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MAPKAPK5 (human)

Overview MAPKAPK5 a member of the MAPKAPK family of protein kinases. Activated through phosphorylation by MAP kinases including ERK, p38-alpha, and MAPp38-beta In response to cellular stress and proinflammatory cytokines. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CAMK group; MAPKAPK family; MAPKAPK subfamily Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; p53 binding; mitogen-activated protein kinase binding; ATP binding Biological Process: regulation of translation; negative regulation of TOR signaling pathway; activation of MAPK activity; protein amino acid autophosphorylation; Ras protein signal transduction; MAPKKK cascade; response to stress; signal transduction Reference #:  Q8IW41 (UniProtKB) Alt. Names/Synonyms: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPK5; MAPKAP kinase 5; MAPKAPK-5; MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; p38-regulated/activated protein kinase; PRAK Gene Symbols: MAPKAPK5 Molecular weight: 54,220 Da Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states CST Pathways:  Regulation of Microtubule Dynamics  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MAPKAPK5

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	Sites Implicated In
cell growth, altered: T182‑p cytoskeletal reorganization: S115‑p enzymatic activity, induced: T182‑p intracellular localization: S115‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S115-p	GELFHRIsQHRHFTE
5	71		T182-p	IDQGDLMtPQFtPyY
0	7		T186-p	DLMtPQFtPyYVAPQ
0	1		Y188-p	MtPQFtPyYVAPQVL
0	1		S206-p	RRHQKEKsGIIPTsP
0	1		S212-p	KsGIIPTsPTPYTYN
0	1		S472-p	EQTTSHEsQ______

	mouse
S115	GELFHRISQHRHFTE
T182-p	VDQGDLMtPQFTPYY
T186	DLMtPQFTPYYVAPQ
Y188	MtPQFTPYYVAPQVL
S206	RRHQKEKSGIIPTSP
S212	KSGIIPTSPTPYTYN
P472	EQTLPHEPQ______

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