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Syk (human)

Overview Syk a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Syk family Cellular Component: T cell receptor complex; plasma membrane; cytosol; B cell receptor complex Molecular Function: integrin binding; protein domain specific binding; protein binding; non-membrane spanning protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; protein kinase binding; ATP binding; protein kinase activity Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of interleukin-3 biosynthetic process; positive regulation of calcium-mediated signaling; regulation of phagocytosis; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; activation of JNK activity; leukocyte adhesion; B cell receptor signaling pathway; positive regulation of bone resorption; beta selection; angiogenesis; positive regulation of gamma-delta T cell differentiation; integrin-mediated signaling pathway; platelet activation; neutrophil chemotaxis; adaptive immune response; regulation of superoxide release; positive regulation of cell adhesion mediated by integrin; positive regulation of mast cell degranulation; regulation of neutrophil degranulation; leukotriene biosynthetic process; cell proliferation; organ morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; neutrophil activation during immune response; serotonin secretion by platelet; leukocyte activation during immune response; virus-host interaction; macrophage activation during immune response; defense response to bacterium; blood vessel morphogenesis; positive regulation of B cell differentiation; innate immune response; positive regulation of alpha-beta T cell proliferation; lymph vessel development; blood coagulation; positive regulation of alpha-beta T cell differentiation; positive regulation of cytokine secretion Reference #:  P43405 (UniProtKB) Alt. Names/Synonyms: DKFZp313N1010; FLJ25043; FLJ37489; KSYK; Spleen tyrosine kinase; SYK; Tyrosine-protein kinase SYK Gene Symbols: SYK Molecular weight: 72,066 Da Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  PI3K/Akt Signaling  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Syk 1A81 - A/C/E/G/I/K=9-262 (human) 1CSY - A=163-265 (human) 1CSZ - A=163-265 (human) 1XBA - A=356-635 (human) 1XBB - A=356-635 (human) 1XBC - A=356-635 (human) 3BUW - A/C=317-329 (human) 3EMG - A=349-635 (human) 3FQE - A=356-635 (human) 3FQH - A/B=356-635 (human) 3FQS - A=356-635 (human) 3SRV - A/B=360-635 (human) 3TUB - A=343-635 (human) 3TUC - A=343-635 (human) 3TUD - A=343-635 (human) 3VF8 - A=343-635 (human) 3VF9 - A=343-635 (human) 4DFL - A=363-635 (human) 4DFN - A=363-635 (human) 4F4P - A=365-635 (human) 4FL1 - A=356-635 (human) 4FL2 - A=1-635 (human) 4FL3 - A=1-635 (human) 4FYN - A=356-635 (human) 4FYO - A=356-635 (human) 4FZ6 - A=356-635 (human) 2LCT - B=338-350 (mouse) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
carcinogenesis, induced: S295‑p cell cycle regulation: S295‑p enzymatic activity, induced: Y323‑p, Y348‑p, Y352‑p, Y525‑p, Y526‑p molecular association, regulation: Y323‑p, Y348‑p, Y352‑p protein degradation: S295‑p ubiquitination: S295‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y28-p	TREEAEDyLVQGGMS
0	2		Y47-p	LLRQSRNyLGGFALS
0	3		K60-u	LSVAHGRkAHHYTIE
0	1		T73-p	IERELNGtyAIAGGR
0	54		Y74-p	ERELNGtyAIAGGRT
0	2		Y91-p	SPADLCHyHSQESDG
0	1		K105-a	GLVCLLKkPFNRPQG
0	1		K116-a	RPQGVQPkTGPFEDL
3	1		Y131	KENLIREYVKQTWNL
1	0		S178-p	GKISREEsEQIVLIG
0	1		S202-p	RARDNNGsyALCLLH
0	32		Y203-p	ARDNNGsyALCLLHE
0	2		Y244-p	LWQLVEHySYKADGL
0	4		L276	NFGGRPQLPGSHPAT
0	1		S285	GSHPATWSAGGIISR
1	16		S295-p	GIISRIKsysFPKPG
2	111		Y296-p	IISRIKsysFPKPGH
2	29		S297-p	ISRIKsysFPKPGHR
0	1		S316-p	AQGNRQEsTVsFNPy
0	2		S319-p	NRQEsTVsFNPyEPE
14	1025		Y323-p	sTVsFNPyEPELAPW
0	8		E326	sFNPyEPELAPWAAD
0	9		T345-p	REALPMDtEVyEsPy
9	121		Y348-p	LPMDtEVyEsPyADP
0	7		S350-p	MDtEVyEsPyADPEE
21	261		Y352-p	tEVyEsPyADPEEIR
0	1		Y390	GTVKKGYYQMKkVVK
0	1		K394-a	KGYYQMKkVVKTVAV
0	1		K402-a	VVKTVAVkILKNEAN
0	1		T504-p	ARNVLLVtQHyAkIS
0	5		Y507-p	VLLVtQHyAkISDFG
0	6		K509-u	LVtQHyAkISDFGLS
0	3		K517-u	ISDFGLSkALRADEN
18	80		Y525-p	ALRADENyyKAQtHG
18	74		Y526-p	LRADENyyKAQtHGK
0	1		T530-p	ENyyKAQtHGKWPVK
0	3		Y546-p	YAPECINyYKFSSKS
0	1		Y568-p	LMWEAFSyGQkPYRG
0	2		K571-a	EAFSyGQkPYRGMKG
1	1		Y629-p	VELRLRNyyyDVVN_
1	6		Y630-p	ELRLRNyyyDVVN__
1	2		Y631-p	LRLRNyyyDVVN___

	mouse
Y27	TREEAEDYLVQGGMT
Y46	LLRQSRNYLGGFALS
K59	LSVAHNRKAHHYTIE
T72	IERELNGTyAISGGR
Y73-p	ERELNGTyAISGGRA
Y90	SPADLCHYHSQEPDG
K104	GLICLLKKPFNRPPG
K115	RPPGVQPKTGPFEDL
Y130-p	KENLIREyVKQTWNL
S177	GNISRDESEQTVLIG
S201	RARDNSGSyALCLLH
Y202-p	ARDNSGSyALCLLHE
Y243	LWQLVEHYSYKPDGL
S270-p	AQMGHPGsPNAHPVT
S279-p	NAHPVTWsPGGIISR
S289	GIISRIKSysFPKPG
Y290-p	IISRIKSysFPKPGH
S291-p	ISRIKSysFPKPGHK
S310	PQGSRPESTVSFNPy
S313	SRPESTVSFNPyEPt
Y317-p	STVSFNPyEPtGGPW
T320-p	SFNPyEPtGGPWGPD
T339	REALPMDTEVyESPy
Y342-p	LPMDTEVyESPyADP
S344	MDTEVyESPyADPEE
Y346-p	TEVyESPyADPEEIR
Y384-p	GTVKKGYyQMKKVVK
K388	KGYyQMKKVVKTVAV
K396	VVKTVAVKILKNEAN
T498	ARNVLLVTQHYAKIS
Y501	VLLVTQHYAKISDFG
K503	LVTQHYAKISDFGLS
K511	ISDFGLSKALRADEN
Y519-p	ALRADENyyKAQTHG
Y520-p	LRADENyyKAQTHGK
T524	ENyyKAQTHGKWPVK
Y540-p	YAPECINyYKFSSKS
Y562	LMWEAFSYGQkPYRG
K565-a	EAFSYGQkPYRGMKG
Y623	VELRLRNYyYDVVN_
Y624-p	ELRLRNYyYDVVN__
Y625	LRLRNYyYDVVN___

	rat
Y27	TREEAEDYLVQGGMT
Y46	LLRQSRNYLGGFALS
K59	LSVAHNRKAHHYTIE
T72	IERELNGTYAISGGR
Y73	ERELNGTYAISGGRA
Y90	SPADLCHYHSQEPEG
K104	GLVCLLKKPFNRPPG
K115	RPPGVQPKTGPFEDL
Y130-p	KENLIREyVKQTWNL
S177	GNISRDESEQTVLIG
S201	RARDNNGSFALCLLH
F202	ARDNNGSFALCLLHE
Y243	LWQLVEHYSYKPDGL
S270	VQMGHPGSSNAHPVT
S279	NAHPVTWSPGGIISR
S289	GIISRIKSYSFPKPG
Y290	IISRIKSYSFPKPGH
S291	ISRIKSYSFPKPGHK
S310	PQGSRPESTVSFNPy
S313	SRPESTVSFNPyEPT
Y317-p	STVSFNPyEPTGGAW
T320	SFNPyEPTGGAWGPD
T339	REALPMDTEVyESPy
Y342-p	LPMDTEVyESPyADP
S344	MDTEVyESPyADPEE
Y346-p	TEVyESPyADPEEIR
Y384	GTVKKGYYQMKKVVK
K388	KGYYQMKKVVKTVAV
K396	VVKTVAVKILKNEAN
T498	ARNVLLVTQHYAKIS
Y501	VLLVTQHYAKISDFG
K503	LVTQHYAKISDFGLS
K511	ISDFGLSKALRADEN
Y519-p	ALRADENyyKAQTHG
Y520-p	LRADENyyKAQTHGK
T524	ENyyKAQTHGKWPVK
Y540	YAPECINYFKFSSKS
Y562	LMWEAFSYGQKPYRG
K565	EAFSYGQKPYRGMKG
Y623-p	VELRLRNyyyDVVN_
Y624-p	ELRLRNyyyDVVN__
Y625-p	LRLRNyyyDVVN___

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