an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 22.214.171.124; Kinase, protein; AGC group; RSK family; RSK subfamily
Chromosomal Location of Human Ortholog: Xp22.2-p22.1
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein serine/threonine kinase activity; caspase inhibitor activity; magnesium ion binding; protein kinase binding; ATP binding; protein kinase activity
Biological Process: axon guidance; central nervous system development; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; signal transduction; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; synaptic transmission; skeletal development; toll-like receptor 4 signaling pathway; regulation of transcription in response to stress; MyD88-independent toll-like receptor signaling pathway; regulation of translation in response to stress; cell cycle; positive regulation of cell growth; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.