an AGC protein kinase of the PKC family. A calcium-independent, phospholipid-dependent atypical protein kinase C. Is not activated by phorbolesters or diaglycerol. May play role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Note: This description may include information from UniProtKB.
Protein type: EC 3.-.-.-; Kinase, protein; EC 220.127.116.11; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Motility/polarity/chemotaxis; Cell adhesion; Cell development/differentiation; AGC group; PKC family; Iota subfamily
Molecular Function: protein domain specific binding; protein serine/threonine kinase activity; protein binding; protein kinase C activity; zinc ion binding; phospholipid binding; ATP binding; protein kinase activity
Biological Process: intercellular junction assembly and maintenance; cell migration; secretion; nerve growth factor receptor signaling pathway; establishment of apical/basal cell polarity; actin filament organization; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; vesicle-mediated transport; establishment and/or maintenance of epithelial cell polarity; positive regulation of glucose import; eye photoreceptor cell development; cellular response to insulin stimulus; negative regulation of neuron apoptosis; Golgi vesicle budding; protein targeting to membrane; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.