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Protein Page:
Ret (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ret a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.10.1; TK group; Ret family
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: integral to plasma membrane; endosome membrane; receptor complex; lipid raft
Molecular Function: protein binding; protein-tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity; calcium ion binding; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of cell size; membrane protein proteolysis; positive regulation of transcription, DNA-dependent; response to pain; signal transduction; regulation of axonogenesis; neuron maturation; protein amino acid phosphorylation; enteric nervous system development; ureteric bud development; embryonic epithelial tube formation; neuron adhesion; neural crest cell migration; caspase activation; response to drug; regulation of cell adhesion; positive regulation of neuron maturation; posterior midgut development; MAPKKK cascade; positive regulation of cell adhesion mediated by integrin; retina development in camera-type eye; homophilic cell adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
Reference #:  P07949 (UniProtKB)
Alt. Names/Synonyms: Cadherin family member 12; cadherin-related family member 16; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; PTC; RET; ret proto-oncogene; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); RET transforming sequence; RET-ELE1; RET51
Gene Symbols: RET
Molecular weight: 124,319 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Ret

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, induced: Y1062‑p
apoptosis, inhibited: Y1062‑p
cell growth, altered: Y687‑p, Y806‑p, Y809‑p, Y864‑p, Y905‑p, Y952‑p, Y1015‑p, Y1062‑p
cytoskeletal reorganization: S696‑p, Y1062‑p
signaling pathway regulation: T675‑p
transcription, altered: Y791‑p, S891‑p, Y1015‑p, Y1062‑p
enzymatic activity, induced: S696‑p, Y806‑p, Y809‑p, Y864‑p, Y900‑p, Y905‑p, Y928‑p, Y952‑p, Y981‑p, Y1062‑p
intracellular localization: T675‑p
molecular association, regulation: Y687‑p, S696‑p, Y981‑p, Y1062‑p, Y1096‑p
phosphorylation: Y791‑p, S891‑p, Y905‑p, Y1062‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 S159-p TSFPACSsLKPRELC
0 1 Q499 TSRQAQAQLLVTVEG
1 0 T675-p PISSAEMtFRRPAQA
0 1 S686-p PAQAFPVsySSSGAR
3 29 Y687-p AQAFPVsySSSGARR
1 0 G691 PVsySSSGARRPsLD
5 3 S696-p SSGARRPsLDSMENQ
0 1 - under review  
0 1 S705-p DSMENQVsVDAFKIL
0 3 - gap
0 4 - gap
0 34 - gap
0 251 - gap
0 2 - gap
1 0 Y752-p HLKGRAGyTtVAVKM
0 1 T754-p KGRAGyTtVAVKMLK
2 0 Y791-p HPHVIKLyGACSQDG
1 0 Y806-p PLLLIVEyAKyGSLR
1 0 Y809-p LIVEyAKyGSLRGFL
0 1 R820 RGFLRESRKVGPGyL
3 10 Y826-p SRKVGPGyLGSGGSR
1 0 Y864-p QISQGMQyLAEMKLV
1 0 S891-p EGRKMKIsDFGLSRD
2 20 Y900-p FGLSRDVyEEDsyVK
0 5 S904-p RDVyEEDsyVKRSQG
12 21 Y905-p DVyEEDsyVKRSQGR
2 0 Y928-p ESLFDHIyTTQSDVW
2 0 Y952-p VTLGGNPyPGIPPER
7 0 Y981-p DNCSEEMyRLMLQCW
11 0 Y1015-p MMVKRRDyLDLAAST
3 0 Y1029-p TPSDSLIyDDGLSEE
1 0 K1060-ub PSTWIENkLyGMsDP
36 2 Y1062-p TWIENkLyGMsDPNW
0 1 S1065-p ENkLyGMsDPNWPGE
1 0 Y1090-p TNTGFPRyPNDSVyA
7 4 Y1096-p RyPNDSVyANWMLSP
1 0 K1107-ub MLSPSAAkLMDtFDs
0 1 T1111-p SAAkLMDtFDs____
0 1 S1114-p kLMDtFDs_______
3221 : Phospho-Ret (Tyr905) Antibody
  Ret iso2  
- gap
S159 TSFPACSSLKPRELC
Q499 TSRQAQAQLLVTVEG
T675 PISSAEMTFRRPAQA
S686 PAQAFPVSYSSSgAR
Y687 AQAFPVSYSSSgARR
G691-p PVSYSSSgARRPSLD
S696 SSgARRPSLDSMENQ
- under review  
S705 DSMENQVSVDAFKIL
- gap
- gap
- gap
- gap
- gap
Y752 HLKGRAGYTTVAVKM
T754 KGRAGYTTVAVKMLK
Y791 HPHVIKLYGACSQDG
Y806 PLLLIVEYAKYGSLR
Y809 LIVEYAKYGSLRGFL
R820 RGFLRESRKVGPGYL
Y826 SRKVGPGYLGSGGSR
Y864 QISQGMQYLAEMKLV
S891 EGRKMKISDFGLSRD
Y900 FGLSRDVYEEDSYVK
S904 RDVYEEDSYVKRSQG
Y905 DVYEEDSYVKRSQGR
Y928 ESLFDHIYTTQSDVW
Y952 VTLGGNPYPGIPPER
Y981 DNCSEEMYRLMLQCW
Y1015 MMVKRRDYLDLAAST
Y1029 TPSDSLIYDDGLSEE
K1060 PSTWIENKLyGRISH
Y1062-p TWIENKLyGRISHAF
- gap
- gap
- gap
- gap
- gap
- gap
  Ret iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
G225 KTNVKLWGIDRDSYR
- gap
K63-ub RLEKEEAkQIQNLQk
K70-ub kQIQNLQkAGTRTDs
S77-p kAGTRTDsREDEIsP
S83-p DsREDEIsPPPPNPV
K130-ac KTMAALAkAIEKNVL
Y276 HLKGRAGYTTVAVKM
T278 KGRAGYTTVAVKMLK
Y315 HPHVIKLYGACSQDG
Y330 PLLLIVEYAKYGSLR
Y333 LIVEYAKYGSLRGFL
R344 RGFLRESRKVGPGYL
Y350 SRKVGPGYLGSGGSR
Y388 QISQGMQYLAEMKLV
S415 EGRKMKISDFGLSRD
Y424 FGLSRDVYEEDPYVK
P428 RDVYEEDPYVKRSQG
Y429 DVYEEDPYVKRSQGR
Y452 ESLFDHIYTTQSDVW
Y476 VTLGGNPYPGIPPER
Y505 DNCSEEMYRLMLQCW
Y539 MMVKRRDYLDLAAST
Y553 TPSDSLIYDDGLSEE
K584 PSTWIENKLyGRISH
Y586-p TWIENKLyGRISHAF
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
- gap
S159 DTFPNCSSFKAQDLC
S501-p TRRQTQAsLVVTVEG
T676 PIASAEMTFCRPAQG
S687 PAQGFPISYSSSGTR
Y688 AQGFPISYSSSGTRR
G692 PISYSSSGTRRPsLD
S697-p SSGTRRPsLDSTENQ
- under review  
P706 DSTENQVPVDSFKIP
- gap
- gap
- gap
- gap
- gap
Y753 RLKGRAGYTTVAVKM
T755 KGRAGYTTVAVKMLK
Y792 HPHVIKLYGACSQDG
Y807 PLLLIVEYAKYGSLR
Y810 LIVEYAKYGSLRGFL
R821-m1 RGFLRDSrKIGPAYV
Y827 SrKIGPAYVSGGGSR
Y865 QISRGMQYLAEMKLV
S892 EGRKMKISDFGLSRD
Y901 FGLSRDVYEEDSYVK
S905 RDVYEEDSYVKKSKG
Y906 DVYEEDSYVKKSKGR
Y929 ESLFDHIYTTQSDVW
Y953 VTLGGNPYPGIPPER
Y982-p DNCSEEMyRLMLQCW
Y1016-p MMVKSRDyLDLAAST
Y1030 TPSDSLLYDDGLSEE
K1061 PSTWIENKLyGMSDP
Y1063-p TWIENKLyGMSDPNW
S1066 ENKLyGMSDPNWPGE
Y1091 TSTGFPRYANDSVYA
Y1097 RYANDSVYANWMVSP
K1108 MVSPSAAKLMDTFDS
T1112 SAAKLMDTFDS____
S1115 KLMDTFDS_______
  Ret iso2  
- gap
S159 DTFPNCSSFKAQDLC
S501 TRRQTQASLVVTVEG
T676 PIASAEMTFCRPAQG
S687 PAQGFPISYSSSGTR
Y688 AQGFPISYSSSGTRR
G692 PISYSSSGTRRPSLD
S697 SSGTRRPSLDSTENQ
- under review  
P706 DSTENQVPVDSFKIP
- gap
- gap
- gap
- gap
- gap
Y753 RLKGRAGYTTVAVKM
T755 KGRAGYTTVAVKMLK
Y792 HPHVIKLYGACSQDG
Y807 PLLLIVEYAKYGSLR
Y810 LIVEYAKYGSLRGFL
R821 RGFLRDSRKIGPAYV
Y827 SRKIGPAYVSGGGSR
Y865 QISRGMQYLAEMKLV
S892 EGRKMKISDFGLSRD
Y901 FGLSRDVYEEDSYVK
S905 RDVYEEDSYVKKSKG
Y906 DVYEEDSYVKKSKGR
Y929 ESLFDHIYTTQSDVW
Y953 VTLGGNPYPGIPPER
Y982 DNCSEEMYRLMLQCW
Y1016 MMVKSRDYLDLAAST
Y1030 TPSDSLLYDDGLSEE
K1061 PSTWIENKLYGRISH
Y1063 TWIENKLYGRISHAF
- gap
- gap
- gap
- gap
- gap
- gap
  Ret iso4  
S2-p ______MsMPYGMPL
S108 DTFPNCSSFKAQDLC
S450 TRRQTQASLVVTVEG
T625 PIASAEMTFCRPAQG
S636 PAQGFPISYSSSGTR
Y637 AQGFPISYSSSGTRR
G641 PISYSSSGTRRPSLD
S646 SSGTRRPSLDSTENQ
- under review  
P655 DSTENQVPVDSFKIP
- gap
- gap
- gap
- gap
- gap
Y702 RLKGRAGYTTVAVKM
T704 KGRAGYTTVAVKMLK
Y741 HPHVIKLYGACSQDG
Y756 PLLLIVEYAKYGSLR
Y759 LIVEYAKYGSLRGFL
R770 RGFLRDSRKIGPAYV
Y776 SRKIGPAYVSGGGSR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
- gap
S159 DTFPNCSSFKARDLC
S500 TRRQTQASLVVTVEG
T676 PIASAEMTFCRPAQG
S687 PAQGFPISYSSSGTR
Y688 AQGFPISYSSSGTRR
G692 PISYSSSGTRRPsLD
S697-p SSGTRRPsLDsMENQ
S700-p TRRPsLDsMENQVSV
S706 DsMENQVSVDSFKIP
- gap
- gap
- gap
- gap
- gap
Y753 RLKGRAGYTTVAVKM
T755 KGRAGYTTVAVKMLK
Y792 HPHVIKLYGACSQDG
Y807 PLLLIVEYAKYGSLR
Y810 LIVEYAKYGSLRGFL
R821 RGFLRDSRKIGPAYV
Y827 SRKIGPAYVSSGGSR
Y865 QISRGMQYLAEMKLV
S892 EGRKMKISDFGLSRD
Y901 FGLSRDVYEEDSyVK
S905 RDVYEEDSyVKKSKG
Y906-p DVYEEDSyVKKSKGR
Y929 ESLFDHIYTTQSDVW
Y953 VTLGGNPYPGIPPER
Y982 DNCSEEMYRLMLQCW
Y1016-p MMVKSRDyLDLAAST
Y1030 TPSDSLLYDDGLSEE
K1061 PSTWIENKLyGMSDP
Y1063-p TWIENKLyGMSDPNW
S1066 ENKLyGMSDPNWPGE
Y1091 TSTGFPRYANDSVyA
Y1097-p RYANDSVyANWMVSP
K1108 MVSPSAAKLMDTFDS
T1112 SAAKLMDTFDS____
S1115 KLMDTFDS_______
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