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PKCI (human)

Overview PKCI an AGC protein kinase of the PKC family. A calcium-independent, phospholipid-dependent atypical protein kinase C. Is not activated by phorbolesters or diaglycerol. May play role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.13; Cell development/differentiation; Protein kinase, Ser/Thr (non-receptor); EC 3.-.-.-; Protein kinase, AGC; Cell adhesion; Motility/polarity/chemotaxis; Kinase, protein; AGC group; PKC family; Iota subfamily Cellular Component: polarisome; apical plasma membrane; plasma membrane; nucleus; cytosol; endosome Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; zinc ion binding; phospholipid binding; ATP binding; protein kinase activity Biological Process: intercellular junction assembly and maintenance; secretion; nerve growth factor receptor signaling pathway; establishment of apical/basal cell polarity; actin filament organization; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; membrane organization and biogenesis; activation of NF-kappaB transcription factor; establishment and/or maintenance of epithelial cell polarity; vesicle-mediated transport; positive regulation of glucose import; eye photoreceptor cell development; cellular response to insulin stimulus; negative regulation of neuron apoptosis; protein targeting to membrane Reference #:  P41743 (UniProtKB) Alt. Names/Synonyms: aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; DXS1179E; KPCI; MGC26534; nPKC-iota; PKCI; PRKC-lambda/iota; PRKCI; Protein kinase C iota type; protein kinase C, iota Gene Symbols: PRKCI Molecular weight: 68,262 Da Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKCI 1VD2 - A=16-99 (human) 1WMH - A=16-99 (human) 1ZRZ - A=224-587 (human) 3A8W - A/B=249-588 (human) 3A8X - A/B=249-588 (human) 3ZH8 - A/C/B=248-596 (human) 4DC2 - A=231-595 (mouse) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8  |  ENZYME 2.7.11.13 3.-.-.-  |  Phospho3D  |  DISEASE 300094 600539  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: T412‑p protein conformation: Y430‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		-	gap
0	1		-	gap
0	1		T3-p	_____MPtQRDsstM
0	1		S7-p	_MPtQRDsstMsHtV
0	1		S8-p	MPtQRDsstMsHtVA
0	1		T9-p	PtQRDsstMsHtVAG
0	1		S11-p	QRDsstMsHtVAGGG
0	1		T13-p	DsstMsHtVAGGGsG
0	1		S19-p	HtVAGGGsGDHSHQV
1	1		S44-p	MITHFEPsIsFEGLC
1	1		S46-p	THFEPsIsFEGLCNE
0	1		Y125-p	PGEDKSIyRRGARRW
0	59		Y136-p	ARRWRKLyCANGHTF
0	1		S206	PVMPMDQSSMHSDHA
0	1		A213	SSMHSDHAQTVIPYN
1	1		S222-p	TVIPYNPssHEsLDQ
1	1		S223-p	VIPYNPssHEsLDQV
1	1		S226-p	YNPssHEsLDQVGEE
0	1		K244	MNTRESGKAssSLGL
1	1		S246-p	TRESGKAssSLGLQD
1	1		S247-p	RESGKAssSLGLQDF
2	0		Y265	RVIGRGSYAKVLLVR
1	0		Y280	LKKTDRIYAMKVVKK
1	0		Y334	RLFFVIEYVNGGDLM
0	2		R377	HERGIIYRDLkLDNV
0	2		K380-u	GIIYRDLkLDNVLLD
0	1		Y397-p	GHIKLTDyGMCKEGL
0	2		T409-p	EGLRPGDttstFCGt
0	3		T410-p	GLRPGDttstFCGtP
1	7		S411-p	LRPGDttstFCGtPN
7	34		T412-p	RPGDttstFCGtPNY
1	3		T416-p	ttstFCGtPNYIAPE
1	0		Y430-p	EILRGEDyGFSVDWW
1	1		S459-p	PFDIVGSsDNPDQNT
0	2		K488-u	IPRSLSVkAASVLKS
5	10		T564-p	TNEPVQLtPDDDDIV
0	7		Y584-p	SEFEGFEyINPLLMs
1	4		S591-p	yINPLLMsAEECV__

	mouse
-	gap
-	gap
T3	_____MPTQRDSSTM
S7	_MPTQRDSSTMSHTV
S8	MPTQRDSSTMSHTVA
T9	PTQRDSSTMSHTVAC
S11	QRDSSTMSHTVACGG
T13	DSSTMSHTVACGGGG
G19	HTVACGGGGDHSHQV
S44	MITHFEPSISFEGLC
S46	THFEPSISFEGLCSE
Y125	PGEDKSIYRRGARRW
Y136-p	ARRWRKLyCANGHTF
T206-p	PMMPMDQtMHPDHtQ
T212-p	QtMHPDHtQTVIPYN
S221	TVIPYNPSSHESLDQ
S222	VIPYNPSSHESLDQV
S225	YNPSSHESLDQVGEE
K243-u	MNTRESGkASsSLGL
S245	TRESGkASsSLGLQD
S246-p	RESGkASsSLGLQDF
Y264	RVIGRGSYAKVLLVR
Y279	LKKTDRIYAMKVVKK
Y333	RLFFVIEYVNGGDLM
R376-m1	HERGIIYrDLkLDNV
K379-u	GIIYrDLkLDNVLLD
Y396	GHIKLTDYGMCKEGL
T408-p	EGLRPGDttstFCGt
T409-p	GLRPGDttstFCGtP
S410-p	LRPGDttstFCGtPN
T411-p	RPGDttstFCGtPNY
T415-p	ttstFCGtPNYIAPE
Y429	EILRGEDYGFSVDWW
S458	PFDIVGSSDNPDQNT
K487	IPRSLSVKAASVLKS
T563-p	TNEPVQLtPDDDDIV
Y583	SEFEGFEYINPLLMS
S590	YINPLLMSAEECV__

	rat
T53-p	IHSAPPSttTITSGS
T54-p	HSAPPSttTITSGSA
T304	RGSEEMPTQRDSSTM
S308	EMPTQRDSSTMSHTV
S309	MPTQRDSSTMSHTVA
T310	PTQRDSSTMSHTVAC
S312	QRDSSTMSHTVACGG
T314	DSSTMSHTVACGGGG
G320	HTVACGGGGDHSHQV
S345	MITHFEPSISFEGLC
S347	THFEPSISFEGLCSE
Y426	PGEDKSIYRRGARRW
Y437-p	ARRWRKLyCANGHTF
S507	PMMPMDQSSMHPDHT
T514	SSMHPDHTQTVIPYN
S523	TVIPYNPSSHESLDQ
S524	VIPYNPSSHESLDQV
S527	YNPSSHESLDQVGEE
K545	MNTRESGKASSSLGL
S547	TRESGKASSSLGLQD
S548	RESGKASSSLGLQDF
Y566-p	RVIGRGSyAKVLLVR
Y581-p	LKKTDRIyAMKVVKK
Y635-p	RLFFVIEyVNGGDLM
R678	HERGIIYRDLKLDNV
K681	GIIYRDLKLDNVLLD
Y698	GHIKLTDYGMCKEGL
T710	EGLRPGDTTStFCGT
T711	GLRPGDTTStFCGTP
S712	LRPGDTTStFCGTPN
T713-p	RPGDTTStFCGTPNY
T717	TTStFCGTPNYIAPE
Y731	EILRGEDYGFSVDWW
S760	PFDIVGSSDNPDQNT
K789	IPRSLSVKAASVLKS
T865-p	TNEPVQLtPDDDDIV
Y885	SEFEGFEYINPLLMS
S892	YINPLLMSAEECV__

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