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Protein Page:
SKAR (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SKAR Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Cellular Component: intracellular membrane-bound organelle; cytoplasm; nucleolus; nuclear speck; nucleus
Molecular Function: protein binding; RNA binding; nucleotide binding
Biological Process: positive regulation of translation
Reference #:  Q9BY77 (UniProtKB)
Alt. Names/Synonyms: 46 kDa DNA polymerase delta interaction protein; KIAA1649; p46; PDIP3; PDIP46; POLDIP3; polymerase (DNA-directed), delta interacting protein 3; polymerase delta interacting protein 46; Polymerase delta-interacting protein 3; RNA-binding protein P46; S6K1 Aly/REF-like target; SKAR
Gene Symbols: POLDIP3
Molecular weight: 46,089 Da
Basal Isoelectric point: 10  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SKAR
Protein Structure Not Found.


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Sites Implicated In
activation: S383‑p, S385‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 S5-p ___MADIsLDELIRK
0 2 S42-p GIQQGLLsQSTRTAT
0 1 S63-p ARQKIGLsDARLKLG
0 2 T105-p LNSRKQQttVPQKPR
0 1 T106-p NSRKQQttVPQKPRQ
0 3 S126-p EKISLKRssPAAFIN
1 35 S127-p KISLKRssPAAFINP
0 1 I132 RssPAAFINPPIGTV
0 6 T140-p NPPIGTVtPALKLTK
0 1 K197-u GIASVPTkQMKFAAS
0 1 K229-u SKALPLTkVVQNdAy
0 1 D234-ca LTkVVQNdAytAPAL
0 23 Y236-p kVVQNdAytAPALPS
0 1 T237-p VVQNdAytAPALPSS
1 2 S275-p PAAEPVLsPLEGTKM
0 2 K307-a FCVCGALkRARLVHP
0 1 T329-p VKKDDAItAYkKYNN
0 1 K332-u DDAItAYkKYNNRCL
0 1 K372 LSDSPSMKKESELPR
2 9 S383-p ELPRRVNsAsSSNPP
2 2 S385-p PRRVNsAsSSNPPAE
1 1 S405-p ILKALFKssGAsVTT
1 1 S406-p LKALFKssGAsVTTQ
0 1 S409-p LFKssGAsVTTQPTE
0 1 K418-u TTQPTEFkIKL____
  SKAR iso2  
S5 ___MADISLDELIRK
S42 GIQQGLLSQSTRTAT
S63 ARQKIGLSDARLKLG
T105 LNSRKQQTTVPQKPR
T106 NSRKQQTTVPQKPRQ
S126 EKISLKRSSPAAFIN
S127 KISLKRSSPAAFINP
I132 RSSPAAFINPPIGTV
T140 NPPIGTVTPALKLTK
K168-u GIASVPTkQMKFAAS
K200 SKALPLTKVVQNDAY
D205 LTKVVQNDAYTAPAL
Y207 KVVQNDAYTAPALPS
T208 VVQNDAYTAPALPSS
S246 PAAEPVLSPLEGTKM
K278 FCVCGALKRARLVHP
T300 VKKDDAITAYKKYNN
K303 DDAITAYKKYNNRCL
K343 LSDSPSMKKESELPR
S354 ELPRRVNSASSSNPP
S356 PRRVNSASSSNPPAE
S376 ILKALFKSSGASVTT
S377 LKALFKSSGASVTTQ
S380 LFKSSGASVTTQPTE
K389 TTQPTEFKIKL____
  mouse

 
S5 ___MADLSLDELIRK
N42 GIQHSLVNQPARTAT
S63 ARQKIGLSDARLKLG
G105 LNSRKQQGTVPQKPR
T106 NSRKQQGTVPQKPRQ
R126 EKISLKRRsPAAFtS
S127-p KISLKRRsPAAFtSP
T132-p RRsPAAFtSPPIGTV
T140-p SPPIGTVtPALKLTK
K197 IVVPVPPKQMKFAAT
K229 SKALPLTKVVQNDAY
D234 LTKVVQNDAYTAPVL
Y236 KVVQNDAYTAPVLPS
T237 VVQNDAYTAPVLPSS
S275 PPAEPVLSPLEGTKM
K307 FCVCGALKRARLVHP
T329 VKKDDAITAYKKYNN
K332 DDAITAYKKYNNRCL
K372-a LSDSPSVkKESELPR
P383 ELPRRGNPASSNPPA
S385 PRRGNPASSNPPAEV
S404 VLRALFKSSGASVTT
S405 LRALFKSSGASVTTQ
S408 LFKSSGASVTTQPTE
K417 TTQPTEFKIKL____
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