a nonreceptor tyrosine kinase of the Fak family. Predominantly expressed in the cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for G-protein-coupled receptors. Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. It plays an important role in cell motility such as spreading and migration. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Protein kinase, TK; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, tyrosine (non-receptor); TK group; Fak family
Cellular Component: focal adhesion; dendrite; postsynaptic density; cell cortex; cytosol; lipid raft; N-methyl-D-aspartate selective glutamate receptor complex; nucleoplasm; extrinsic to internal side of plasma membrane; cytoskeleton; growth cone; cell soma; perinuclear region of cytoplasm; lamellipodium; axon; cytoplasm; nucleus
Molecular Function: protein binding; signal transducer activity; calmodulin-dependent protein kinase activity; 3-phosphoinositide-dependent protein kinase binding; protein-tyrosine kinase activity; N-methyl-D-aspartate selective glutamate receptor activity; protein complex binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: focal adhesion formation; positive regulation of JNK activity; regulation of nitric oxide biosynthetic process; regulation of cGMP biosynthetic process; protein amino acid phosphorylation; glial cell proliferation; regulation of cell shape; regulation of inositol trisphosphate biosynthetic process; negative regulation of bone mineralization; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; response to glucose stimulus; protein complex assembly; negative regulation of neuron apoptosis; neurite development; bone resorption; response to drug; negative regulation of myeloid cell differentiation; positive regulation of nitric-oxide synthase activity; response to osmotic stress; positive regulation of cell growth; marginal zone B cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; response to ethanol; response to mechanical stimulus; ionotropic glutamate receptor signaling pathway; response to calcium ion; negative regulation of apoptosis; activation of JAK protein; peptidyl-tyrosine phosphorylation; response to cAMP; positive regulation of translation; blood vessel endothelial cell migration; apoptosis; protein amino acid autophosphorylation; response to lithium ion; negative regulation of potassium ion transport; response to hormone stimulus; regulation of calcium-mediated signaling; positive regulation of JNK cascade; signal transduction; positive regulation of synaptic transmission, glutamatergic; negative regulation of cell proliferation; positive regulation of cell proliferation; response to stress; angiogenesis; positive regulation of cell-matrix adhesion; epidermal growth factor receptor signaling pathway; regulation of cell adhesion; integrin-mediated signaling pathway; MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; signal complex assembly; response to cocaine; oocyte maturation; regulation of release of sequestered calcium ion into cytosol; positive regulation of actin filament polymerization; response to hydrogen peroxide; positive regulation of protein kinase activity; response to hypoxia; stress fiber formation; cellular defense response; innate immune response; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.