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Protein Page:
NFE2L1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NFE2L1 Activates erythroid-specific, globin gene expression. Interacts with KEAP1. Belongs to the bZIP family. CNC subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: endoplasmic reticulum membrane; integral to membrane; nucleus
Molecular Function: sequence-specific DNA binding; transcription cofactor activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; heme biosynthetic process
Reference #:  Q14494 (UniProtKB)
Alt. Names/Synonyms: FLJ00380; HBZ17; LCR-F1; Locus control region-factor 1; NF-E2-related factor 1; NF2L1; NFE2-related factor 1; NFE2L1; NRF1; nuclear factor (erythroid-derived 2)-like 1; Nuclear factor erythroid 2-related factor 1; Nuclear factor, erythroid derived 2, like 1; TCF-11; TCF11; Transcription factor 11; transcription factor 11 (basic leucine zipper type); Transcription factor HBZ17; Transcription factor LCR-F1
Gene Symbols: NFE2L1
Molecular weight: 84,704 Da
Basal Isoelectric point: 4.52  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFE2L1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S379‑p
molecular association, regulation: S599‑p
protein degradation: S379‑p
ubiquitination: S379‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MLsLKKYLTE
0 11 K70-ub DGYGIHPkSIDLDNY
0 7 K205-ub QKEQDVEkELRDGGE
0 1 S285-p SITEAVPsESEPPAL
1 0 S379-p SQDFLLFsPEVESLP
0 1 S483 DSGLSLDSSHSPSSL
0 1 S486 LSLDSSHSPSSLSSS
0 1 S492 HSPSSLSSSEGSSSS
0 1 S505 SSSSSSSSSSSSASS
1 0 S528 EGAVGYSSDSETLDL
1 0 S599-p PSALKKGsKEKQADF
0 1 K622-ub EHRARAMkIPFTNDk
0 4 K629-ub kIPFTNDkIINLPVE
0 1 S643-p EEFNELLsKYQLSEA
0 1 K644 EFNELLsKYQLSEAQ
0 1 K675-ub AQNCRKRkLDTILNL
0 10 K713-ub SLRQMKQkVQSLYQE
0 1 S734-p DENGRPYsPSQyALQ
0 3 Y738-p RPYsPSQyALQYAGD
  mouse

 
S3 _____MLSLKKYLTE
K70-ub DGYGIHPkSIDLDNY
K205 QKEQDVDKELQDGRE
S256 SIPEAVPSESESPAL
S350 SQDFSLFSPEVESLP
S454-p DSGLSLDsSHsPSSL
S457-p LSLDsSHsPSSLSsS
S463-p HsPSSLSsSEGSSSS
S474-p SSSSSSSsSSSSASS
S497-p EGAVGYSsDSETLDL
S568 PSTLKKGSKEKQADF
K591 EHRARAMKIPFTNDK
K598 KIPFTNDKIINLPVE
S612 EEFNELLSkYQLSEA
K613-ub EFNELLSkYQLSEAQ
K644 AQNCRKRKLDTILNL
K682 SLRQMKQKVQSLYQE
S703 DEHGRPYSPSQYALQ
Y707 RPYSPSQYALQYAGD
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