a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; EC 188.8.131.52; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Ret family
Cellular Component: integral to plasma membrane; endosome membrane; receptor complex; lipid raft
Molecular Function: protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; receptor activity; calcium ion binding; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of cell size; positive regulation of transcription, DNA-dependent; membrane protein proteolysis; response to pain; signal transduction; regulation of axonogenesis; enteric nervous system development; protein amino acid phosphorylation; neuron maturation; ureteric bud development; embryonic epithelial tube formation; neuron adhesion; neural crest cell migration; response to drug; caspase activation; regulation of cell adhesion; positive regulation of neuron maturation; posterior midgut development; MAPKKK cascade; positive regulation of cell adhesion mediated by integrin; retina development in camera-type eye; homophilic cell adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.