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TD-60 (human)

Overview TD-60 Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1. Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules. Note: This description may include information from UniProtKB. Protein type: Guanine nucleotide exchange factor, misc. Cellular Component: microtubule; nucleolus; spindle; cytosol; chromosome, pericentric region Biological Process: M phase of mitotic cell cycle; cell division; mitotic cell cycle; mitotic prometaphase Reference #:  Q9P258 (UniProtKB) Alt. Names/Synonyms: DKFZp762N0610; KIAA1470; Protein RCC2; RCC1-like protein TD-60; RCC2; regulator of chromosome condensation 2; TD-60; TD60; Telophase disk protein of 60 kDa Gene Symbols: RCC2 Molecular weight: 56,085 Da Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TD-60

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S16-p	AAWEEPSsGNGtARA
0	9		T20-p	EPSsGNGtARAGPRk
0	1		K27-u	tARAGPRkRGGPAGR
0	4		S43-p	RERPERCssssGGGs
0	3		S44-p	ERPERCssssGGGss
0	4		S45-p	RPERCssssGGGssG
0	5		S46-p	PERCssssGGGssGD
0	13		S50-p	ssssGGGssGDEDGL
0	14		S51-p	sssGGGssGDEDGLE
0	1		T74-p	KRAARPAtAGKAGGA
0	1		T91-p	VITEPEHtkERVKLE
0	1		K92-a	ITEPEHtkERVKLEG
0	1		K92-u	ITEPEHtkERVKLEG
0	1		K170-u	LLITTEGkLWSWGRN
0	1		K179-u	WSWGRNEkGQLGHGD
0	19		Y276-p	MDCKGNLysFGCPEy
0	1		S277-p	DCKGNLysFGCPEyG
0	16		Y283-p	ysFGCPEyGQLGHNs
0	23		S290-p	yGQLGHNsDGkFIAR
0	15		K293-a	LGHNsDGkFIARAQR
0	6		K320-u	AIFIEKTkDGQILPV
0	1		T342-p	VACGANHtLVLDsQk
0	2		S347-p	NHtLVLDsQkRVFSW
0	6		K349-a	tLVLDsQkRVFSWGF
0	1		K349-u	tLVLDsQkRVFSWGF
0	12		Y359-p	FSWGFGGyGRLGHAE
0	2		K368-u	RLGHAEQkDEMVPRL
0	6		K377-a	EMVPRLVkLFDFPGR
0	10		K377-u	EMVPRLVkLFDFPGR
0	1		T473-p	DHKPKSStAAQEVkT
0	6		K479-u	StAAQEVkTLDGIFS

	mouse
S14	AAWEEPSSGNGTARA
T18	EPSSGNGTARAGPRR
R25	TARAGPRRRGGPAGR
S41-p	RERPERCssssGGGs
S42-p	ERPERCssssGGGss
S43-p	RPERCssssGGGssG
S44-p	PERCssssGGGssGD
S48-p	ssssGGGssGDEDGP
S49-p	sssGGGssGDEDGPE
T72	KRTARPATAGKAAGA
T89	IITEPEHTKERVKLE
K90	ITEPEHTKERVKLEG
K90	ITEPEHTKERVKLEG
K168	LLITTEGKLWSWGRN
K177	WSWGRNEKGQLGHGD
Y274	MDCKGNLYSFGCPEY
S275	DCKGNLYSFGCPEYG
Y281	YSFGCPEYGQLGHNS
S288	YGQLGHNSDGKFIAR
K291	LGHNSDGKFIARAQR
K318	AIFIEKTKDGQILPV
T340	VACGANHTLVLDSQK
S345	NHTLVLDSQKRVFSW
K347	TLVLDSQKRVFSWGF
K347	TLVLDSQKRVFSWGF
Y357-p	FSWGFGGyGRLGHAE
K366	RLGHAEQKDEMVPRL
K375	EMVPRLVKLFDFPGR
K375	EMVPRLVKLFDFPGR
T471	DHKPKSSTAAQEVKT
K477	STAAQEVKTLDGIFS

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