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ATRIP (human)

Overview ATRIP is required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Heterodimerizes with ATR. The heterodimer binds replication protein A (RPA), a protein complex that subsequently is recruited to single stranded DNA (ssDNA). Its EEXXXDDL motif is required for the interaction with catalytic subunit of DNA-PK and its recruitment to sites of DNA damage. e for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame. Three alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation; DNA repair; DNA binding protein Cellular Component: nucleoplasm Molecular Function: protein binding Biological Process: DNA damage checkpoint; DNA replication; DNA repair; cell cycle checkpoint Reference #:  Q8WXE1 (UniProtKB) Alt. Names/Synonyms: AGS1; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; ATRIP; DKFZp762J2115; FLJ12343; MGC20625; MGC21482; MGC26740 Gene Symbols: ATRIP Molecular weight: 85,838 Da Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATRIP

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	Sites Implicated In
cell cycle regulation: S224‑p, S239‑p intracellular localization: S68‑p, S72‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S13	APGSKRRSEPPAPRP
0	3		K32-a	GTGHPPSkRARGFsA
0	1		S38-p	SkRARGFsAAAAPDP
1	0		S68-p	EELDTLAsQALsQCP
1	0		S72-p	TLAsQALsQCPAAAR
0	1		K96-u	RLLDGMSkNPSGKNR
0	14		N97	LLDGMSkNPSGKNRE
0	1		N102	SkNPSGKNRETVPIK
0	1		A212	KLQTSERANkLAAPS
0	1		K214-u	QTSERANkLAAPSVs
0	1		S221-p	kLAAPSVsHVsPRKN
1	14		S224-p	APSVsHVsPRKNPSV
1	16		S239-p	VIKPEACsPQFGKTS
0	6		S518-p	RSLVHRLsDGDMtSA
0	1		T523-p	RLsDGDMtSALRGVA
0	2		Y636-p	GCLLLLLyMYITSRP
0	1		T691	VEVVRALTVMLHRQW

	ATRIP iso2
S13	APGSKRRSEPPAPRP
K32	GTGHPPSKRARGFSA
S38	SKRARGFSAAAAPDP
S68	EELDTLASQALSQCP
S72	TLASQALSQCPAAAR
K96	RLLDGMSKNPSGKNR
N97	LLDGMSKNPSGKNRE
N102	SKNPSGKNRETVPIK
A212	KLQTSERANKLAAPS
K214	QTSERANKLAAPSVS
S221	KLAAPSVSHVSPRKN
S224	APSVSHVSPRKNPSV
S239	VIKPEACSPQFGKTS
S518	RSLVHRLSDGDMTSA
T523	RLSDGDMTSALRGVA
Y636	GCLLLLLYMYITSRP
T664-p	QEVVRALtVMLHRQW

	mouse
S14-p	PNSHRKQsGGLEPFP
K33	SIENPPSKRARSFSE
S39	SKRARSFSETTVPDP
S69	EELDILASQALSQCP
S73	ILASQALSQCPVAPR
N96	RRLDGLPNsPIRKsR
S97-p	RLDGLPNsPIRKsRE
S102-p	PNsPIRKsREDIPVK
T212-p	KSQSNGRtNKPAAPS
K214	QSNGRtNKPAAPSVS
S221	KPAAPSVSHVsPRKG
S224-p	APSVSHVsPRKGSSV
S239-p	VLKSEACsPHVGKTT
A515	GNLVQTCADTTSASR
T518	VQTCADTTSASREDA
Y631	GCLLLRLYMYITSRP
T686	VEAVRALTVMLHRQW

	rat
S14	PNSHRKQSGGLEPFL
K33	SIENPPSKRARSFSE
S39	SKRARSFSETTVPDP
S69	EELDILASQALSQCP
S73	ILASQALSQCPVAPP
N96	RRLDGLPNsPIRKNR
S97-p	RLDGLPNsPIRKNRE
N102	PNsPIRKNREDIPVK
T212	KLQSNERTNKLTIPS
K214	QSNERTNKLTIPSVS
S221	KLTIPSVSQVSPRKG
S224	IPSVSQVSPRKGSSV
S239	VVKSEACSPHVGKTT
A514	GDLSQTCADTVSASR
V517	SQTCADTVSASREDA
Y630	GCLLLRLYMYITSRP
T685	VEAVRALTVMLHRQW

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