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Protein Page:
MAPKAPK5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MAPKAPK5 a member of the MAPKAPK family of protein kinases. Activated through phosphorylation by MAP kinases including ERK, p38-alpha, and MAPp38-beta In response to cellular stress and proinflammatory cytokines. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; CAMK group; MAPKAPK family; MAPKAPK subfamily
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; p53 binding; mitogen-activated protein kinase binding; ATP binding
Biological Process: regulation of translation; negative regulation of TOR signaling pathway; activation of MAPK activity; protein amino acid autophosphorylation; Ras protein signal transduction; MAPKKK cascade; signal transduction
Reference #:  Q8IW41 (UniProtKB)
Alt. Names/Synonyms: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPK5; MAPKAP kinase 5; MAPKAPK-5; MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; p38-regulated/activated protein kinase; PRAK
Gene Symbols: MAPKAPK5
Molecular weight: 54,220 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAPKAPK5

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: T182‑p
cytoskeletal reorganization: S115‑p
enzymatic activity, induced: T182‑p
intracellular localization: S115‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K51 TQERFALKILLDRPK
1 0 S115-p GELFHRIsQHRHFTE
6 88 T182-p IDQGDLMtPQFtPyY
0 11 T186-p DLMtPQFtPyYVAPQ
0 1 Y188-p MtPQFtPyYVAPQVL
0 1 S206-p RRHQKEKsGIIPTsP
0 3 S212-p KsGIIPTsPTPYTYN
0 1 S348-p RIQDLKVsLKPLHsV
0 3 S354-p VsLKPLHsVNNPILR
1 0 K364 NPILRKRKLLGtKPK
0 1 T368-p RKRKLLGtKPKDSVY
0 2 S472-p EQTTSHEsQ______
  mouse

 
K51-ac TQERFALkILLDRPK
S115 GELFHRISQHRHFTE
T182-p VDQGDLMtPQFTPYY
T186 DLMtPQFTPYYVAPQ
Y188 MtPQFTPYYVAPQVL
S206 RRHQKEKSGIIPTsP
S212-p KSGIIPTsPTPYTYN
S348 RIQDLKVSLKPLHSV
S354 VSLKPLHSVNNPILR
K364-ac NPILRKRkLLGTKPK
T368 RKRkLLGTKPKDGIY
P472 EQTLPHEPQ______
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