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Protein Page:
RPA40 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RPA40 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Defects in POLR1C are the cause of Treacher Collins syndrome type 3 (TCS3). A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.7.6; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Nucleotide Metabolism - purine; Transferase
Cellular Component: nucleoplasm; DNA-directed RNA polymerase III complex; cytosol; DNA-directed RNA polymerase I complex
Molecular Function: protein dimerization activity; DNA binding; DNA-directed RNA polymerase activity
Biological Process: transcription from RNA polymerase III promoter; termination of RNA polymerase III transcription; positive regulation of interferon type I production; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; innate immune response; gene expression; transcription initiation from RNA polymerase I promoter; termination of RNA polymerase I transcription; RNA elongation from RNA polymerase III promoter
Reference #:  O15160 (UniProtKB)
Alt. Names/Synonyms: AC40; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC1; POLR1C; POLR1E; polymerase (RNA) I polypeptide C, 30kDa; RNA polymerase I subunit; RNA polymerases I and III subunit AC1; RPA39; RPA40; RPA5; RPAC1; RPC40
Gene Symbols: POLR1C
Molecular weight: 39,250 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
Select Structure to View Below

RPA40

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S4-p ____MAAsQAVEEMR
0 22 Y33-p TTDFPGNysGyDDAW
0 1 S34-p TDFPGNysGyDDAWD
0 7 Y36-p FPGNysGyDDAWDQD
0 1 K47-ub WDQDRFEkNFRVDVV
0 1 Y124-p ADPRLFEyRNQGDEE
0 1 K154-ub TRNPHAAkDSSDPNE
0 1 K167-ub NELYVNHkVYTRHMT
0 3 K224-ub GIGKDHAkFSPVATA
0 1 S258-p EELSRCFsPGVIEVQ
0 14 T282-p VANPRLDtFsREIFR
0 3 S284-p NPRLDtFsREIFRNE
  mouse

 
A4 ____MAAAQAVEEMR
Y33-p TTDFPGNyAGYDDAW
A34 TDFPGNyAGYDDAWD
Y36 FPGNyAGYDDAWDQN
K47 WDQNRFEKNFRVDVV
Y124 ADPRLFEYRNQGEEE
K154 TRNPNAAKDSSDPNE
K167 NELYVNHKVYTRHMT
K224-ub GIGKDHAkFSPVATA
S258 EELSQCFSPGVIEVE
T282 VANARLDTFSREIFR
S284 NARLDTFSREIFRHE
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