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TGFBR1 (human)

Overview TGFBR1 a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TKL; Receptor, misc.; Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 2.7.11.30; Membrane protein, integral; TKL group; STKR family; Type1 subfamily Cellular Component: tight junction; basolateral plasma membrane; apical plasma membrane; plasma membrane; receptor complex Molecular Function: metal ion binding; punt binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta binding; protein heterodimerization activity; transforming growth factor beta receptor activity, type I; ubiquitin protein ligase binding; growth factor binding; SMAD binding; ATP binding Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; positive regulation of transcription, DNA-dependent; response to toxin; heart development; negative regulation of chondrocyte differentiation; cell motility involved in cell locomotion; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; regulation of apoptosis; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; response to electrical stimulus; cell cycle arrest; kidney development; organ regeneration; neuron fate commitment; embryonic cranial skeleton morphogenesis; parathyroid gland development; positive regulation of cell growth; mesenchymal cell differentiation; response to estrogen stimulus; endothelial cell migration; negative regulation of apoptosis; lens development in camera-type eye; wound healing; apoptosis; regulation of protein ubiquitination; protein amino acid autophosphorylation; palate development; signal transduction; negative regulation of endothelial cell differentiation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; aging; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; gut development; skeletal morphogenesis; regulation of protein binding; induction of apoptosis; response to hypoxia; artery morphogenesis; epithelial to mesenchymal transition; negative regulation of transforming growth factor beta receptor signaling pathway; embryo implantation; lung development Reference #:  P36897 (UniProtKB) Alt. Names/Synonyms: AAT5; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; Activin receptor-like kinase 5; ACVRLK4; ALK-5; ALK5; LDS1A; LDS2A; Serine/threonine-protein kinase receptor R4; SKR4; TbetaR-I; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFBR1; TGFR-1; TGFR1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); Transforming growth factor-beta receptor type I Gene Symbols: TGFBR1 Molecular weight: 55,960 Da Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TGFBR1 1B6C - B/D/F/H=162-503 (human) 1IAS - A/B/C/D/E=162-503 (human) 1PY5 - A=175-500 (human) 1RW8 - A=200-500 (human) 1TBI - A=34-114 (human) 1VJY - A=201-503 (human) 2L5S - A=31-115 (human) 2PJY - C=33-111 (human) 2WOT - A=200-503 (human) 2WOU - A=200-503 (human) 2X7O - A/D/C/E/B=162-503 (human) 3FAA - A/D/C/E/B=162-503 (human) 3GXL - A=201-503 (human) 3HMM - A=201-503 (human) 3KCF - A/D/C/E/B=162-503 (human) 3KFD - J/K/I/L=31-115 (human) 3TZM - A=200-503 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM  |  ENZYME  |  Phospho3D  |  DISEASE 190181 608967 609129 609192  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: S172‑p, T176‑p enzymatic activity, induced: T200‑p, T204‑p phosphorylation: T200‑p, T204‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T47	LCTKDNFTCVTDGLC
2	1		S165-p	VPNEEDPsLDRPFIs
1	0		S172-p	sLDRPFIsEGTtLKD
1	0		T176-p	PFIsEGTtLKDLIYD
0	2		Y182	TtLKDLIYDMttsGs
2	0		T185-p	KDLIYDMttsGsGsG
2	0		T186-p	DLIYDMttsGsGsGL
2	0		S187-p	LIYDMttsGsGsGLP
2	0		S189-p	YDMttsGsGsGLPLL
2	0		S191-p	MttsGsGsGLPLLVQ
2	0		T200-p	LPLLVQRtIARtIVL
2	0		T204-p	VQRtIARtIVLQEsI
0	1		S210-p	RtIVLQEsIGKGRFG
0	1		T298-p	YLNRYTVtVEGMIKL
0	1		K391-u	LDDSINMkHFESFKR
0	1		K502-u	LSQQEGIkM______

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	mouse
T43-p	LCTKDNFtCETDGLC
S165-p	VPNEEDPsLDRPFIS
S172	sLDRPFISEGTTLKD
T176	PFISEGTTLKDLIyD
Y182-p	TTLKDLIyDMttsGs
T185-p	KDLIyDMttsGsGsG
T186-p	DLIyDMttsGsGsGL
S187-p	LIyDMttsGsGsGLP
S189-p	yDMttsGsGsGLPLL
S191-p	MttsGsGsGLPLLVQ
T200	LPLLVQRTIARTIVL
T204	VQRTIARTIVLQESI
S210	RTIVLQESIGKGRFG
T298	YLNRYTVTVEGMIKL
K391	LDDSINMKHFESFKR
K502	LSQQEGIKM______

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