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Protein Page:
NCAM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NCAM1 This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, GPI anchor; Motility/polarity/chemotaxis
Cellular Component: Golgi membrane; cell surface; cytoplasm; integral to membrane; plasma membrane; external side of plasma membrane
Molecular Function: identical protein binding
Biological Process: axon guidance; extracellular matrix organization and biogenesis; cytokine and chemokine mediated signaling pathway; cell adhesion
Reference #:  P13591 (UniProtKB)
Alt. Names/Synonyms: antigen recognized by monoclonal antibody 5.1H11; CD56; MSK39; N-CAM-1; NCAM; NCAM-1; NCAM1; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM
Gene Symbols: NCAM1
Molecular weight: 94,574 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NCAM1

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: Y744‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T125-ga LMFKNAPtPQEFrEG
1 1 R130-m2 APtPQEFrEGEDAVI
0 1 T328-p LEEQVTLtCEASGDP
0 1 K563 HSKWYDAKEAsMEGI
0 1 S566-p WYDAKEAsMEGIVTI
0 1 S598 GKGLGEISAASEFKT
0 1 T702 AAHFVFRTSAQPTAI
2 0 Y744-p VVVDITCyFLNKCGL
0 1 K768 GKAGPGAKGKDMEEG
0 4 K776-ub GKDMEEGkAAFsKDE
0 9 S780-p EEGkAAFsKDEskEP
0 1 K781 EGkAAFsKDEskEPI
2 19 S784-p AAFsKDEskEPIVEV
0 4 K785-ub AFsKDEskEPIVEVR
0 1 T798 VRTEEERTPNHDGGK
0 1 T812 KHTEPNETTPLTEPE
0 1 T813 HTEPNETTPLTEPEK
0 1 - gap
0 2 - gap
0 1 - gap
0 2 - gap
0 10 - gap
0 1 - gap
0 2 - gap
0 1 - gap
0 6 - gap
0 3 - gap
0 2 - gap
0 7 - gap
0 4 - gap
0 18 - gap
0 1 - gap
0 6 - gap
0 1 - gap
0 1 K820 TPLTEPEKGPVEAKP
0 1 K826 EKGPVEAKPECQETE
0 1 P827 KGPVEAKPECQETET
0 3 K835 ECQETETKPAPAEVK
0 1 K842 KPAPAEVKTVPNDAT
1 0 S856 TQTKENESKA_____
  NCAM1 iso2  
T125 LMFKNAPTPQEFREG
R130 APTPQEFREGEDAVI
T328 LEEQVTLTCEASGDP
K553 HSKWYDAKEASMEGI
S556 WYDAKEASMEGIVTI
S588 GKGLGEISAASEFKT
T692 AAHFVFRTSAQPTAI
Y734 VVVDITCYFLNKCGL
K758 GKAGPGAKGKDMEEG
K766 GKDMEEGKAAFSKDE
S770 EEGKAAFSKDEsKEP
K771 EGKAAFSKDEsKEPI
S774-p AAFSKDEsKEPIVEV
K775 AFSKDEsKEPIVEVR
T788 VRTEEERTPNHDGGK
T802 KHTEPNETTPLTEPE
T803 HTEPNETTPLTEPEK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K810 TPLTEPEKGPVEAKP
K816 EKGPVEAKPECQETE
P817 KGPVEAKPECQETET
K825 ECQETETKPAPAEVK
K832 KPAPAEVKTVPNDAT
S846 TQTKENESKA_____
  NCAM1 iso3  
T125 LMFKNAPTPQEFREG
R130 APTPQEFREGEDAVI
T328 LEEQVTLTCEASGDP
K553 HSKWYDAKEASMEGI
S556 WYDAKEASMEGIVTI
S588 GKGLGEISAASEFKT
T727-p AAHFVFRtSAQPTAI
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
T125 LMFKNAPTPQEFKEG
K130 APTPQEFKEGEDAVI
T329 LEEQVTLTCEASGDP
K554-ub HFKWYDAkEANMEGI
N557 WYDAkEANMEGIVTI
S589-p GKGLGEIsAATEFKT
T692 AAHFVFRTSAQPTAI
Y734-p VVMDITCyFLNKCGL
K758-ub GKAGPGAkGKDMEEG
K766-ub GKDMEEGkAAFskDE
S770-p EEGkAAFskDEskEP
K771-ub EGkAAFskDEskEPI
S774-p AAFskDEskEPIVEV
K775-ub AFskDEskEPIVEVR
T788-p VRTEEERtPNHDGGK
T802 KHTEPNETTPLTEPE
T803 HTEPNETTPLTEPEL
T882-gl ATPSKGVtAssssPA
S884-p PSKGVtAssssPAsA
S885-p SKGVtAssssPAsAP
S886-p KGVtAssssPAsAPK
S887-p GVtAssssPAsAPKV
S890-p AssssPAsAPKVAPL
S926-p ANQGAVLsPStPASA
T929-p GAVLsPStPASAGET
S946-p APPASKAsPAPtPtP
T950-p SKAsPAPtPtPAGAA
T952-p AsPAPtPtPAGAAsP
S958-p PtPAGAAsPLAAVAA
T1001-p KNPPEAAtAPAsPKS
S1005-p EAAtAPAsPKSkAAT
K1009-m1 APAsPKSkAATTNPS
T1030-p MDEGNFKtPDIDLAK
S1053-p PRPATGAsGQASELA
K1077 PAPAKTEKGPVETks
K1083-ub EKGPVETksEPPESE
S1084-p KGPVETksEPPESEA
K1092 EPPESEAKPAPTEVk
K1099-ub KPAPTEVkTVPNDAT
S1113-p TQTKENEsKA_____
  NCAM1 iso2  
T125 LMFKNAPTPQEFKEG
K130 APTPQEFKEGEDAVI
T329 LEEQVTLTCEASGDP
K554 HFKWYDAKEANMEGI
N557 WYDAKEANMEGIVTI
S589 GKGLGEISAATEFKT
T692 AAHFVFRTSAQPTAI
Y734 VVMDITCYFLNKCGL
K758 GKAGPGAKGKDMEEG
K766 GKDMEEGKAAFSKDE
S770 EEGKAAFSKDESKEP
K771 EGKAAFSKDESKEPI
S774 AAFSKDESKEPIVEV
K775 AFSKDESKEPIVEVR
T788 VRTEEERTPNHDGGK
T802-p KHTEPNEttPLTEPE
T803-p HTEPNEttPLTEPEk
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K810-ub tPLTEPEkGPVETKS
K816 EkGPVETKSEPPESE
S817 kGPVETKSEPPESEA
K825 EPPESEAKPAPTEVK
K832 KPAPTEVKTVPNDAT
S846 TQTKENESKA_____
  rat

 
T125 LMFKNAPTPQEFKEG
K130 APTPQEFKEGEDAVI
T329 LEEQVTLTCEASGDP
K564 HSKWYDAKEANMEGI
N567 WYDAKEANMEGIVTI
S599 GKGLGEISAATEFKT
T702 AAHFVFRTSAQPTAI
Y744-p VVMDITCyFLNKCGL
K768 GKAGPGAKGKDMEEG
K776 GKDMEEGKAAFSKDE
S780 EEGKAAFSKDEsKEP
K781 EGKAAFSKDEsKEPI
S784-p AAFSKDEsKEPIVEV
K785 AFSKDEsKEPIVEVR
T798 VRTEEERTPNHDGGK
T812 KHTEPNETTPLTEPE
T813 HTEPNETTPLTEPEK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K820 TPLTEPEKGPVETKS
K826 EKGPVETKSEPQESE
S827 KGPVETKSEPQESEA
K835-ub EPQESEAkPAPTEVK
K842 kPAPTEVKTVPNEAT
S856 TQTKENESKA_____
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