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Protein Page:
TAK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TAK1 a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; TKL group; MLK family; TAK1 subfamily
Cellular Component: cytoplasm; plasma membrane; endosome membrane; IkappaB kinase complex; nucleus; cytosol
Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK activity; activation of MAPKK activity; apoptosis; activation of MAPK activity; stress-activated MAPK cascade; positive regulation of JNK cascade; positive regulation of T cell cytokine production; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; transforming growth factor beta receptor signaling pathway; JNK cascade; angiogenesis; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; positive regulation of interleukin-2 production; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of T cell activation; neural tube formation; I-kappaB phosphorylation
Reference #:  O43318 (UniProtKB)
Alt. Names/Synonyms: M3K7; MAP3K7; MEKK7; Mitogen-activated protein kinase kinase kinase 7; TAK1; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; TGF1a; Transforming growth factor-beta-activated kinase 1
Gene Symbols: MAP3K7
Molecular weight: 67,196 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAK1

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: T187‑p
enzymatic activity, induced: T178‑p, T184‑p, T187‑p, S192‑p
phosphorylation: T178‑p, T184‑p, T187‑p, S192‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K72-ub IESESERkAFIVELR
2 0 K158-ub ALIHRDLkPPNLLLV
2 0 T178-p LKICDFGtACDIQtH
9 0 T184-p GtACDIQtHMtNNKG
15 0 T187-p CDIQtHMtNNKGsAA
4 0 S192-p HMtNNKGsAAWMAPE
1 0 K209-ub EGSNYSEkCDVFSWG
0 1 T333-p NTSNKSDtNMEQVPA
0 1 K346-ub PATNDTIkRLESkLL
0 1 K351-ub TIkRLESkLLkNQAK
0 1 K354-ub RLESkLLkNQAKQQS
0 2 S367-p QSESGRLsLGASRGS
0 1 K386-ac LPPTSEGkRMsADMs
0 26 S389-p TSEGkRMsADMsEIE
0 2 S393-p kRMsADMsEIEARIA
0 8 Y405-p RIAATTAysKPKRGH
0 1 S406-p IAATTAysKPKRGHR
0 2 T415-p PKRGHRKtAsFGNIL
0 4 S417-p RGHRKtAsFGNILDV
2 100 S439-p NGQPRRRsIQDLtVT
0 2 T444-p RRsIQDLtVTGTEPG
0 2 S454-p GTEPGQVssRSssPS
0 5 S455-p TEPGQVssRSssPSV
0 1 S458-p GQVssRSssPSVRMI
0 1 S459-p QVssRSssPSVRMIT
0 1 S492 DSTDTNGSDNSIPMA
0 1 K573-ac RLVQEHKkLLDENKS
0 2 Y584-p ENKSLSTyyQQCKkQ
0 2 Y585-p NKSLSTyyQQCKkQL
0 2 K590-ub TyyQQCKkQLEVIRS
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4537 : Phospho-TAK1 (Thr184) Antibody
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4536 : Phospho-TAK1 (Thr187) Antibody
9339 : Phospho-TAK1 (Ser412) Antibody
  mouse

► Hide Isoforms
 
K72 IESESERKAFIVELR
K158 ALIHRDLKPPNLLLV
T178 LKICDFGTACDIQtH
T184-p GTACDIQtHMtNNKG
T187-p CDIQtHMtNNKGsAA
S192-p HMtNNKGsAAWMAPE
K209 EGSNYSEKCDVFSWG
T333 NTSNKSDTNMEQVPA
K346 PATNDTIKRLESKLL
K351 TIKRLESKLLKNQAK
K354 RLESKLLKNQAKQQS
S367 QSESGRLSLGASRGS
K386 LPPTSEGKRMsADMs
S389-p TSEGKRMsADMsEIE
S393-p KRMsADMsEIEARIV
- gap
- gap
- gap
- gap
S412-p NGQPRRRsIQDLtVT
T417-p RRsIQDLtVTGTEPG
S427-p GTEPGQVssRSSSPS
S428-p TEPGQVssRSSSPSV
S431 GQVssRSSSPSVRMI
S432 QVssRSSSPSVRMIT
S465-p DSTDTNGsDNSIPMA
K546 RLVQEHKKLLDENKS
Y557 ENKSLSTYYQQCKkQ
Y558 NKSLSTYYQQCKkQL
K563-ub TYYQQCKkQLEVIRS
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4537 : Phospho-TAK1 (Thr184) Antibody
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4536 : Phospho-TAK1 (Thr187) Antibody
9339 : Phospho-TAK1 (Ser412) Antibody
  TAK1 iso3  
K72 IESESERKAFIVELR
K158 ALIHRDLKPPNLLLV
T178 LKICDFGTACDIQTH
T184 GTACDIQTHMTNNKG
T187 CDIQTHMTNNKGSAA
S192 HMTNNKGSAAWMAPE
K209 EGSNYSEKCDVFSWG
T333 NTSNKSDTNMEQVPA
K346 PATNDTIKRLESKLL
K351 TIKRLESKLLKNQAK
K354 RLESKLLKNQAKQQS
S367 QSESGRLSLGASRGS
K386 LPPTSEGKRMSADMS
S389 TSEGKRMSADMSEIE
S393 KRMSADMSEIEARIV
Y405-p RIVATAAySKPKRGH
S406 IVATAAySKPKRGHR
T415-p PKRGHRKtAsFGNIL
S417-p RGHRKtAsFGNILDV
S439 NGQPRRRSIQDLTVT
T444 RRSIQDLTVTGTEPG
S454 GTEPGQVSSRSSSPS
S455 TEPGQVSSRSSSPSV
S458 GQVSSRSSSPSVRMI
S459 QVSSRSSSPSVRMIT
S492 DSTDTNGSDNSIPMA
K573 RLVQEHKKLLDENKS
Y584 ENKSLSTYYQQCKKQ
Y585 NKSLSTYYQQCKKQL
K590 TYYQQCKKQLEVIRS
  rat

 
K72 IESESERKAFIVELR
K158 ALIHRDLKPPNLLLV
T178 LKICDFGTACDIQTH
T184 GTACDIQTHMtNNKG
T187-p CDIQTHMtNNKGSAA
S192 HMtNNKGSAAWMAPE
K209 EGSNYSEKCDVFSWG
T333 NTSNKSDTNMEQVPA
K346 PATNDTIKRLESKLL
K351 TIKRLESKLLKNQAK
K354 RLESKLLKNQAKQQS
S367 QSDSGRLSLGASRGS
K386 LPPTSEGKRMsADMS
S389-p TSEGKRMsADMSEIE
S393 KRMsADMSEIEARIV
Y405 RIVATTAYTKPKRGH
T406 IVATTAYTKPKRGHR
T415 PKRGHRKTASFGNIL
S417 RGHRKTASFGNILDV
S439-p NGQPRRRsIQDLTVT
T444 RRsIQDLTVTGTEPG
S454 GTEPGQVSSRSSSPS
S455 TEPGQVSSRSSSPSV
S458 GQVSSRSSSPSVRMI
S459 QVSSRSSSPSVRMIT
S492 DSTDTNGSDNSIPMA
K573 RLVQEHKKLLDENKS
Y584 ENKSLSTYYQQCKKQ
Y585 NKSLSTYYQQCKKQL
K590 TYYQQCKKQLEVIRS
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4537 : Phospho-TAK1 (Thr184) Antibody
4508 : Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb
4531 : Phospho-TAK1 (Thr184/187) Antibody
4536 : Phospho-TAK1 (Thr187) Antibody
9339 : Phospho-TAK1 (Ser412) Antibody
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