a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; Receptor, misc.; Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 22.214.171.124; Membrane protein, integral; TKL group; STKR family; Type1 subfamily
Molecular Function: metal ion binding; punt binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta binding; protein heterodimerization activity; transforming growth factor beta receptor activity, type I; ubiquitin protein ligase binding; growth factor binding; SMAD binding; ATP binding
Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; positive regulation of transcription, DNA-dependent; response to toxin; heart development; negative regulation of chondrocyte differentiation; cell motility involved in cell locomotion; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; regulation of apoptosis; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; response to electrical stimulus; cell cycle arrest; kidney development; organ regeneration; neuron fate commitment; embryonic cranial skeleton morphogenesis; parathyroid gland development; positive regulation of cell growth; mesenchymal cell differentiation; response to estrogen stimulus; endothelial cell migration; negative regulation of apoptosis; lens development in camera-type eye; wound healing; apoptosis; regulation of protein ubiquitination; protein amino acid autophosphorylation; palate development; signal transduction; negative regulation of endothelial cell differentiation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; aging; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; gut development; skeletal morphogenesis; regulation of protein binding; induction of apoptosis; response to hypoxia; artery morphogenesis; epithelial to mesenchymal transition; negative regulation of transforming growth factor beta receptor signaling pathway; embryo implantation; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.