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Src (human)

Overview Src proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; TK group; Src family Cellular Component: cytoskeleton; lysosome; mitochondrial inner membrane; late endosome; plasma membrane; caveola; nucleus; cytosol Molecular Function: identical protein binding; ephrin receptor binding; non-membrane spanning protein tyrosine kinase activity; protein kinase activity; integrin binding; protein binding; SH3/SH2 adaptor activity; protein-tyrosine kinase activity; heme binding; SH2 domain binding; kinase activity; ATP binding; receptor binding Biological Process: oogenesis; axon guidance; regulation of estrogen receptor signaling pathway; peptidyl-tyrosine phosphorylation; progesterone receptor signaling pathway; nerve growth factor receptor signaling pathway; protein kinase cascade; negative regulation of caspase activity; uterus development; signal transduction; membrane organization and biogenesis; negative regulation of protein homooligomerization; forebrain development; cell adhesion; bone resorption; epidermal growth factor receptor signaling pathway; platelet activation; regulation of bone resorption; fibroblast growth factor receptor signaling pathway; negative regulation of focal adhesion formation; signal complex assembly; cell cycle; positive regulation of integrin activation; positive regulation of protein kinase B signaling cascade; virus-host interaction; T cell costimulation; Ras protein signal transduction; regulation of vascular permeability; blood coagulation; leukocyte migration Reference #:  P12931 (UniProtKB) Alt. Names/Synonyms: ASV; c-SRC; p60-Src; pp60c-src; Proto-oncogene c-Src; Proto-oncogene tyrosine-protein kinase Src; protooncogene SRC, Rous sarcoma; SRC; SRC1; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Gene Symbols: SRC Molecular weight: 59,835 Da Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Angiogenesis  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics  |  Tyrosine Kinases  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Src 1A07 - A/B=144-249 (human) 1A08 - A/B=144-249 (human) 1A09 - A/B=144-249 (human) 1A1A - A/B=144-249 (human) 1A1B - A/B=144-249 (human) 1A1C - A/B=144-249 (human) 1A1E - A/B=144-249 (human) 1FMK - A=86-536 (human) 1HCS - B=144-249 (human) 1HCT - B=144-249 (human) 1KSW - A=86-536 (human) 1O41 - A=145-252 (human) 1O42 - A=145-252 (human) 1O43 - A=145-252 (human) 1O44 - A=145-252 (human) 1O45 - A=145-252 (human) 1O46 - A=145-252 (human) 1O47 - A=145-252 (human) 1O48 - A=145-252 (human) 1O49 - A=145-252 (human) 1O4A - A=145-252 (human) 1O4B - A=145-252 (human) 1O4C - A=145-252 (human) 1O4D - A=145-252 (human) 1O4E - A=145-252 (human) 1O4F - A=145-252 (human) 1O4G - A=145-252 (human) 1O4H - A=145-252 (human) 1O4I - A=145-252 (human) 1O4J - A=145-252 (human) 1O4K - A=145-252 (human) 1O4L - A=145-252 (human) 1O4M - A=145-252 (human) 1O4N - A=145-252 (human) 1O4O - A=145-252 (human) 1O4P - A=145-252 (human) 1O4Q - A=145-252 (human) 1O4R - A=145-252 (human) 1SHD - A=144-249 (human) 1Y57 - A=86-536 (human) 1YI6 - A/B=261-536 (human) 1YOJ - A/B=254-536 (human) 1YOL - A/B=254-536 (human) 1YOM - A/B=254-536 (human) 2BDF - A/B=258-536 (human) 2BDJ - A=258-536 (human) 2H8H - A=2-536 (human) 2SRC - A=86-536 (human) 3VRO - B=412-424 (human) 4F59 - A=144-252 (human) 4F5A - A=144-252 (human) 4F5B - A=144-252 (human) 4HXJ - A/B=87-144 (human) 1F1W - A=145-247 (chicken) 1F2F - A=145-247 (chicken) 1NLO - C=81-140 (chicken) 1NLP - C=81-140 (chicken) 1P13 - A/B=145-246 (chicken) 1PRL - C=77-140 (chicken) 1PRM - C=77-140 (chicken) 1RLP - C=77-140 (chicken) 1RLQ - C=77-140 (chicken) 1SRL - A=77-140 (chicken) 1SRM - A=77-140 (chicken) 2HWO - A/B=251-533 (chicken) 2HWP - A/B=251-533 (chicken) 2OIQ - A/B=251-533 (chicken) 2PTK - A=81-533 (chicken) 2QI8 - A/B=251-533 (chicken) 2QLQ - A/B=251-533 (chicken) 2QQ7 - A/B=251-533 (chicken) 3D7T - B=258-533 (chicken) 3D7U - D/B=260-523 (chicken) 3DQW - A/D/C/B=251-533 (chicken) 3DQX - A/B=251-533 (chicken) 3EL7 - A=251-533 (chicken) 3EL8 - A/B=251-533 (chicken) 3EN4 - A/B=251-533 (chicken) 3EN5 - A/B=251-533 (chicken) 3EN6 - A/B=251-533 (chicken) 3EN7 - A/B=251-533 (chicken) 3F3T - A/B=251-533 (chicken) 3F3U - A/B=251-533 (chicken) 3F3V - A/B=251-533 (chicken) 3F3W - A/B=251-533 (chicken) 3F6X - A/D/C/B=251-533 (chicken) 3FJ5 - A/B=85-140 (chicken) 3G5D - A/B=251-533 (chicken) 3G6G - A/B=251-533 (chicken) 3G6H - A/B=251-533 (chicken) 3GEQ - A/B=251-533 (chicken) 3LOK - A/B=251-533 (chicken) 3OEZ - A/B=251-533 (chicken) 3OF0 - A/B=251-533 (chicken) 3QLF - A/B=251-533 (chicken) 3QLG - A/B=251-533 (chicken) 3SVV - A/B=251-533 (chicken) 3TZ7 - A/B=251-533 (chicken) 3TZ8 - A/B=251-533 (chicken) 3TZ9 - A/B=251-533 (chicken) 3U4W - A=259-533 (chicken) 3U51 - A/B=259-533 (chicken) 3UQF - A/B=251-533 (chicken) 3UQG - A/B=251-533 (chicken) 4AGW - A/B=251-533 (chicken) 4DGG - A/B=251-533 (chicken) 4FIC - A/B=251-533 (chicken) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 4F59 4F5A 4F5B 4HXJ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
carcinogenesis, altered: Y419‑p cell adhesion, altered: Y419‑p cell cycle regulation: Y419‑p cell growth, altered: S75‑p, Y419‑p cell motility, altered: Y419‑p cytoskeletal reorganization: S75‑p, Y419‑p signaling pathway regulation: Y419‑p enzymatic activity, induced: S12‑p, S17‑p, S75‑p, Y419‑p enzymatic activity, inhibited: S97‑p, Y530‑p molecular association, regulation: S12‑p, Y419‑p, Y530‑p protein conformation: Y530‑p protein processing: Y530‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
5	0		S12-p	KSKPKDAsQRRRsLE
9	28		S17-p	DAsQRRRsLEPAENV
0	6		A21	RRRsLEPAENVHGAG
0	2		S35-p	GGGAFPAsQtPsKPA
2	1		T37-p	GAFPAsQtPsKPASA
0	1		S39-p	FPAsQtPsKPASAdG
0	1		D45-ca	PsKPASAdGHRGPsA
2	0		G49	ASAdGHRGPsAAFAP
1	0		S51-p	AdGHRGPsAAFAPAA
0	1		K62-a	APAAAEPkLFGGFNs
0	1		S69-p	kLFGGFNssDtVtsP
0	1		S70-p	LFGGFNssDtVtsPQ
0	2		T72-p	GGFNssDtVtsPQRA
0	2		T74-p	FNssDtVtsPQRAGP
7	16		S75-p	NssDtVtsPQRAGPL
0	1		Y93	VTTFVALYDYEsRtE
1	0		S97-p	VALYDYEsRtEtDLs
0	1		T99-p	LYDYEsRtEtDLsFK
0	1		T101-p	DYEsRtEtDLsFKKG
0	2		S104-p	sRtEtDLsFKKGERL
1	0		Y134	LSTGQTGYIPSNYVA
2	0		Y139	TGYIPSNYVAPSDSI
0	4		T182-p	FLVRESEttKGAyCL
0	15		T183-p	LVRESEttKGAyCLS
0	57		Y187-p	SEttKGAyCLSVSDF
8	22		Y216-p	KLDSGGFyITSRTQF
0	14		Y232-p	SLQQLVAyYSKHADG
0	1		T246-p	GLCHRLTtVCPtSKP
0	1		T250-p	RLTtVCPtSKPQTQG
0	1		K252	TtVCPtSKPQTQGLA
0	2		T304-p	IKTLKPGtMsPEAFL
0	2		S306-p	TLKPGtMsPEAFLQE
1	3		Y338-p	VVSEEPIyIVTEYMS
254	3098		Y419-p	RLIEDNEytARQGAK
0	16		T420-p	LIEDNEytARQGAKF
1	520		Y439-p	TAPEAALyGRFTIKS
4	0		Y522-p	LQAFLEDyFTstEPQ
0	1		S525-p	FLEDyFTstEPQyQP
0	2		T526-p	LEDyFTstEPQyQPG
101	970		Y530-p	FTstEPQyQPGENL_

	mouse ► Hide Isoforms
S12	KSKPKDASQRRRsLE
S17-p	DASQRRRsLEPsENV
S21-p	RRRsLEPsENVHGAG
S34-p	AGGAFPAsQtPSKPA
T36-p	GAFPAsQtPSKPASA
S38	FPAsQtPSKPASADG
D44	PSKPASADGHRGPSA
G48	ASADGHRGPSAAFVP
S50	ADGHRGPSAAFVPPA
K61	VPPAAEPKLFGGFNS
S68	KLFGGFNSSDtVTsP
S69	LFGGFNSSDtVTsPQ
T71-p	GGFNSSDtVTsPQRA
T73	FNSSDtVTsPQRAGP
S74-p	NSSDtVTsPQRAGPL
Y92-p	VTTFVALyDYESRtE
S96	VALyDYESRtEtDLs
T98-p	LyDYESRtEtDLsFK
T100-p	DYESRtEtDLsFKKG
S103-p	SRtEtDLsFKKGERL
Y139	LSTGQTGYIPSNYVA
Y144	TGYIPSNYVAPSDSI
T187	FLVRESETtKGAyCL
T188-p	LVRESETtKGAyCLS
Y192-p	SETtKGAyCLSVSDF
Y221-p	KLDSGGFyITSRTQF
Y237-p	SLQQLVAyYSKHADG
T251	GLCHRLTTVCPTSKP
T255	RLTTVCPTSKPQTQG
K257	TTVCPTSKPQTQGLA
T309	IKTLKPGTMSPEAFL
S311	TLKPGTMSPEAFLQE
Y343-p	VVSEEPIyIVTEYMN
Y424-p	RLIEDNEyTARQGAK
T425	LIEDNEyTARQGAKF
Y444-p	TAPEAALyGRFTIKS
Y527-p	LQAFLEDyFTSTEPQ
S530	FLEDyFTSTEPQyQP
T531	LEDyFTSTEPQyQPG
Y535-p	FTSTEPQyQPGENL_

	Src iso2
S12-p	KSKPKDAsQRRRsLE
S17-p	DAsQRRRsLEPsENV
S21-p	RRRsLEPsENVHGAG
S34-p	AGGAFPAsQtPSKPA
T36-p	GAFPAsQtPSKPASA
S38	FPAsQtPSKPASADG
D44	PSKPASADGHRGPSA
G48	ASADGHRGPSAAFVP
S50	ADGHRGPSAAFVPPA
K61	VPPAAEPKLFGGFNS
S68	KLFGGFNSSDTVTsP
S69	LFGGFNSSDTVTsPQ
T71	GGFNSSDTVTsPQRA
T73	FNSSDTVTsPQRAGP
S74-p	NSSDTVTsPQRAGPL
Y92-p	VTTFVALyDYESRTE
S96	VALyDYESRTETDLS
T98	LyDYESRTETDLSFK
T100	DYESRTETDLSFKKG
S103	SRTETDLSFKKGERL
Y133-p	LSTGQTGyIPSNyVA
Y138-p	TGyIPSNyVAPSDSI
T181	FLVRESETTKGAYCL
T182	LVRESETTKGAYCLS
Y186	SETTKGAYCLSVSDF
Y215	KLDSGGFYITSRTQF
Y231	SLQQLVAYYSKHADG
T245	GLCHRLTTVCPTSKP
T249	RLTTVCPTSKPQTQG
K251	TTVCPTSKPQTQGLA
T303	IKTLKPGTMSPEAFL
S305	TLKPGTMSPEAFLQE
Y337	VVSEEPIYIVTEYMN
Y418-p	RLIEDNEyTARQGAK
T419	LIEDNEyTARQGAKF
Y438-p	TAPEAALyGRFTIKS
Y521	LQAFLEDYFTSTEPQ
S524	FLEDYFTSTEPQyQP
T525	LEDYFTSTEPQyQPG
Y529-p	FTSTEPQyQPGENL_

	rat
S12	KSKPKDASQRRRsLE
S17-p	DASQRRRsLEPAENV
A21	RRRsLEPAENVHGAG
S34	AGGAFPASQTPSKPA
T36	GAFPASQTPSKPASA
S38	FPASQTPSKPASADG
D44	PSKPASADGHRGPNA
G48	ASADGHRGPNAAFVP
N50	ADGHRGPNAAFVPPA
K62	PPAAAEPKLFGGFNS
S69	KLFGGFNSSDTVTSP
S70	LFGGFNSSDTVTSPQ
T72	GGFNSSDTVTSPQRA
T74	FNSSDTVTSPQRAGP
S75	NSSDTVTSPQRAGPL
Y93	VTTFVALYDYESRTE
S97	VALYDYESRTETDLS
T99	LYDYESRTETDLSFK
T101	DYESRTETDLSFKKG
S104	SRTETDLSFKKGERL
Y134	LSTGQTGYIPSNYVA
Y139	TGYIPSNYVAPFDSI
T182	FLVRESETTKGAyCL
T183	LVRESETTKGAyCLS
Y187-p	SETTKGAyCLSVSDF
Y216-p	KLDSGGFyITSRTQF
Y232-p	SLQQLVAyYSKHADG
T246	GLCHRLTTVCPTSkP
T250	RLTTVCPTSkPQTQG
K252-u	TTVCPTSkPQTQGLA
T304	IKTLKPGTMSPEAFL
S306	TLKPGTMSPEAFLQE
Y338	VVSEEPIYIVTEYMN
Y419-p	RLIEDNEyTARQGAK
T420	LIEDNEyTARQGAKF
Y439-p	TAPEAALyGRFTIKS
Y522	LQAFLEDYFTSTERQ
S525	FLEDYFTSTERQyQP
T526	LEDYFTSTERQyQPG
Y530-p	FTSTERQyQPGENL_

	chicken
S12-p	KSKPKDPsQRRRsLE
S17-p	DPsQRRRsLEPPDST
P21	RRRsLEPPDSTHHGG
S32	HHGGFPASQtPNKTA
T34-p	GGFPASQtPNKTAAP
N36	FPASQtPNKTAAPDT
D42	PNKTAAPDTHRtPsR
T46-p	AAPDTHRtPsRSFGT
S48-p	PDTHRtPsRSFGTVA
K59	GTVATEPKLFGGFNT
T66	KLFGGFNTSDTVTsP
S67	LFGGFNTSDTVTsPQ
T69	GGFNTSDTVTsPQRA
T71	FNTSDTVTsPQRAGA
S72-p	NTSDTVTsPQRAGAL
Y90	VTTFVALYDYESRTE
S94	VALYDYESRTETDLS
T96	LYDYESRTETDLSFK
T98	DYESRTETDLSFKKG
S101	SRTETDLSFKKGERL
Y131	LTTGQTGYIPSNYVA
Y136	TGYIPSNYVAPSDSI
T179	FLVRESETTKGAYCL
T180	LVRESETTKGAYCLS
Y184	SETTKGAYCLSVSDF
Y213	KLDSGGFYITSRTQF
Y229	SLQQLVAYYSKHADG
N243	GLCHRLTNVCPTSKP
T247	RLTNVCPTSKPQTQG
K249	TNVCPTSKPQTQGLA
T301	IKTLKPGTMSPEAFL
S303	TLKPGTMSPEAFLQE
Y335	VVSEEPIYIVTEYMS
Y416-p	RLIEDNEyTARQGAK
T417	LIEDNEyTARQGAKF
Y436	TAPEAALYGRFTIKS
Y519-p	LQAFLEDyFTSTEPQ
S522	FLEDyFTSTEPQyQP
T523	LEDyFTSTEPQyQPG
Y527-p	FTSTEPQyQPGENL_

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