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Pyk2
a nonreceptor tyrosine kinase of the Fak family. Predominantly expressed in the cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for G-protein-coupled receptors. Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. It plays an important role in cell motility such as spreading and migration. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; Nuclear receptor co-regulator; TK group; Fak family |
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Cellular Component: focal adhesion; postsynaptic density; cell cortex; cytosol; lipid raft; growth cone; perinuclear region of cytoplasm; lamellipodium; axon; cytoplasm; nucleolus; plasma membrane; nucleus
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Molecular Function: protein binding; signal transducer activity; 3-phosphoinositide-dependent protein kinase binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
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Biological Process: focal adhesion formation; positive regulation of JNK activity; protein amino acid phosphorylation; glial cell proliferation; regulation of cell shape; negative regulation of bone mineralization; regulation of inositol trisphosphate biosynthetic process; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; response to glucose stimulus; protein complex assembly; neurite development; bone resorption; response to drug; negative regulation of myeloid cell differentiation; activation of Rac GTPase; response to osmotic stress; positive regulation of cell growth; marginal zone B cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to mechanical stimulus; response to calcium ion; negative regulation of apoptosis; activation of JAK protein; peptidyl-tyrosine phosphorylation; response to cAMP; blood vessel endothelial cell migration; positive regulation of translation; apoptosis; response to lithium ion; negative regulation of potassium ion transport; protein amino acid autophosphorylation; response to hormone stimulus; positive regulation of JNK cascade; signal transduction; negative regulation of cell proliferation; positive regulation of cell proliferation; response to stress; positive regulation of cell-matrix adhesion; epidermal growth factor receptor signaling pathway; regulation of cell adhesion; integrin-mediated signaling pathway; MAPKKK cascade; signal complex assembly; positive regulation of phosphoinositide 3-kinase activity; response to cocaine; oocyte maturation; regulation of release of sequestered calcium ion into cytosol; positive regulation of actin filament polymerization; response to hydrogen peroxide; positive regulation of protein kinase activity; stress fiber formation; response to hypoxia; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; positive regulation of cell migration
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Reference #:
Q14289 (UniProtKB)
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| Alt. Names/Synonyms: CADTK; CAK beta; CAK-beta; CAKB; Calcium-dependent tyrosine kinase; Cell adhesion kinase beta; FADK 2; FADK2; FAK2; Focal adhesion kinase 2; PKB; Proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; Protein-tyrosine kinase 2-beta; PTK; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; Related adhesion focal tyrosine kinase |
| Gene Symbols: PTK2B |
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Molecular weight: 115,875 Da
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Basal Isoelectric point: 5.91
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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GPCRs Signaling to MAPK/Erk
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MAPK/Erk in Growth and Differentiation
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Tyrosine Kinases
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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