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Protein Page:
RSK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RSK3 an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Note: This description may include information from UniProtKB.
Protein type: Translation; Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; AGC group; RSK family; RSK subfamily
Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleolus; spindle; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; magnesium ion binding; ribosomal protein S6 kinase activity; ATP binding
Biological Process: axon guidance; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; heart development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; brain renin-angiotensin system; oocyte maturation; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; negative regulation of cell cycle; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cell proliferation; synaptic transmission; peptidyl-serine phosphorylation; heart contraction; negative regulation of meiosis; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  Q15349 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 2; HU-2; KS6A2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; p90-RSK 2; p90-RSK3; p90RSK2; pp90RSK3; ribosomal protein S6 kinase alpha 2; Ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; Ribosomal S6 kinase 3; RPS6KA2; RSK; RSK-3; RSK3; S6K-alpha; S6K-alpha-2; S6K-alpha2
Gene Symbols: RPS6KA2
Molecular weight: 83,239 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RSK3

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S218‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K21 FSVYLRRKSRSKsss
0 1 K25 LRRKSRSKsssLsRL
0 1 S26-p RRKSRSKsssLsRLE
0 2 S27-p RKSRSKsssLsRLEE
0 1 S28-p KSRSKsssLsRLEEE
0 2 S30-p RSKsssLsRLEEEGV
0 1 K39 LEEEGVVKEIDISHH
0 1 K91-ac AGQLYAMkVLkKATL
0 1 K94-ac LYAMkVLkKATLKVR
0 1 S106-p KVRDRVRsKMERDIL
0 2 R183 HSLGIIYRDLKPENI
0 5 Y217-p IDHDKRAysFCGtIE
1 6 S218-p DHDKRAysFCGtIEY
0 2 T222-p RAysFCGtIEYMAPE
0 1 K295-ac SLLRALFkRNPCNRL
0 1 T356 DPEFTARTPTDSPGV
0 1 S360 TARTPTDSPGVPPSA
0 9 S377-p HHLFRGFsFVAsSLI
0 1 S381-p RGFsFVAsSLIQEPs
0 1 S382 GFsFVAsSLIQEPsQ
0 1 S388-p sSLIQEPsQQDLHKV
0 4 Y463-p EIEILLRyGQHPNII
0 1 C514 REASDVLCTITKTMD
0 1 Y540-p LKPSNILyRDESGsP
0 2 S546-p LyRDESGsPESIRVC
0 3 K559 VCDFGFAKQLRAGNG
0 11 T570-p AGNGLLMtPCytANF
0 8 Y573-p GLLMtPCytANFVAP
0 2 T574-p LLMtPCytANFVAPE
0 2 S628-p EILARIGsGkYALSG
1 1 K630-ub LARIGsGkYALSGGN
0 1 S650-p DAAKDVVsKMLHVDP
0 1 T662-p VDPHQRLtAMQVLKH
9348 : Phospho-RSK3 (Thr356/Ser360) Antibody
9348 : Phospho-RSK3 (Thr356/Ser360) Antibody
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  mouse

 
K21-ac FSVYLRKkSRSkSSS
K25-ac LRKkSRSkSSSLSRL
S26 RKkSRSkSSSLSRLE
S27 KkSRSkSSSLSRLEE
S28 kSRSkSSSLSRLEEE
S30 RSkSSSLSRLEEEGI
K39-ac LEEEGIVkEIDISNH
K91 AGQLYAMKVLKKATL
K94 LYAMKVLKKATLKVR
S106 KVRDRVRSKMERDIL
R183-m1 HGLGIIYrDLKPENI
Y217-p TDHDKRAysFCGtIE
S218-p DHDKRAysFCGtIEY
T222-p RAysFCGtIEYMAPE
K295 SLLRALFKRNPCNRL
T356-p DPEFTARtPTDsPGV
S360-p TARtPTDsPGVPPSA
S377-p HHLFRGFsFVASsLV
S381 RGFsFVASsLVQEPS
S382-p GFsFVASsLVQEPSQ
S388 SsLVQEPSQQDVPKA
Y463 EIEILLRYGQHPNII
Y514 REASDVLYTIARTMD
Y540 LKPSNILYMDESGNP
N546 LYMDESGNPESIRIC
K559-ub ICDFGFAkQLRAENG
T570-p AENGLLMtPCYTANF
Y573 GLLMtPCYTANFVAP
T574 LLMtPCYTANFVAPE
S628 EILARIGSGKYALSG
K630 LARIGSGKYALSGGN
S650 DAAKDVVSKMLHVDP
T662 VDPQQRLTAVQVLKH
9348 : Phospho-RSK3 (Thr356/Ser360) Antibody
9348 : Phospho-RSK3 (Thr356/Ser360) Antibody
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  rat

 
K21 FSVYLRKKSRSKSSS
K25 LRKKSRSKSSSLSRL
S26 RKKSRSKSSSLSRLE
S27 KKSRSKSSSLSRLEE
S28 KSRSKSSSLSRLEEE
S30 RSKSSSLSRLEEEGI
K39 LEEEGIVKEIDISSH
K91 AGQLYAMKVLKKATL
K94 LYAMKVLKKATLKVR
S106 KVRDRVRSKMERDIL
R183 HGLGIIYRDLKPENI
Y217 IDHDKRAYSFCGTIE
S218 DHDKRAYSFCGTIEY
T222 RAYSFCGTIEYMAPE
K295 SLLRALFKRNPCNRL
T356 DPEFTARTPTDSPGV
S360 TARTPTDSPGVPPSA
S377 HHLFRGFSFVASSLV
S381 RGFSFVASSLVQEPS
S382 GFSFVASSLVQEPSQ
S388 SSLVQEPSQQDVPKA
Y463 EIEILLRYGQHPNII
Y514-p REASDVLyTIARTMD
Y540 LKPSNILYMDESGNP
N546 LYMDESGNPESIRIC
K559 ICDFGFAKQLRAENG
T570 AENGLLMTPCYTANF
Y573 GLLMTPCYTANFVAP
T574 LLMTPCYTANFVAPE
S628 EILARIGSGKYALSG
K630 LARIGSGKYALSGGN
S650 DAAKDVVSKMLHVDP
T662 VDPQQRLTAVQVLKH
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
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