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Protein Page:
TD-60 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TD-60 Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1. Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules. Note: This description may include information from UniProtKB.
Protein type: GEFs, misc.; GEFs; Nucleolus
Cellular Component: microtubule; nucleolus; midbody; cytosol
Molecular Function: protein binding; microtubule binding; Rac GTPase binding
Biological Process: focal adhesion formation; integrin-mediated signaling pathway; mitosis; endosome organization and biogenesis; negative regulation of focal adhesion formation; positive regulation of attachment of spindle microtubules to kinetochore; mitotic cell cycle; regulation of cell migration
Reference #:  Q9P258 (UniProtKB)
Alt. Names/Synonyms: DKFZp762N0610; KIAA1470; Protein RCC2; RCC1-like protein TD-60; RCC2; regulator of chromosome condensation 2; TD-60; TD60; Telophase disk protein of 60 kDa
Gene Symbols: RCC2
Molecular weight: 56,085 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TD-60

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S16-p AAWEEPSsGNGtARA
0 10 T20-p EPSsGNGtARAGPRk
0 1 K27-ub tARAGPRkrGGPAGR
0 1 R28-m1 ARAGPRkrGGPAGRK
0 4 S43-p RERPERCssssGGGs
0 3 S44-p ERPERCssssGGGss
0 4 S45-p RPERCssssGGGssG
0 6 S46-p PERCssssGGGssGD
0 16 S50-p ssssGGGssGDEDGL
0 17 S51-p sssGGGssGDEDGLE
0 1 T74-p KRAARPAtAGKAGGA
0 1 T91-p VITEPEHtkERVKLE
0 2 K92-ac ITEPEHtkERVKLEG
0 1 K92-ub ITEPEHtkERVKLEG
0 1 K170-ub LLITTEGkLWSWGRN
0 1 K179-ub WSWGRNEkGQLGHGD
0 19 Y276-p MDCKGNLysFGCPEy
0 1 S277-p DCKGNLysFGCPEyG
0 17 Y283-p ysFGCPEyGQLGHNs
0 23 S290-p yGQLGHNsDGkFIAR
0 16 K293-ac LGHNsDGkFIARAQR
0 1 T319-p VAIFIEKtkDGQILP
0 6 K320-ub AIFIEKtkDGQILPV
0 1 T342-p VACGANHtLVLDsQk
0 2 S347-p NHtLVLDsQkRVFSW
0 6 K349-ac tLVLDsQkRVFSWGF
0 1 K349-ub tLVLDsQkRVFSWGF
0 12 Y359-p FSWGFGGyGRLGHAE
0 2 K368-ub RLGHAEQkDEMVPRL
0 7 K377-ac EMVPRLVkLFDFPGR
0 10 K377-ub EMVPRLVkLFDFPGR
0 1 K422-ac RESTMYPkAVQDLCG
0 1 T473-p DHKPKSStAAQEVkT
0 6 K479-ub StAAQEVkTLDGIFS
0 6 T521-p LPEYNPRtL______
  mouse

 
S14 AAWEEPSSGNGTARA
T18 EPSSGNGTARAGPRR
R25 TARAGPRRRGGPAGR
R26 ARAGPRRRGGPAGRK
S41-p RERPERCssssGGGs
S42-p ERPERCssssGGGss
S43-p RPERCssssGGGssG
S44-p PERCssssGGGssGD
S48-p ssssGGGssGDEDGP
S49-p sssGGGssGDEDGPE
T72 KRTARPATAGKAAGA
T89 IITEPEHTKERVKLE
K90 ITEPEHTKERVKLEG
K90 ITEPEHTKERVKLEG
K168 LLITTEGKLWSWGRN
K177 WSWGRNEKGQLGHGD
Y274 MDCKGNLYSFGCPEY
S275 DCKGNLYSFGCPEYG
Y281 YSFGCPEYGQLGHNS
S288 YGQLGHNSDGKFIAR
K291 LGHNSDGKFIARAQR
T317 VAIFIEKTKDGQILP
K318 AIFIEKTKDGQILPV
T340 VACGANHTLVLDSQK
S345 NHTLVLDSQKRVFSW
K347 TLVLDSQKRVFSWGF
K347 TLVLDSQKRVFSWGF
Y357-p FSWGFGGyGRLGHAE
K366 RLGHAEQKDEMVPRL
K375 EMVPRLVKLFDFPGR
K375 EMVPRLVKLFDFPGR
K420 RESTMYPKAVQDLCG
T471 DHKPKSSTAAQEVKT
K477 STAAQEVKTLDGIFS
T519 LPEYTPRTL______
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