p TLRDVVPsPDTQEKG
3 0 K399-sm LNIVQYIkPEPDGAF
0 1 S424-p INSDSSFsVPIkQES
2 0 K428-sm SSFsVPIkQESTKHS
0 2 K464-ac YFSFMDDkDYYSLSG
3 0 K494-sm SGFPVGIkQEPDDGS
0 1 T532-p YRIGAQGtISLSRSA
0 1 S534 IGAQGtISLSRSARD
0 1 S536 AQGtISLSRSARDQs
0 1 S538 GtISLSRSARDQsFQ
0 1 S543-p SRSARDQsFQHLSSF
0 3 K680-ub RKSKKLGkLKGIHEE
0 2 T735-p STISRALtPsPVMVL
0 1 S737-p ISRALtPsPVMVLEN
0 1 T761-p YDSSKPDtAENLLST
1 1 S843-p NEEKMHQsAMYELCQ
3 0 K953-sm FRESHALkVEFPAML
0 1 K970-ub IISDQLPkVESGNAk
0 1 K977-ub kVESGNAkPLYFHRK
  mouse

 
T3 _____METKGYHSLP
Y6 __METKGYHSLPEGL
S8 METKGYHSLPEGLDM
S23 ERRWSQVSQTLERSS
K89 GILPSDIKTELESKE
S129 QNQQGSLSPAKIYQN
S168 LRSFMPDSGTSMNGG
S183-p ALRAIVKsPIICHEK
S196 EKSPSVCSPLNMPSS
S227 FGSFPVHSPITQGTS
S238 QGTSLTCSPSVENRG
S248-p VENRGSRsHsPVHAS
S250-p NRGSRsHsPVHASNV
S255 sHsPVHASNVGsPLs
S259-p VHASNVGsPLssPLS
S262-p SNVGsPLssPLSSMK
S263-p NVGsPLssPLSSMKS
S274 SMKSPISSPPSHCSV
S283-p PSHCSVKsPVSsPNN
S287-p SVKsPVSsPNNVPLR
S299-p PLRSSVSsPANLNNS
S311 NNSRCSVSSPSNTNN
S361 AIQDMVPSPDTHEKG
K399 LNIVQYIKPEPDGAF
S424 INPSSPFSVPIKQES
K428 SPFSVPIKQESSKHS
K464 YFSFMDDKDYYSLSG
K494 SAFPGGIKQEPDDGS
T532 YRIGAQGTIsLsRsP
S534-p IGAQGTIsLsRsPRD
S536-p AQGTIsLsRsPRDQS
S538-p GTIsLsRsPRDQSFQ
S543 sRsPRDQSFQHLSSF
K678-ub RKSKKLGkLKGLHEE
T729 ASITRALTPSPSMIL
S731 ITRALTPSPSMILEN
T755 YDNSKPDTAESLLST
S837 NEEKMHQSAMYELCQ
K947 FRESQALKVEFPAML
K964 IISDQLPKVESGNAK
K971 KVESGNAKPLYFHRK
  rat

 
T3 _____METKGYHSLP
Y6 __METKGYHSLPEGL
S8 METKGYHSLPEGLDM
S23 ERRWSQVSQTLERSS
K89 GILPSDIKTELESKE
S129 QNQQGSLSPTKIYQN
S168 LRSFMPDSAASMNGG
S183 ALRAIVKSPIICHEK
S196 EKSSSVSSPLNMASS
S227 FGSFPVHSPITQGTS
S238 QGTSLTCSPSVENRG
S248 VENRGSRSHSPTHAS
S250 NRGSRSHSPTHASNV
S255 SHSPTHASNVGSPLS
S259 THASNVGSPLSSPLS
S262 SNVGSPLSSPLSSMK
S263 NVGSPLSSPLSSMKS
S274 SMKSPISSPPSHCSV
S283 PSHCSVKSPVSSPNN
S287 SVKSPVSSPNNVPLR
S299 PLRSSVSSPANLNNS
S311 NNSRCSVSSPSNNTN
S362 AIQDVVPSPDTHEKG
K400 LNIVQYIKSEPDGAF
S425 ISPSSPFSVPIKQES
K429 SPFSVPIKQESSKHS
K465 YFSFMDDKDYYSLSG
K495 SAFPVGIKQEPDDGS
T533 YRIGAQGTISLSRSP
S535 IGAQGTISLSRSPRD
S537 AQGTISLSRSPRDQS
S539 GTISLSRSPRDQSFQ
S544 SRSPRDQSFQHLSSF
K681 RKSKKLGKLKGLHEE
T732 TSITHALTPSPAMIL
S734 ITHALTPSPAMILEN
T758 YDNSKPDTAESLLST
S840 NEEKMHQSAMYELCQ
K950 FRESQALKVEFPAML
K967 IITDQLPKVESGNAK
K974 KVESGNAKPLYFHRK
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