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NFE2L1 (human)

Overview NFE2L1 Activates erythroid-specific, globin gene expression. Interacts with KEAP1. Belongs to the bZIP family. CNC subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: endoplasmic reticulum membrane; integral to membrane; nucleus Molecular Function: sequence-specific DNA binding; transcription cofactor activity; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; inflammatory response; heme biosynthetic process Reference #:  Q14494 (UniProtKB) Alt. Names/Synonyms: FLJ00380; HBZ17; LCR-F1; Locus control region-factor 1; NF-E2-related factor 1; NF2L1; NFE2-related factor 1; NFE2L1; NRF1; nuclear factor (erythroid-derived 2)-like 1; Nuclear factor erythroid 2-related factor 1; Nuclear factor, erythroid derived 2, like 1; TCF-11; TCF11; Transcription factor 11; transcription factor 11 (basic leucine zipper type); Transcription factor HBZ17; Transcription factor LCR-F1 Gene Symbols: NFE2L1 Molecular weight: 84,704 Da Basal Isoelectric point: 4.52  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NFE2L1

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	Sites Implicated In
molecular association, regulation: S599‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3-p	_____MLsLKKYLTE
0	11		K70-u	DGYGIHPkSIDLDNY
0	7		K205-u	QKEQDVEkELRDGGE
1	0		S379-p	SQDFLLFsPEVESLP
0	1		S483	DSGLSLDSSHSPSSL
0	1		S486	LSLDSSHSPSSLSSS
0	1		S492	HSPSSLSSSEGSSSS
0	1		S505	SSSSSSSSSSSSASS
1	0		S599-p	PSALKKGsKEKQADF
0	1		K622-u	EHRARAMkIPFTNDk
0	4		K629-u	kIPFTNDkIINLPVE
0	1		K644	EFNELLSKYQLSEAQ
0	1		K675-u	AQNCRKRkLDTILNL
0	10		K713-u	SLRQMKQkVQSLYQE
0	1		S734-p	DENGRPYsPSQyALQ
0	3		Y738-p	RPYsPSQyALQYAGD

	mouse
S3	_____MLSLKKYLTE
K70-u	DGYGIHPkSIDLDNY
K205	QKEQDVDKELQDGRE
S350	SQDFSLFSPEVESLP
S454-p	DSGLSLDsSHsPSSL
S457-p	LSLDsSHsPSSLSsS
S463-p	HsPSSLSsSEGSSSS
S474-p	SSSSSSSsSSSSASS
S568	PSTLKKGSKEKQADF
K591	EHRARAMKIPFTNDK
K598	KIPFTNDKIINLPVE
K613-u	EFNELLSkYQLSEAQ
K644	AQNCRKRKLDTILNL
K682	SLRQMKQKVQSLYQE
S703	DEHGRPYSPSQYALQ
Y707	RPYSPSQYALQYAGD

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