a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 220.127.116.11; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 3p22
Cellular Component: integral to membrane; plasma membrane; caveola; cytosol; receptor complex; external side of plasma membrane
Molecular Function: transforming growth factor beta receptor activity; protein binding; glycosaminoglycan binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: lens development in camera-type eye; wound healing; apoptosis; positive regulation of smooth muscle cell proliferation; heart development; gastrulation; myeloid dendritic cell differentiation; palate development; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; negative regulation of cardiac muscle cell proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to glucose stimulus; positive regulation of NK T cell differentiation; vasculogenesis; positive regulation of T cell tolerance induction; response to nutrient; aging; response to drug; receptor-mediated endocytosis; blood vessel development; smoothened signaling pathway; organ regeneration; positive regulation of skeletal muscle regeneration; in utero embryonic development; embryonic hemopoiesis; common-partner SMAD protein phosphorylation; peptidyl-threonine phosphorylation; embryonic cranial skeleton morphogenesis; regulation of cell proliferation; patterning of blood vessels; positive regulation of angiogenesis; peptidyl-serine phosphorylation; regulation of gene expression; response to mechanical stimulus; response to estrogen stimulus; positive regulation of B cell tolerance induction; activation of protein kinase activity; brain development; negative regulation of transforming growth factor beta receptor signaling pathway; embryo implantation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.