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Protein Page:
TGFBR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TGFBR1 a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Receptor, misc.; Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: tight junction; membrane; cell; plasma membrane; endosome; receptor complex
Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; metal ion binding; growth factor binding; punt binding; receptor signaling protein activity; SMAD binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; positive regulation of transcription, DNA-dependent; heart development; negative regulation of chondrocyte differentiation; activin receptor signaling pathway; cell motility involved in cell locomotion; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; cell cycle arrest; kidney development; neuron fate commitment; embryonic cranial skeleton morphogenesis; positive regulation of cell growth; parathyroid gland development; endothelial cell activation; mesenchymal cell differentiation; regulation of gene expression; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of endothelial cell proliferation; lens development in camera-type eye; wound healing; apoptosis; regulation of protein ubiquitination; palate development; signal transduction; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; skeletal morphogenesis; regulation of protein binding; artery morphogenesis; epithelial to mesenchymal transition; negative regulation of transforming growth factor beta receptor signaling pathway
Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To
Reference #:  P36897 (UniProtKB)
Alt. Names/Synonyms: AAT5; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; Activin receptor-like kinase 5; ACVRLK4; ALK-5; ALK5; LDS1A; LDS2A; Serine/threonine-protein kinase receptor R4; SKR4; TbetaR-I; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFBR1; TGFR-1; TGFR1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); Transforming growth factor-beta receptor type I
Gene Symbols: TGFBR1
Molecular weight: 55,960 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGFBR1

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S172‑p, T176‑p
enzymatic activity, induced: T200‑p, T204‑p
phosphorylation: T200‑p, T204‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T47 LCTKDNFTCVTDGLC
2 1 S165-p VPNEEDPsLDRPFIs
1 0 S172-p sLDRPFIsEGTtLkD
1 0 T176-p PFIsEGTtLkDLIYD
1 0 K178-ub IsEGTtLkDLIYDMt
0 2 Y182 TtLkDLIYDMttsGs
2 0 T185-p kDLIYDMttsGsGsG
2 0 T186-p DLIYDMttsGsGsGL
2 0 S187-p LIYDMttsGsGsGLP
2 0 S189-p YDMttsGsGsGLPLL
2 0 S191-p MttsGsGsGLPLLVQ
2 0 T200-p LPLLVQRtIARtIVL
2 0 T204-p VQRtIARtIVLQEsI
0 1 S210-p RtIVLQEsIGKGRFG
0 1 T298-p YLNRYTVtVEGMIKL
0 1 K391-ub LDDSINMkHFESFKR
0 1 K502-ub LSQQEGIkM______
  mouse

 
T43-p LCTKDNFtCETDGLC
S165-p VPNEEDPsLDRPFIS
S172 sLDRPFISEGTTLKD
T176 PFISEGTTLKDLIyD
K178 ISEGTTLKDLIyDMt
Y182-p TTLKDLIyDMttsGs
T185-p KDLIyDMttsGsGsG
T186-p DLIyDMttsGsGsGL
S187-p LIyDMttsGsGsGLP
S189-p yDMttsGsGsGLPLL
S191-p MttsGsGsGLPLLVQ
T200 LPLLVQRTIARTIVL
T204 VQRTIARTIVLQESI
S210 RTIVLQESIGKGRFG
T298 YLNRYTVTVEGMIKL
K391 LDDSINMKHFESFKR
K502 LSQQEGIKM______
  rat

 
T43 LCTKDNFTCETDGLC
S163 VPNEEDPSLDRPFIS
S170 SLDRPFISEGTTLKD
T174 PFISEGTTLKDLIYD
K176 ISEGTTLKDLIYDMT
Y180 TTLKDLIYDMTTSGS
T183 KDLIYDMTTSGSGSG
T184 DLIYDMTTSGSGSGL
S185 LIYDMTTSGSGSGLP
S187 YDMTTSGSGSGLPLL
S189 MTTSGSGSGLPLLVQ
T198 LPLLVQRTIARTIVL
T202 VQRTIARTIVLQESI
S208 RTIVLQESIGKGRFG
T296 YLNRYTVTVEGMIKL
K389 LDDSINMKHFESFKR
K500 LSQQEGIKM______
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