Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Inhibitor protein; Protein kinase, regulatory subunit; Kinase, protein
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein kinase binding
Biological Process: negative regulation of cell proliferation; induction of apoptosis; negative regulation of phosphorylation; oligodendrocyte differentiation; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; negative regulation of cell growth; G1 phase of mitotic cell cycle; cell cycle arrest; G1/S transition of mitotic cell cycle
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.