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Protein Page:
NFE2L1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NFE2L1 Activates erythroid-specific, globin gene expression. Interacts with KEAP1. Belongs to the bZIP family. CNC subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: endoplasmic reticulum membrane; integral to membrane; nucleus
Molecular Function: sequence-specific DNA binding; transcription cofactor activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; erythrocyte differentiation; inflammatory response; heme biosynthetic process
Reference #:  Q14494 (UniProtKB)
Alt. Names/Synonyms: FLJ00380; HBZ17; LCR-F1; Locus control region-factor 1; NF-E2-related factor 1; NF2L1; NFE2-related factor 1; NFE2L1; NRF1; nuclear factor (erythroid-derived 2)-like 1; Nuclear factor erythroid 2-related factor 1; Nuclear factor, erythroid derived 2, like 1; TCF-11; TCF11; Transcription factor 11; transcription factor 11 (basic leucine zipper type); Transcription factor HBZ17; Transcription factor LCR-F1
Gene Symbols: NFE2L1
Molecular weight: 84,704 Da
Basal Isoelectric point: 4.52  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFE2L1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
apoptosis, induced: S379‑p
molecular association, regulation: S599‑p
protein degradation: S379‑p
ubiquitination: S379‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 11 K70-u DGYGIHPkSIDLDNY
0 7 K205-u QKEQDVEkELRDGGE
1 0 S379-p SQDFLLFsPEVESLP
1 0 S528 EGAVGYSSDSETLDL
1 0 S599-p PSALKKGsKEKQADF
0 4 K629-u KIPFTNDkIINLPVE
0 1 S643-p EEFNELLsKYQLSEA
0 10 K713-u SLRQMKQkVQSLYQE
0 3 Y738-p RPYSPSQyALQYAGD
  mouse

 
K70-u DGYGIHPkSIDLDNY
K205 QKEQDVDKELQDGRE
S350 SQDFSLFSPEVESLP
S497-p EGAVGYSsDSETLDL
S568 PSTLKKGSKEKQADF
K598 KIPFTNDKIINLPVE
S612 EEFNELLSKYQLSEA
K682 SLRQMKQKVQSLYQE
Y707 RPYSPSQYALQYAGD
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