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Protein Page:
CDKN2C (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDKN2C Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit; Cell cycle regulation; Inhibitor protein
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding
Biological Process: negative regulation of cell proliferation; oligodendrocyte differentiation; negative regulation of phosphorylation; mitotic cell cycle; negative regulation of cell growth; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G1/S transition of mitotic cell cycle
Reference #:  P42773 (UniProtKB)
Alt. Names/Synonyms: CDK6 inhibitor p18; CDKN2C; CDKN6; CDN2C; cyclin-dependent inhibitor; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase 6 inhibitor p18; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); INK4C; p18; p18-INK4c; p18-INK6
Gene Symbols: CDKN2C
Molecular weight: 18,127 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDKN2C

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 5 K46-ub RTALQVMkLGNPEIA
0 1 K66-ub RGANPDLkDRTGFAV
1 0 K112 LPLHLAAKEGHLRVV
0 4 K136-ub NVGHRNHkGDTACDL
  mouse

 
K46-ub RTALQVMkLGNPEIA
K66 RGANPNLKDGTGFAV
K112-ub LPLHLAAkEGHLPVV
K136 NVGHRNHKGDTAFDL
  rat

 
K46 RTALQVMKLGNPEIA
K66 RGANPNLKDRTGFAV
K112 LPLHLAAKEGHLPVV
K136 NVGHRNHKGDTAFDL
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