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TAK1 (human)

Overview TAK1 a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TKL; EC 2.7.11.25; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; TAK1 subfamily Cellular Component: plasma membrane; endosome membrane; IkappaB kinase complex; cytosol Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; protein kinase activity Biological Process: positive regulation of JNK activity; I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; apoptosis; activation of MAPK activity; stress-activated MAPK cascade; positive regulation of JNK cascade; positive regulation of T cell cytokine production; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; transforming growth factor beta receptor signaling pathway; JNK cascade; angiogenesis; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; positive regulation of T cell activation; neural tube formation; I-kappaB phosphorylation; negative regulation of apoptosis Reference #:  O43318 (UniProtKB) Alt. Names/Synonyms: M3K7; MAP3K7; MEKK7; Mitogen-activated protein kinase kinase kinase 7; TAK1; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; TGF1a; Transforming growth factor-beta-activated kinase 1 Gene Symbols: MAP3K7 Molecular weight: 67,196 Da Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  MAPK/Erk in Growth and Differentiation  |  NF-kB Signaling  |  Regulation of Actin Dynamics  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-like Receptors Pathway  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TAK1 2EVA - A=31-328 (human) 2YIY - A=31-303 (human) 4GS6 - A=468-504 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2EVA 2YIY 4GS6  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, altered: T187‑p enzymatic activity, induced: T178‑p, T184‑p, T187‑p, S192‑p phosphorylation: T178‑p, T184‑p, T187‑p, S192‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		K72-u	IESESERkAFIVELR
2	0		K158-u	ALIHRDLkPPNLLLV
2	0		T178-p	LKICDFGtACDIQtH
8	0		T184-p	GtACDIQtHMtNNKG
14	0		T187-p	CDIQtHMtNNKGsAA
4	0		S192-p	HMtNNKGsAAWMAPE
1	0		K209-u	EGSNYSEkCDVFSWG
0	1		T333-p	NTSNKSDtNMEQVPA
0	1		K346-u	PATNDTIkRLESkLL
0	1		K351-u	TIkRLESkLLkNQAK
0	1		K354-u	RLESkLLkNQAKQQS
0	1		K386-a	LPPTSEGkRMsADMS
0	17		S389-p	TSEGkRMsADMSEIE
0	1		S393	kRMsADMSEIEARIA
0	8		Y405-p	RIAATTAysKPKRGH
0	1		S406-p	IAATTAysKPKRGHR
0	1		T415-p	PKRGHRKtAsFGNIL
0	3		S417-p	RGHRKtAsFGNILDV
2	90		S439-p	NGQPRRRsIQDLtVT
0	1		T444-p	RRsIQDLtVTGTEPG
0	2		S454-p	GTEPGQVssRSSSPS
0	3		S455-p	TEPGQVssRSSSPSV
0	1		S492	DSTDTNGSDNSIPMA
0	1		K573-a	RLVQEHKkLLDENKS
0	2		Y584-p	ENKSLSTyyQQCKkQ
0	2		Y585-p	NKSLSTyyQQCKkQL
0	2		K590-u	TyyQQCKkQLEVIRS

	mouse ► Hide Isoforms
K72	IESESERKAFIVELR
K158	ALIHRDLKPPNLLLV
T178	LKICDFGTACDIQtH
T184-p	GTACDIQtHMtNNKG
T187-p	CDIQtHMtNNKGsAA
S192-p	HMtNNKGsAAWMAPE
K209	EGSNYSEKCDVFSWG
T333	NTSNKSDTNMEQVPA
K346	PATNDTIKRLESKLL
K351	TIKRLESKLLKNQAK
K354	RLESKLLKNQAKQQS
K386	LPPTSEGKRMsADMs
S389-p	TSEGKRMsADMsEIE
S393-p	KRMsADMsEIEARIV
-	gap
-	gap
-	gap
-	gap
S412-p	NGQPRRRsIQDLtVT
T417-p	RRsIQDLtVTGTEPG
S427-p	GTEPGQVssRSSSPS
S428-p	TEPGQVssRSSSPSV
S465-p	DSTDTNGsDNSIPMA
K546	RLVQEHKKLLDENKS
Y557	ENKSLSTYYQQCKkQ
Y558	NKSLSTYYQQCKkQL
K563-u	TYYQQCKkQLEVIRS

	TAK1 iso3
K72	IESESERKAFIVELR
K158	ALIHRDLKPPNLLLV
T178	LKICDFGTACDIQTH
T184	GTACDIQTHMTNNKG
T187	CDIQTHMTNNKGSAA
S192	HMTNNKGSAAWMAPE
K209	EGSNYSEKCDVFSWG
T333	NTSNKSDTNMEQVPA
K346	PATNDTIKRLESKLL
K351	TIKRLESKLLKNQAK
K354	RLESKLLKNQAKQQS
K386	LPPTSEGKRMSADMS
S389	TSEGKRMSADMSEIE
S393	KRMSADMSEIEARIV
Y405-p	RIVATAAySKPKRGH
S406	IVATAAySKPKRGHR
T415	PKRGHRKTAsFGNIL
S417-p	RGHRKTAsFGNILDV
S439	NGQPRRRSIQDLTVT
T444	RRSIQDLTVTGTEPG
S454	GTEPGQVSSRSSSPS
S455	TEPGQVSSRSSSPSV
S492	DSTDTNGSDNSIPMA
K573	RLVQEHKKLLDENKS
Y584	ENKSLSTYYQQCKKQ
Y585	NKSLSTYYQQCKKQL
K590	TYYQQCKKQLEVIRS

	rat
K72	IESESERKAFIVELR
K158	ALIHRDLKPPNLLLV
T178	LKICDFGTACDIQTH
T184	GTACDIQTHMtNNKG
T187-p	CDIQTHMtNNKGSAA
S192	HMtNNKGSAAWMAPE
K209	EGSNYSEKCDVFSWG
T333	NTSNKSDTNMEQVPA
K346	PATNDTIKRLESKLL
K351	TIKRLESKLLKNQAK
K354	RLESKLLKNQAKQQS
K386	LPPTSEGKRMSADMS
S389	TSEGKRMSADMSEIE
S393	KRMSADMSEIEARIV
Y405	RIVATTAYTKPKRGH
T406	IVATTAYTKPKRGHR
T415	PKRGHRKTASFGNIL
S417	RGHRKTASFGNILDV
S439-p	NGQPRRRsIQDLTVT
T444	RRsIQDLTVTGTEPG
S454	GTEPGQVSSRSSSPS
S455	TEPGQVSSRSSSPSV
S492	DSTDTNGSDNSIPMA
K573	RLVQEHKKLLDENKS
Y584	ENKSLSTYYQQCKKQ
Y585	NKSLSTYYQQCKKQL
K590	TYYQQCKKQLEVIRS

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