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Protein Page:
MYST4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MYST4 Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. A chromosomal aberration involving KAT6B may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP. Defects in KAT6B are a cause of Ohdo syndrome, SBBYS variant (SBBYSS). SBBYSS is a syndrome characterized by distinctive facial appearance with severe blepharophimosis, an immobile mask-like face, a bulbous nasal tip, and a small mouth with a thin upper lip. The condition presents in infancy with severe hypotonia and feeding problems. Associated skeletal problems include joint laxity, abnormally long thumbs and great toes, and dislocated or hypoplastic patellae. Structural cardiac defects are present in around 50% of cases, and dental anomalies, including small and pointed teeth, are common. Many affected individuals have abnormalities of thyroid structure or function. SBBYSS is usually associated with severe mental retardation, delayed motor milestones, and significantly impaired speech. Defects in KAT6B are a cause of genitopatellar syndrome (GTPTS). GTPTS is a rare disorder consisting of microcephaly, severe psychomotor retardation, and characteristic coarse facial features, including broad nose and small or retracted chin, associated with congenital flexion contractures of the lower extremities, abnormal or missing patellae, and urogenital anomalies. Belongs to the MYST (SAS/MOZ) family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.1.-; Acetyltransferase; EC 2.3.1.48
Cellular Component: nucleoplasm; nucleosome; nucleus
Molecular Function: protein binding; histone acetyltransferase activity; DNA binding; zinc ion binding; acetyltransferase activity; transcription factor binding
Biological Process: nucleosome assembly; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone acetylation; negative regulation of transcription, DNA-dependent
Reference #:  Q8WYB5 (UniProtKB)
Alt. Names/Synonyms: DKFZp313G1618; FLJ90335; Histone acetyltransferase MORF; Histone acetyltransferase MOZ2; Histone acetyltransferase MYST4; KAT6B; KIAA0383; Monocytic leukemia zinc finger protein-related factor; MORF; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MOZ-related factor; MOZ2; MYST histone acetyltransferase (monocytic leukemia) 4; MYST-4; MYST4; qkf; querkopf
Gene Symbols: KAT6B
Molecular weight: 231,378 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs
Select Structure to View Below

MYST4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K127-ub EPNGSSLkNIEKYLR
0 1 K131 SSLkNIEKYLRSQSD
0 1 S217-p ADPIPICsFCLGtKE
0 1 T222-p ICsFCLGtKESNREK
0 2 S355-p KLKQRLLsVTSDEGS
0 2 T367-p EGSMNAFtGRGSPGr
0 1 R374-m2 tGRGSPGrGQKTKVC
0 1 S391-p PSSGHAAsGKDSSSR
0 1 T402-p SSSRLAVtDPTRPGA
0 1 K412-ac TRPGATTkITTtsty
0 1 T416-p ATTkITTtstyISAS
0 1 S417-p TTkITTtstyISAST
0 1 T418-p TkITTtstyISASTL
0 1 Y419-p kITTtstyISASTLK
0 2 K440-ac GLIDGLTkFFtPSPD
0 3 T443-p DGLTkFFtPSPDGRR
0 1 K584-ac LSSTAKSkAHFFGkR
0 1 K590-ac SkAHFFGkRDIRSRF
0 1 K615-ac MARGSIFkAIAHFKR
0 1 T640-p GRLKYKVtPQMGtPs
0 2 T645-p KVtPQMGtPsPGKGs
0 3 S647-p tPQMGtPsPGKGsLt
0 2 S652-p tPsPGKGsLtDGRIK
0 1 T654-p sPGKGsLtDGRIKPD
0 1 Y728-p SVIEFGKyEIQTWyS
0 1 Y734-p KyEIQTWySSPyPQE
0 1 Y738-p QTWySSPyPQEYARL
0 1 Y757-p LCEFCLKyMKSKNIL
0 1 K785-ub ANEIYRRkDLSVFEV
0 9 K815-ac AKLFLDHkTLYYDVE
0 1 Y818 FLDHkTLYYDVEPFL
0 1 Y827 DVEPFLFYVLTKNDE
0 1 K845 HLVGYFSKEKLCQQK
1 1 Y878-p RFLIDFSyLLSRREG
0 1 S1027-p KEEQEILsTRANSRQ
0 89 K1038-ac NSRQSPAkVQSkNkY
0 89 K1042-ac SPAkVQSkNkYLHsP
0 2 K1044-ac AkVQSkNkYLHsPEs
0 48 S1048-p SkNkYLHsPEsRPVT
0 8 S1051-p kYLHsPEsRPVTGER
0 1 T1114-p QSSPPRLtKPQSVAI
0 1 R1265-m1 KWRQNKErKTGFKLN
0 1 T1275 GFKLNLYTPPETPME
0 1 S1296 VEEQKETSEGKTSPs
0 8 S1303-p SEGKTSPsPIRIEEE
0 1 S1338 APVSPNTSPGEKPED
0 3 S1502-p DPEAVPEsDEEPPPG
0 1 T1877 GGPQAQATMTPPPNL
0 1 T1879 PQAQATMTPPPNLTP
0 1 T1885 MTPPPNLTPPPMNLP
0 1 S1903-p LQRNMAAsNIGISHS
0 1 S1924-p IASKGHIsMRTKSAS
0 1 S1933-p RTKSASLsPAAATHQ
0 1 S1947-p QSQIYGRsQTVAMQG
  mouse

 
K128 EPNGSSLKNIEKYLR
K132 SSLKNIEKYLRSQSD
S218 ADPIPICSFCLGTKE
T223 ICSFCLGTKESNREK
S356 KLKQRLLSVTSDEGS
T368 EGSMSAFTGRGSPGR
R375 TGRGSPGRGQKTKVS
S392 PSSGHAASGKHSSSR
T403 SSSRLAVTDPTRPGA
K413 TRPGATTKTTTSSTY
S417 ATTKTTTSSTYISAS
S418 TTKTTTSSTYISAST
T419 TKTTTSSTYISASTL
Y420 KTTTSSTYISASTLK
K441 GLIDGLTKFFTPSPD
T444 DGLTKFFTPSPDGRR
- gap
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Y546 SVIEFGKYEIQTWYS
Y552 KYEIQTWYSSPYPQE
Y556 QTWYSSPYPQEYARL
Y575 LCEFCLKYMKSKNIL
K603 ANEIYRRKDLSVFEV
K633 AKLFLDHKTLyYDVE
Y636-p FLDHKTLyYDVEPFL
Y645-p DVEPFLFyVLTKNDE
K663-ac HLVGYFSkEKLCQQK
Y696 RFLIDFSYLLSRREG
S845 KEEQEILSSRVSSRQ
K856-ac SSRQSSAkVQSkNKY
K860-ac SSAkVQSkNKYLHSP
K862 AkVQSkNKYLHSPER
S866 SkNKYLHSPERRPVA
R869 KYLHSPERRPVAGER
T918 QTSPPRLTKPQSVSI
R1069 KWKQSKERKTGFKLN
T1079-p GFKLNLYtPPETPME
S1100-p IEEQKELsEDKGsPV
S1105-p ELsEDKGsPVGMERE
S1140-p IPVSPHKsPGGKVDE
S1302-p DTGTAPEsDAEPPEE
T1676-p GGPQAQAtMtPPPNL
T1678-p PQAQAtMtPPPNLtP
T1684-p MtPPPNLtPPPMNLP
S1702 LQRNMAASNIGISHS
S1723 IASKGHVSMRTKAAS
S1732 RTKAASLSPAAATHQ
S1746 QSQIYGRSQTVAMQG
  rat

 
K128 EPSGSSLKSIEkYLR
K132-ub SSLKSIEkYLRSQSD
S218 ADPIPICSFCLGTKE
T223 ICSFCLGTKESNREK
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- under review  
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