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Protein Page:
Ret (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Ret a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; TK group; Ret family
Cellular Component: integral to plasma membrane; endosome membrane; receptor complex; lipid raft
Molecular Function: protein binding; protein-tyrosine kinase activity; calcium ion binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of cell size; positive regulation of transcription, DNA-dependent; membrane protein proteolysis; response to pain; signal transduction; regulation of axonogenesis; neuron maturation; enteric nervous system development; protein amino acid phosphorylation; ureteric bud development; embryonic epithelial tube formation; neuron adhesion; neural crest cell migration; regulation of cell adhesion; caspase activation; response to drug; positive regulation of neuron maturation; posterior midgut development; MAPKKK cascade; positive regulation of cell adhesion mediated by integrin; retina development in camera-type eye; homophilic cell adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
Reference #:  P07949 (UniProtKB)
Alt. Names/Synonyms: Cadherin family member 12; cadherin-related family member 16; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; PTC; RET; ret proto-oncogene; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); RET transforming sequence; RET-ELE1; RET51
Gene Symbols: RET
Molecular weight: 124,319 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ret

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, induced: Y1062‑p
apoptosis, inhibited: Y1062‑p
cell growth, altered: Y687‑p, Y806‑p, Y809‑p, Y864‑p, Y905‑p, Y952‑p, Y1015‑p, Y1062‑p
cytoskeletal reorganization: S696‑p, Y1062‑p
signaling pathway regulation: T675‑p
transcription, altered: Y791‑p, S891‑p, Y1015‑p, Y1062‑p
enzymatic activity, induced: S696‑p, Y806‑p, Y809‑p, Y864‑p, Y900‑p, Y905‑p, Y928‑p, Y952‑p, Y981‑p, Y1062‑p
intracellular localization: T675‑p
molecular association, regulation: Y687‑p, S696‑p, Y981‑p, Y1062‑p, Y1096‑p
phosphorylation: Y791‑p, S891‑p, Y905‑p, Y1062‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
1 0 T675-p PISSAEMtFRRPAQA
3 31 Y687-p AQAFPVSySSSGARR
1 0 G691 PVSySSSGARRPsLD
5 2 S696-p SSGARRPsLDSMENQ
0 3 - gap
0 4 - gap
0 29 - gap
0 236 - gap
0 2 - gap
1 0 Y752-p HLKGRAGyTTVAVKM
2 0 Y791-p HPHVIKLyGACSQDG
1 0 Y806-p PLLLIVEyAKyGSLR
1 0 Y809-p LIVEyAKyGSLRGFL
3 10 Y826-p SRKVGPGyLGSGGSR
1 0 Y864-p QISQGMQyLAEMKLV
1 0 S891-p EGRKMKIsDFGLSRD
2 20 Y900-p FGLSRDVyEEDsyVK
0 5 S904-p RDVyEEDsyVKRSQG
12 21 Y905-p DVyEEDsyVKRSQGR
2 0 Y928-p ESLFDHIyTTQSDVW
2 0 Y952-p VTLGGNPyPGIPPER
7 0 Y981-p DNCSEEMyRLMLQCW
11 0 Y1015-p MMVKRRDyLDLAAST
3 0 Y1029-p TPSDSLIyDDGLSEE
1 0 K1060-u PSTWIENkLyGMSDP
36 2 Y1062-p TWIENkLyGMSDPNW
1 0 Y1090-p TNTGFPRyPNDSVyA
7 4 Y1096-p RyPNDSVyANWMLSP
1 0 K1107-u MLSPSAAkLMDTFDS
3221 : Phospho-Ret (Tyr905) Antibody
  Ret iso2  
- gap
T675 PISSAEMTFRRPAQA
Y687 AQAFPVSYSSSgARR
G691-p PVSYSSSgARRPSLD
S696 SSgARRPSLDSMENQ
- gap
- gap
- gap
- gap
- gap
Y752 HLKGRAGYTTVAVKM
Y791 HPHVIKLYGACSQDG
Y806 PLLLIVEYAKYGSLR
Y809 LIVEYAKYGSLRGFL
Y826 SRKVGPGYLGSGGSR
Y864 QISQGMQYLAEMKLV
S891 EGRKMKISDFGLSRD
Y900 FGLSRDVYEEDSYVK
S904 RDVYEEDSYVKRSQG
Y905 DVYEEDSYVKRSQGR
Y928 ESLFDHIYTTQSDVW
Y952 VTLGGNPYPGIPPER
Y981 DNCSEEMYRLMLQCW
Y1015 MMVKRRDYLDLAAST
Y1029 TPSDSLIYDDGLSEE
K1060 PSTWIENKLyGRISH
Y1062-p TWIENKLyGRISHAF
- gap
- gap
- gap
  Ret iso3  
- gap
- gap
- gap
- gap
- gap
K63-u RLEKEEAkQIQNLQk
K70-u kQIQNLQkAGTRTDs
S77-p kAGTRTDsREDEIsP
S83-p DsREDEIsPPPPNPV
K130-a KTMAALAkAIEKNVL
Y276 HLKGRAGYTTVAVKM
Y315 HPHVIKLYGACSQDG
Y330 PLLLIVEYAKYGSLR
Y333 LIVEYAKYGSLRGFL
Y350 SRKVGPGYLGSGGSR
Y388 QISQGMQYLAEMKLV
S415 EGRKMKISDFGLSRD
Y424 FGLSRDVYEEDPYVK
P428 RDVYEEDPYVKRSQG
Y429 DVYEEDPYVKRSQGR
Y452 ESLFDHIYTTQSDVW
Y476 VTLGGNPYPGIPPER
Y505 DNCSEEMYRLMLQCW
Y539 MMVKRRDYLDLAAST
Y553 TPSDSLIYDDGLSEE
K584 PSTWIENKLyGRISH
Y586-p TWIENKLyGRISHAF
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
- gap
T676 PIASAEMTFCRPAQG
Y688 AQGFPISYSSSGTRR
G692 PISYSSSGTRRPsLD
S697-p SSGTRRPsLDSTENQ
- gap
- gap
- gap
- gap
- gap
Y753 RLKGRAGYTTVAVKM
Y792 HPHVIKLYGACSQDG
Y807 PLLLIVEYAKYGSLR
Y810 LIVEYAKYGSLRGFL
Y827 SRKIGPAYVSGGGSR
Y865 QISRGMQYLAEMKLV
S892 EGRKMKISDFGLSRD
Y901 FGLSRDVYEEDSYVK
S905 RDVYEEDSYVKKSKG
Y906 DVYEEDSYVKKSKGR
Y929 ESLFDHIYTTQSDVW
Y953 VTLGGNPYPGIPPER
Y982-p DNCSEEMyRLMLQCW
Y1016-p MMVKSRDyLDLAAST
Y1030 TPSDSLLYDDGLSEE
K1061 PSTWIENKLyGMSDP
Y1063-p TWIENKLyGMSDPNW
Y1091 TSTGFPRYANDSVYA
Y1097 RYANDSVYANWMVSP
K1108 MVSPSAAKLMDTFDS
  Ret iso2  
- gap
T676 PIASAEMTFCRPAQG
Y688 AQGFPISYSSSGTRR
G692 PISYSSSGTRRPSLD
S697 SSGTRRPSLDSTENQ
- gap
- gap
- gap
- gap
- gap
Y753 RLKGRAGYTTVAVKM
Y792 HPHVIKLYGACSQDG
Y807 PLLLIVEYAKYGSLR
Y810 LIVEYAKYGSLRGFL
Y827 SRKIGPAYVSGGGSR
Y865 QISRGMQYLAEMKLV
S892 EGRKMKISDFGLSRD
Y901 FGLSRDVYEEDSYVK
S905 RDVYEEDSYVKKSKG
Y906 DVYEEDSYVKKSKGR
Y929 ESLFDHIYTTQSDVW
Y953 VTLGGNPYPGIPPER
Y982 DNCSEEMYRLMLQCW
Y1016 MMVKSRDYLDLAAST
Y1030 TPSDSLLYDDGLSEE
K1061 PSTWIENKLYGRISH
Y1063 TWIENKLYGRISHAF
- gap
- gap
- gap
  Ret iso4  
S2-p ______MsMPYGMPL
T625 PIASAEMTFCRPAQG
Y637 AQGFPISYSSSGTRR
G641 PISYSSSGTRRPSLD
S646 SSGTRRPSLDSTENQ
- gap
- gap
- gap
- gap
- gap
Y702 RLKGRAGYTTVAVKM
Y741 HPHVIKLYGACSQDG
Y756 PLLLIVEYAKYGSLR
Y759 LIVEYAKYGSLRGFL
Y776 SRKIGPAYVSGGGSR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
- gap
T677 PIXSAEMTFCRPAQG
Y689 AQGFPISYSSSGXRR
G693 PISYSSSGXRRPSLD
S698 SSGXRRPSLDSMENQ
- gap
- gap
- gap
- gap
- gap
Y754 RLKDRAGYTTVAVKM
Y793 HPHVIKLYGACSQDG
Y808 PLLLIVEYAKYGSLR
Y811 LIVEYAKYGSLRGFL
Y828 SRKIGPAYVSSGGSR
Y866 QISRGMQYLAEMKLV
S893 EGRKMKISDFGLSRD
Y902 FGLSRDVYEEDSyVK
S906 RDVYEEDSyVKKSXG
Y907-p DVYEEDSyVKKSXGR
Y930 NSLSDHFYTTQSDVW
Y954 VTLGGNPYPGIPPER
Y983 NNCSEEMYRLMLQCW
Y1017-p MMVKSRDyLDLAAST
Y1031 TPSDSLLYDDGLSEE
K1062 PSTWIENKLyGMSDP
Y1064-p TWIENKLyGMSDPNW
Y1092 TSTGFPRYANDSVyA
Y1098-p RYANDSVyANWMVSP
K1109 MVSPSAAKLMDTFDS
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