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Protein Page:
TGFBR2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TGFBR2 a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.30; Kinase, protein; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily
Cellular Component: plasma membrane; integral to membrane; caveola; receptor complex; external side of plasma membrane
Molecular Function: transforming growth factor beta receptor activity; protein binding; glycosaminoglycan binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta binding; metal ion binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: lens development in camera-type eye; apoptosis; heart development; gastrulation; myeloid dendritic cell differentiation; palate development; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway; regulation of growth; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; vasculogenesis; positive regulation of T cell tolerance induction; response to drug; blood vessel development; smoothened signaling pathway; embryonic hemopoiesis; in utero embryonic development; peptidyl-threonine phosphorylation; embryonic cranial skeleton morphogenesis; regulation of cell proliferation; patterning of blood vessels; peptidyl-serine phosphorylation; positive regulation of B cell tolerance induction; cartilage development; activation of protein kinase activity; brain development; negative regulation of transforming growth factor beta receptor signaling pathway
Reference #:  P37173 (UniProtKB)
Alt. Names/Synonyms: AAT3; FAA3; LDS1B; LDS2B; MFS2; RIIC; TAAD2; TbetaR-II; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta-RII; TGFBR2; TGFR-2; TGFR2; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); Transforming growth factor-beta receptor type II
Gene Symbols: TGFBR2
Molecular weight: 64,568 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGFBR2
Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S213‑p, Y284‑p
cytoskeletal reorganization: Y284‑p
transcription, altered: Y259‑p, Y336‑p, Y424‑p
enzymatic activity, induced: Y259‑p, Y336‑p, S409‑p, Y424‑p
enzymatic activity, inhibited: S416‑p
molecular association, regulation: Y284‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 S31 IPPHVQKSVNNDMIV
0 2 K205 SSTWETGKTRKLMEF
1 0 S213-p TRKLMEFsEHCAIIL
1 0 S225 IILEDDRSDISSTCA
1 0 S228 EDDRSDISSTCANNI
1 0 S229 DDRSDISSTCANNIN
2 0 Y259-p KGRFAEVykAKLKQN
1 0 K260-n GRFAEVykAKLKQNT
2 0 Y284-p KIFPYEEyASWKTEK
2 0 Y336-p AKGNLQEyLTRHVIS
1 3 S409-p LRLDPTLsVDDLANs
1 0 S416-p sVDDLANsGQVGTAR
2 0 Y424-p GQVGTARyMAPEVLE
1 0 K488-n HPCVESMkDNVLRDR
0 3 S548-p LEHLDRLsGRsCsEE
1 1 S551-p LDRLsGRsCsEEkIP
1 4 S553-p RLsGRsCsEEkIPED
1 0 K556-n GRsCsEEkIPEDGsL
0 1 S562-p EkIPEDGsLNTTk__
1 0 K567-n DGsLNTTk_______
  TGFBR2 iso2  
S31-p IPPHVQKsDVEMEAQ
K230 SSTWETGKTRKLMEF
S238 TRKLMEFSEHCAIIL
S250 IILEDDRSDISSTCA
S253 EDDRSDISSTCANNI
S254 DDRSDISSTCANNIN
Y284 KGRFAEVYKAKLKQN
K285 GRFAEVYKAKLKQNT
Y309 KIFPYEEYASWKTEK
Y361 AKGNLQEYLTRHVIS
S434 LRLDPTLSVDDLANS
S441 SVDDLANSGQVGTAR
Y449 GQVGTARYMAPEVLE
K513 HPCVESMKDNVLRDR
S573 LEHLDRLSGRSCSEE
S576 LDRLSGRSCSEEKIP
S578 RLSGRSCSEEKIPED
K581 GRSCSEEKIPEDGSL
S587 EKIPEDGSLNTTK__
K592 DGSLNTTK_______
  mouse

 
S31 IPPHVPKSDVEMEAQ
K230-u SPSWESSkPRKLMDF
S238 PRKLMDFSDNCAIIL
S250-p IILEDDRsDIssTCA
S253-p EDDRsDIssTCANNI
S254-p DDRsDIssTCANNIN
Y284 KGRFAEVYKAKLKQN
K285 GRFAEVYKAKLKQNT
Y309-p KIFPYEEySSWKTEK
Y361 AKGNLQEYLTRHVIS
S434-p LRLDPTLsVDDLANS
S441 sVDDLANSGQVGTAR
Y449 GQVGTARYMAPEVLE
K513 HPCVESMKDSVLRDR
S573 LEHPERLSGRsCsQE
S576-p PERLSGRsCsQEKIP
S578-p RLSGRsCsQEKIPED
K581 GRsCsQEKIPEDGSL
S587 EKIPEDGSLNTTK__
K592 DGSLNTTK_______
  rat

 
S31 IPPHVPKSVNSDLMA
K205 SPSWESSKPRKLMDF
S213 PRKLMDFSDNCAIIL
S225 IILEDDRSDISSTCA
S228 EDDRSDISSTCANNI
S229 DDRSDISSTCANNIN
Y259 KGRFAEVYKAKLKQN
K260 GRFAEVYKAKLKQNT
Y284 KIFPYEEYSSWKTEK
Y336 AKGNLQEYLTRHVIS
S409 LRLDPTLSVDDLANS
S416 SVDDLANSGQVGTAR
Y424 GQVGTARYMAPEVLE
K488 HPCVESMKDNVLRDR
S548 LEHPDRLSGRSCSQE
S551 PDRLSGRSCSQEKIP
S553 RLSGRSCSQEKIPED
K556 GRSCSQEKIPEDGSL
S562 EKIPEDGSLNTTK__
K567 DGSLNTTK_______
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