a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Oxidoreductase; Demethylase
Cellular Component: nucleolus; nucleus
Molecular Function: dioxygenase activity; metal ion binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.