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Protein Page:
ENaC-alpha (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ENaC-alpha Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. By aldosterone. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Activated by WNK1, WNK2, WNK3 and WNK4. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; Channel, sodium
Cellular Component: cortical actin cytoskeleton; integral to plasma membrane; apical plasma membrane; plasma membrane; cytosol; external side of plasma membrane
Molecular Function: amiloride-sensitive sodium channel activity; protein binding; WW domain binding; actin binding
Biological Process: sensory perception of taste; response to stimulus; sodium ion transport; sodium ion homeostasis; multicellular organismal water homeostasis; excretion; transmembrane transport
Reference #:  P37088 (UniProtKB)
Alt. Names/Synonyms: alpha ENaC-2; Alpha-ENaC; Alpha-NaCH; amiloride-sensitive epithelial sodium channel alpha subunit; Amiloride-sensitive sodium channel subunit alpha; amiloride-sensitive sodium channel subunit alpha 2; BESC2; ENaC-alpha; ENaCA; ENaCalpha; Epithelial Na(+) channel subunit alpha; FLJ21883; nasal epithelial sodium channel alpha subunit; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN1; SCNN1A; SCNNA; sodium channel, nonvoltage-gated 1 alpha
Gene Symbols: SCNN1A
Molecular weight: 75,704 Da
Basal Isoelectric point: 7.47  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below

ENaC-alpha

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 E7 _MEGNKLEEQDSSPP
0 1 K22-ub QSTPGLMkGNKREEQ
0 8 T154-p LEELDRItEQTLFDL
0 1 S174-p FTTLVAGsRSRRDLR
0 1 R177 LVAGsRSRRDLRGTL
0 1 R181 sRSRRDLRGTLPHPL
0 1 K220-ub NNPQVDWkDWKIGFQ
0 1 K233-ub FQLCNQNkSDCFYQT
0 1 S376-p LRPGVETsIsMRKEt
0 1 S378-p PGVETsIsMRKEtLD
0 1 T383-p sIsMRKEtLDRLGGD
0 1 K529-ub AKVNIFFkELNYKTN
3 0 S594-p RFRSRYWsPGRGGRG
2 0 T663-p SAGASSStCPLGGP_
  mouse

 
K32-ac SMKGNNFkEQDLCPP
K47 LPMQGLGKGDKREEQ
T179 LEELDRITEQTLFDL
G199 SYTRQAGGRRrSTRD
R202-m1 RQAGGRRrSTRDLrG
R208-m1 RrSTRDLrGALPHPL
K247 NNPQVDRKDWKIGFQ
K260 FQLCNQNKSDCFYQT
S403 VRPGVETSISMRKEA
S405 PGVETSISMRKEALD
A410 SISMRKEALDSLGGN
K556 AKLNIFFKELNYKTN
S621 RFRSRYWSPGRGARG
A692 SAVPGSSACAPAMAL
  rat

 
K32 SMKGNQFKEQDPCPP
K47 QPMQGLGKGDKREEQ
T179 LEELDRITEQTLFDL
A199 SYTRQAGARRRSSRD
R202 RQAGARRRSSRDLLG
L208 RRSSRDLLGAFPHPL
K247 NNPQVDRKDWKIGFQ
K260 FQLCNQNKSDCFYQT
S403 LRPGVETSISMRKEA
S405 PGVETSISMRKEALD
A410 SISMRKEALDSLGGN
K556 AKLNIFFKELNYKTN
S621-p RFRSRYWsPGRGARG
A692 SAAPDCSACALAAL_
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