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Nna1 (human)

Overview Nna1 Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Interacts with MYLK. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protease; EC 3.4.17.- Cellular Component: mitochondrion; cytosol; nucleus Molecular Function: tubulin binding; zinc ion binding; metallocarboxypeptidase activity Biological Process: mitochondrion organization and biogenesis; neurotransmitter metabolic process; retina development in camera-type eye; olfactory bulb development; neuromuscular process; cerebellar Purkinje cell differentiation; proteolysis; eye photoreceptor cell differentiation; adult walking behavior Reference #:  Q9UPW5 (UniProtKB) Alt. Names/Synonyms: AGTPBP1; ATP/GTP binding protein 1; ATP/GTP-binding protein 1; CBPC1; CCP1; Cytosolic carboxypeptidase 1; DKFZp686M20191; KIAA1035; Nervous system nuclear protein induced by axotomy; NNA1 Gene Symbols: AGTPBP1 Molecular weight: 138,448 Da Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Nna1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K44-u	TARYVTSkILHLAQS
0	2		T60-p	EKTRREMtAKGstGM
0	1		S64-p	REMtAKGstGMEILL
0	1		T65-p	EMtAKGstGMEILLS
0	1		S213-p	FKIIGPFsKKNSSLI
0	1		K232-u	DTLAALLkSKTNARR
0	1		S278-p	GILQSLKsVtNIKLG
0	1		T280-p	LQSLKsVtNIKLGRK
0	2		Y826	GGQKGKSYYTITFTV
0	2		Y827	GQKGKSYYTITFTVN
0	1		R1121-m2	KGLQIGTrELEEMGA
0	10		S1168-p	ESSCKVTsPTTYVLD
0	3		Y1206-p	LAENVGDyEPSAQEE

	mouse
K44	TARYVTSKILHLAQS
T60	EKTRREMTTKGSTGM
S64	REMTTKGSTGMEVLL
T65	EMTTKGSTGMEVLLS
S213	FKIIGPFSKKNSGLM
K232	DTLAALLKSKTNARR
S278	GILQSLKSVTNIKLG
T280	LQSLKSVTNIKLGRK
Y818	GGQKGKSYYTITFTV
Y819	GQKGKSYYTITFTVN
R1113	KGLQIGTRELEEMGA
S1160-p	ESSCKVTsPTTYVLD
Y1198	LAENTGDYEPSAQEE

	rat
K44	TARHVTSKILHLAQS
T60	EKTRREMTTKGSTGM
S64	REMTTKGSTGMEVLL
T65	EMTTKGSTGMEVLLS
S213	FKIIGPFSKKNSGLM
K232	DTLAALLKSKTNARR
S278	GILQSLKSVTNIKLG
T280	LQSLKSVTNIKLGRK
Y819-p	GGQKGKSyyTITFTV
Y820-p	GQKGKSyyTITFTVV
R1114	KGLQIGTRELEEMGA
S1161	ESSCKVTSPTTYVLD
Y1199	LAENTGDYEPSAQDE

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