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SGK1 (human)

Overview SGK1 serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; AGC group; SGK family Cellular Component: endoplasmic reticulum membrane; mitochondrion; plasma membrane; nucleus Molecular Function: protein serine/threonine kinase activity; potassium channel regulator activity; chloride channel regulator activity; sodium channel regulator activity; calcium channel regulator activity; ATP binding Biological Process: apoptosis; sodium ion transport; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of cell migration; regulation of cell proliferation; regulation of apoptosis; long-term memory; regulation of transcription factor activity; regulation of catalytic activity; regulation of blood pressure; response to stress; regulation of cell growth; response to DNA damage stimulus Reference #:  O00141 (UniProtKB) Alt. Names/Synonyms: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid-regulated kinase 1; SGK; SGK1 Gene Symbols: SGK1 Molecular weight: 48,942 Da Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SGK1 2R5T - A=60-431 (human) 3HDM - A=60-431 (human) 3HDN - A=60-431 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2R5T 3HDM 3HDN  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: T256‑p, S422‑p cell cycle regulation: S78‑p enzymatic activity, induced: T256‑p, T369‑p, S422‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K41-a	GLNDFIQkIANNSYA
0	2		S74-p	ELMNANPsPPPsPSQ
2	2		S78-p	ANPsPPPsPSQQINL
0	1		Y124-p	HKAEEVFyAVKVLQK
1	0		S255	IEHNSTTStFCGTPE
12	0		T256-p	EHNSTTStFCGTPEY
2	0		T369-p	DLINKKItPPFNPNV
1	0		S377-p	PPFNPNVsGPNDLRH
0	3		S397-p	TEEPVPNsIGKsPDS
0	2		S401-p	VPNsIGKsPDSVLVT
19	0		S422-p	AEAFLGFsYAPPTDS

	SGK1 iso3
K55	GLNDFIQKIANNSYA
S88	ELMNANPSPPPSPSQ
S92	ANPSPPPSPSQQINL
Y138	HKAEEVFYAVKVLQK
S269	IEHNSTTSTFCGTPE
T270	EHNSTTSTFCGTPEY
T383	DLINKKITPPFNPNV
S391	PPFNPNVSGPNDLRH
S411	TEEPVPNSIGKSPDS
S415	VPNSIGKSPDSVLVT
S436	AEAFLGFSYAPPTDS

	mouse
K41	GLNDFIQKIASNTYA
S74	ELMNANPSPPPSPSQ
S78	ANPSPPPSPSQQINL
Y124	HKAEEVFYAVKVLQK
S255	IEHNGTTSTFCGTPE
T256	EHNGTTSTFCGTPEY
T369	DLINKKITPPFNPNV
S377	PPFNPNVSGPSDLRH
S397	TEEPVPSSIGRSPDS
S401	VPSSIGRSPDSILVT
S422-p	AEAFLGFsYAPPVDS

	rat
K41	GLNDFIQKLANNSYA
S74	ELMNANPSPPPSPSQ
S78	ANPSPPPSPSQQINL
Y124	HKAEEAFYAVKVLQK
S255-p	IEHNGTTstFCGTPE
T256-p	EHNGTTstFCGTPEY
T368	DLINKKITPPFNPNV
S376	PPFNPNVSGPSDLRH
S396	TEEPVPSSIGRSPDS
S400	VPSSIGRSPDSILVT
S421-p	AEAFLGFsYAPPMDS

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