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Protein Page:
Syk (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Syk a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Syk family
Cellular Component: T cell receptor complex; plasma membrane; cytosol; B cell receptor complex
Molecular Function: integrin binding; protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; positive regulation of interleukin-3 biosynthetic process; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of calcium-mediated signaling; regulation of phagocytosis; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; activation of JNK activity; leukocyte adhesion; B cell receptor signaling pathway; positive regulation of bone resorption; beta selection; positive regulation of gamma-delta T cell differentiation; angiogenesis; integrin-mediated signaling pathway; platelet activation; neutrophil chemotaxis; adaptive immune response; regulation of superoxide release; positive regulation of cell adhesion mediated by integrin; positive regulation of mast cell degranulation; regulation of neutrophil degranulation; leukotriene biosynthetic process; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; neutrophil activation during immune response; organ morphogenesis; leukocyte activation during immune response; serotonin secretion by platelet; defense response to bacterium; macrophage activation during immune response; blood vessel morphogenesis; innate immune response; positive regulation of B cell differentiation; positive regulation of alpha-beta T cell proliferation; lymph vessel development; blood coagulation; positive regulation of alpha-beta T cell differentiation; positive regulation of cytokine secretion
Reference #:  P43405 (UniProtKB)
Alt. Names/Synonyms: DKFZp313N1010; FLJ25043; FLJ37489; KSYK; Spleen tyrosine kinase; SYK; Tyrosine-protein kinase SYK
Gene Symbols: SYK
Molecular weight: 72,066 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Syk

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
carcinogenesis, induced: S295‑p
cell cycle regulation: S295‑p
enzymatic activity, induced: Y323‑p, Y348‑p, Y352‑p, Y525‑p, Y526‑p
molecular association, regulation: Y323‑p, Y348‑p, Y352‑p
protein degradation: S295‑p
ubiquitination: S295‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 Y28-p TREEAEDyLVQGGMS
0 2 Y47-p LLRQSRNyLGGFALS
0 3 K60-ub LSVAHGRkAHHYTIE
0 1 T73-p IERELNGtyAIAGGR
0 54 Y74-p ERELNGtyAIAGGRT
0 2 Y91-p SPADLCHyHSQESDG
0 1 K105-ac GLVCLLKkPFNRPQG
0 1 K116-ac RPQGVQPkTGPFEDL
3 1 Y131 KENLIREYVKQTWNL
1 0 S178-p GKISREEsEQIVLIG
0 1 S202-p RARDNNGsyALCLLH
0 31 Y203-p ARDNNGsyALCLLHE
0 2 Y244-p LWQLVEHySYKADGL
0 5 L276 NFGGRPQLPGSHPAT
0 1 S285 GSHPATWSAGGIISR
1 13 S295-p GIISRIKsysFPKPG
2 100 Y296-p IISRIKsysFPKPGH
2 28 S297-p ISRIKsysFPKPGHR
0 1 S316-p AQGNRQEsTVsFNPy
0 3 S319-p NRQEsTVsFNPyEPE
16 1019 Y323-p sTVsFNPyEPELAPW
0 8 E326 sFNPyEPELAPWAAD
0 9 T345-p REALPMDtEVyEsPy
9 119 Y348-p LPMDtEVyEsPyADP
0 7 S350-p MDtEVyEsPyADPEE
22 260 Y352-p tEVyEsPyADPEEIR
0 1 Y390 GTVKKGYYQMKkVVK
0 1 K394-ac KGYYQMKkVVKTVAV
0 1 K402-ac VVKTVAVkILKNEAN
0 1 T504-p ARNVLLVtQHyAkIS
0 5 Y507-p VLLVtQHyAkISDFG
0 6 K509-ub LVtQHyAkISDFGLS
0 3 K517-ub ISDFGLSkALRADEN
20 80 Y525-p ALRADENyyKAQtHG
20 74 Y526-p LRADENyyKAQtHGK
0 1 T530-p ENyyKAQtHGKWPVK
0 1 Y539-p GKWPVKWyAPECINy
0 3 Y546-p yAPECINyYKFSSKS
0 1 Y568-p LMWEAFSyGQkPYRG
0 2 K571-ac EAFSyGQkPYRGMKG
0 1 S579-p PYRGMKGsEVTAMLE
2 1 Y629-p VELRLRNyyyDVVN_
2 5 Y630-p ELRLRNyyyDVVN__
2 2 Y631-p LRLRNyyyDVVN___
2715 : Phospho-Syk (Tyr323) Antibody
2701 : Phospho-Zap-70 (Tyr319)/Syk (Tyr352) Antibody
2717 : Phospho-Zap-70 (Tyr319)/Syk (Tyr352) (65E4) Rabbit mAb
2710 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb
2711 : Phospho-Syk (Tyr525/526) Antibody
4349 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5514 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Biotinylated)
6485 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (PE Conjugate)
12081 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
12967 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Pacific Blue(TM) Conjugate)
2710 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb
2711 : Phospho-Syk (Tyr525/526) Antibody
4349 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5514 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Biotinylated)
6485 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (PE Conjugate)
12081 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
12967 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Pacific Blue(TM) Conjugate)
  Syk iso2  
Y28 TREEAEDYLVQGGMS
Y47 LLRQSRNYLGGFALS
K60 LSVAHGRKAHHYTIE
T73 IERELNGTYAIAGGR
Y74 ERELNGTYAIAGGRT
Y91 SPADLCHYHSQESDG
K105 GLVCLLKKPFNRPQG
K116 RPQGVQPKTGPFEDL
Y131 KENLIREYVKQTWNL
S178 GKISREESEQIVLIG
S202 RARDNNGSYALCLLH
Y203 ARDNNGSYALCLLHE
Y244 LWQLVEHYSYKADGL
L276 NFGGRPQLPGSHPAS
- gap
- gap
- gap
- gap
S293 AQGNRQESTVSFNPY
S296 NRQESTVSFNPYEPE
Y300 STVSFNPYEPELAPW
E303 SFNPYEPELAPWAAD
T322 REALPMDTEVYESPY
Y325 LPMDTEVYESPYADP
S327 MDTEVYESPYADPEE
Y329 TEVYESPYADPEEIR
Y367 GTVKKGYYQMKKVVK
K371 KGYYQMKKVVKTVAV
K379 VVKTVAVKILKNEAN
T481 ARNVLLVTQHYAKIS
Y484 VLLVTQHYAKISDFG
K486 LVTQHYAKISDFGLS
K494 ISDFGLSKALRADEN
Y502 ALRADENYYKAQTHG
Y503 LRADENYYKAQTHGK
T507 ENYYKAQTHGKWPVK
Y516 GKWPVKWYAPECINY
Y523 YAPECINYYKFSSKS
Y545 LMWEAFSYGQKPYRG
K548 EAFSYGQKPYRGMKG
S556 PYRGMKGSEVTAMLE
Y606 VELRLRNYYYDVVN_
Y607 ELRLRNYYYDVVN__
Y608 LRLRNYYYDVVN___
  mouse

 
Y27 TREEAEDYLVQGGMT
Y46 LLRQSRNYLGGFALS
K59 LSVAHNRKAHHYTIE
T72 IERELNGTyAISGGR
Y73-p ERELNGTyAISGGRA
Y90 SPADLCHYHSQEPDG
K104 GLICLLKKPFNRPPG
K115 RPPGVQPKTGPFEDL
Y130-p KENLIREyVKQTWNL
S177 GNISRDESEQTVLIG
S201 RARDNSGSyALCLLH
Y202-p ARDNSGSyALCLLHE
Y243 LWQLVEHYSYKPDGL
S270-p AQMGHPGsPNAHPVT
S279-p NAHPVTWsPGGIISR
S289 GIISRIKSysFPKPG
Y290-p IISRIKSysFPKPGH
S291-p ISRIKSysFPKPGHK
S310 PQGSRPESTVSFNPy
S313 SRPESTVSFNPyEPt
Y317-p STVSFNPyEPtGGPW
T320-p SFNPyEPtGGPWGPD
T339 REALPMDTEVyESPy
Y342-p LPMDTEVyESPyADP
S344 MDTEVyESPyADPEE
Y346-p TEVyESPyADPEEIR
Y384-p GTVKKGYyQMKKVVK
K388 KGYyQMKKVVKTVAV
K396 VVKTVAVKILKNEAN
T498 ARNVLLVTQHYAKIS
Y501 VLLVTQHYAKISDFG
K503 LVTQHYAKISDFGLS
K511 ISDFGLSKALRADEN
Y519-p ALRADENyyKAQTHG
Y520-p LRADENyyKAQTHGK
T524 ENyyKAQTHGKWPVK
Y533 GKWPVKWYAPECINy
Y540-p YAPECINyYKFSSKS
Y562 LMWEAFSYGQkPYRG
K565-ac EAFSYGQkPYRGMKG
S573 PYRGMKGSEVTAMLE
Y623 VELRLRNYyYDVVN_
Y624-p ELRLRNYyYDVVN__
Y625 LRLRNYyYDVVN___
2715 : Phospho-Syk (Tyr323) Antibody
2701 : Phospho-Zap-70 (Tyr319)/Syk (Tyr352) Antibody
2717 : Phospho-Zap-70 (Tyr319)/Syk (Tyr352) (65E4) Rabbit mAb
2710 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb
2711 : Phospho-Syk (Tyr525/526) Antibody
4349 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5514 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Biotinylated)
6485 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (PE Conjugate)
12081 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
12967 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Pacific Blue(TM) Conjugate)
2710 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb
2711 : Phospho-Syk (Tyr525/526) Antibody
4349 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5514 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Biotinylated)
6485 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (PE Conjugate)
12081 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
12967 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Pacific Blue(TM) Conjugate)
  rat

 
Y27 TREEAEDYLVQGGMT
Y46 LLRQSRNYLGGFALS
K59 LSVAHNRKAHHYTIE
T72 IERELNGTYAISGGR
Y73 ERELNGTYAISGGRA
Y90 SPADLCHYHSQEPEG
K104 GLVCLLKKPFNRPPG
K115 RPPGVQPKTGPFEDL
Y130-p KENLIREyVKQTWNL
S177 GNISRDESEQTVLIG
S201 RARDNNGSFALCLLH
F202 ARDNNGSFALCLLHE
Y243 LWQLVEHYSYKPDGL
S270 VQMGHPGSSNAHPVT
S279 NAHPVTWSPGGIISR
S289 GIISRIKSYSFPKPG
Y290 IISRIKSYSFPKPGH
S291 ISRIKSYSFPKPGHK
S310 PQGSRPESTVSFNPy
S313 SRPESTVSFNPyEPT
Y317-p STVSFNPyEPTGGAW
T320 SFNPyEPTGGAWGPD
T339 REALPMDTEVyESPy
Y342-p LPMDTEVyESPyADP
S344 MDTEVyESPyADPEE
Y346-p TEVyESPyADPEEIR
Y384 GTVKKGYYQMKKVVK
K388 KGYYQMKKVVKTVAV
K396 VVKTVAVKILKNEAN
T498 ARNVLLVTQHYAKIS
Y501 VLLVTQHYAKISDFG
K503 LVTQHYAKISDFGLS
K511 ISDFGLSKALRADEN
Y519-p ALRADENyyKAQTHG
Y520-p LRADENyyKAQTHGK
T524 ENyyKAQTHGKWPVK
Y533 GKWPVKWYAPECINY
Y540 YAPECINYFKFSSKS
Y562 LMWEAFSYGQKPYRG
K565 EAFSYGQKPYRGMKG
S573 PYRGMKGSEVTAMLE
Y623-p VELRLRNyyyDVVN_
Y624-p ELRLRNyyyDVVN__
Y625-p LRLRNyyyDVVN___
2710 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb
4349 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5514 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Biotinylated)
6485 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (PE Conjugate)
12081 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
12967 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Pacific Blue(TM) Conjugate)
2710 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb
4349 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
5514 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Biotinylated)
6485 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (PE Conjugate)
12081 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
12967 : Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (Pacific Blue(TM) Conjugate)
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