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Protein Page:
Pim3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Pim3 a Ca(2 )/calmodulin-dependent protein kinase of the PIM family. Highly expressed in hematopoietic tissues, in leukemia and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.1; Kinase, protein; CAMK group; PIM family
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: apoptosis; histone phosphorylation; protein amino acid autophosphorylation; regulation of mitotic cell cycle; cell cycle; protein amino acid phosphorylation; negative regulation of apoptosis
Reference #:  Q86V86 (UniProtKB)
Alt. Names/Synonyms: pim-3; pim-3 oncogene; PIM3; serine/threonine kinase Pim-3; serine/threonine protein kinase pim-3; Serine/threonine-protein kinase pim-3
Gene Symbols: PIM3
Molecular weight: 35,891 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Pim3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S8-p MLLSKFGsLAHLCGP
0 1 K30-ub VKILQPAkADKESFE
0 1 K38-ub ADKESFEkAYQVGAV
0 1 K69-ub DGLPVAVkHVVKERV
0 1 T77-p HVVKERVtEWGsLGG
0 1 S81-p ERVtEWGsLGGAtVP
0 1 T86-p WGsLGGAtVPLEVVL
0 3 K172-ub GVVHRDIkDENLLVD
0 4 K186-ub DLRSGELkLIDFGSG
0 10 K197-ub FGSGALLkDTVYTDF
  mouse

 
S8 MLLSKFGSLAHLCGP
K30 VKILQPAKADKESFE
K38 ADKESFEKVYQVGAV
K69 DGLPVAVKHVVKERV
T77 HVVKERVTEWGSLGG
S81 ERVTEWGSLGGVAVP
A86 WGSLGGVAVPLEVVL
K172 GVVHRDIKDENLLVD
K186 DLRSGELKLIDFGSG
K197 FGSGAVLKDTVYTDF
  rat

 
S8 MLLSKFGSLAHLCGP
K30 VKILQPAKADKESFE
K38 ADKESFEKVYQVGAV
K69 DGLPVAVKHVVKERV
T77 HVVKERVTEWGSLGG
S81 ERVTEWGSLGGMAVP
A86 WGSLGGMAVPLEVVL
K172 GVVHRDIKDENLLVD
K186 DLRSGELKLIDFGSG
K197 FGSGAVLKDTVYTDF
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