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Protein Page:
JMJD1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JMJD1B a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Demethylase; EC 1.14.11.-
Cellular Component: nucleus
Molecular Function: dioxygenase activity; metal ion binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification
Reference #:  Q7LBC6 (UniProtKB)
Alt. Names/Synonyms: 5qNCA; C5orf7; JHDM2B; JmjC domain-containing histone demethylation protein 2B; JMJD1B; jumonji domain containing 1B; Jumonji domain-containing protein 1B; KDM3B; KIAA1082; lysine (K)-specific demethylase 3B; Lysine-specific demethylase 3B; NET22; Nuclear protein 5qNCA
Gene Symbols: KDM3B
Molecular weight: 191,581 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD1B

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S241 TESGEIKSVDPRLIH
0 1 I247 KSVDPRLIHVMLMDN
0 1 N254 IHVMLMDNSAPQSEG
0 3 T263-p APQSEGGtLKAVKSS
0 3 S278-p KGKKKREsIEGKDGR
0 8 S289-p KDGRRRKsAsDSGCD
0 3 S291-p GRRRKsAsDSGCDPA
0 1 S299-p DSGCDPAskKLKGDR
0 32 K300-ac SGCDPAskKLKGDRG
0 2 S311-p GDRGEVDsNGsDGGE
0 3 S314-p GEVDsNGsDGGEAsR
0 1 S320-p GsDGGEAsRGPWKGG
0 1 R355-m1 PQINRNIrFAtYTkE
0 2 T358-p NRNIrFAtYTkENGR
0 1 K361-ac IrFAtYTkENGRTLV
0 1 T378-p DEPVGGDtPASFtPY
0 1 T383-p GDtPASFtPYSTATG
0 1 S437-p TPNTVRIsDtGLAAG
0 2 T439-p NTVRIsDtGLAAGTV
0 1 S480-p GAPLPSSsQPLtFGs
0 1 T484-p PSSsQPLtFGsGRSQ
0 1 S487-p sQPLtFGsGRSQsNG
0 1 S492-p FGsGRSQsNGVLATE
0 1 K501-ac GVLATENkPLGFSFG
0 1 S546 YFTTVSESLADDsss
0 2 S551-p SESLADDsssRDsFK
0 3 S552-p ESLADDsssRDsFKQ
0 8 S553-p SLADDsssRDsFKQs
0 12 S556-p DDsssRDsFKQsLES
0 3 S560-p sRDsFKQsLESLSSG
0 1 S573-p SGLCKGRsVLGTDtK
0 1 T579-p RsVLGTDtKPGSKAG
0 1 S588-p PGSKAGSsVDRKVPA
0 17 T602-p AESMPTLtPAFPRsL
0 1 S608-p LtPAFPRsLLNARtP
0 16 T614-p RsLLNARtPENHENL
0 1 S647-p FVEKVEHsPFSSFAS
0 1 T696 KKPLFITTDSSKLVs
0 2 S703-p TDSSKLVsGVLGsAL
0 1 S708-p LVsGVLGsALtSGGP
0 1 T711-p GVLGsALtSGGPSLS
0 1 G714 GsALtSGGPSLSAMG
0 1 S716 ALtSGGPSLSAMGNG
0 3 S725-p SAMGNGRssSPtssL
0 1 S726-p AMGNGRssSPtssLt
0 5 T729-p NGRssSPtssLtQPI
0 1 S730-p GRssSPtssLtQPIE
0 2 S731-p RssSPtssLtQPIEM
0 3 T733-p sSPtssLtQPIEMPt
0 3 T740-p tQPIEMPtLSSsPtE
0 1 S742 PIEMPtLSSsPtEER
0 5 S744-p EMPtLSSsPtEERPT
0 1 T746-p PtLSSsPtEERPTVG
0 3 T751 sPtEERPTVGPGQQD
0 2 S766-p NPLLKTFsNVFGRHs
0 44 S773-p sNVFGRHsGGFLssP
0 13 S778-p RHsGGFLssPADFsQ
0 37 S779-p HsGGFLssPADFsQE
0 6 S784-p LssPADFsQENKAPF
0 9 S798-p FEAVKRFsLDERSLA
0 1 K1193-ub IRSEEPLktDssAsN
0 1 T1194-p RSEEPLktDssAsNS
0 1 S1196-p EEPLktDssAsNSNs
0 1 S1197-p EPLktDssAsNSNsE
0 1 S1199-p LktDssAsNSNsELK
0 1 S1203-p ssAsNSNsELKAIRP
0 1 S1245-p KEAGSLRsVLNkEsH
0 2 K1249-ub SLRsVLNkEsHsPFG
0 2 S1251-p RsVLNkEsHsPFGLD
0 20 S1253-p VLNkEsHsPFGLDsF
0 3 S1259-p HsPFGLDsFNstAkV
0 1 S1262-p FGLDsFNstAkVsPL
0 1 T1263-p GLDsFNstAkVsPLt
0 1 K1265-ub DsFNstAkVsPLtPk
0 6 S1267-p FNstAkVsPLtPkLF
0 6 T1270-p tAkVsPLtPkLFNsL
0 3 K1272-ub kVsPLtPkLFNsLLL
0 1 S1276-p LtPkLFNsLLLGPTA
0 2 K1287-ub GPTASNNktEGSSLR
0 1 T1288-p PTASNNktEGSSLRD
0 4 S1299-p SLRDLLHsGPGkLPQ
0 2 K1303-ub LLHsGPGkLPQtPLD
0 27 T1307-p GPGkLPQtPLDtGIP
0 2 T1311-p LPQtPLDtGIPFPPV
0 2 K1327-ub STSSAGVkSkAsLPN
0 1 K1329-ub SSAGVkSkAsLPNFL
0 1 S1331-p AGVkSkAsLPNFLDH
0 1 K1347-ub IASVVENkKTSDASK
0 1 K1516-ub LPLPEYTkRDGRLNL
0 1 K1600-ub GDADEVTkQRIHDGK
0 1 K1752-m2 KDAVGTLkAHESKLA
  mouse

► Hide Isoforms
 
S242 TETGEVKSVDPRLTH
T248 KSVDPRLTHVMLMDS
S255 THVMLMDSSTPQSEN
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S281 GVSLSSLSQPLTFGS
T285 SSLSQPLTFGSGRSQ
S288 SQPLTFGSGRSQSNG
S293 FGSGRSQSNGVLATD
K302 GVLATDNKPLGFSFS
S347-p YLSRVSEsVADDsss
S352-p SEsVADDsssRDsFT
S353-p EsVADDsssRDsFTQ
S354-p sVADDsssRDsFTQs
S357-p DDsssRDsFTQsLES
S361-p sRDsFTQsLESLTSG
S374 SGLCKGRSVLGADTQ
T380 RSVLGADTQPGPKAG
S389 PGPKAGSSVDRKVPA
T403 AESMPTLTPAFPRSL
S409 LTPAFPRSLLNTRTP
T415 RSLLNTRTPENHENL
S448 FVEKVEHSPFSSFVS
T497-gl KKPLFITtDSSKLVs
S504-p tDSSKLVsGVLGSAL
S509 LVsGVLGSALSTGsP
S512 GVLGSALSTGsPsLS
S515-p GSALSTGsPsLSAVG
S517-p ALSTGsPsLSAVGNG
S526-p SAVGNGRssSPtNsL
S527-p AVGNGRssSPtNsLt
T530-p NGRssSPtNsLtQPI
N531 GRssSPtNsLtQPIE
S532-p RssSPtNsLtQPIEM
T534-p sSPtNsLtQPIEMPt
T541-p tQPIEMPtLsSsPtE
S543-p PIEMPtLsSsPtEER
S545-p EMPtLsSsPtEERPt
T547-p PtLsSsPtEERPtVG
T552-p sPtEERPtVGPGQQD
S567 NPLLKTFSTVFGRHS
S574 STVFGRHSGSFLSAP
S579 RHSGSFLSAPAEFAQ
A580 HSGSFLSAPAEFAQE
A585 LSAPAEFAQENKAPF
S599-p FEAVKRFsLDERSLA
K994 GRSEEPLKAEGSASN
A995 RSEEPLKAEGSASNS
G997 EEPLKAEGSASNSNS
S998 EPLKAEGSASNSNSE
S1000 LKAEGSASNSNSELK
S1004 GSASNSNSELKAIRP
S1046 KDAGSLRSVLNKESH
K1050 SLRSVLNKESHsPFG
S1052 RSVLNKESHsPFGLD
S1054-p VLNKESHsPFGLDSF
S1060 HsPFGLDSFNSTAKV
S1063 FGLDSFNSTAKVsPL
T1064 GLDSFNSTAKVsPLt
K1066 DSFNSTAKVsPLtPk
S1068-p FNSTAKVsPLtPkLF
T1071-p TAKVsPLtPkLFNSL
K1073-ub KVsPLtPkLFNSLLL
S1077 LtPkLFNSLLLGPTA
K1088-ub GPTASNSkTEGSSLR
T1089 PTASNSkTEGSSLRD
S1100 SLRDLLHSGPGKLPQ
K1104 LLHSGPGKLPQTPLD
T1108 GPGKLPQTPLDTGIP
T1112 LPQTPLDTGIPFPPV
K1128 SSSSAVAKSKASLPD
K1130 SSAVAKSKASLPDFL
S1132 AVAKSKASLPDFLDH
K1148 IASVVENKKTSDPSK
K1317 LPLPEYTKRDGRLNL
K1401 GDADEVTKQRIHDGK
K1553 KDAVGTLKAHESKLA
  JMJD1B iso3  
S242-p TETGEVKsVDPRLtH
T248-p KsVDPRLtHVMLMDs
S255-p tHVMLMDsSTPQSEG
T264-p TPQSEGGtIKAVKSS
S279-p KGKKKREsIEGRDGR
S290-p RDGRRRKsASDSGCD
S292 GRRRKsASDSGCDPA
T300 DSGCDPATKKLKGDR
K301 SGCDPATKKLKGDRG
S312 GDRGEVDSNGSDGGE
S315 GEVDSNGSDGGEASR
S321 GSDGGEASRGPWKGG
R356 PQINRNIRFATYTKE
T359 NRNIRFATYTKENGR
K362 IRFATYTKENGRTLV
T379 DEPVGGDTPVPFTPY
T384 GDTPVPFTPYASATG
S438 TPTTVRISDtGLASG
T440-p TTVRISDtGLASGTG
S481 GVSLSSLSQPLTFGS
T485 SSLSQPLTFGSGRSQ
S488 SQPLTFGSGRSQSNG
S493 FGSGRSQSNGVLATD
K502 GVLATDNKPLGFSFS
S547 YLSRVSESVADDSSS
S552 SESVADDSSSRDSFT
S553 ESVADDSSSRDSFTQ
S554 SVADDSSSRDSFTQS
S557 DDSSSRDSFTQSLES
S561 SRDSFTQSLESLTSG
S574 SGLCKGRSVLGADTQ
T580 RSVLGADTQPGPKAG
S589 PGPKAGSSVDRKVPA
T603 AESMPTLTPAFPRSL
S609 LTPAFPRSLLNTRTP
T615 RSLLNTRTPENHENL
S648 FVEKVEHSPFSSFVS
T697 KKPLFITTDSSKLVS
S704 TDSSKLVSGVLGSAL
S709 LVSGVLGSALSTGSP
S712 GVLGSALSTGSPSLS
S715 GSALSTGSPSLSAVG
S717 ALSTGSPSLSAVGNG
S726 SAVGNGRSSSPTNSL
S727 AVGNGRSSSPTNSLT
T730 NGRSSSPTNSLTQPI
N731 GRSSSPTNSLTQPIE
S732 RSSSPTNSLTQPIEM
T734 SSPTNSLTQPIEMPT
T741 TQPIEMPTLSSSPTE
S743 PIEMPTLSSSPTEER
S745 EMPTLSSSPTEERPT
T747 PTLSSSPTEERPTVG
T752 SPTEERPTVGPGQQD
S767 NPLLKTFSTVFGRHS
S774 STVFGRHSGSFLSAP
S779 RHSGSFLSAPAEFAQ
A780 HSGSFLSAPAEFAQE
A785 LSAPAEFAQENKAPF
S799 FEAVKRFSLDERSLA
K1194 GRSEEPLKAEGSASN
A1195 RSEEPLKAEGSASNS
G1197 EEPLKAEGSASNSNS
S1198 EPLKAEGSASNSNSE
S1200 LKAEGSASNSNSELK
S1204 GSASNSNSELKAIRP
S1246 KDAGSLRSVLNKESH
K1250 SLRSVLNKESHSPFG
S1252 RSVLNKESHSPFGLD
S1254 VLNKESHSPFGLDSF
S1260 HSPFGLDSFNSTAKV
S1263 FGLDSFNSTAKVSPL
T1264 GLDSFNSTAKVSPLT
K1266 DSFNSTAKVSPLTPK
S1268 FNSTAKVSPLTPKLF
T1271 TAKVSPLTPKLFNSL
K1273 KVSPLTPKLFNSLLL
S1277 LTPKLFNSLLLGPTA
K1288 GPTASNSKTEGSSLR
T1289 PTASNSKTEGSSLRD
S1300 SLRDLLHSGPGKLPQ
K1304 LLHSGPGKLPQTPLD
T1308 GPGKLPQTPLDTGIP
T1312 LPQTPLDTGIPFPPV
K1328 SSSSAVAKSKASLPD
K1330 SSAVAKSKASLPDFL
S1332 AVAKSKASLPDFLDH
K1348 IASVVENKKTSDPSK
K1517 LPLPEYTKRDGRLNL
K1601 GDADEVTKQRIHDGK
K1753 KDAVGTLKAHESKLA
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