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Protein Page:
SH2D1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SH2D1A Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. Interacts with NTRK1, NTRK2 and NTRK3. Interacts with CD84, CD244, LY9, SLAMF1 and FYN. Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Adaptor/scaffold
Cellular Component: cytoplasm
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: cell-cell signaling; positive regulation of signal transduction; cellular defense response; positive regulation of natural killer cell mediated cytotoxicity; humoral immune response
Reference #:  O60880 (UniProtKB)
Alt. Names/Synonyms: DSHP; Duncan disease SH2-protein; Duncan's disease; EBVS; FLJ18687; FLJ92177; IMD5; LYP; MTCP1; SAP; SH2 domain containing 1A; SH2 domain protein 1A; SH2 domain-containing protein 1A; SH21A; SH2D1A; signaling lymphocyte activation molecule-associated protein; Signaling lymphocytic activation molecule-associated protein; SLAM-associated protein; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP; XLP; XLPD
Gene Symbols: SH2D1A
Molecular weight: 14,187 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SH2D1A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K18-ub ISRETGEkLLLATGL
0 1 K89-ac NLISAFQkPDQGIVI
0 1 S106-p QYPVEKKssARStQG
0 1 S107-p YPVEKKssARStQGt
0 1 T111-p KKssARStQGttGIR
0 1 T114-p sARStQGttGIREDP
0 2 T115-p ARStQGttGIREDPD
0 2 P121 ttGIREDPDVCLkAP
0 5 K126-ub EDPDVCLkAP_____
  mouse

 
K18 ISRETGEKLLLATGL
K89 NLISAFQKPDQGIVT
S105 LQYPVEKSSGRGPQA
S106 QYPVEKSSGRGPQAP
P110 EKSSGRGPQAPTGRR
P113 SGRGPQAPTGRRDsD
T114 GRGPQAPTGRRDsDI
S119-p APTGRRDsDICLNAP
N124 RDsDICLNAP_____
  rat

 
K18 ISREMGEKLLLATGL
K89 NLISAFQKPDQGIVT
S105 LQYPVEKSSARSPQA
S106 QYPVEKSSARSPQAP
P110 EKSSARSPQAPTGRR
P113 SARSPQAPTGRRDsD
T114 ARSPQAPTGRRDsDI
S119-p APTGRRDsDICLKAP
K124 RDsDICLKAP_____
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