Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
RSK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RSK2 an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; AGC group; RSK family; RSK subfamily
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein serine/threonine kinase activity; caspase inhibitor activity; magnesium ion binding; protein kinase binding; ATP binding; protein kinase activity
Biological Process: regulation of transcription in response to stress; axon guidance; central nervous system development; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; regulation of translation in response to stress; stress-activated MAPK cascade; response to lipopolysaccharide; negative regulation of caspase activity; toll-like receptor 3 signaling pathway; cell cycle; signal transduction; protein amino acid phosphorylation; positive regulation of cell growth; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; synaptic transmission; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; skeletal development; toll-like receptor 4 signaling pathway; negative regulation of apoptosis
Reference #:  P51812 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 3; CLS; HU-3; Insulin-stimulated protein kinase 1; ISPK-1; ISPK1; KS6A3; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; MAPKAPK1B; mental retardation, X-linked 19; MRX19; p90-RSK 3; p90-RSK2; p90RSK3; pp90RSK2; Ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RPS6KA3; RSK; RSK-2; RSK2; S6K-alpha-3; S6K-alpha3
Gene Symbols: RPS6KA3
Molecular weight: 83,736 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RSK2

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: Y529‑p
transcription, induced: S369‑p
enzymatic activity, induced: S227‑p, S369‑p, T577‑p
molecular association, regulation: Y529‑p
protein conformation: S369‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S17-p WQKMAVEsPsDSAEN
0 2 S19-p KMAVEsPsDSAENGQ
0 2 K72-ub PSQFELLkVLGQGsF
0 2 S78-p LkVLGQGsFGkVFLV
0 3 K81-ac LGQGsFGkVFLVKKI
0 1 K100-ac ARQLYAMkVLkKATL
0 1 K103-ac LYAMkVLkKATLKVR
0 2 R192 HSLGIIYRDLKPENI
0 41 Y226-p IDHEKKAysFCGtVE
8 166 S227-p DHEKKAysFCGtVEy
0 61 T231-p KAysFCGtVEyMAPE
0 7 Y234-p sFCGtVEyMAPEVVN
0 2 K274 PFQGKDRKETMtMIL
0 1 T278-p KDRKETMtMILKAKL
0 2 K282 ETMtMILKAKLGMPQ
0 1 K284 MtMILKAKLGMPQFL
0 5 K322-ub PDGVEEIkRHSFFST
0 1 S325 VEEIkRHSFFSTIDW
0 1 S328 IkRHSFFSTIDWNKL
0 4 Y356-p GRPEDTFyFDPEFtA
0 3 T362-p FyFDPEFtAKtPKDs
5 32 T365-p DPEFtAKtPKDsPGI
9 41 S369-p tAKtPKDsPGIPPsA
0 16 S375-p DsPGIPPsANAHQLF
8 69 S386-p HQLFRGFsFVAItsD
0 1 T391-p GFsFVAItsDDEsQA
0 3 S392-p FsFVAItsDDEsQAM
0 2 S396-p AItsDDEsQAMQTVG
0 20 S415-p VQQLHRNsIQFTDGY
1 5 Y470-p EIEILLRyGQHPNII
1 4 Y483-p IITLKDVyDDGKyVY
2 14 Y488-p DVyDDGKyVYVVTEL
0 1 Y490 yDDGKyVYVVTELMK
0 1 S517-p FFSEREAsAVLFTIT
2 5 Y529-p TITKTVEyLHAQGVV
0 1 S556-p DESGNPEsIRICDFG
0 3 K566 ICDFGFAKQLRAENG
5 180 T577-p AENGLLMtPCytANF
1 85 Y580-p GLLMtPCytANFVAP
0 26 T581-p LLMtPCytANFVAPE
1 3 Y644-p KFSLSGGyWNSVSDT
0 20 Y688-p HWDQLPQyQLNRQDA
2 86 Y707-p KGAMAATysALNRNQ
0 1 S708-p GAMAATysALNRNQs
0 45 S715-p sALNRNQsPVLEPVG
0 3 S737-p RGIKKITsTAL____
3556 : Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9324 : Phospho-RSK2 (Tyr529) Antibody
  mouse

 
S17 WQKMAVESPsDSAEN
S19-p KMAVESPsDSAENGQ
K72 PSQFELLKVLGQGSF
S78 LKVLGQGSFGKVFLV
K81 LGQGSFGKVFLVKKI
K100 ARQLYAMKVLKKATL
K103 LYAMKVLKKATLKVR
R192-m1 HSLGIIYrDLKPENI
Y226-p IDHEKKAysFCGtVE
S227-p DHEKKAysFCGtVEy
T231-p KAysFCGtVEyMAPE
Y234-p sFCGtVEyMAPEVVN
K274-ub PFQGKDRkETMTMIL
T278 KDRkETMTMILkAkL
K282-ub ETMTMILkAkLGMPQ
K284-ac MTMILkAkLGMPQFL
K322 PDGVEEIKRHsFFsT
S325-p VEEIKRHsFFsTIDW
S328-p IKRHsFFsTIDWNKL
Y356 GRPEDTFYFDPEFtA
T362-p FYFDPEFtAKtPKDs
T365-p DPEFtAKtPKDsPGI
S369-p tAKtPKDsPGIPPsA
S375-p DsPGIPPsANAHQLF
S386-p HQLFRGFsFVAITSD
T391 GFsFVAITSDDESQA
S392 FsFVAITSDDESQAM
S396 AITSDDESQAMQTVG
S415-p VQQLHRNsIQFTDGY
Y470 EIEILLRYGQHPNII
Y483-p IITLKDVyDDGKyVy
Y488-p DVyDDGKyVyVVTEL
Y490-p yDDGKyVyVVTELMK
S517 FFSEREASAVLFTIT
Y529-p TITKTVEyLHAQGVV
S556 DESGNPESIRICDFG
K566-ub ICDFGFAkQLRAENG
T577-p AENGLLMtPCYTANF
Y580 GLLMtPCYTANFVAP
T581 LLMtPCYTANFVAPE
Y644 KFSLSGGYWNSVSDT
Y688 HWDQLPQYQLNRQDA
Y707 KGAMAATYSALNRNQ
S708 GAMAATYSALNRNQs
S715-p SALNRNQsPVLEPVG
S737-p RGIKKITsTAL____
3556 : Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9324 : Phospho-RSK2 (Tyr529) Antibody
  rat

 
S17 WQKMAVESPSDSAEN
S19 KMAVESPSDSAENGQ
K72 PSQFELLKVLGQGSF
S78 LKVLGQGSFGKVFLV
K81 LGQGSFGKVFLVKKI
K100 ARQLYAMKVLKKATL
K103 LYAMKVLKKATLKVR
R192 HSLGIIYRDLKPENI
Y226 IDHEKKAYsFCGTVE
S227-p DHEKKAYsFCGTVEY
T231 KAYsFCGTVEYMAPE
Y234 sFCGTVEYMAPEVVN
K274 PFQGKDRKETMTMIL
T278 KDRKETMTMILKAKL
K282 ETMTMILKAKLGMPQ
K284 MTMILKAKLGMPQFL
K322 PDGVEEIKRHSFFST
S325 VEEIKRHSFFSTIDW
S328 IKRHSFFSTIDWNKL
Y356 GRPEDTFYFDPEFTA
T362 FYFDPEFTAKtPKDs
T365-p DPEFTAKtPKDsPGI
S369-p TAKtPKDsPGIPPSA
S375 DsPGIPPSANAHQLF
S386 HQLFRGFSFVAITSD
T391 GFSFVAITSDDESQA
S392 FSFVAITSDDESQAM
S396 AITSDDESQAMQTVG
S415 VQQLHRNSIQFTDGY
Y470 EIEILLRYGQHPNII
Y483 IITLKDVYDDGKYVY
Y488 DVYDDGKYVYVVTEL
Y490 YDDGKYVYVVTELMK
S517 FFSEREASAVLFTIT
Y529 TITKTVEYLHTQGVV
S556 DESGNPESIRICDFG
K566 ICDFGFAKQLRAENG
T577 AENGLLMTPCYTANF
Y580 GLLMTPCYTANFVAP
T581 LLMTPCYTANFVAPE
Y644 KFSLSGGYWNSVSDT
Y688 HWDQLPQYQLNRQDA
Y707 KGAMAATYSALNRNQ
S708 GAMAATYSALNRNQs
S715-p SALNRNQsPVLEPVG
S737 RGIKKITSTAL____
3556 : Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb
9335 : Phospho-p90RSK (Ser380) (9D9) Rabbit mAb
9341 : Phospho-p90RSK (Ser380) Antibody
11989 : Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb
12032 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb
13397 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate)
13575 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
13588 : Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.