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Protein Page:
TGFBR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TGFBR2 a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (receptor); Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; Kinase, protein; TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 3p22
Cellular Component: plasma membrane; integral to membrane; caveola; cytosol; receptor complex; external side of plasma membrane
Molecular Function: transforming growth factor beta receptor activity; protein binding; glycosaminoglycan binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: lens development in camera-type eye; wound healing; apoptosis; heart development; positive regulation of smooth muscle cell proliferation; myeloid dendritic cell differentiation; gastrulation; palate development; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; negative regulation of cardiac muscle cell proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to glucose stimulus; positive regulation of NK T cell differentiation; vasculogenesis; positive regulation of T cell tolerance induction; response to nutrient; aging; response to drug; receptor-mediated endocytosis; blood vessel development; smoothened signaling pathway; organ regeneration; positive regulation of skeletal muscle regeneration; embryonic hemopoiesis; in utero embryonic development; common-partner SMAD protein phosphorylation; peptidyl-threonine phosphorylation; embryonic cranial skeleton morphogenesis; regulation of cell proliferation; patterning of blood vessels; peptidyl-serine phosphorylation; gut development; response to estrogen stimulus; response to mechanical stimulus; cartilage development; positive regulation of B cell tolerance induction; activation of protein kinase activity; brain development; negative regulation of transforming growth factor beta receptor signaling pathway; embryo implantation
Reference #:  P37173 (UniProtKB)
Alt. Names/Synonyms: AAT3; FAA3; LDS1B; LDS2B; MFS2; RIIC; TAAD2; TbetaR-II; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta-RII; TGFBR2; TGFR-2; TGFR2; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); Transforming growth factor-beta receptor type II
Gene Symbols: TGFBR2
Molecular weight: 64,568 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGFBR2

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S213‑p, Y284‑p
cytoskeletal reorganization: Y284‑p
transcription, altered: Y259‑p, Y336‑p, Y424‑p
enzymatic activity, induced: Y259‑p, Y336‑p, S409‑p, Y424‑p
enzymatic activity, inhibited: S416‑p
molecular association, regulation: Y284‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S31 IPPHVQKSVNNDMIV
0 1 T39-ga VNNDMIVtDNNGAVK
0 2 K205 SSTWETGKTRKLMEF
1 0 S213-p TRKLMEFsEHCAIIL
1 0 S225 IILEDDRSDISSTCA
1 0 S228 EDDRSDISSTCANNI
1 0 S229 DDRSDISSTCANNIN
2 0 Y259-p KGRFAEVykAKLKQN
1 0 K260-ne GRFAEVykAKLKQNT
3 0 Y284-p KIFPYEEyASWKTEK
3 0 Y336-p AKGNLQEyLTRHVIS
1 3 S409-p LRLDPTLsVDDLANs
1 0 S416-p sVDDLANsGQVGTAR
2 6 Y424-p GQVGTARyMAPEVLE
1 0 Y470-p AVGEVKDyEPPFGSK
1 0 K488-ne HPCVESMkDNVLRDR
0 7 S548-p LEHLDRLsGRsCsEE
1 1 S551-p LDRLsGRsCsEEkIP
1 6 S553-p RLsGRsCsEEkIPED
1 0 K556-ne GRsCsEEkIPEDGsL
0 1 S562-p EkIPEDGsLNTtk__
0 1 T566-p EDGsLNTtk______
1 0 K567-ne DGsLNTtk_______
  TGFBR2 iso2  
S31-p IPPHVQKsDVEMEAQ
T64 INNDMIVTDNNGAVK
K230 SSTWETGKTRKLMEF
S238 TRKLMEFSEHCAIIL
S250 IILEDDRSDISSTCA
S253 EDDRSDISSTCANNI
S254 DDRSDISSTCANNIN
Y284 KGRFAEVYKAKLKQN
K285 GRFAEVYKAKLKQNT
Y309 KIFPYEEYASWKTEK
Y361 AKGNLQEYLTRHVIS
S434 LRLDPTLSVDDLANS
S441 SVDDLANSGQVGTAR
Y449 GQVGTARYMAPEVLE
Y495 AVGEVKDYEPPFGSK
K513 HPCVESMKDNVLRDR
S573 LEHLDRLSGRSCSEE
S576 LDRLSGRSCSEEKIP
S578 RLSGRSCSEEKIPED
K581 GRSCSEEKIPEDGSL
S587 EKIPEDGSLNTTK__
T591 EDGSLNTTK______
K592 DGSLNTTK_______
  mouse

 
S31 IPPHVPKSDVEMEAQ
S64 FNSDVMASDNGGAVK
K230-ub SPSWESSkPRKLMDF
S238 PRKLMDFSDNCAIIL
S250-p IILEDDRsDIssTCA
S253-p EDDRsDIssTCANNI
S254-p DDRsDIssTCANNIN
Y284 KGRFAEVYKAKLKQN
K285 GRFAEVYKAKLKQNT
Y309-p KIFPYEEySSWKTEK
Y361 AKGNLQEYLTRHVIS
S434-p LRLDPTLsVDDLANS
S441 sVDDLANSGQVGTAR
Y449 GQVGTARYMAPEVLE
Y495 AVGEVKDYEPPFGSK
K513 HPCVESMKDSVLRDR
S573 LEHPERLSGRsCsQE
S576-p PERLSGRsCsQEKIP
S578-p RLSGRsCsQEKIPED
K581 GRsCsQEKIPEDGSL
S587 EKIPEDGSLNTTK__
T591 EDGSLNTTK______
K592 DGSLNTTK_______
  rat

 
S31 IPPHVPKSVNSDLMA
G39 VNSDLMAGDNSGAVK
K205 SPSWESSKPRKLMDF
S213 PRKLMDFSDNCAIIL
S225 IILEDDRSDISSTCA
S228 EDDRSDISSTCANNI
S229 DDRSDISSTCANNIN
Y259 KGRFAEVYKAKLKQN
K260 GRFAEVYKAKLKQNT
Y284 KIFPYEEYSSWKTEK
Y336 AKGNLQEYLTRHVIS
S409 LRLDPTLSVDDLANS
S416 SVDDLANSGQVGTAR
Y424 GQVGTARYMAPEVLE
Y470 AVGEVKDYEPPFGSK
K488 HPCVESMKDNVLRDR
S548-p LEHPDRLsGRSCSQE
S551 PDRLsGRSCSQEKIP
S553 RLsGRSCSQEKIPED
K556 GRSCSQEKIPEDGSL
S562 EKIPEDGSLNTTK__
T566 EDGSLNTTK______
K567 DGSLNTTK_______
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