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Protein Page:
JMJD1B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
JMJD1B a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.14.11.-; Demethylase
Cellular Component: nucleus
Molecular Function: dioxygenase activity; metal ion binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification
Reference #:  Q7LBC6 (UniProtKB)
Alt. Names/Synonyms: 5qNCA; C5orf7; JHDM2B; JmjC domain-containing histone demethylation protein 2B; JMJD1B; jumonji domain containing 1B; Jumonji domain-containing protein 1B; KDM3B; KIAA1082; lysine (K)-specific demethylase 3B; Lysine-specific demethylase 3B; NET22; Nuclear protein 5qNCA
Gene Symbols: KDM3B
Molecular weight: 191,581 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S241 TESGEIKSVDPRLIH
0 1 I247 KSVDPRLIHVMLMDN
0 1 N254 IHVMLMDNSAPQSEG
0 3 T263-p APQSEGGtLKAVKSS
0 3 S278-p KGKKKREsIEGKDGR
0 8 S289-p KDGRRRKsAsDSGCD
0 2 S291-p GRRRKsAsDSGCDPA
0 32 K300-a SGCDPASkKLKGDRG
0 1 S311-p GDRGEVDsNGsDGGE
0 2 S314-p GEVDsNGsDGGEASR
0 1 R355-m1 PQINRNIrFAtYTkE
0 2 T358-p NRNIrFAtYTkENGR
0 1 K361-a IrFAtYTkENGRTLV
0 1 S492-p FGSGRSQsNGVLATE
0 1 S546 YFTTVSESLADDsss
0 2 S551-p SESLADDsssRDsFK
0 3 S552-p ESLADDsssRDsFKQ
0 8 S553-p SLADDsssRDsFKQs
0 12 S556-p DDsssRDsFKQsLES
0 3 S560-p sRDsFKQsLESLSSG
0 1 S573-p SGLCKGRsVLGTDTK
0 17 T602-p AESMPTLtPAFPRsL
0 1 S608-p LtPAFPRsLLNARtP
0 16 T614-p RsLLNARtPENHENL
0 1 T696 KKPLFITTDSSKLVS
0 3 S725-p SAMGNGRssSPtssL
0 1 S726-p AMGNGRssSPtssLt
0 4 T729-p NGRssSPtssLtQPI
0 1 S730-p GRssSPtssLtQPIE
0 2 S731-p RssSPtssLtQPIEM
0 3 T733-p sSPtssLtQPIEMPt
0 3 T740-p tQPIEMPtLSSsPTE
0 1 S742 PIEMPtLSSsPTEER
0 5 S744-p EMPtLSSsPTEERPT
0 1 T746 PtLSSsPTEERPTVG
0 2 T751 sPTEERPTVGPGQQD
0 2 S766-p NPLLKTFsNVFGRHs
0 43 S773-p sNVFGRHsGGFLssP
0 13 S778-p RHsGGFLssPADFsQ
0 36 S779-p HsGGFLssPADFsQE
0 5 S784-p LssPADFsQENKAPF
0 8 S798-p FEAVKRFsLDERSLA
0 1 K1193-u IRSEEPLkTDSSASN
0 2 K1249-u SLRSVLNkEsHsPFG
0 1 S1251-p RSVLNkEsHsPFGLD
0 20 S1253-p VLNkEsHsPFGLDsF
0 2 S1259-p HsPFGLDsFNSTAKV
0 5 S1267-p FNSTAKVsPLtPkLF
0 5 T1270-p TAKVsPLtPkLFNSL
0 3 K1272-u KVsPLtPkLFNSLLL
0 2 K1287-u GPTASNNkTEGSSLR
0 4 S1299-p SLRDLLHsGPGkLPQ
0 2 K1303-u LLHsGPGkLPQtPLD
0 27 T1307-p GPGkLPQtPLDtGIP
0 2 T1311-p LPQtPLDtGIPFPPV
0 2 K1327-u STSSAGVkSKASLPN
0 1 K1516-u LPLPEYTkRDGRLNL
0 1 K1600-u GDADEVTkQRIHDGK
  mouse

 
S242-p TETGEVKsVDPRLtH
T248-p KsVDPRLtHVMLMDs
S255-p tHVMLMDsSTPQSEG
T264-p TPQSEGGtIKAVKSS
S279-p KGKKKREsIEGRDGR
S290-p RDGRRRKsASDSGCD
S292 GRRRKsASDSGCDPA
K301 SGCDPATKKLKGDRG
S312 GDRGEVDSNGSDGGE
S315 GEVDSNGSDGGEASR
R356 PQINRNIRFATYTKE
T359 NRNIRFATYTKENGR
K362 IRFATYTKENGRTLV
S493 FGSGRSQSNGVLATD
S547-p YLSRVSEsVADDsss
S552-p SEsVADDsssRDsFT
S553-p EsVADDsssRDsFTQ
S554-p sVADDsssRDsFTQs
S557-p DDsssRDsFTQsLES
S561-p sRDsFTQsLESLTSG
S574 SGLCKGRSVLGADTQ
T603 AESMPTLTPAFPRSL
S609 LTPAFPRSLLNTRTP
T615 RSLLNTRTPENHENL
T697-gl KKPLFITtDSSKLVS
S726-p SAVGNGRssSPtNsL
S727-p AVGNGRssSPtNsLt
T730-p NGRssSPtNsLtQPI
N731 GRssSPtNsLtQPIE
S732-p RssSPtNsLtQPIEM
T734-p sSPtNsLtQPIEMPt
T741-p tQPIEMPtLsSsPtE
S743-p PIEMPtLsSsPtEER
S745-p EMPtLsSsPtEERPt
T747-p PtLsSsPtEERPtVG
T752-p sPtEERPtVGPGQQD
S767 NPLLKTFSTVFGRHS
S774 STVFGRHSGSFLSAP
S779 RHSGSFLSAPAEFAQ
A780 HSGSFLSAPAEFAQE
A785 LSAPAEFAQENKAPF
S799-p FEAVKRFsLDERSLA
K1194 GRSEEPLKAEGSASN
K1250 SLRSVLNKESHsPFG
S1252 RSVLNKESHsPFGLD
S1254-p VLNKESHsPFGLDSF
S1260 HsPFGLDSFNSTAKV
S1268-p FNSTAKVsPLtPkLF
T1271-p TAKVsPLtPkLFNSL
K1273-u KVsPLtPkLFNSLLL
K1288-u GPTASNSkTEGSSLR
S1300 SLRDLLHSGPGKLPQ
K1304 LLHSGPGKLPQTPLD
T1308 GPGKLPQTPLDTGIP
T1312 LPQTPLDTGIPFPPV
K1328 SSSSAVAKSKASLPD
K1517 LPLPEYTKRDGRLNL
K1601 GDADEVTKQRIHDGK
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