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Protein Page:
PKCI (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKCI an AGC protein kinase of the PKC family. A calcium-independent, phospholipid-dependent atypical protein kinase C. Is not activated by phorbolesters or diaglycerol. May play role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.13; Motility/polarity/chemotaxis; Cell adhesion; Cell development/differentiation; Kinase, protein; EC 3.-.-.-; AGC group; PKC family; Iota subfamily
Cellular Component: microtubule cytoskeleton; Golgi membrane; intercellular bridge; polarisome; apical plasma membrane; cytoplasm; leading edge; plasma membrane; nucleus; cytosol; endosome
Molecular Function: protein serine/threonine kinase activity; protein domain specific binding; protein binding; protein kinase C activity; zinc ion binding; phospholipid binding; ATP binding; protein kinase activity
Biological Process: intercellular junction assembly and maintenance; cell migration; secretion; nerve growth factor receptor signaling pathway; establishment of apical/basal cell polarity; actin filament organization; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; vesicle-mediated transport; establishment and/or maintenance of epithelial cell polarity; positive regulation of glucose import; eye photoreceptor cell development; cellular response to insulin stimulus; negative regulation of neuron apoptosis; Golgi vesicle budding; protein targeting to membrane; negative regulation of apoptosis
Reference #:  P41743 (UniProtKB)
Alt. Names/Synonyms: aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; DXS1179E; KPCI; MGC26534; nPKC-iota; PKCI; PRKC-lambda/iota; PRKCI; Protein kinase C iota type; protein kinase C, iota
Gene Symbols: PRKCI
Molecular weight: 68,262 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKCI

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: T412‑p
protein conformation: Y430‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T3-p _____MPtQRDsstM
0 2 S7-p _MPtQRDsstMsHtV
0 2 S8-p MPtQRDsstMsHtVA
0 2 T9-p PtQRDsstMsHtVAG
0 2 S11-p QRDsstMsHtVAGGG
0 1 T13-p DsstMsHtVAGGGsG
0 2 S19-p HtVAGGGsGDHSHQV
1 1 S44-p MITHFEPsIsFEGLC
1 1 S46-p THFEPsIsFEGLCNE
0 55 Y136-p ARRWRKLyCANGHTF
0 1 S206 PVMPMDQSSMHSDHA
0 1 A213 SSMHSDHAQTVIPYN
1 1 S222-p TVIPYNPssHEsLDQ
1 1 S223-p VIPYNPssHEsLDQV
1 1 S226-p YNPssHEsLDQVGEE
0 1 K244 MNTRESGKAssSLGL
1 1 S246-p TRESGKAssSLGLQD
1 2 S247-p RESGKAssSLGLQDF
2 0 Y265 RVIGRGSYAKVLLVR
1 0 Y280 LKKTDRIYAMKVVKK
1 0 Y334 RLFFVIEYVNGGDLM
0 2 R377 HERGIIYRDLkLDNV
0 2 K380-ub GIIYRDLkLDNVLLD
0 1 Y397-p GHIKLTDyGMCKEGL
0 3 T409-p EGLRPGDttstFCGt
0 5 T410-p GLRPGDttstFCGtP
1 9 S411-p LRPGDttstFCGtPN
8 43 T412-p RPGDttstFCGtPNY
1 3 T416-p ttstFCGtPNYIAPE
1 0 Y430-p EILRGEDyGFSVDWW
1 1 S459-p PFDIVGSsDNPDQNT
0 2 K488-ub IPRSLSVkAASVLKS
0 1 T557-p DNFDSQFtNEPVQLt
6 16 T564-p tNEPVQLtPDDDDIV
0 8 Y584-p SEFEGFEyINPLLMs
1 4 S591-p yINPLLMsAEECV__
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9378 : Phospho-PKCzeta/lambda (Thr410/403) Antibody
  mouse

 
T3 _____MPTQRDSSTM
S7 _MPTQRDSSTMSHTV
S8 MPTQRDSSTMSHTVA
T9 PTQRDSSTMSHTVAC
S11 QRDSSTMSHTVACGG
T13 DSSTMSHTVACGGGG
G19 HTVACGGGGDHSHQV
S44 MITHFEPSISFEGLC
S46 THFEPSISFEGLCSE
Y136-p ARRWRKLyCANGHTF
T206-p PMMPMDQtMHPDHtQ
T212-p QtMHPDHtQTVIPYN
S221 TVIPYNPSSHESLDQ
S222 VIPYNPSSHESLDQV
S225 YNPSSHESLDQVGEE
K243-ub MNTRESGkASsSLGL
S245 TRESGkASsSLGLQD
S246-p RESGkASsSLGLQDF
Y264 RVIGRGSYAKVLLVR
Y279 LKKTDRIYAMKVVKK
Y333 RLFFVIEYVNGGDLM
R376-m1 HERGIIYrDLkLDNV
K379-ub GIIYrDLkLDNVLLD
Y396 GHIKLTDYGMCKEGL
T408-p EGLRPGDttstFCGt
T409-p GLRPGDttstFCGtP
S410-p LRPGDttstFCGtPN
T411-p RPGDttstFCGtPNY
T415-p ttstFCGtPNYIAPE
Y429 EILRGEDYGFSVDWW
S458 PFDIVGSSDNPDQNT
K487 IPRSLSVKAASVLKS
T556 DNFDSQFTNEPVQLt
T563-p TNEPVQLtPDDDDIV
Y583 SEFEGFEYINPLLMS
S590 YINPLLMSAEECV__
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9378 : Phospho-PKCzeta/lambda (Thr410/403) Antibody
  rat

 
T3 _____MPTQRDSSTM
S7 _MPTQRDSSTMSHTV
S8 MPTQRDSSTMSHTVA
T9 PTQRDSSTMSHTVAC
S11 QRDSSTMSHTVACGG
T13 DSSTMSHTVACGGGG
G19 HTVACGGGGDHSHQV
S44 MITHFEPSISFEGLC
S46 THFEPSISFEGLCSE
Y136-p ARRWRKLyCANGHTF
S206 PMMPMDQSSMHPDHT
T213 SSMHPDHTQTVIPYN
S222 TVIPYNPSSHESLDQ
S223 VIPYNPSSHESLDQV
S226 YNPSSHESLDQVGEE
K244 MNTRESGKASSSLGL
S246 TRESGKASSSLGLQD
S247 RESGKASSSLGLQDF
Y265-p RVIGRGSyAKVLLVR
Y280-p LKKTDRIyAMKVVKK
Y334-p RLFFVIEyVNGGDLM
R377 HERGIIYRDLKLDNV
K380 GIIYRDLKLDNVLLD
Y397 GHIKLTDYGMCKEGL
T409 EGLRPGDTTStFCGT
T410 GLRPGDTTStFCGTP
S411 LRPGDTTStFCGTPN
T412-p RPGDTTStFCGTPNY
T416 TTStFCGTPNYIAPE
Y430 EILRGEDYGFSVDWW
S459 PFDIVGSSDNPDQNT
K488 IPRSLSVKAASVLKS
T557 DNFDSQFTNEPVQLt
T564-p TNEPVQLtPDDDDIV
Y584 SEFEGFEYINPLLMS
S591 YINPLLMSAEECV__
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9378 : Phospho-PKCzeta/lambda (Thr410/403) Antibody
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