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RPA40 (human)

Overview RPA40 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Defects in POLR1C are the cause of Treacher Collins syndrome type 3 (TCS3). A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Nucleotide Metabolism - pyrimidine; EC 2.7.7.6; Transferase; Transcription initiation complex; Nucleotide Metabolism - purine Cellular Component: nucleoplasm; DNA-directed RNA polymerase I complex Molecular Function: protein dimerization activity; DNA binding; DNA-directed RNA polymerase activity Biological Process: transcription from RNA polymerase III promoter; termination of RNA polymerase III transcription; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; gene expression; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; RNA elongation from RNA polymerase III promoter Reference #:  O15160 (UniProtKB) Alt. Names/Synonyms: AC40; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC1; POLR1C; POLR1E; polymerase (RNA) I polypeptide C, 30kDa; RNA polymerase I subunit; RNA polymerases I and III subunit AC1; RPA39; RPA40; RPA5; RPAC1; RPC40 Gene Symbols: POLR1C Molecular weight: 39,250 Da Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states

Select Structure to View Below RPA40

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S4-p	____MAAsQAVEEMR
0	32		Y33-p	TTDFPGNysGyDDAW
0	1		S34-p	TDFPGNysGyDDAWD
0	11		Y36-p	FPGNysGyDDAWDQD
0	1		K47-u	WDQDRFEkNFRVDVV
0	1		Y124-p	ADPRLFEyRNQGDEE
0	1		K154-u	TRNPHAAkDSSDPNE
0	1		K167-u	NELYVNHkVYTRHMT
0	3		K224-u	GIGKDHAkFSPVATA
0	13		T282-p	VANPRLDtFsREIFR
0	3		S284-p	NPRLDtFsREIFRNE

	mouse
A4	____MAAAQAVEEMR
Y33-p	TTDFPGNyAGYDDAW
A34	TDFPGNyAGYDDAWD
Y36	FPGNyAGYDDAWDQN
K47	WDQNRFEKNFRVDVV
Y124	ADPRLFEYRNQGEEE
K154	TRNPNAAKDSSDPNE
K167	NELYVNHKVYTRHMT
K224-u	GIGKDHAkFSPVATA
T282	VANARLDTFSREIFR
S284	NARLDTFSREIFRHE

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