serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 126.96.36.199; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; AGC group; SGK family
Molecular Function: protein serine/threonine kinase activity; protein binding; chloride channel regulator activity; potassium channel regulator activity; sodium channel regulator activity; calcium channel regulator activity; protein serine/threonine/tyrosine kinase activity; ATP binding
Biological Process: cellular sodium ion homeostasis; apoptosis; sodium ion transport; positive regulation of transporter activity; regulation of cell migration; protein amino acid phosphorylation; regulation of cell proliferation; regulation of apoptosis; peptidyl-serine phosphorylation; long-term memory; regulation of transcription factor activity; regulation of catalytic activity; regulation of blood pressure; response to stress; regulation of cell growth; transmembrane transport; response to DNA damage stimulus; neurite morphogenesis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.