a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 126.96.36.199; TK group; Ret family
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: integral to plasma membrane; endosome membrane; receptor complex; lipid raft
Molecular Function: protein binding; protein-tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity; calcium ion binding; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of cell size; membrane protein proteolysis; positive regulation of transcription, DNA-dependent; response to pain; signal transduction; regulation of axonogenesis; neuron maturation; protein amino acid phosphorylation; enteric nervous system development; ureteric bud development; embryonic epithelial tube formation; neuron adhesion; neural crest cell migration; caspase activation; response to drug; regulation of cell adhesion; positive regulation of neuron maturation; posterior midgut development; MAPKKK cascade; positive regulation of cell adhesion mediated by integrin; retina development in camera-type eye; homophilic cell adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.