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CDKN2C (human)

Overview CDKN2C Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit; Kinase, protein Cellular Component: cytoplasm; cytosol; nucleus Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein kinase binding Biological Process: negative regulation of cell proliferation; induction of apoptosis; negative regulation of phosphorylation; oligodendrocyte differentiation; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; negative regulation of cell growth; G1 phase of mitotic cell cycle; cell cycle arrest; G1/S transition of mitotic cell cycle Reference #:  P42773 (UniProtKB) Alt. Names/Synonyms: CDK6 inhibitor p18; CDKN2C; CDKN6; CDN2C; cyclin-dependent inhibitor; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase 6 inhibitor p18; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); INK4C; p18; p18-INK4c; p18-INK6 Gene Symbols: CDKN2C Molecular weight: 18,127 Da Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDKN2C 1BU9 - A=1-168 (human) 1IHB - A/B=1-162 (human) 1MX2 - A/B=1-168 (human) 1MX4 - A/B=1-168 (human) 1MX6 - A/B=1-168 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1BU9 1G3N 1IHB 1MX2 1MX4 1MX6  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	5		K46-u	RTALQVMkLGNPEIA
0	1		K66-u	RGANPDLkDRTGFAV
1	0		K112	LPLHLAAKEGHLRVV
0	4		K136-u	NVGHRNHkGDTACDL

	mouse
K46-u	RTALQVMkLGNPEIA
K66	RGANPNLKDGTGFAV
K112-u	LPLHLAAkEGHLPVV
K136	NVGHRNHKGDTAFDL

	rat
K46	RTALQVMKLGNPEIA
K66	RGANPNLKDRTGFAV
K112	LPLHLAAKEGHLPVV
K136	NVGHRNHKGDTAFDL

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