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JMJD1B (human)

Overview JMJD1B a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Oxidoreductase; EC 1.14.11.-; Demethylase Cellular Component: nucleolus; nucleus Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; metal ion binding Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification Reference #:  Q7LBC6 (UniProtKB) Alt. Names/Synonyms: 5qNCA; C5orf7; JHDM2B; JmjC domain-containing histone demethylation protein 2B; JMJD1B; jumonji domain containing 1B; Jumonji domain-containing protein 1B; KDM3B; KIAA1082; lysine (K)-specific demethylase 3B; Lysine-specific demethylase 3B; NET22; Nuclear protein 5qNCA Gene Symbols: KDM3B Molecular weight: 191,581 Da Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states CST Pathways:  Histone Methylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below JMJD1B

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		T263-p	APQSEGGtLKAVKSS
0	1		S278-p	KGKKKREsIEGKDGR
0	7		S289-p	KDGRRRKsAsDSGCD
0	2		S291-p	GRRRKsAsDSGCDPA
0	1		S299-p	DSGCDPAskKLKGDR
0	32		K300-a	SGCDPAskKLKGDRG
0	1		S311-p	GDRGEVDsNGsDGGE
0	1		S314-p	GEVDsNGsDGGEASR
0	2		T358-p	NRNIRFAtYTkENGR
0	1		K361-a	IRFAtYTkENGRTLV
0	1		T378-p	DEPVGGDtPASFtPY
0	1		T383-p	GDtPASFtPYSTATG
0	1		S437-p	TPNTVRIsDtGLAAG
0	1		T439-p	NTVRIsDtGLAAGTV
0	1		S480-p	GAPLPSSsQPLTFGS
0	1		S546	YFTTVSESLADDsss
0	2		S551-p	SESLADDsssRDsFK
0	3		S552-p	ESLADDsssRDsFKQ
0	8		S553-p	SLADDsssRDsFKQs
0	12		S556-p	DDsssRDsFKQsLES
0	2		S560-p	sRDsFKQsLESLSSG
0	1		S573-p	SGLCKGRsVLGTDtK
0	1		T579-p	RsVLGTDtKPGSKAG
0	1		S588-p	PGSKAGSsVDRKVPA
0	17		T602-p	AESMPTLtPAFPRsL
0	1		S608-p	LtPAFPRsLLNARtP
0	15		T614-p	RsLLNARtPENHENL
0	1		T696	KKPLFITTDSSKLVs
0	1		S703-p	TDSSKLVsGVLGsAL
0	1		S708-p	LVsGVLGsALtSGGP
0	1		T711-p	GVLGsALtSGGPSLS
0	1		S725	SAMGNGRSsSPtssL
0	1		S726-p	AMGNGRSsSPtssLt
0	4		T729-p	NGRSsSPtssLtQPI
0	1		S730-p	GRSsSPtssLtQPIE
0	2		S731-p	RSsSPtssLtQPIEM
0	3		T733-p	sSPtssLtQPIEMPt
0	2		T740-p	tQPIEMPtLSSsPTE
0	1		S742	PIEMPtLSSsPTEER
0	4		S744-p	EMPtLSSsPTEERPT
0	1		T746	PtLSSsPTEERPTVG
0	1		T751	sPTEERPTVGPGQQD
0	1		S766-p	NPLLKTFsNVFGRHs
0	41		S773-p	sNVFGRHsGGFLssP
0	12		S778-p	RHsGGFLssPADFsQ
0	34		S779-p	HsGGFLssPADFsQE
0	5		S784-p	LssPADFsQENKAPF
0	5		S798-p	FEAVKRFsLDERSLA
0	1		K1193-u	IRSEEPLktDssAsN
0	1		T1194-p	RSEEPLktDssAsNS
0	1		S1196-p	EEPLktDssAsNSNS
0	1		S1197-p	EPLktDssAsNSNSE
0	1		S1199-p	LktDssAsNSNSELK
0	2		K1249-u	SLRSVLNkEsHsPFG
0	1		S1251-p	RSVLNkEsHsPFGLD
0	18		S1253-p	VLNkEsHsPFGLDsF
0	1		S1259-p	HsPFGLDsFNSTAkV
0	1		K1265-u	DsFNSTAkVsPLtPk
0	4		S1267-p	FNSTAkVsPLtPkLF
0	5		T1270-p	TAkVsPLtPkLFNsL
0	3		K1272-u	kVsPLtPkLFNsLLL
0	1		S1276-p	LtPkLFNsLLLGPTA
0	2		K1287-u	GPTASNNkTEGSSLR
0	4		S1299-p	SLRDLLHsGPGkLPQ
0	2		K1303-u	LLHsGPGkLPQtPLD
0	27		T1307-p	GPGkLPQtPLDtGIP
0	2		T1311-p	LPQtPLDtGIPFPPV
0	2		K1327-u	STSSAGVkSkAsLPN
0	1		K1329-u	SSAGVkSkAsLPNFL
0	1		S1331-p	AGVkSkAsLPNFLDH
0	1		K1347-u	IASVVENkKTSDASK
0	1		K1516-u	LPLPEYTkRDGRLNL
0	1		K1600-u	GDADEVTkQRIHDGK
0	1		K1752-m2	KDAVGTLkAHESKLA

	mouse
T264	TPQSEGGTIKAVKSS
S279-p	KGKKKREsIEGRDGR
S290-p	RDGRRRKsASDSGCD
S292	GRRRKsASDSGCDPA
T300	DSGCDPATKKLKGDR
K301	SGCDPATKKLKGDRG
S312	GDRGEVDSNGSDGGE
S315	GEVDSNGSDGGEASR
T359	NRNIRFATYTKENGR
K362	IRFATYTKENGRTLV
T379	DEPVGGDTPVPFTPY
T384	GDTPVPFTPYASATG
S438	TPTTVRISDTGLASG
T440	TTVRISDTGLASGTG
S481	GVSLSSLSQPLTFGS
S547-p	YLSRVSEsVADDsss
S552-p	SEsVADDsssRDsFT
S553-p	EsVADDsssRDsFTQ
S554-p	sVADDsssRDsFTQs
S557-p	DDsssRDsFTQsLES
S561-p	sRDsFTQsLESLTSG
S574	SGLCKGRSVLGADTQ
T580	RSVLGADTQPGPKAG
S589	PGPKAGSSVDRKVPA
T603	AESMPTLTPAFPRSL
S609	LTPAFPRSLLNTRTP
T615	RSLLNTRTPENHENL
T697-g	KKPLFITtDSSKLVS
S704	tDSSKLVSGVLGSAL
S709	LVSGVLGSALSTGSP
S712	GVLGSALSTGSPSLS
S726-p	SAVGNGRssSPtNsL
S727-p	AVGNGRssSPtNsLt
T730-p	NGRssSPtNsLtQPI
N731	GRssSPtNsLtQPIE
S732-p	RssSPtNsLtQPIEM
T734-p	sSPtNsLtQPIEMPT
T741	tQPIEMPTLsSsPtE
S743-p	PIEMPTLsSsPtEER
S745-p	EMPTLsSsPtEERPt
T747-p	PTLsSsPtEERPtVG
T752-p	sPtEERPtVGPGQQD
S767	NPLLKTFSTVFGRHS
S774	STVFGRHSGSFLSAP
S779	RHSGSFLSAPAEFAQ
A780	HSGSFLSAPAEFAQE
A785	LSAPAEFAQENKAPF
S799-p	FEAVKRFsLDERSLA
K1194	GRSEEPLKAEGSASN
A1195	RSEEPLKAEGSASNS
G1197	EEPLKAEGSASNSNS
S1198	EPLKAEGSASNSNSE
S1200	LKAEGSASNSNSELK
K1250	SLRSVLNKESHsPFG
S1252	RSVLNKESHsPFGLD
S1254-p	VLNKESHsPFGLDSF
S1260	HsPFGLDSFNSTAKV
K1266	DSFNSTAKVsPLtPk
S1268-p	FNSTAKVsPLtPkLF
T1271-p	TAKVsPLtPkLFNSL
K1273-u	KVsPLtPkLFNSLLL
S1277	LtPkLFNSLLLGPTA
K1288-u	GPTASNSkTEGSSLR
S1300	SLRDLLHSGPGKLPQ
K1304	LLHSGPGKLPQTPLD
T1308	GPGKLPQTPLDTGIP
T1312	LPQTPLDTGIPFPPV
K1328	SSSSAVAKSKASLPD
K1330	SSAVAKSKASLPDFL
S1332	AVAKSKASLPDFLDH
K1348	IASVVENKKTSDPSK
K1517	LPLPEYTKRDGRLNL
K1601	GDADEVTKQRIHDGK
K1753	KDAVGTLKAHESKLA

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