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RSK3 (human)

Overview RSK3 an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Translation; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; AGC group; RSK family; RSK subfamily Cellular Component: nucleoplasm; cytoplasm; spindle; cytosol; nucleus Molecular Function: protein serine/threonine kinase activity; magnesium ion binding; ribosomal protein S6 kinase activity; ATP binding Biological Process: axon guidance; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; heart development; MyD88-independent toll-like receptor signaling pathway; protein kinase cascade; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; oocyte maturation; brain renin-angiotensin system; mitotic metaphase; Toll signaling pathway; negative regulation of cell cycle; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; synaptic transmission; negative regulation of cell proliferation; peptidyl-serine phosphorylation; heart contraction; toll-like receptor signaling pathway; innate immune response; toll-like receptor 4 signaling pathway Reference #:  Q15349 (UniProtKB) Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 2; HU-2; KS6A2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; p90-RSK 2; p90-RSK3; p90RSK2; pp90RSK3; ribosomal protein S6 kinase alpha 2; Ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; Ribosomal S6 kinase 3; RPS6KA2; RSK; RSK-3; RSK3; S6K-alpha; S6K-alpha-2; S6K-alpha2 Gene Symbols: RPS6KA2 Molecular weight: 83,239 Da Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Cell Cycle: G2/M DNA Damage Checkpoint  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  Regulation of Microtubule Dynamics  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RSK3

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	Sites Implicated In
molecular association, regulation: S218‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K21	FSVYLRRKSRSKsss
0	1		K25	LRRKSRSKsssLsRL
0	1		S26-p	RRKSRSKsssLsRLE
0	1		S27-p	RKSRSKsssLsRLEE
0	1		S28-p	KSRSKsssLsRLEEE
0	1		S30-p	RSKsssLsRLEEEGV
0	1		K39	LEEEGVVKEIDISHH
0	1		K91-a	AGQLYAMkVLkKATL
0	1		K94-a	LYAMkVLkKATLKVR
0	1		S106-p	KVRDRVRsKMERDIL
0	2		R183	HSLGIIYRDLKPENI
0	5		Y217-p	IDHDKRAysFCGtIE
1	6		S218-p	DHDKRAysFCGtIEY
0	2		T222-p	RAysFCGtIEYMAPE
0	1		K295-a	SLLRALFkRNPCNRL
1	1		T356-p	DPEFTARtPTDsPGV
1	1		S360-p	TARtPTDsPGVPPSA
0	7		S377-p	HHLFRGFsFVAsSLI
0	1		S381-p	RGFsFVAsSLIQEPs
0	1		S382	GFsFVAsSLIQEPsQ
0	1		S388-p	sSLIQEPsQQDLHKV
0	3		Y426-p	EDIGVGSySVCKRCV
0	3		Y463-p	EIEILLRyGQHPNII
0	1		C514	REASDVLCTITKTMD
0	1		Y540-p	LKPSNILyRDESGsP
0	1		S546-p	LyRDESGsPESIRVC
0	3		K559	VCDFGFAKQLRAGNG
0	10		T570-p	AGNGLLMtPCytANF
0	10		Y573-p	GLLMtPCytANFVAP
0	2		T574-p	LLMtPCytANFVAPE
0	2		S628-p	EILARIGsGkYALSG
1	1		K630-u	LARIGsGkYALSGGN
0	1		S650-p	DAAKDVVsKMLHVDP

	mouse
K21-a	FSVYLRKkSRSkSSS
K25-a	LRKkSRSkSSSLSRL
S26	RKkSRSkSSSLSRLE
S27	KkSRSkSSSLSRLEE
S28	kSRSkSSSLSRLEEE
S30	RSkSSSLSRLEEEGI
K39-a	LEEEGIVkEIDISNH
K91	AGQLYAMKVLKKATL
K94	LYAMKVLKKATLKVR
S106	KVRDRVRSKMERDIL
R183-m1	HGLGIIYrDLKPENI
Y217-p	TDHDKRAysFCGtIE
S218-p	DHDKRAysFCGtIEY
T222-p	RAysFCGtIEYMAPE
K295	SLLRALFKRNPCNRL
T356-p	DPEFTARtPTDsPGV
S360-p	TARtPTDsPGVPPSA
S377-p	HHLFRGFsFVASsLV
S381	RGFsFVASsLVQEPS
S382-p	GFsFVASsLVQEPSQ
S388	SsLVQEPSQQDVPKA
Y426	EDIGVGSYSVCKRCV
Y463	EIEILLRYGQHPNII
Y514	REASDVLYTIARTMD
Y540	LKPSNILYMDESGNP
N546	LYMDESGNPESIRIC
K559-u	ICDFGFAkQLRAENG
T570-p	AENGLLMtPCYTANF
Y573	GLLMtPCYTANFVAP
T574	LLMtPCYTANFVAPE
S628	EILARIGSGKYALSG
K630	LARIGSGKYALSGGN
S650	DAAKDVVSKMLHVDP

	rat
K21	FSVYLRKKSRSKSSS
K25	LRKKSRSKSSSLSRL
S26	RKKSRSKSSSLSRLE
S27	KKSRSKSSSLSRLEE
S28	KSRSKSSSLSRLEEE
S30	RSKSSSLSRLEEEGI
K39	LEEEGIVKEIDISSH
K91	AGQLYAMKVLKKATL
K94	LYAMKVLKKATLKVR
S106	KVRDRVRSKMERDIL
R183	HGLGIIYRDLKPENI
Y217	IDHDKRAYSFCGTIE
S218	DHDKRAYSFCGTIEY
T222	RAYSFCGTIEYMAPE
K295	SLLRALFKRNPCNRL
T356	DPEFTARTPTDSPGV
S360	TARTPTDSPGVPPSA
S377	HHLFRGFSFVASSLV
S381	RGFSFVASSLVQEPS
S382	GFSFVASSLVQEPSQ
S388	SSLVQEPSQQDVPKA
Y426	EDIGVGSYSVCKRCV
Y463	EIEILLRYGQHPNII
Y514-p	REASDVLyTIARTMD
Y540	LKPSNILYMDESGNP
N546	LYMDESGNPESIRIC
K559	ICDFGFAKQLRAENG
T570	AENGLLMTPCYTANF
Y573	GLLMTPCYTANFVAP
T574	LLMTPCYTANFVAPE
S628	EILARIGSGKYALSG
K630	LARIGSGKYALSGGN
S650	DAAKDVVSKMLHVDP

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