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Protein Page:
SGK1 (human)

Overview
SGK1 serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; AGC group; SGK family
Cellular Component: endoplasmic reticulum membrane; mitochondrion; cytoplasm; nucleolus; plasma membrane; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; chloride channel regulator activity; potassium channel regulator activity; sodium channel regulator activity; calcium channel regulator activity; ATP binding
Biological Process: apoptosis; positive regulation of transporter activity; sodium ion transport; protein amino acid phosphorylation; regulation of cell migration; regulation of cell proliferation; regulation of apoptosis; long-term memory; regulation of transcription factor activity; regulation of catalytic activity; regulation of blood pressure; response to stress; regulation of cell growth; response to DNA damage stimulus; transmembrane transport
Reference #:  O00141 (UniProtKB)
Alt. Names/Synonyms: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid-regulated kinase 1; SGK; SGK1
Gene Symbols: SGK1
Molecular weight: 48,942 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SGK1

Protein Structure Not Found.

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Sites Implicated In
apoptosis, inhibited: T256‑p, S422‑p
cell cycle regulation: S78‑p
enzymatic activity, induced: T256‑p, T369‑p, S422‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S74-p ELMNANPsPPPsPSQ
2 2 S78-p ANPsPPPsPSQQINL
1 0 S255 IEHNSTTStFCGTPE
12 0 T256-p EHNSTTStFCGTPEY
2 0 T369-p DLINKKItPPFNPNV
1 0 S377-p PPFNPNVsGPNDLRH
0 3 S397-p TEEPVPNsIGKsPDS
0 2 S401-p VPNsIGKsPDSVLVT
19 0 S422-p AEAFLGFsYAPPTDS
3271 : Phospho-SGK (Ser78) Antibody
5599 : Phospho-SGK1 (Ser78) (D36D11) Rabbit mAb
  SGK1 iso3  
S88 ELMNANPSPPPSPSQ
S92 ANPSPPPSPSQQINL
S269 IEHNSTTSTFCGTPE
T270 EHNSTTSTFCGTPEY
T383 DLINKKITPPFNPNV
S391 PPFNPNVSGPNDLRH
S411 TEEPVPNSIGKSPDS
S415 VPNSIGKSPDSVLVT
S436 AEAFLGFSYAPPTDS
3271 : Phospho-SGK (Ser78) Antibody
5599 : Phospho-SGK1 (Ser78) (D36D11) Rabbit mAb
  mouse

 
S74 ELMNANPSPPPSPSQ
S78 ANPSPPPSPSQQINL
S255 IEHNGTTSTFCGTPE
T256 EHNGTTSTFCGTPEY
T369 DLINKKITPPFNPNV
S377 PPFNPNVSGPSDLRH
S397 TEEPVPSSIGRSPDS
S401 VPSSIGRSPDSILVT
S422-p AEAFLGFsYAPPVDS
3271 : Phospho-SGK (Ser78) Antibody
5599 : Phospho-SGK1 (Ser78) (D36D11) Rabbit mAb
  rat

 
S74 ELMNANPSPPPSPSQ
S78 ANPSPPPSPSQQINL
S255-p IEHNGTTstFCGTPE
T256-p EHNGTTstFCGTPEY
T368 DLINKKITPPFNPNV
S376 PPFNPNVSGPSDLRH
S396 TEEPVPSSIGRSPDS
S400 VPSSIGRSPDSILVT
S421-p AEAFLGFsYAPPMDS
3271 : Phospho-SGK (Ser78) Antibody
5599 : Phospho-SGK1 (Ser78) (D36D11) Rabbit mAb
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