a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Kinase, protein; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily
Cellular Component: plasma membrane; integral to membrane; caveola; receptor complex; external side of plasma membrane
Molecular Function: transforming growth factor beta receptor activity; protein binding; glycosaminoglycan binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta binding; metal ion binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: lens development in camera-type eye; apoptosis; heart development; gastrulation; myeloid dendritic cell differentiation; palate development; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway; regulation of growth; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; vasculogenesis; positive regulation of T cell tolerance induction; response to drug; blood vessel development; smoothened signaling pathway; embryonic hemopoiesis; in utero embryonic development; peptidyl-threonine phosphorylation; embryonic cranial skeleton morphogenesis; regulation of cell proliferation; patterning of blood vessels; peptidyl-serine phosphorylation; positive regulation of B cell tolerance induction; cartilage development; activation of protein kinase activity; brain development; negative regulation of transforming growth factor beta receptor signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.