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HNK1ST (human)

Overview HNK1ST Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. Belongs to the sulfotransferase 2 family. Note: This description may include information from UniProtKB. Protein type: Transferase; Membrane protein, integral; EC 2.8.2.- Cellular Component: Golgi membrane; Golgi apparatus; membrane; integral to membrane Molecular Function: sulfotransferase activity; HNK-1 sulfotransferase activity Biological Process: long-term memory; learning; cell adhesion; carbohydrate biosynthetic process Reference #:  O43529 (UniProtKB) Alt. Names/Synonyms: Carbohydrate sulfotransferase 10; CHST10; CHSTA; HNK-1 sulfotransferase; HNK-1ST; HNK1ST; HuHNK-1ST; MGC17148 Gene Symbols: CHST10 Molecular weight: 42,207 Da Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states

Select Structure to View Below HNK1ST

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S328-p	EHYFLGIsKRDIRRL
0	1		Y348-p	GDFKLFGyQKPDFLL

	mouse
S328	EQYFLGISKRDIRRL
Y348	GDFKLFGYQKPDFLL

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