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Protein Page:
Nna1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Nna1 Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Interacts with MYLK. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.17.-; Protease
Cellular Component: mitochondrion; cytosol; nucleus
Molecular Function: tubulin binding; zinc ion binding; metallocarboxypeptidase activity
Biological Process: mitochondrion organization and biogenesis; neurotransmitter metabolic process; retina development in camera-type eye; olfactory bulb development; neuromuscular process; cerebellar Purkinje cell differentiation; eye photoreceptor cell differentiation; proteolysis; adult walking behavior
Reference #:  Q9UPW5 (UniProtKB)
Alt. Names/Synonyms: AGTPBP1; ATP/GTP binding protein 1; ATP/GTP-binding protein 1; CBPC1; CCP1; Cytosolic carboxypeptidase 1; DKFZp686M20191; KIAA1035; Nervous system nuclear protein induced by axotomy; NNA1
Gene Symbols: AGTPBP1
Molecular weight: 138,448 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Nna1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K44-ub TARYVTSkILHLAQS
0 2 T60-p EKTRREMtAKGstGM
0 1 S64-p REMtAKGstGMEILL
0 1 T65-p EMtAKGstGMEILLS
0 1 S213-p FKIIGPFsKKNSSLI
0 1 K232-ub DTLAALLkSKTNARR
0 1 S278-p GILQSLKsVtNIKLG
0 1 T280-p LQSLKsVtNIKLGRK
0 2 Y826 GGQKGKSYYTITFTV
0 2 Y827 GQKGKSYYTITFTVN
0 1 R1121-m2 KGLQIGTrELEEMGA
0 14 S1168-p ESSCKVTsPTTYVLD
0 2 Y1206-p LAENVGDyEPSAQEE
  mouse

 
K44 TARYVTSKILHLAQS
T60 EKTRREMTTKGSTGM
S64 REMTTKGSTGMEVLL
T65 EMTTKGSTGMEVLLS
S213 FKIIGPFSKKNSGLM
K232 DTLAALLKSKTNARR
S278 GILQSLKSVTNIKLG
T280 LQSLKSVTNIKLGRK
Y818 GGQKGKSYYTITFTV
Y819 GQKGKSYYTITFTVN
R1113 KGLQIGTRELEEMGA
S1160-p ESSCKVTsPTTYVLD
Y1198 LAENTGDYEPSAQEE
  rat

 
K44 TARHVTSKILHLAQS
T60 EKTRREMTTKGSTGM
S64 REMTTKGSTGMEVLL
T65 EMTTKGSTGMEVLLS
S213 FKIIGPFSKKNSGLM
K232 DTLAALLKSKTNARR
S278 GILQSLKSVTNIKLG
T280 LQSLKSVTNIKLGRK
Y819-p GGQKGKSyyTITFTV
Y820-p GQKGKSyyTITFTVV
R1114 KGLQIGTRELEEMGA
S1161-p ESSCKVTsPTTYVLD
Y1199 LAENTGDYEPSAQDE
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